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Browsing MIT Open Access Articles by Title

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  • Weis, Victoria G.; Sousa, Josane F.; LaFleur, Bonnie J.; Nam, Ki Taek; Weis, Jared A.; Finke, Paul E.; Ameen, Nadia A.; Fox, James G.; Goldenrign, James R. (BMJ Publishing Group, 2012-07)
    Objectives: Spasmolytic polypeptide-expressing metaplasia (SPEM) develops as a preneoplastic lesion in the stomachs of mice and humans after parietal cell loss. To identify the commonalities and differences between phenotypic ...
  • Hu, Jie; Locasale, Jason W; Bielas, Jason H; O'Sullivan, Jacintha; Sheahan, Kieran; Cantley, Lewis C; Vander Heiden, Matthew G.; Vitkup, Dennis (Nature Publishing Group, 2013-04)
    Reprogramming of cellular metabolism is an emerging hallmark of neoplastic transformation. However, it is not known how the expression of metabolic genes in tumors differs from that in normal tissues, or whether different ...
  • Chen, Hui; Joslin, Scott Stephen Walter; Tran, Ngoc-Khanh (American Economic Association, 2010-01)
    We illustrate the effects of heterogeneous beliefs about disasters on the equity premium and individual agents’ trading activities. When investors disagree about the chances or severity of disasters, those optimistic ...
  • Jungreis, Irwin; Kellis, Manolis; Chan, Clara Sophia (Public Library of Science, 2013-03)
    Recent analysis of genomic signatures in mammals, flies, and worms indicates that functional translational stop codon readthrough is considerably more abundant in metazoa than previously recognized, but this analysis ...
  • Paepe, Gael De; Lewandowski, Jozef R.; Loquet, Antoine; Eddy, Matthew Thomas; Megy, Simon; Bockmann, Anja; Griffin, Robert Guy (American Institute of Physics (AIP), 2011-03)
    We describe a theoretical framework for understanding the heteronuclear version of the third spin assisted recoupling polarization transfer mechanism and demonstrate its potential for detecting long-distance intramolecular ...
  • Miller, B. R.; Rigby, Matthew; Kuijpers, L. J. M.; Krummel, P. B.; Steele, L. P.; Leist, M.; Fraser, P. J.; McCulloch, A.; Harth, C.; Salameh, P.; Muhle, J.; Weiss, R. F.; Prinn, Ronald G.; Wang, R. H. J.; O'Doherty, S.; Greally, B. R.; Simmonds, P. G. (European Geosciences Union, 2010-08)
    HFC-23 (also known as CHF3 [CHF subscript 3], fluoroform or trifluoromethane) is a potent greenhouse gas (GHG), with a global warming potential (GWP) of 14 800 for a 100-year time horizon. It is an unavoidable by-product ...
  • García, Alexis; Zeng, Yu; Muthupalani, Sureshkumar; Ge, Zhongming; Potter, Amanda; Mobley, Melissa W.; Boussahmain, Chakib; Feng, Yan; Wishnok, John S.; Fox, James G. (American Association for Cancer Research, 2011-02)
    Chronic microbial infection influences cancer progression, but the mechanisms that link them remain unclear. Constitutive androstane receptor (CAR) is a nuclear receptor that regulates enzymes involved in endobiotic and ...
  • van Berkum, Nynke L.; Lieberman-Aiden, Erez; Williams, Louise; Gnirke, Andreas; Mirny, Leonid A.; Dekker, Job; Lander, Eric S.; Imakaev, Maksim Viktorovich (MyJoVE Corporation, 2010-05)
    The three-dimensional folding of chromosomes compartmentalizes the genome and and can bring distant functional elements, such as promoters and enhancers, into close spatial proximity. Deciphering the relationship between ...
  • Tan, Longzhi; Serene, Stephen R.; Chao, Hui Xiao; Gore, Jeff (American Physical Society, 2011-05)
    In biological evolution, adaptations to one environment can in some cases reverse adaptations to another environment. To study this “reverse evolution” on a genotypic level, we measured the fitness of E. coli strains with ...
  • Langs, Georg; Paragios, Nikos; Essafi, Salma (Institute of Electrical and Electronics Engineers, 2010-05)
    In this paper, we propose a novel representation of prior knowledge for image segmentation, using diffusion wavelets that can reflect arbitrary continuous interdependencies in shape data. The application of diffusion ...
  • Barry, Jennifer; Kaelbling, Leslie P.; Lozano-Perez, Tomas (Institute of Electrical and Electronics Engineers (IEEE), 2013-05)
    We define the Diverse Action Manipulation (DAMA) problem in which we are given a mobile robot, a set of movable objects, and a set of diverse, possibly non-prehensile manipulation actions, and the goal is to find a sequence ...
  • Wu, Wei; Chen, Zhe; Gao, Shangkai; Brown, Emery N. (Institute of Electrical and Electronics Engineers, 2010-06)
    In numerous neuroscience studies, multichannel EEG data are often recorded over multiple trial periods under the same experimental condition. To date, little effort is aimed to learn spatial patterns from EEG data to account ...
  • Yu, Jiangbo; Low, Kian Hsiang; Oran, Ali; Jaillet, Patrick (Institute of Electrical and Electronics Engineers (IEEE), 2012-12)
    Route prediction is important to analyzing and understanding the route patterns and behavior of traffic crowds. Its objective is to predict the most likely or "popular" route of road segments from a given point in a road ...
  • Kiritani, Taro; Wickersham, Ian R.; Seung, H. Sebastian; Shepherd, Gordon M. G. (Society for Neuroscience, 2012-04)
    The generation of purposive movement by mammals involves coordinated activity in the corticospinal and corticostriatal systems, which are involved in different aspects of motor control. In the motor cortex, corticospinal ...
  • Johnson, Matthew James; Willsky, Alan S (Association for Uncertainty in Artificial Intelligence (AUAI), 2010)
    There is much interest in the Hierarchical Dirichlet Process Hidden Markov Model (HDP-HMM) as a natural Bayesian nonparametric extension of the traditional HMM. However, in many settings the HDP-HMM's strict Markovian ...
  • El-Moselhy, Tarek Ali; Elfadel, Ibrahim M.; Daniel, Luca (Institute of Electrical and Electronics Engineers, 2009-12)
    With the adoption of ultra regular fabric paradigms for controlling design printability at the 22 nm node and beyond, there is an emerging need for a layout-driven, pattern-based parasitic extraction of alternative fabric ...
  • Masaki, Ichiro; Fang, Yajun; Horn, Berthold Klaus Paul (Institute of Electrical and Electronics Engineers, 2009-07)
    he time-to-contact (TTC) estimation is a simple and convenient way to detect approaching objects, potential danger, and to analyze surrounding environment. TTC can be estimated directly from single camera though neither ...
  • Schneider, Ben Ross (Cambridge University Press, 2009-08)
    The extensive scholarship on ‘varieties of capitalism’ offers some conceptual and theoretical innovations that can be fruitfully employed to analyze the distinctive institutional foundations of capitalism in Latin America ...
  • Gautieri, Alfonso; Vesentini, Simone; Redaelli, Alberto; Buehler, Markus J. (American Chemical Society, 2011-01)
    Collagen constitutes one-third of the human proteome, providing mechanical stability, elasticity, and strength to organisms and is the prime construction material in biology. Collagen is also the dominating material in the ...
  • Bertschinger, Edmund; Mohayaee, Roya; Afshordi, Niayesh (American Physical Society, 2009-04)
    Most of the mass content of dark matter haloes is expected to be in the form of tidal debris. The density of debris is not constant, but rather can grow due to formation of caustics at the apocenters and pericenters of ...
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