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Browsing MIT Open Access Articles by Title

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  • Chow, Clement Y.; Landers, John E.; Bergren, Sarah K.; Sapp, Peter C.; Grant, Adrienne E.; Jones, Julie M.; Everett, Lesley; Lenk, Guy M.; McKenna-Yasek, Diane M.; Weisman, Lois S.; Figlewicz, Denise; Brown, Robert H.; Meisler, Miriam H. (Elsevier B.V., 2009-01)
    Mutations of the lipid phosphatase FIG4 that regulates PI(3,5)P2 are responsible for the recessive peripheral-nerve disorder CMT4J. We now describe nonsynonymous variants of FIG4 in 2% (9/473) of patients with amyotrophic ...
  • Darrow, Emily M.; Huntley, Miriam H.; Dudchenko, Olga; Stamenova, Elena K.; Durand, Neva C.; Sun, Zhuo; Huang, Su-Chen; Sanborn, Adrian L.; Machol, Ido; Shamim, Muhammad; Seberg, Andrew P.; Chadwick, Brian P.; Aiden, Erez Lieberman; Lander, Eric Steven (Proceedings of the National Academy of Sciences, 2016-07)
    During interphase, the inactive X chromosome (Xi) is largely transcriptionally silent and adopts an unusual 3D configuration known as the "Barr body." Despite the importance of X chromosome inactivation, little is known ...
  • Ajore, Ram; Raiser, David; McConkey, Marie; Jöud, Magnus; Boidol, Bernd; Mar, Brenton; Saksena, Gordon; Weinstock, David M; Armstrong, Scott; Ellis, Steven R; Ebert, Benjamin L; Nilsson, Bjorn (Wiley Blackwell, 2017-03)
    Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. Here we ...
  • Gao, Qing; Steine, Eveline J.; Barrasa, M. Inmaculada; Hockemeyer, Dirk; Pawlak, Mathias; Fu, Dongdong; Reddy, Seshamma; Bell, George W.; Jaenisch, Rudolf (National Academy of Sciences, 2011-10)
    Alterations in DNA methylation have been associated with genome-wide hypomethylation and regional de novo methylation in numerous cancers. De novo methylation is mediated by the de novo methyltransferases Dnmt3a and 3b, ...
  • Zapotecatl, Jorge L.; Rosenblueth, David A.; Gershenson Garcia, Carlos (Hindawi Publishing Corporation, 2017-05)
    Self-organizing traffic lights have shown considerable improvements compared to traditional methods in computer simulations. Self-organizing methods, however, use sophisticated sensors, increasing their cost and limiting ...
  • Entova-Aizenbud, Inna (Springer US, 2016-02)
    The Kronecker coefficients are the structural constants for the tensor categories of representations of the symmetric groups, namely, given three partitions λ,μ,τ of n, the multiplicity of λ in μ⊗τ is called the Kronecker ...
  • Sobolevsky, Stanislav; Szell, Michael; Campari, Riccardo; Smoreda, Zbigniew; Ratti, Carlo; Couronne, Thomas (Public Library of Science, 2013-12)
    Large-scale networks of human interaction, in particular country-wide telephone call networks, can be used to redraw geographical maps by applying algorithms of topological community detection. The geographic projections ...
  • Chen, Qingfeng; Ye, Weijian; Jian Tan, Wei; Yong, Kylie Su Mei; Liu, Min; Qi Tan, Shu; Loh, Eva; TE Chang, Kenneth; Chye Tan, Thiam; Preiser, Peter R.; Chen, Jianzhu (Nature Publishing Group, 2015-10)
    Understanding of natural killer (NK) cell development in human is incomplete partly because of limited access to appropriate human tissues. We have developed a cytokine-enhanced humanized mouse model with greatly improved ...
  • Greenlee, Alison S.; Murray, Timothy; Lesniewski, Victor; Jeunnette, Mark Nathaniel; Winter, Amos (ASME International, 2014-08)
    The cylindrical filters presently used in drip irrigation systems frequently clog, increasing pressure loss and lowering the flow rate through the filters. This work investigates alternative filtration strategies that ...
  • Miller, Rachel Elizabeth; Mroszczyk, Keri A.; Lee, Richard T.; Patwari, Parth; Grodzinsky, Alan J.; Florine, Emily Marie; Liebesny, Paul Hancock (Mary Ann Liebert, Inc., 2014-10)
    Heparin-binding insulin-like growth factor 1 (HB-IGF-1) is a fusion protein of IGF-1 with the HB domain of heparin-binding epidermal growth factor-like growth factor. A single dose of HB-IGF-1 has been shown to bind ...
  • Gruber, Jonathan (American Economic Association, 2017)
    The United States has seen a sea change in the way that publicly financed health insurance coverage is provided to low-income, elderly, and disabled enrollees. When programs such as Medicare and Medicaid were introduced ...
  • Liao, Xiaoli; Rabideau, Amy E.; Pentelute, Bradley L. (WILEY-VCH Verlag GmbH & Co., 2014-09)
    Antibody mimics have significant scientific and therapeutic utility for the disruption of protein–protein interactions inside cells; however, their delivery to the cell cytosol remains a major challenge. Here we show that ...
  • Rabideau, Amy E.; Liao, Xiaoli; Pentelute, Bradley L. (Royal Society of Chemistry, The, 2014-09)
    Mirror image peptides have unique stability and immunogenic properties in mammals, making them attractive agents to investigate. Their properties inside cells have been mostly unexplored because biopolymers are difficult ...
  • Sollins, Karen R.; Sastry, Nishanth; Crowcroft, Jon (Institute of Electrical and Electronics Engineers, 2009-06)
    The recently proposed packet switched network paradigm takes advantage of human social contacts to opportunistically create data paths over time. Our goal is to examine the effect of the human contact process on data ...
  • Nugent, Helen M.; Ng, Yin-Shan; White, Desmond; Groothuis, Adam R.; Kanner, Glenn; Edelman, Elazer R. (Elsevier, 2009-12)
    PURPOSE: High restenosis rates are a major limitation of peripheral interventions. Endothelial cells, grown within gelatin matrices and implanted onto the adventitia of injured vessels, inhibit stenosis in experimental ...
  • Aliakbargolkar, Alessandro; Crawley, Edward F (Elsevier B.V., 2013-08)
    The current debate in the U.S. Human Spaceflight Program focuses on the development of the next generation of man-rated heavy lift launch vehicles. While launch vehicle systems are of critical importance for future ...
  • Alexandrou, Constantia; Korzec, Tomasz; Koutsou, Giannis; Lorce, C.; Negele, John W.; Pascalutsa, V.; Tsapalis, A.; Vanderhaeghen, M. (American Physical Society, 2009-01)
    We develop techniques to calculate the four Δ electromagnetic form factors using lattice QCD, with particular emphasis on the subdominant electric quadrupole form factor that probes deformation of the Δ. Results are presented ...
  • Duan, Aranda R.; Varela, Carmen; Zhang, Yuchun; Lisman, John; Shen, Yinghua; Xiong, Lealia Li; Wilson, Matthew A (Elsevier, 2015-02)
    Background: Low-frequency (delta/theta) oscillations in the thalamocortical system are elevated in schizophrenia during wakefulness and are also induced in the N-methyl-D-asparate receptor hypofunction rat model. To determine ...
  • Jiang, Shan; Chodrow, Philip Samuel; Gonzalez, Marta C. (Public Library of Science, 2016-09)
    Urban transportation systems are multimodal, sociotechnical systems; however, while their multimodal aspect has received extensive attention in recent literature on multiplex networks, their sociotechnical aspect has been ...
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