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Browsing MIT Open Access Articles by Title

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  • Haward, Simon J.; Oliveira, M. S. N.; Alves, Manuel A.; Jaishankar, Aditya; McKinley, Gareth H. (American Institute of Physics (AIP), 2013-07)
    We utilize a recently developed microfluidic device, the Optimized Shape Cross-slot Extensional Rheometer (OSCER), to study the elongational flow behavior and rheological properties of hyaluronic acid (HA) solutions ...
  • Timmerman, Chayil S.; Wright, Michael; Brick, Todd A. (Institute of Electrical and Electronics Engineers, 2009-10)
    In 2007, MIT Lincoln Laboratory began supporting the United States Air Force (USAF) MILSATCOM family of advanced beyond line of sight terminals increment 2 (FAB-T Inc 2) program. The Laboratory led the development and ...
  • Rangan, Sundeep; Fletcher, Alyson K.; Goyal, Vivek K. (Institute of Electrical and Electronics Engineers (IEEE), 2010-07)
    The replica method is a non-rigorous but widely-accepted technique from statistical physics used in the asymptotic analysis of large, random, nonlinear problems. This paper applies the replica method to analyze non-Gaussian ...
  • Bertschinger, Edmund; Prescod-Weinstein, Chanda (IOP Publishing, 2015-03)
    The Legendre transformation on singular Lagrangians, e.g. Lagrangians representing gauge theories, fails due to the presence of constraints. The Faddeev–Jackiw technique, which offers an alternative to that of Dirac, is a ...
  • Moitra, Ankur; Leighton, Frank Thomson (Association for Computing Machinery (ACM), 2010-06)
    Suppose we are given a graph G = (V, E) and a set of terminals K ⊂ V. We consider the problem of constructing a graph H = (K, E[subscript H]) that approximately preserves the congestion of every multicommodity flow with ...
  • Megias, G. D.; Barbaro, M. B.; Caballero, J. A.; Donnelly, T. William; Gonzalez-Jimenez, R. (American Physical Society, 2014-09)
    We present a systematic analysis of the quasielastic scaling functions computed within the relativistic mean field (RMF) theory and we propose an extension of the superscaling approach (SuSA) model based on these results. ...
  • Kopparty, Swastik; Saraf, Shubhangi; Sudan, Madhu; Dvir, Zeev (Institute of Electrical and Electronics Engineers, 2009-10)
    We extend the "method of multiplicities" to get the following results, of interest in combinatorics and randomness extraction. 1) We show that every Kakeya set (a set of points that contains a line in every direction) in ...
  • Ulitsky, Igor; Shkumatava, Alena; Jan, Calvin H.; Subtelny, Alexander Orest; Koppstein, David Neal Pira; Bell, George W.; Sive, Hazel L.; Bartel, David (Cold Spring Harbor Laboratory Press, 2012-06)
    The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3′ untranslated regions (3′ UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling ...
  • Hung, Tiffany; Wang, Yulei; Lin, Michael F.; Koegel, Ashley K.; Kotake, Yojiro; Grant, Gavin D.; Horlings, Hugo M.; Shah, Nilay; Umbricht, Christopher; Wang, Pei; Wang, Yu; Kong, Benjamin; Langerød, Anita; Børresen-Dale, Anne-Lise; Kim, Seung K.; van de Vijver, Marc; Sukumar, Saraswati; Whitfield, Michael L.; Kellis, Manolis; Xiong, Yue; Wong, David J.; Chang, Howard Y.; Lin, Michael F. (Nature Publishing Group, 2011-06)
    Transcription of long noncoding RNAs (lncRNAs) within gene regulatory elements can modulate gene activity in response to external stimuli, but the scope and functions of such activity are not known. Here we use an ...
  • Ng, Christopher W.; Yildirim, Ferah; Yap, Soon Ming Micha; Dalin, Simona Sara; Matthews, Bryan; Velez, Patricio J.; Labadorf, Adam; Housman, David E.; Fraenkel, Ernest (National Academy of Sciences (U.S.), 2013-01)
    The earliest stages of Huntington disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin (HTT) protein. To explore the ...
  • Wong, Daniel; Teixeira, Ana; Oikonomopoulos, Spyros; Humburg, Peter; Lone, Imtiaz N.; Saliba, David; Siggers, Trevor; Bulyk, Martha L.; Angelov, Dimitar; Dimitrov, Stefan; Udalova, Irina A.; Ragoussis, Jiannis (BioMed Central Ltd., 2011-07)
    Background Genetic studies have provided ample evidence of the influence of non-coding DNA polymorphisms on trait variance, particularly those occurring within transcription factor binding sites. Protein binding microarrays ...
  • Gehring, Mary; Bubb, Kerry L.; Henikoff, Steven (American Association for the Advancement of Science (AAAS), 2009-06)
    DNA methylation is an epigenetic mark associated with transposable element silencing and gene imprinting in flowering plants and mammals. In plants, imprinting occurs in the endosperm, which nourishes the embryo during ...
  • Parker, R. R.; Davis, E.; Golfinopoulos, Theodore; Labombard, Brian; Burke, William M.; Granetz, Robert S.; Greenwald, Martin J.; Irby, James Henderson; Leccacorvi, Rick; Marmar, Earl S.; Parkin, William C.; Porkolab, Miklos; Terry, James L.; Vieira, Rui F.; Wolfe, Stephen M. (American Institute of Physics (AIP), 2014-05)
    A novel “Shoelace” antenna has been used to inductively excite a short-wavelength edge fluctuation in a tokamak boundary layer for the first time. The principal design parameters, k[subscript ⊥] = 1.5 ± 0.1 cm[superscript ...
  • Badertscher, Brad; Shroff, Nemit; White, Hal D. (Elsevier, 2013-04)
    Public firms provide a large amount of information through their disclosures. In addition, information intermediaries publicly analyze, discuss, and disseminate these disclosures. Thus, greater public firm presence in an ...
  • Andoni, Alexandr; Indyk, Piotr; Onak, Krzysztof; Rubinfeld, Ronitt (Springer Berlin / Heidelberg, 2009-07)
    We initiate the study of sublinear-time algorithms in the external memory model [1]. In this model, the data is stored in blocks of a certain size B, and the algorithm is charged a unit cost for each block access. This ...
  • Taylor, M.; Gisin, E.; Sidorov, Michael; Krueger, Dilja; Osterweil, Emily; Bear, Mark (Wiley Blackwell, 2014-04)
    Fragile X (FX) is the most common genetic cause of intellectual disability and autism. Previous studies have shown that partial inhibition of metabotropic glutamate receptor signaling is sufficient to correct behavioral ...
  • Kasahara, Shunichi; Niiyama, Ryuma; Ishii, Hiroshi; Heun, Valentin Markus Josef (Association for Computing Machinery (ACM), 2013-02)
    As domestic robots and smart appliances become increasingly common, they require a simple, universal interface to control their motion. Such an interface must support a simple selection of a connected device, highlight its ...
  • Jagielska, Anna; Wilhite, Kristen D.; Van Vliet, Krystyn J. (Public Library of Science, 2013-09)
    Axon remyelination in the central nervous system requires oligodendrocytes that produce myelin. Failure of this repair process is characteristic of neurodegeneration in demyelinating diseases such as multiple sclerosis, ...
  • Ramirez Millan, Maria; Caldara, Marina; Rusconi, Roberto; Tarasova, Yekaterina; Stocker, Roman; Ribbeck, Katharina; Billings, Amanda Nicole (Public Library of Science, 2013-08)
    Bacteria within biofilms secrete and surround themselves with an extracellular matrix, which serves as a first line of defense against antibiotic attack. Polysaccharides constitute major elements of the biofilm matrix and ...
  • Shin, Yoojin; Kim, Hyunju; Han, Sewoon; Won, Jihee; Jeong, Hyo Eun; Lee, Eun-Sook; Kim, Jae-Hong; Chung, Seok; Kamm, Roger Dale (Wiley Blackwell, 2012-11)
    Plasticity and reciprocity of breast cancer cells to various extracellular matrice (ECMs) are three-dimensionally analyzed in quantitative way in a novel and powerful microfluidic in vitro platform. This successfully ...
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