Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Possemato, Richard; Marks, Kevin M.; Shaul, Yoav D.; Pacold, Michael E.; Kim, Dohoon; Birsoy, Kivanc; Sethumadhavan, Shalini; Woo, Hin-Koon; Jang, Hyun G.; Jha, Abhishek K.; Chen, Walter W.; Barrett, Francesca G.; Stransky, Nicolas; Tsun, Zhi-Yang; Cowley, Glenn S.; Barretina, Jordi; Kalaany, Nada Y.; Hsu, Peggy P.; Ottina, Kathleen; Chan, Albert M.; Yuan, Bingbing B.; Garraway, Levi A.; Root, David E.; Mino-Kenudson, Mari; Brachtel, Elena F.; Driggers, Edward M.; Sabatini, David M. (Nature Publishing Group, 2011-08)
    Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation[superscript 1, 2]. RNA interference (RNAi)-based loss-of-function screening has proven powerful for ...
  • Langs, Georg; Golland, Polina; Tie, Yanmei; Rigolo, Laura; Golby, Alexandra J. (2010-12)
    Matching functional brain regions across individuals is a challenging task, largely due to the variability in their location and extent. It is particularly difficult, but highly relevant, for patients with pathologies such ...
  • Swager, Timothy M.; Sydlik, Stefanie Arlene (Wiley Blackwell, 2012-11)
    Current research in materials has devoted much attention to graphene, with a considerable amount of the chemical manipulation going through the oxidized state of the material, known as graphene oxide (GO). In this report, ...
  • Gupta, Piyush; Rudnick, Jenny A.; Arendt, Lisa M.; Klebba, Ina; Hinds, John W.; Iyer, Vandana; Naber, Stephen P.; Kuperwasser, Charlotte (Public Library of Science, 2011-09)
    Fibroblasts are important in orchestrating various functions necessary for maintaining normal tissue homeostasis as well as promoting malignant tumor growth. Significant evidence indicates that fibroblasts are functionally ...
  • Bric, Anka; Miething, Cornelius; Bialucha, Carl Uli; Scuoppo, Claudio; Zender, Lars; Krasnitz, Alexander; Xuan, Zhenyu; Zuber, Johannes; Wigler, Michael; Hicks, James; McCombie, Richard W.; Hemann, Michael; Hannon, Gregory J.; Powers, Scott; Lowe, Scott W. (Elsevier, 2009-10)
    Short hairpin RNAs (shRNAs) capable of stably suppressing gene function by RNA interference (RNAi) can mimic tumor-suppressor-gene loss in mice. By selecting for shRNAs capable of accelerating lymphomagenesis in a ...
  • Choi, WooJhon; Baumann, Bernhard; Clermont, Allen C.; Feener, Edward P.; Boas, David A.; Fujimoto, James G. (SPIE, 2013-03)
    Measuring retinal hemodynamics in response to flicker stimulus is important for investigating pathophysiology in small animal models of diabetic retinopathy, because a reduction in the hyperemic response is thought to be ...
  • Kim, Jongpil; Su, Susan C.; Wang, Haoyi; Cheng, Albert W.; Cassady, John P.; Lodato, Michael A.; Lengner, Christopher J.; Chung, Chee-Yeun; Dawlaty, Meelad M.; Tsai, Li-Huei; Jaenisch, Rudolf; Su, Susan C.; Cheng, Albert W.; Cassady, John P.; Lodato, Michael A. (Elsevier, 2011-10)
    Recent advances in somatic cell reprogramming have highlighted the plasticity of the somatic epigenome, particularly through demonstrations of direct lineage reprogramming of one somatic cell type to another by defined ...
  • Van Dyke, Aaron R.; Jamison, Timothy F. (Wiley Blackwell, 2009-05)
    Extension ladder: The successful application of epoxide-opening strategies towards the synthesis of ladder-type polyethers is contingent upon further elaboration of the product. By employing two different functionalized ...
  • Shulman, J. M.; Parrado, A.; Lindhagen-Persson, M.; Reiman, E. M.; Evans, D. A.; Bennett, D. A.; Olofsson, A.; DeJager, P. L.; Tanzi, R. E.; Caldwell, K. A.; Caldwell, G. A.; Lindquist, S.; Treusch, Sebastian; Hamamichi, Shusei; Goodman, Jessica L.; Matlack, Kent E. S.; Chung, Chee Yeun; Baru, Valeriya; Valastyan, Julie Suzanne; Han, Haesun; Lindquist, Susan; Bevis, Brooke J. (American Association for the Advancement of Science (AAAS), 2011-10)
    Aβ (beta-amyloid peptide) is an important contributor to Alzheimer’s disease (AD). We modeled Aβ toxicity in yeast by directing the peptide to the secretory pathway. A genome-wide screen for toxicity modifiers identified ...
  • Lang, Matthew J.; Appleyard, David C. (Institute of Electrical and Electronics Engineers, 2009-08)
    We present a parts perspective using biological components to form complex systems and discuss: connectivity, network formation, and motility. Challenges associated with characterization and assembly are discussed relative ...
  • Caterson, Stephanie A.; Fox, Sharon E.; Tobias, Adam M.; Lee, Bernard T. (Public Library of Science, 2012-11)
    Background: Breast reconstruction is associated with high levels of patient satisfaction. Previous patient satisfaction studies have been subjective. This study utilizes functional magnetic resonance imaging (fMRI) to ...
  • Hashmi, Javeria Ali; Kong, Jian; Spaeth, Rosa; Khan, Sheraz; Kaptchuk, Ted J.; Gollub, Randy L. (Society for Neuroscience, 2014-03)
    Placebo analgesia is an indicator of how efficiently the brain translates psychological signals conveyed by a treatment procedure into pain relief. It has been demonstrated that functional connectivity between distributed ...
  • Wang, Fa; Lee, Dung-Hai; Wang, Qiang-Hua; Wang, Wan-Sheng; Xiang, Yuan-Yuan; Yang, Fan (American Physical Society, 2012-01)
    We study the electronic instabilities of near 1/4 electron doped graphene using the singular-mode functional renormalization group, with a self-adaptive k mesh to improve the treatment of the van Hove singularities, and ...
  • Habib, Naomi; Wapinski, Ilan; Margalit, Hanah; Regev, Aviv; Friedman, Nir (Nature Publishing Group, 2012-10)
    Evolutionary rewiring of regulatory networks is an important source of diversity among species. Previous evidence suggested substantial divergence of regulatory networks across species. However, systematically assessing ...
  • Boyle, Elette; Goldwasser, Shafi; Ivan, Ioana (Springer-Verlag Berlin Heidelberg, 2014)
    We introduce two new cryptographic primitives: functional digital signatures and functional pseudorandom functions. In a functional signature scheme, in addition to a master signing key that can be used to sign any ...
  • Torres, Alexis J.; Contento, Rita Lucia; Gordo, Susana; Wucherpfennig, Kai W.; Love, J. Christopher (Royal Society of Chemistry, 2012-09)
    Supported lipid bilayers are an important biomolecular tool for characterizing immunological synapses. Immobilized bilayers presenting tethered ligands on planar substrates have yielded both spatio-temporal and structural ...
  • Fedorenko, Evelina G.; Behr, Michael K.; Kanwisher, Nancy (National Academy of Sciences (U.S.), 2011-09)
    Neuroscientists have debated for centuries whether some regions of the human brain are selectively engaged in specific high-level mental functions or whether, instead, cognition is implemented in multifunctional brain ...
  • Kanwisher, Nancy (National Academy of Sciences (U.S.), 2010-06)
    Is the human mind/brain composed of a set of highly specialized components, each carrying out a specific aspect of human cognition, or is it more of a general-purpose device, in which each component participates in a wide ...
  • Sabuncu, Mert R.; Singer, Benjamin D.; Conroy, Bryan,; Bryan, Ronald E.; Ramadge, Peter J.; Haxby, James V. (Oxford University Press, 2009-05)
    Making conclusions about the functional neuroanatomical organization of the human brain requires methods for relating the functional anatomy of an individual's brain to population variability. We have developed a method ...
  • Rago, Florencia; Cheeseman, Iain McPherson (Rockefeller University Press, The, 2013-03)
    Chromosome segregation requires the generation of force at the kinetochore—the multiprotein structure that facilitates attachment of chromosomes to spindle microtubules. This force is required both to move chromosomes and ...
Open Access