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Browsing MIT Open Access Articles by Title

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  • Pardo-Martin, Carlos; Chang, Tsung-Yao; Koo, Bryan Kyo; Gilleland, Cody Lee; Wasserman, Steven Charles; Yanik, Mehmet Fatih (Nature Publishing Group, 2010-07)
    We demonstrate a high-throughput platform for cellular-resolution in vivo chemical and genetic screens on zebrafish larvae. The system automatically loads zebrafish from reservoirs or multiwell plates, and positions and ...
  • Xu, Feng; Beyazoglu, Turker; Emre, Ahmet E.; Hefner, Evan; Manzur, Tariq; Demirci, Utkan; Moon, SangJun (Society of Photo-optical Instrumentation Engineers, 2010-04)
    Cell-based biosensors (CBBs) have important applications in biosecurity and rapid diagnostics. Current CBB technologies have challenges including cell immobilization on the sensors, high throughput fabrication and portability, ...
  • Kothapalli, Chandrasekhar R.; Van Veen, Ed; de Valence, Sarra; Chung, Seok; Zervantonakis, Ioannis; Gertler, Frank; Kamm, Roger Dale (Royal Society of Chemistry, 2010-11)
    Studying neurite guidance by diffusible or substrate bound gradients is challenging with current techniques. In this study, we present the design, fabrication and utility of a microfluidic device to study neurite guidance ...
  • Rohde, Christopher Benjamin; Gilleland, Cody Lee; Samara, Chrysanthi; Yanik, Mehmet Fatih (SPIE, 2010-02)
    Therapeutic treatment of spinal cord injuries, brain trauma, stroke, and neurodegenerative diseases will greatly benefit from the discovery of compounds that enhance neuronal regeneration following injury. We previously ...
  • Chen, Chia-Hung; Miller, Miles Aaron; Sarkar, Aniruddh; Beste, Michael T.; Lauffenburger, Douglas A.; Griffith, Linda G.; Han, Jongyoon (2012-10)
    In this study, we integrated several components, including a droplet generator, a pico-injector, and an analytical inference technique, Proteolytic Activity Matrix Analysis (PrAMA), to create a platform for assessing ...
  • Samara, Chrysanthi; Gilleland, Cody Lee; Zeng, Fei; Rohde, Christopher Benjamin; Yanik, Mehmet Fatih (Society of Photo-optical Instrumentation Engineers, 2009-02)
    In recent years, the advantages of using small invertebrate animals as model systems for human disease have become increasingly apparent and have resulted in three Nobel Prizes in medicine or chemistry during the last six ...
  • Cox, David D.; Pinto, Nicolas; Doukhan, David; DiCarlo, James (Public Library of Science, 2009-11)
    While many models of biological object recognition share a common set of ‘‘broad-stroke’’ properties, the performance of any one model depends strongly on the choice of parameters in a particular instantiation of that ...
  • Pinto, Nicolas; Doukhan, David; DiCarlo, James; Cox, David D. (Public Library of Science, 2009-11)
    While many models of biological object recognition share a common set of “broad-stroke” properties, the performance of any one model depends strongly on the choice of parameters in a particular instantiation of that ...
  • Armiento, R.; Kozinsky, B.; Hautier, G.; Fornari, M.; Ceder, Gerbrand (American Physical Society, 2014-04)
    We screen a large chemical space of perovskite alloys for systems with optimal properties to accommodate a morphotropic phase boundary (MPB) in their composition-temperature phase diagram, a crucial feature for high ...
  • Steinmeyer, Joseph Daly; Yanik, Mehmet Fatih (Public Library of Science, 2012-04)
    The complexity of neurons and neuronal circuits in brain tissue requires the genetic manipulation, labeling, and tracking of single cells. However, current methods for manipulating cells in brain tissue are limited to ...
  • Kim, Daekeun; So, Peter T. C. (Society of Photo-optical Instrumentation Engineers, 2010-02)
    Two-photon excitation microfabrication has been shown to be useful in the field of photonics and biomedicine. It generates 3D microstructures and provides sub-diffraction fabrication resolution. Nevertheless, laser direct ...
  • Alver, Burak Han; Ballintijn, Maarten; Busza, Wit; Decowski, Michael P.; Gulbrandsen, K.; Henderson, C.; Kane, J. L.; Kulinich, Piotr; Li, Wei; Loizides, Constantin; Reed, C.; Roland, Christof E.; Roland, Gunther M.; Stephans, George S. F.; Vale, C.; van Nieuwenhuizen, Gerrit Jan; Vaurynovich, Siarhei S.; Verdier, Robin; Veres, Gabor; Wenger, Edward Allen; Wyslouch, Boleslaw (American Physical Society, 2010-02)
    A measurement of two-particle correlations with a high transverse momentum trigger particle (p[subscript T][superscript trig]>2.5  GeV/c) is presented for Au+Au collisions at √sNN=200   GeV over the uniquely broad ...
  • Speck, Jared R.; Strain, Robert M. (Springer-Verlag, 2011-02)
    We study the local-in-time hydrodynamic limit of the relativistic Boltzmann equation using a Hilbert expansion. More specifically, we prove the existence of local solutions to the relativistic Boltzmann equation that are ...
  • Abbott, Timothy G.; Abel, Zachary Ryan; Charlton, David; Demaine, Erik D.; Demaine, Martin L.; Kominers, Scott Duke (Springer-Verlag, 2012-01)
    We prove that any finite collection of polygons of equal area has a common hinged dissection. That is, for any such collection of polygons there exists a chain of polygons hinged at vertices that can be folded in the ...
  • Tonegawa, Susumu; Nakashiba, Toshiaki; Buhl, Derek L.; McHugh, Thomas J. (Cell Press, 2009-06)
    A widely held memory consolidation theory posits that memory of events and space is initially stored in the hippocampus (HPC) in a time-limited manner and is consolidated in the neocortex for permanent storage. Although ...
  • Kitamura, Takashi; Okubo-suzuki, Reiko; Takashima, Noriko; Murayama, Akiko; Hino, Toshiaki; Nishizono, Hirofumi; Kida, Satoshi; Inokuchi, Kaoru (BioMed Central Ltd, 2012-02)
    Background: During permanent memory formation, recall of acquired place memories initially depends on the hippocampus and eventually become hippocampus-independent with time. It has been suggested that the quality of ...
  • Neve, Rachael L.; Xia, Yan; Portugal, George S.; Fakira, Amanda K.; Melyan, Zara; Lee, H. Thomas; Russo, Scott J.; Liu, Jie; Morón, Jose A. (Society for Neuroscience, 2011-11)
    Glutamatergic systems, including AMPA receptors (AMPARs), are involved in opiate-induced neuronal and behavioral plasticity, although the mechanisms underlying these effects are not fully understood. In the present study, ...
  • Lamar, John Michael; Stern, Patrick; Liu, Hui; Schindler, Jeffrey W.; Jiang, Zhigang; Hynes, Richard O. (National Academy of Sciences (U.S.), 2012-09)
    The transcriptional coactivator Yes-associated protein (YAP) is a major regulator of organ size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue types if its activity is increased ...
  • Yang, Linfeng; Zhang, Jing; Ho, Bow; Ding, Jeak Ling (Public Library of Science, 2011-05)
    Background: M-ficolin, a pathogen recognition molecule in the innate immune system, binds sugar residues including N-acetyl-D-glucosamine (GlcNAc), which is displayed on invading microbes and on apoptotic cells. The cis ...
  • Vu, Quang Hieu; Ooi, Beng Chin; Rinard, Martin C.; Tan, Kian-Lee (Institute of Electrical and Electronics Engineers, 2009-04)
    Over the past few years, peer-to-peer (P2P) systems have rapidly grown in popularity and have become a dominant means for sharing resources. In these systems, load balancing is a key challenge because nodes are often ...
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