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Browsing MIT Open Access Articles by Title

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  • Shriver, Zachary H.; Capila, Ishan; Venkataraman, Ganesh; Sasisekharan, Ram (Springer-Verlag Berlin Heidelberg, 2012)
    The structural microheterogeneity of heparin and heparan sulfate is one of the major reasons for the multifunctionality exhibited by this class of molecules. In a physiological context, these molecules primarily exert their ...
  • Prince, Robin N.; Schreiter, Eric R.; Zou, Peng; Wiley, H. Steven; Ting, Alice Y.; Lee, Richard T.; Lauffenburger, Douglas A. (Company of Biologists, The, 2010-06)
    Heparin-binding EGF-like growth factor (HB-EGF) is a ligand for EGF receptor (EGFR) and possesses the ability to signal in juxtacrine, autocrine and/or paracrine mode, with these alternatives being governed by the degree ...
  • Shriver, Zachary H.; Sasisekharan, Ram (Nature Publishing Group, 2013-07)
    Heparin is an anionic polysaccharide that has tremendous clinical importance as an anticoagulant. Several dyes have been developed that can detect heparin, and the latest example — named Mallard Blue — has now been shown ...
  • Narmada, Balakrishnan Chakrapani; Kang, Yuzhan; Venkatraman, Lakshmi; Peng, Qiwen; Sakban, Rashidah Binte; Nugraha, Bramasta; Jiang, Xuan; Bunte, Ralph M.; So, Peter T.C.; Tucker-Kellogg, Lisa; Mao, Hai-Quan; Yu, Hanry; So, Peter T. C. (Mary Ann Liebert, 2013-03)
    Liver fibrosis generates fibrotic foci with abundant activated hepatic stellate cells and excessive collagen deposition juxtaposed with healthy regions. Targeted delivery of antifibrotic therapeutics to hepatic stellate ...
  • Bandyopadhyay, Sarmistha; Friedman, Robin Carl; Marquez, Rebecca T.; Keck, Kathy; Kong, Benjamin; Icardi, Michael S.; Brown, Kyle E.; Burge, Christopher B.; Schmidt, Warren N.; Wang, Yulei; McCaffrey, Anton P. (Oxford University Press, 2011-01)
    Background. Chronic hepatitis C virus (HCV)–induced liver fibrosis involves upregulation of transforming growth factor (TGF)–β and subsequent hepatic stellate cell (HSC) activation. MicroRNAs (miRNAs) regulate HCV infection ...
  • Huang, Tao; Wang, Junjie; Cai, Yu-Dong; Yu, Hanry; Chou, Kuo-Chen (Public Library of Science, 2012-04)
    Hepatitis C virus (HCV) is a main risk factor for liver cirrhosis and hepatocellular carcinoma, particularly to those patients with chronic liver disease or injury. The similar etiology leads to a high correlation of the ...
  • Kinsy, Michel A.; Pellauer, Michael; Devadas, Srinivas (Association for Computing Machinery (ACM), 2013-02)
    This paper presents Heracles, an open-source, functional, parameterized, synthesizable multicore system toolkit. Such a multi/many-core design platform is a powerful and versatile research and teaching tool for architectural ...
  • Tanji, Haruka; Simon, Jonathan; Ghosh, Saikat; Bloom, Benjamin; Vuletic, Vladan (Royal Swedish Academy of Sciences, 2009-07)
    We describe the mapping of quantum states between single photons and an atomic ensemble. In particular, we demonstrate a heralded quantum memory based on the mapping of a photon polarization state onto a single collective-spin ...
  • Simon, Jonathan; Ghosh, Saikat; Vuletic, Vladan; Bloom, Benjamin; Tanji, Haruka (American Physical Society, 2009-07)
    We demonstrate a heralded quantum memory where a photon announces the mapping of a light polarization state onto a single collective-spin excitation (magnon) shared between two atomic ensembles. The magnon can be converted ...
  • Ofer, Oren; Keren, Amit; Brewer, Jess H.; Han, Tianheng; Lee, Young S. (IOP Publishing, 2011-04)
    We present transverse field muon spin rotation/relaxation measurements on single crystals of the spin-1/2 kagome antiferromagnet Herbertsmithite. We find that the spins are more easily polarized when the field is perpendicular ...
  • Cesarini, David Alexander; Johannesson, Magnus; Lichtenstein, Paul; Wallance, Bjorn (MIT Press, 2009-04)
    Empirical evidence suggests that people on average overestimate their own ability in a variety of circumstances. Little is known, however, about the origins of such overconfidence. To shed some light on this issue, we use ...
  • Zhu, Qi; Song, Yiying; Hu, Siyuan; Li, Xiaobai; Tian, Moqian; Zhen, Zonglei; Dong, Qi; Kanwisher, Nancy; Liu, Jia (Elsevier Ltd., 2010-01)
    What makes one person socially insightful but mathematically challenged, and another musically gifted yet devoid of a sense of direction? Individual differences in general cognitive ability are thought to be mediated by ...
  • Lindquist, Susan; Brown, Jessica C.S. (Cold Spring Harbor Laboratory Press, 2009-10)
    Several well-characterized fungal proteins act as prions, proteins capable of multiple conformations, each with different activities, at least one of which is self-propagating. Through such self-propagating changes in ...
  • Lindquist, Susan; Saibil, Helen R.; Seybert, Anja; Habermann, Anja; Winkler, Juliane; Eltsov, Mikhail; Perkovic, Mario; Castano-Diez, Daniel (National Academy of Sciences (U.S.), 2012-08)
    Yeast prions constitute a “protein-only” mechanism of inheritance that is widely deployed by wild yeast to create diverse phenotypes. One of the best-characterized prions, [PSI+], is governed by a conformational change in ...
  • Koutsoyiannis, D.; Makropoulos, C.; Langousis, Andreas; Baki, S.; Efstratiadis, A.; Christofides, A.; Karavokiros, G.; Mamassis, N. (European Geosciences Union / Copernicus, 2009-02)
    Since 1990 extensive funds have been spent on research in climate change. Although Earth Sciences, including climatology and hydrology, have benefited significantly, progress has proved incommensurate with the effort and ...
  • Jones, Kevin C.; Ganim, Ziad; Tokmakoff, Andrei (American Chemical Society, 2009-11)
    We develop heterodyned dispersed vibrational echo spectroscopy (HDVE) and demonstrate the new capabilities in biophysical applications. HDVE is a robust ultrafast technique that provides a characterization of the real and ...
  • Ren, Y.; Gao, J. R.; Hovenier, J. N.; Higgins, R.; Zhang, W.; Bell, A.; Klein, B.; Klapwijk, T. M.; Shi, S. C.; Kao, Tsung-Yu; Kumar, S.; Hu, Qing; Reno, J. L. (SPIE, 2010-07)
    High-resolution heterodyne spectrometers operating at above 2 THz are crucial for detecting, e.g., the HD line at 2.7 THz and oxygen OI line at 4.7 THz in astronomy. The potential receiver technology is a combination of a ...
  • Yao, Huajian; van der Hilst, Robert D.; Montagner, Jean-Paul (American Geophysical Union, 2010-12)
    Understanding the geotectonic evolution of the southeastern Tibetan plateau requires knowledge about the structure of the lithosphere. Using data from 77 broadband stations in SW China, we invert Rayleigh wave phase velocity ...
  • Ryan, Stephen; Tucker, Catherine Elizabeth (Springer-Verlag, 2011-08)
    We estimate the demand for a videocalling technology in the presence of both network effects and heterogeneity. Using a unique dataset from a large multinational firm, we pose and estimate a fully dynamic model of technology ...
  • Abaluck, Jason; Gruber, Jonathan (American Economic Association, 2011-05)
    This paper investigates the degree to which choice inconsistencies documented in the context of Medicare Part D plan choice vary across consumers and geographic regions. Our main finding is that there is surprisingly little ...
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