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Browsing MIT Open Access Articles by Title

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  • Porter, Michael E.; Delgado-Garcia, Mercedes; Stern, Scott (Oxford University Press, 2015-06)
    Clusters are geographic concentrations of industries related by knowledge, skills, inputs, demand and/or other linkages. There is an increasing need for cluster-based data to support research, facilitate comparisons of ...
  • Kellis, Manolis; Wold, Barbara; Snyder, Michael P.; Bernstein, Bradley E.; Kundaje, Anshul; Marinov, Georgi K.; Ward, Lucas D.; Birney, Ewan; Crawford, Gregory E.; Dekker, Job; Dunham, Ian; Elnitski, Laura L.; Farnham, Peggy J.; Feingold, Elise A.; Gerstein, Mark B.; Giddings, Morgan C.; Gilbert, David M.; Gingeras, Thomas R.; Green, Eric D.; Guigo, Roderic; Hubbard, Tim; Kent, Jim; Lieb, Jason D.; Myers, Richard M.; Pazin, Michael J.; Ren, Bing; Stamatoyannopoulos, John A.; Weng, Zhiping; White, Kevin P.; Hardison, Ross C. (National Academy of Sciences (U.S.), 2014-04)
    With the completion of the human genome sequence, attention turned to identifying and annotating its functional DNA elements. As a complement to genetic and comparative genomics approaches, the Encyclopedia of DNA Elements ...
  • Erdman, Susan E (Impact Journals, 2016-12)
    We all want to live a long life with ‘good health’. But what does that really mean? Clinicians often define ‘good health’ as the absence of disease. Indeed, modern biomedical research focuses on finding remedies for specific ...
  • Buehler, Markus J. (American Society of Mechanical Engineers, 2009-11)
    Here we focus on recent advances in understanding the deformation and fracture behavior of collagen, Nature's most abundant protein material and the basis for many biological composites including bone, dentin or cornea. ...
  • Pritchard, Justin Robert; Bruno, Peter Michael; Gilbert, Luke Andrew; Capron, Kelsey L.; Lauffenburger, Douglas A.; Hemann, Michael (National Academy of Sciences (U.S.), 2012-12)
    Combination chemotherapies have been a mainstay in the treatment of disseminated malignancies for almost 60 y, yet even successful regimens fail to cure many patients. Although their single-drug components are well studied, ...
  • Solís, Eric J.; Pandey, Jai P.; Zheng, Xu; Airoldi, Edoardo M.; Pincus, David; Denic, Vladimir; Jin, Dexter X.; Gupta, Piyush (Elsevier, 2016-06)
    Despite its eponymous association with the heat shock response, yeast heat shock factor 1 (Hsf1) is essential even at low temperatures. Here we show that engineered nuclear export of Hsf1 results in cytotoxicity associated ...
  • Sim, Adrian Chong Nyi; Too, Chien Tei; Oo, Min Zin; Lai, Junyun; Eio, Michelle Yating; Song, Zhenying; Srinivasan, Nalini; Tan, Diane Ai Lin; Pang, Shyue Wei; Gan, Shu Uin; Lee, Kok Onn; Loh, Thomas Kwok Seng; Chen, Jianzhu; Chan, Soh Ha; MacAry, Paul Anthony (Nature Publishing Group, 2013-11)
    Epstein-Barr virus (EBV) is a gamma herpesvirus that causes a life-long latent infection in human hosts. The latent gene products LMP1, LMP2A and EBNA1 are expressed by EBV-associated tumors and peptide epitopes derived ...
  • Capellera-Garcia, Sandra; Pulecio, Julian; Dhulipala, Kishori; Siva, Kavitha; Rayon-Estrada, Violeta; Singbrant, Sofie; Sommarin, Mikael N.E.; Walkley, Carl R.; Soneji, Shamit; Karlsson, Göran; Raya, Ángel; Flygare, Johan; Sankaran, Vijay G. (Elsevier, 2016-06)
    Erythroid cell commitment and differentiation proceed through activation of a lineage-restricted transcriptional network orchestrated by a group of well characterized genes. However, the minimal set of factors necessary ...
  • von Fintel, Kai; Fox, Daniel; Iatridou, Sabine (MIT Working Papers in Linguistics, 2014)
    We argue that definites are interpreted as denoting the maximally informative object that falls under the relevant predicate.
  • Jewison, Christopher Michael; Sternberg, David C.; McCarthy, Bryan Patrick; Miller, David W; Saenz Otero, Alvar (International Astronautical Federation, 2014-10)
    This paper proposes a set of eight architectures that fully span the design tradespace of on-orbit assembler and servicer satellites. A framework is presented that defines the tradespace for servicing and assembly architectures ...
  • Cheung, Clifford; Mardon, Jeremy; Nomura, Yasunori; Thaler, Jesse (Springer / SISSA, 2010-07)
    If the lightest observable-sector supersymmetric particle (LOSP) is charged and long-lived, then it may be possible to indirectly measure the Planck mass at the LHC and provide a spectacular confirmation of supergravity ...
  • Byun, Sangwon; Begum, Shahinoor; Miyamoto, David T.; Maheswaran, Shyamala; Stott, Shannon L.; Toner, Mehmet; Hynes, Richard O.; Manalis, Scott R.; Bagnall, Josephine; Hecht, Vivian Chaya (Nature Publishing Group, 2015-12)
    The potential for circulating tumor cells (CTCs) to elucidate the process of cancer metastasis and inform clinical decision-making has made their isolation of great importance. However, CTCs are rare in the blood, and ...
  • da Silva, Marco; Barbic, Jernej; Popovic, Jovan (Association for Computing Machinery (ACM), 2009-07)
    Keyframe animation is a common technique to generate animations of deformable characters and other soft bodies. With spline interpolation, however, it can be difficult to achieve secondary motion effects such as plausible ...
  • Ishii, Hiroshi; Follmer, Sean Weston; Johnson, Micah K.; Adelson, Edward H. (Association for Computing Machinery (ACM), 2011-10)
    We introduce a novel input device, deForm, that supports 2.5D touch gestures, tangible tools, and arbitrary objects through real-time structured light scanning of a malleable surface of interaction. DeForm captures ...
  • Whelan, Thomas; Kaess, Michael; McDonald, John; Leonard, John Joseph (Institute of Electrical and Electronics Engineers (IEEE), 2013-11)
    In this paper we present a system for capturing large scale dense maps in an online setting with a low cost RGB-D sensor. Central to this work is the use of an “as-rigid-as-possible” space deformation for efficient dense ...
  • Li, Wenbin; Rieser, Jennifer M.; Liu, Andrea J.; Durian, Douglas J.; Li, Ju (American Physical Society, 2015-06)
    We report a combined experimental and simulation study of deformation-induced diffusion in compacted quasi-two-dimensional amorphous granular pillars, in which thermal fluctuations play a negligible role. The pillars, ...
  • Ravela, Srinivas; Yang, Christopher M. (Institute of Electrical and Electronics Engineers (IEEE), 2010-05)
    We present a new approach to deformation invariant image matching. Our matcher (a) aligns templates to targets over a broad range of nonlinear deformations, (b) factors the total deformation into spectral categories, where ...
  • Chang, Chi-Ming; Lin, Ying-Hsuan; Wang, Yifan; Yin, Xi (Springer Berlin Heidelberg, 2016-04)
    Continuing our exploration of maximally supersymmetric gauge theories (MSYM) deformed by higher dimensional operators, in this paper we consider an off-shell approach based on pure spinor superspace and focus on constructing ...
  • Ulitsky, Igor; Shamir, Ron; Krishnamurthy, Akshay; Karp, Richard M. (Public Library of Science, 2010-10)
    Background Molecular studies of the human disease transcriptome typically involve a search for genes whose expression is significantly dysregulated in sick individuals compared to healthy controls. Recent studies have ...
  • Ramirez, David M.; Rodriguez, Alejandro W.; Hashemi, Hila; Joannopoulos, John D.; Soljacic, Marin; Johnson, Steven G. (American Physical Society, 2011-03)
    We demonstrate theoretical conditions for highly efficient degenerate four-wave mixing in triply resonant nonlinear (Kerr) cavities. We employ a general and accurate temporal coupled-mode analysis in which the interaction ...
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