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Browsing MIT Open Access Articles by Title

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  • Ploegh, Hidde; Yuan, Bingbing B.; Carette, Jan E.; Guimaraes, Carla P.; Wuethrich, Irene; Blomen, Vincent A.; Varadarajan, Malini; Sun, Chong; Bell, George W.; Muellner, Markus K.; Nijman, Sebastian M.; Brummelkamp, Thijn R. (Nature Publishing Group, 2011-05)
    Insertional mutagenesis in a haploid background can disrupt gene function[superscript 1]. We extend our earlier work by using a retroviral gene-trap vector to generate insertions in >98% of the genes expressed in a human ...
  • Wunsch, Carl; Heimbach, Patrick; Ponte, Rui M.; Fukumori, Ichiro; ECCO-GODAE Consortium (Oceanography Society (Virginia Beach, Va.), 2009-06)
    Following on the heels of the World Ocean Circulation Experiment, the Estimating the Circulation and Climate of the Ocean (ECCO) consortium has been directed at making the best possible estimates of ocean circulation ...
  • Selin, Noelle Eckley; Wu, S.; Nam, Kyung-min; Reilly, J. M.; Paltsev, Sergey; Prinn, Ronald G.; Webster, Mort David (Institute of Physics Publishing, 2009-12)
    We assess the human health and economic impacts of projected 2000–2050 changes in ozone pollution using the MIT Emissions Prediction and Policy Analysis - Health Effects (EPPA-HE) model, in combination with results from ...
  • Caballero, Ricardo J.; Krishnamurthy, Arvind (American Economic Association, 2009-05)
    The United States is currently engulfed in the most severe financial crisis since the Great Depression. The crisis was triggered by the crash in the real estate “bubble” and amplified by the extreme concentration of ...
  • Lohmeyer, Whitney Quinne; Dwyer, Morgan Maeve; Gettliffe, Gwendolyn Vines; Marinan, Anne D.; Stockham, Erik; Weigel, Annalisa L.; Cahoy, Kerri; Alibay, Farah (International Astronautical Federation, 2012-10)
    Under the United States Arms Export Control Act, the International Traffic in Arms Regulations (ITAR) control the export of technologies that are specified as defense articles on the United States Munitions List (USML). ...
  • Mazlish, Bruce (Berkeley Electronic Press, 2009-11)
    Globalism and globalization have been seen as competitors to other allegiances, namely regionalism and nationalism. A look at recent efforts at reconceptualizing global history in China, Korea and the U.S., however, suggests ...
  • Koldewyn, Kami; Jiang, Yuhong V.; Weigelt, Sarah; Kanwisher, Nancy (Springer-Verlag, 2013-02)
    It is widely suggested that ASD is characterized by atypical local/global processing, but the published findings are contradictory. In an effort to resolve this question, we tested a large group of children on both a ...
  • Chen, Sidi; Xue, Yuan; Wu, Xuebing; Le, Cong; Bhutkar, Arjun; Bell, Eric L.; Zhang, Feng; Langer, Robert; Sharp, Phillip A.; Wu, Xuebing (Cold Spring Harbor Laboratory Press, 2014-05)
    MicroRNAs delicately regulate the balance of angiogenesis. Here we show that depletion of all microRNAs suppresses tumor angiogenesis. We generated microRNA-deficient tumors by knocking out Dicer1. These tumors are highly ...
  • Chen, Harr; Branavan, Satchuthanan R.; Barzilay, Regina; Karger, David R. (Association for Computational Linguistics, 2009-06)
    We present a novel Bayesian topic model for learning discourse-level document structure. Our model leverages insights from discourse theory to constrain latent topic assignments in a way that reflects the underlying ...
  • Britter, Rex E.; Waitz, Ian A.; Barrett, Steven (American Chemical Society (ACS), 2010-10)
    Aircraft emissions impact human health though degradation of air quality. The majority of previous analyses of air quality impacts from aviation have considered only landing and takeoff emissions. We show that aircraft ...
  • Poliannikov, Oleg V.; Zhizhina, Elena; Krim, Hamid (Institute of Electrical and Electronics Engineers, 2010-12)
    In this paper, we study a diffusion stochastic dynamics with a general diffusion coefficient. The main result is that adapting the diffusion coefficient to the Hamiltonian allows to escape local wide minima and to speed ...
  • Ghebrebrhan, Michael; Bermel, Peter; Joannopoulos, John D.; Johnson, Steven G.; Avniel, Yehuda B. (Optical Society of America, 2009-04)
    The front-coating (FC) of a solar cell controls its efficiency, determining admission of light into the absorbing material and potentially trapping light to enhance thin absorbers. Single-layer FC designs are well known, ...
  • Surussavadee, Chinnawat; Staelin, David H. (Institute of Electrical and Electronics Engineers (IEEE), 2010-07)
    This paper presents and evaluates a global precipitation retrieval algorithm for the Special Sensor Microwave Imager/Sounder (SSMIS). It is based on those developed earlier for the Advanced Microwave Sounding Unit (AMSU) ...
  • Surussavadee, Chinnawat; Staelin, David H. (American Meteorological Society, 2010-01)
    A surface-precipitation-rate retrieval algorithm for 13-channel Advanced Microwave Sounding Unit (AMSU) millimeter-wave spectral observations from 23 to 191 GHz is described. It was trained using cloud-resolving fifth-generation ...
  • Bland, Christopher S.; Wang, Eric T.; Vu, Anthony; David, Marjorie P.; Castle, John C.; Johnson, Jason M.; Burge, Christopher B.; Cooper, Thomas A. (Oxford University Press, 2010-07)
    Recent genome-wide analyses have elucidated the extent of alternative splicing (AS) in mammals, often focusing on comparisons of splice isoforms between differentiated tissues. However, regulated splicing changes are likely ...
  • Levin, Alexander; Lis, Mieszko; Ponty, Yann; O’Donnell, Charles W.; Devadas, Srinivas; Berger, Bonnie; Waldispuhl, Jerome (Oxford University Press, 2012-08)
    The development of algorithms for designing artificial RNA sequences that fold into specific secondary structures has many potential biomedical and synthetic biology applications. To date, this problem remains computationally ...
  • Costinot, Arnaud; Wang, Su; Vogel, Jonathan (American Economic Association, 2012-05)
    A salient feature of globalization in recent decades is the emergence of "global supply chains" in which different countries specialize in different stages of a sequential production process. In Costinot, Vogel and Wang ...
  • Wibawa, M. S.; Dahl, J. M.; Rival, D. E.; Steele, Stephanie C.; Weymouth, Gabriel D.; Triantafyllou, Michael S. (Cambridge University Press, 2012-02)
    If a moving body were made to vanish within a fluid, its boundary-layer vorticity would be released into the fluid at all locations simultaneously, a phenomenon we call global vorticity shedding. We approximate this process ...
  • Emanuel, Kerry Andrew (American Meteorological Society, 2011-10)
    While many studies of the effects of global warming on hurricanes predict an increase in various metrics of Atlantic basin-wide activity, it is less clear that this signal will emerge from background noise in measures of ...
  • Wunsch, Carl; Heimbach, Patrick (American Meteorological Society, 2009-08)
    The zonally integrated meridional and vertical velocities as well as the enthalpy transports and fluxes in a least squares adjusted general circulation model are used to estimate the top-to-bottom oceanic meridional ...
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