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Browsing MIT Open Access Articles by Title

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  • Chesler, Paul M.; Lekaveckas, Mindaugas; Rajagopal, Krishna (Springer-Verlag, 2013-10)
    We compute and study the drag force acting on a heavy quark propagating through the matter produced in the collision of two sheets of energy in a strongly coupled gauge theory that can be analyzed holographically. Although ...
  • Lusztig, George; Vogan, David A. (Institute of Mathematics, Academia Sinica, )
    0.1. LetW be aWeyl group with standard set of generators S; let ≤ be the Bruhat order on W. In [KL1],[KL2], certain polynomials ... N, u is an indeterminate) were defined and computed in terms of an algorithm for any y ...
  • Beatty, Anne; Petacchi, Reining; Zhang, Haiwen (Springer-Verlag, 2012-06)
    We provide large sample evidence that credible hedge commitments reduce the agency costs of debt and that accounting conservatism enhances hedge commitments. We examine 2,338 bank loans entered into by 263 mandatory ...
  • Bell, Stephen P.; Kaguni, Jon M. (Cold Spring Harbor Laboratory Press, 2013-04)
    Loading of the replicative DNA helicase at origins of replication is of central importance in DNA replication. As the first of the replication fork proteins assemble at chromosomal origins of replication, the loaded helicase ...
  • Larkoski, A. J.; Lopez-Villarejo, J. J.; Skands, P. (American Physical Society, 2013-03)
    We present an antenna shower formalism that includes helicity dependence for massless partons. The formalism applies to both traditional (global) showers and sector-based variants. We combine the shower with vincia’s ...
  • Fox, James G.; Ge, Zhongming; Whary, Mark T.; Erdman, Susan E.; Horwitz, B. H. (Nature Publishing Group, 2010-10)
    Pioneering work in the 1990s first linked a novel microaerobic bacterium, Helicobacter hepaticus, with chronic active hepatitis and inflammatory bowel disease in several murine models. Targeted H. hepaticus infection ...
  • Beisele, Maike; Shen, Zeli; Parry, Nicola Maria Anne; Mobley, Melissa; Taylor, Nancy S.; Buckley, Ellen Marie; Abedin, Mohammad Z.; Dewhirst, Floyd E.; Fox, James G. (Society for General Microbiology, 2011-05)
    Prairie dogs (Cynomys ludovicianus) are used to study the aetiology and prevention of gallstones because of the similarities of prairie dog and human bile gallstone composition. Epidemiological and experimental studies ...
  • Buti, Ludovico; Spooner, Eric; Van der Veen, Annemarthe G.; Rappuoli, Rino; Covacci, Antonello; Ploegh, Hidde (National Academy of Sciences, 2011-05)
    Type I strains of Helicobacter pylori (Hp) possess a pathogenicity island, cag, that encodes the effector protein cytotoxin-associated gene A (CagA) and a type four secretion system. After translocation into the host cell, ...
  • So, Peter T. C.; Bansil, Rama; Erramilli, Shyamsunder; McKinley, Gareth H.; Ewoldt, Randy H.; Kelly, Ciaran P.; Ghiran, Ionita; Keates, Sarah; Afdhal, Nezam H.; Turner, Bradley S.; Celli, Jonathan P. (United States National Academy of Sciences, 2009-08)
    The ulcer-causing gastric pathogen Helicobacter pylori is the only bacterium known to colonize the harsh acidic environment of the human stomach. H. pylori survives in acidic conditions by producing urease, which catalyzes ...
  • Oelker, Abigail M.; Morey, Shannon M.; Griffith, Linda G.; Hammond, Paula T. (Royal Society of Chemistry, 2012-09)
    As a platform for investigating the individual effects of substrate stiffness, permeability, and ligand density on cellular behavior, we developed a set of hydrogels with stiffness tuned by polymer backbone rigidity, ...
  • Agrawal, Kunal; Leiserson, Charles E.; Sukha, Jim (Association for Computing Machinery / ACM Special Interest Group on Programming Languages., 2010-01)
    Helper locks allow programs with large parallel critical sections, called parallel regions, to execute more efficiently by enlisting processors that might otherwise be waiting on the helper lock to aid in the execution ...
  • Ullman, Tomer David; Tenenbaum, Joshua B.; Baker, Christopher Lawrence; Macindoe, Owen; Evans, Owain Rhys; Goodman, Noah D. (Neural Information Processing Systems Foundation, 2009-12)
    Everyday social interactions are heavily influenced by our snap judgments about others’ goals. Even young infants can infer the goals of intentional agents from observing how they interact with objects and other agents ...
  • Hensley, Scott E.; Das, Suman R.; Bailey, Adam L.; Schmidt, Loren M.; Hickman, Heather D.; Bennink, Jack R.; Yewdell, Jonathan W.; Jayaraman, Akila; Viswanathan, Karthik; Raman, Rahul; Sasisekharan, Ram (American Association for the Advancement of Science, 2009-10)
    Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza vaccine. Neutralizing ...
  • Mukaigawa, Yasuhiro; Tagawa, Seiichi; Kim, Jaewon; Raskar, Ramesh; Matsushita, Yasuyuki; Yagi, Yasushi (Springer, 2010-11)
    We propose a new imaging method called hemispherical confocal imaging to clearly visualize a particular depth in a 3-D scene. The key optical component is a turtleback reflector which is a specially designed polyhedral ...
  • Weinberg, Eli J.; Mack, Peter J.; Shoen, Frederick J.; García-Cardeña, Guillermo; Kaazempur Mofrad, Mohammad R. (Springer Science + Business Media B.V., 2010-01)
    The regulation of valvular endothelial phenotypes by the hemodynamic environments of the human aortic valve is poorly understood. The nodular lesions of calcific aortic stenosis (CAS) develop predominantly beneath the ...
  • Giantsos-Adams, Kristina M.; Koo, Andrew Jia-An; Song, Sukhyun; Sakai, Jiro; Sankaran, Jagadish; Shin, Jennifer H.; Garcia-Cardena, Guillermo; Dewey, C. Forbes (Springer-Verlag, 2013-02)
    The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone regions of the circulation ...
  • Shriver, Zachary H.; Capila, Ishan; Venkataraman, Ganesh; Sasisekharan, Ram (Springer-Verlag Berlin Heidelberg, 2012)
    The structural microheterogeneity of heparin and heparan sulfate is one of the major reasons for the multifunctionality exhibited by this class of molecules. In a physiological context, these molecules primarily exert their ...
  • Prince, Robin N.; Schreiter, Eric R.; Zou, Peng; Wiley, H. Steven; Ting, Alice Y.; Lee, Richard T.; Lauffenburger, Douglas A. (Company of Biologists, The, 2010-06)
    Heparin-binding EGF-like growth factor (HB-EGF) is a ligand for EGF receptor (EGFR) and possesses the ability to signal in juxtacrine, autocrine and/or paracrine mode, with these alternatives being governed by the degree ...
  • Shriver, Zachary H.; Sasisekharan, Ram (Nature Publishing Group, 2013-07)
    Heparin is an anionic polysaccharide that has tremendous clinical importance as an anticoagulant. Several dyes have been developed that can detect heparin, and the latest example — named Mallard Blue — has now been shown ...
  • Narmada, Balakrishnan Chakrapani; Kang, Yuzhan; Venkatraman, Lakshmi; Peng, Qiwen; Sakban, Rashidah Binte; Nugraha, Bramasta; Jiang, Xuan; Bunte, Ralph M.; So, Peter T.C.; Tucker-Kellogg, Lisa; Mao, Hai-Quan; Yu, Hanry; So, Peter T. C. (Mary Ann Liebert, 2013-03)
    Liver fibrosis generates fibrotic foci with abundant activated hepatic stellate cells and excessive collagen deposition juxtaposed with healthy regions. Targeted delivery of antifibrotic therapeutics to hepatic stellate ...
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