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Browsing MIT Open Access Articles by Title

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  • Sainlos, Matthieu; Iskenderian, Wendy S.; Imperiali, Barbara (American Chemical Society, 2009-04)
    A systematic and general approach for identifying efficient probes for class I PDZ domains based on environment-sensitive chromophores is presented. A series of peptides derived from the C-terminal sequence of Stargazin ...
  • Bertsatos, Ioannis; Zanolin, Michele; Ratilal, Purnima; Chen, Tianrun; Makris, Nicholas (American Institute of Physics, 2010-11)
    A method is provided for determining necessary conditions on sample size or signal to noise ratio (SNR) to obtain accurate parameter estimates from remote sensing measurements in fluctuating environments. These conditions ...
  • Daniels, Rachel F.; Mahesh, Nira; Rosen, David; Angelino, Elaine; Neafsey, Daniel E.; Park, Daniel J.; Sabeti, Pardis C.; Wiegand, Roger C.; Volkman, Sarah K.; Milner, Danny A.; Wirth, Dyann F. (BioMed Central Ltd, 2008-10)
    Abstract Background Single nucleotide polymorphism (SNP) genotyping provides the means to develop a practical, rapid, inexpensive assay that will uniquely identify any Plasmodium falciparum parasite using a small amount ...
  • Daniels, Rachel F.; Volkman, Sarah K.; Milner, Danny A.; Mahesh, Nira; Neafsey, Daniel E.; Park, Daniel J.; Rosen, David; Angelino, Elaine; Sabeti, Pardis C.; Wirth, Dyann F.; Wiegand, Roger C. (BioMed Central Ltd., 2008-10)
    Background: Single nucleotide polymorphism (SNP) genotyping provides the means to develop a practical, rapid, inexpensive assay that will uniquely identify any Plasmodium falciparum parasite using a small amount of DNA. ...
  • Kim, Sanggyun; Brown, Emery N. (Institute of Electrical and Electronics Engineers, 2010-03)
    Assessing the causal relationship among multivariate time series is a crucial problem in many fields. Granger causality has been widely used to identify the causal interactions between continuous-valued time series based ...
  • Firat, Aykut; Wu, Lynn; Madnick, Stuart E. (IGI Global, 2009-01)
    Modern database management systems are supporting the inclusion and querying of non-relational sources within a data federation environment via wrappers. Wrapper development for Web sources, however, is a convolution of ...
  • Khan, Asif; Vijayaraghavan, Muralidaran; Mithal, Arvind (Institute of Electrical and Electronics Engineers (IEEE), 2012-07)
    Efficient use of FPGA resources requires FPGA-based performance models of complex hardware to implement one model cycle, i.e., one time-step of the original synchronous system, in several implementation cycles. Generally ...
  • Zhang, Hao; Hu, Jiazhong; Schleier-Smith, Monika; McConnell, Robert Puryear; Cuk, Senka; Vuletic, Vladan (American Physical Society, 2013-12)
    We propose and analyze a probabilistic but heralded scheme to generate pure, entangled, non-Gaussian states of collective spin in large atomic ensembles by means of single-photon detection. One photon announces the preparation ...
  • Rudner, M. S.; Vandersypen, L. M. K.; Vuletic, Vladan; Levitov, Leonid (American Physical Society (APS), 2011-11)
    We present a scheme for achieving coherent spin squeezing of nuclear spin states in semiconductor quantum dots. The nuclear polarization dependence of the electron spin resonance generates a unitary evolution that drives ...
  • Soltero, Daniel E.; Schwager, Mac; Rus, Daniela L. (Institute of Electrical and Electronics Engineers (IEEE), 2012-10)
    We present an online algorithm for a robot to shape its path to a locally optimal configuration for collecting information in an unknown dynamic environment. As the robot travels along its path, it identifies both where ...
  • Vidula, Mahesh K.; Du, Y.; Shim, J.; E. Lo; Khademhosseini, Ali (Institute of Electrical and Electronics Engineers (IEEE), 2009-05)
    Concentration gradients have important applications in chemical and biological studies. Here we have achieved rapid generation of spatially and temporally controllable concentration gradients of diffusible molecules (i.e. ...
  • Karouby, Johanna; Hertzberg, Mark Peter (American Physical Society, 2014-03)
    We propose a mechanism by which the inflaton can generate baryogenesis, by taking the inflaton to be a complex scalar field with a weakly broken global symmetry, and present a new version of the Affleck–Dine mechanism. The ...
  • Lewis, Joel Brewster (Electronic Journal of Combinatorics, 2012-01)
    We extend earlier work of the same author to enumerate alternating permutations avoiding the permutation pattern 2143. We use a generating tree approach to construct a recursive bijection between the set A[subscript ...
  • Li, Qing; Hoogeboom-Pot, Kathleen; Nardi, Damiano; Murnane, Margaret M.; Kapteyn, Henry C.; Siemens, Mark E.; Anderson, Erik H.; Hellwig, Olav; Dobisz, Elizabeth; Gurney, Bruce; Yang, Ronggui; Nelson, Keith Adam (American Physical Society, 2012-05)
    In this work, we generate and probe the shortest wavelength surface acoustic waves to date, at 45 nm, by diffracting coherent extreme ultraviolet beams from a suboptical phononic crystal. The short acoustic wavelengths ...
  • Demirbas, Umit; Sennaroglu, Alphan; Kaertner, Franz X.; Fujimoto, James G. (Optical Society of America, 2008-12)
    We describe the generation of enhanced pulse energies using a multipass-cavity (MPC) Cr[superscript3] +:LiCAF laser, pumped by inexpensive, single spatial mode laser diodes. A semiconductor saturable absorber was used for ...
  • Siddiqui, Aleem M.; Kaertner, Franz X.; Cirmi, G.; Brida, D.; Cerullo, G. (Institute of Electrical and Electronics Engineers, 2009-06)
    In this work we report on a two-stage approach for the generation of few-optical-cycle pulses at 800 nm; (i) a FF- pumped near-IR OPA produces pulses at 1.3 mum, which are used to generate a WLC with smooth spectral amplitude ...
  • Minnihan, Ellen Catherine; Ando, Nozomi; Brignole, Edward J.; Olshansky, Lisa; Chittuluru, Johnathan; Asturias, Francisco J.; Drennan, Catherine L.; Nocera, Daniel G.; Stubbe, JoAnne (National Academy of Sciences (U.S.), 2013-02)
    Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleoside diphosphates (dNDPs). The Escherichia coli class Ia RNR uses a mechanism of radical propagation by which a cysteine in ...
  • Li, Adrienne V.; Moon, James J.; Abraham, Wuhbet; Suh, Heikyung; Elkhader, Jamal; Seidman, Michael A.; Yen, Minmin; Im, Eung-Jun; Foley, Maria Hottelet; Barouch, Dan H.; Irvine, Darrell J.; Elkhader, Jamal; Yen, Minmin (American Association for the Advancement of Science (AAAS), 2013-09)
    Many pathogens infiltrate the body and initiate infection via mucosal surfaces. Hence, eliciting cellular immune responses at mucosal portals of entry is of great interest for vaccine development against mucosal pathogens. ...
  • Chen, Zhao; Zhou, Xibin; Werley, Christopher Alan; Nelson, Keith Adam (American Institute of Physics, 2011-08)
    We demonstrate generation of high-power, multicycle, and frequency-tunable terahertz pulses with microjoule energies by tilting the intensity front of a quasi-sinusoidal intensity-modulated optical waveform. The spatiotemporally ...
  • Soldner, Frank; Cheng, Albert W.; Hockemeyer, Dirk; Gao, Qing; Alagappan, Raaji; Khurana, Vikram; Golbe, Lawrence I.; Myers, Richard H.; Lindquist, Susan; Zhang, Lei; Guschin, Dmitry; Fong, Lauren K.; Vu, B. Joseph; Meng, Xiangdong; Urnov, Fyodor D.; Rebar, Edward J.; Gregory, Philip D.; Zhang, H. Steve; Jaenisch, Rudolf; Laganiere, Josee; Cheng, Albert W. (Elsevier, 2011-07)
    Patient-specific induced pluripotent stem cells (iPSCs) derived from somatic cells provide a unique tool for the study of human disease, as well as a promising source for cell replacement therapies. One crucial limitation ...
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