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Browsing MIT Open Access Articles by Title

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  • Menze, Bjoern Holger; Leemput, Koen Van; Honkela, Antti; Konukoglu, Ender; Weber, Marc-Andre; Ayache, Nicholas; Golland, Polina (Springer Berlin / Heidelberg, 2011-06)
    Extensive imaging is routinely used in brain tumor patients to monitor the state of the disease and to evaluate therapeutic options. A large number of multi-modal and multi-temporal image volumes is acquired in standard ...
  • Sabuncu, Mert R.; Yeo, Boon Thye Thomas; Fischl, Bruce; Van Leemput, Koen; Golland, Polina (Institute of Electrical and Electronics Engineers, 2010-09)
    We propose a nonparametric, probabilistic model for the automatic segmentation of medical images, given a training set of images and corresponding label maps. The resulting inference algorithms rely on pairwise registrations ...
  • Colding, Tobias; Minicozzi, William (Princeton University Press, 2012-03)
    It has long been conjectured that starting at a generic smooth closed embedded surface in R[superscript 3], the mean curvature flow remains smooth until it arrives at a singularity in a neighborhood of which the flow looks ...
  • Wu, Jianlan; Silbey, Robert J.; Cao, Jianshu (American Physical Society, 2013-05)
    An asymptotic scaling theory is presented using the conceptual basis of trapping-free subspace (i.e., orthogonal subspace) to establish the generic mechanism of optimal efficiency of excitation energy transfer in ...
  • Schechter, Paul L.; Levinson, Rebecca Sobel (Society of Photo-Optical Instrumentation Engineers (SPIE), 2012-09)
    Q1: Why deploy N wavefront sensors on a three mirror anastigmat (TMA) and not N + 1? Q2: Why measure M Zernike coefficients and not M + 1? Q3: Why control L rigid body degrees of freedom (total) on the secondary and tertiary ...
  • Schechter, Paul L.; Levinson, Rebecca Sobel (University of Chicago Press, 2011-07)
    Axially symmetric telescopes produce well-known Seidel off-axis third-order aberration patterns: coma, astigmatism, curvature of field, and distortion. When axial symmetry is broken by the small misalignments of optical ...
  • Steine, Eveline J.; Ehrich, Mathias; Bell, George W.; Raj, Arjun; Reddy, Seshamma; van Oudenaarden, Alexander; Jaenisch, Rudolf; Linhart, Heinz G. (American Society for Clinical Investigation, 2011-05)
    Human cancer cells frequently have regions of their DNA hypermethylated, which results in transcriptional silencing of affected genes and promotion of tumor formation. However, it is still unknown whether cancer-associated ...
  • Durrett, Greg; Medard, Muriel; O'Reilly, Una-May (Springer Science + Business Media B.V., 2010-04)
    We present an algorithmic approach to solving the problem of chromatic entropy, a combinatorial optimization problem related to graph coloring. This problem is a component in algorithms for optimizing data compression when ...
  • Lamppa, John W.; Ackerman, Margaret E.; Lai, Jennifer I.; Scanlon, Thomas C.; Griswold, Karl E. (Public Library of Science, 2011-02)
    Alginate lyase enzymes represent prospective biotherapeutic agents for treating bacterial infections, particularly in the cystic fibrosis airway. To effectively deimmunize one therapeutic candidate while maintaining high ...
  • Lee, Ji Hye; Guan, Zhuo; Akbergenova, Yulia; Littleton, J. Troy (Society for Neuroscience, 2013-01)
    Synaptic vesicle fusion mediates communication between neurons and is triggered by rapid influx of Ca[superscript 2+]. The Ca[superscript 2+]-triggering step for fusion is regulated by the synaptic vesicle transmembrane ...
  • Verstrepen, Kevin J.; Fink, Gerald R. (Annual Reviews, 2009-07)
    Eukaryotic microorganisms have evolved ingenious mechanisms to generate variability at their cell surface, permitting differential adherence, rapid adaptation to changing environments, and evasion of immune surveillance. ...
  • Børud, Bente; Viburiene, Raimonda; Paulsen, Berit Smestad; Egge-Jacobsen, Wolfgang; Koomey, Michael; Hartley, Meredith D.; Imperiali, Barbara (Proceedings of the National Academy of Sciences (PNAS), 2011-05)
    Although protein glycosylation systems are becoming widely recognized in bacteria, little is known about the mechanisms and evolutionary forces shaping glycan composition. Species within the genus Neisseria display remarkable ...
  • Hafler, David A. (Public Library of Science, 2011-04)
    Background In the recently published meta-analysis of multiple sclerosis genome-wide association studies De Jager et al. identified three single nucleotide polymorphisms associated to MS: rs17824933 (CD6), rs1800693 ...
  • Niu, Nifang; Schaid, Daniel J; Abo, Ryan P; Kalari, Krishna; Fridley, Brooke L; Feng, Qiping; Jenkins, Gregory; Batzler, Anthony; Brisbin, Abra G; Cunningham, Julie M; Li, Liang; Sun, Zhifu; Yang, Ping; Wang, Liewei (BioMed Central Ltd., 2012-09)
    Background: Taxane is one of the first line treatments of lung cancer. In order to identify novel single nucleotide polymorphisms (SNPs) that might contribute to taxane response, we performed a genome-wide association study ...
  • Hassan, Musa A.; Butty, Vincent; Jensen, Kirk D. C.; Saeij, Jeroen (Cold Spring Harbor Laboratory Press, 2013-11)
    Alternative splicing and mRNA editing are known to contribute to transcriptome diversity. Although alternative splicing is pervasive and contributes to a variety of pathologies, including cancer, the genetic context for ...
  • Yang, Ninghan; Farrell, Andrew; Lu, Diana; Julien, Lindsay; Marth, Gabor T; Gubbels, Marc-Jan; Roberts, Wendy Niedelman; Melo, Mariane Bandeira; Saeij, Jeroen (BioMed Central Ltd, 2013-07)
    Background: Toxoplasma gondii has a largely clonal population in North America and Europe, with types I, II and III clonal lineages accounting for the majority of strains isolated from patients. RH, a particular type I ...
  • Moser, Felix; Broers, Nicolette J.; Hartmans, Sybe; Tamsir, Alvin; Kerkman, Richard; Roubos, Johannes A.; Bovenberg, Roel; Voigt, Christopher A. (American Chemical Society (ACS), 2012-10)
    Synthetic genetic programs promise to enable novel applications in industrial processes. For such applications, the genetic circuits that compose programs will require fidelity in varying and complex environments. In this ...
  • Prindle, Arthur; Selimkhanov, Jangir; Danino, Tal; Samayoa, Phillip; Goldber, Anna; Bhatia, Sangeeta N.; Hasty, Jeff (American Chemical Society (ACS), 2012-08)
    Synthetic biology has rapidly progressed over the past decade and is now positioned to impact important problems in health and energy. In the clinical arena, the field has thus far focused primarily on the use of bacteria ...
  • Peltonen, Leena; Elliott, Paul; McCarthy, Mark I.; Jarvelin, Marjo-Riitta; Widen, Elisabeth; Sovio, Ulla; Bennett, Amanda J.; Millwood, Iona Y.; Molitor, John; O'Reilly, Paul F.; Timpson, Nicholas J.; Kaakinen, Marika; Laitinen, Jaana; Haukka, Jari; Pillas, Demetris; Tzoulaki, Ioanna; Molitor, Jassy; Hoggart, Clive; Coin, Lachlan J. M.; Whittaker, John; Pouta, Anneli; Hartikaninen, Anna-Liisa; Freimer, Nelson B. (Public Library of Science, 2009-03)
    Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height ...
  • Schnall-Levin, Michael; Berger, Bonnie; Bergwitz, Clemens; Wee, Mark J.; Sinha, Sumi; Huang, Joanne; DeRobertis, Charles; Mensah, Lawrence B.; Cohen, Jonathan; Friedman, Adam; Kulkarni, Meghana; Hu, Yanhui; Vinayagam, Arunachalam; Perkins, Lizabeth A.; Mohr, Stephanie E.; Perrimon, Norbert (Public Library of Science, 2013-03)
    Phosphate is required for many important cellular processes and having too little phosphate or too much can cause disease and reduce life span in humans. However, the mechanisms underlying homeostatic control of extracellular ...
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