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Browsing MIT Open Access Articles by Title

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  • Neal, Krista L.; Shakerdge, Naomi B.; Hou, Steven S.; Klunk, William E.; Mathis, Chester A.; McLean, Pamela J.; Bacskai, Brian J.; Nesterov, Evgueni; Swager, Timothy M (Springer US, 2013-04)
    Purpose: The goal was to identify molecular imaging probes that would enter the brain, selectively bind to Parkinson’s disease (PD) pathology, and be detectable with one or more imaging modalities. Procedure: A library ...
  • Blumenstiel, Brendan; DeFelice, Matthew; Birsoy, Ozge; Bleyer, Anthony J.; Kmoch, Stanislav; Carter, Todd A.; Gnirke, Andreas; Kidd, Kendrah; Rehm, Heidi L.; Ronco, Lucienne; Gabriel, Stacey; Lennon, Niall J.; Lander, Eric Steven (Elsevier, 2016-05)
    Mucin-1 kidney disease, previously described as medullary cystic kidney disease type 1 (MCKD1, OMIM 174000), is an autosomal dominant tubulointerstitial kidney disease recently shown to be caused by a single-base insertion ...
  • Fujimoto, James G; Swanson, Eric A (Association for Research in Vision and Ophthalmology, 2016-07)
    This review was written for the special issue of IOVS to describe the history of optical coherence tomography (OCT) and its evolution from a nonscientific, historic perspective. Optical coherence tomography has become a ...
  • Han, Hee-Sun; Devaraj, Neal K.; Lee, Jungmin; Hilderbrand, Scott A.; Weissleder, Ralph; Bawendi, Moungi G. (American Chemical Society, 2010-05)
    We present a bioorthogonal and modular conjugation method for efficient coupling of organic dyes and biomolecules to quantum dots (QDs) using a norbornene−tetrazine cycloaddition. The use of noncoordinating functional ...
  • Yu, Zechuan; Lau, Tak Bun Denvid (Springer Berlin Heidelberg, 2015-04)
    At nanoscale, atomistic simulation is widely used for investigating crystalline chitin fibers, the structural component for many biological materials. However, the longitudinal dimension of naturally occurring chitin fibers ...
  • Martin, Eric S.; Belmont, P. J.; Sinnamon, M. J.; Richard, L. G.; Yuan, J.; Coffee, E. M.; Roper, J.; Lee, L.; Heidari, P.; Goel, G.; Ji, X.; Xie, Z.; Xie, T.; Lamb, J.; Weinrich, S. L.; VanArsdale, T.; Bronson, Roderick T.; Xavier, R. J.; Kan, J. L. C.; Mahmood, Umar; Hung, Kenneth E.; Lunt, Sophia Yunkyungkwon; Vander Heiden, Matthew G. (American Association for Cancer Research, 2013-02)
    Purpose: Effective therapies for KRAS-mutant colorectal cancer (CRC) are a critical unmet clinical need. Previously, we described genetically engineered mouse models (GEMM) for sporadic Kras-mutant and non-mutant CRC ...
  • Smith, Matthew; Schulz, Norbert S.; Schattenburg, Mark Lee; Mukherjee, Pran; Marshall, Herman Lee; Huenemoerder, David P.; Foster, Richard F.; Bautz, Marshall W.; Ahn, Minseung; Heilmann, Ralf K. (The International Society for Optical Engineering, 2009-08)
    We present a high-resolution soft x-ray grating spectrometer concept for the International X-Ray Observatory (IXO) that meets or exceeds the minimum requirements for effective area (> 1, 000 cm[superscript 2] for E < 1 ...
  • Ricks, Sean T.; Lewandowski, John Robert; Lim, Emmanuel; Wendell, Dawn; Winter, Amos (ASME International, 2014-08)
    When developing a first-generation product, an iterative approach often yields the shortest time-to-market. In order to optimize its performance, however, a fundamental understanding of the theory governing its operation ...
  • Cohen, Jason Blake; Prinn, Ronald G. (European Geosciences Union, 2011-08)
    A reduced form metamodel has been produced to simulate the effects of physical, chemical, and meteorological processing of highly reactive trace species in urban areas, which is capable of efficiently simulating the urban ...
  • Goguen, Brenda N.; Loving, Galen S.; Imperiali, Barbara (Elsevier, 2011-04)
    Cdc42, a member of the Rho GTPase family, is a fundamental regulator of the actin cytoskeleton during cell migration. To generate a sensor for Cdc42 activation, we employed a multi-pronged approach, utilizing cysteine ...
  • Leman, Steven W.; Damayanthi, Rathnayaka Mudiyanselage Thushara; Takahashi, Hiroyuki; Ohno, Masashi; Minamikawa, Yasuhiro; Nishimura, Kentaro; Iyomoto, Naoko (Institute of Electrical and Electronics Engineers, 2009-06)
    We have recently started to develop a high-resolution gamma-ray spectrometer for material defect analysis. Our gamma-ray detector is a microcalorimeter consisting of an iridium/gold bilayer transition edge sensor (TES) ...
  • Romano, Paul Kollath; Forget, Benoit; Newton, Thomas H., Jr. (American Nuclear Society, 2009-04)
    In the present work, a graphical user interface is developed to automate in-core fuel management using MCODE, an MCNP-ORIGEN linkage code. Data abstraction is achieved by means of five object classes that define the run, ...
  • Ljubicic, Dean M.; Anthony, Brian (SPIE, 2010-08)
    Optical digital-imaging techniques offer a fast, high-resolution, and wide-range metrology capability for measuring semi-transparent and transparent polymer-based devices during manufacture. This work presents novel ...
  • Ozkumur, Ayca Yalcin; Love, John C; Goods, Brittany A. (Wiley Blackwell, 2015-09)
    Living-cell-based screens can facilitate lead discovery of functional therapeutics of interest. A versatile and scalable method is reported that uses dense arrays of nanowells for imparting defined patterns on monolayers ...
  • Pawl, Andrew; Barrantes, Analia; Cardamone, Carolin; Rayyan, Saif; Pritchard, David E. (American Institute of Physics (AIP), 2012)
    Strategic knowledge is required to appropriately organize procedures and concepts to solve problems. We are developing a standardized instrument assessing strategic knowledge in the domain of introductory mechanics. This ...
  • King, Sandra M; Buchwald, Stephen Leffler (American Chemical Society (ACS), 2016-08)
    A general method for the N-arylation of amino acid esters with aryl triflates is described. Both α- and β-amino acid esters, including methyl, tert-butyl, and benzyl esters, are viable substrates. Reaction optimization was ...
  • Imperiali, Barbara; Morrison, James P.; Troutman, Jerry (Elsevier, 2010-10)
    The human pathogen Campylobacter jejuni possesses a general N-linked glycosylation system that is known to play a role in pathogenicity; however, a detailed understanding of this role remains elusive. A considerable hindrance ...
  • Heider, Patrick L.; Basak, Soubir; Benyahia, Brahim; Lakerveld, Richard; Zhang, Haitao; Hogan, Rachael; Buchbinder, Louis; Wolfe, Aaron; Mascia, Salvatore; Evans, James M. B.; Jamison, Timothy F.; Jensen, Klavs F.; Born, Stephen (American Chemical Society (ACS), 2014-02)
    The development and operation of the synthesis and workup steps of a fully integrated, continuous manufacturing plant for synthesizing aliskiren, a small molecule pharmaceutical, are presented. The plant started with ...
  • Teverovskiy, Georgiy; Park, Nathaniel Hamilton; Buchwald, Stephen Leffler (American Chemical Society (ACS), 2013-11)
    A new air-stable nickel precatalyst for C–N cross-coupling is reported. The developed catalyst system displays a greatly improved substrate scope for C–N bond formation to include both a wide range of aryl and heteroaryl ...
  • Powell, Geralle; Chen, Julie; Goldberg, Manijeh Nazari; Manzi, Aaron; Aydin, Erkin; Singh, Gurtej; Khoshkenar, Payam; Birdi, Amritpreet Kaur; LaPorte, Brandon; Krauskopf, Alejandro A.; Langer, Robert S (ASME International, 2015-07)
    The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin ...
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