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Browsing MIT Open Access Articles by Title

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  • Samara, Chrysanthi; Gilleland, Cody Lee; Zeng, Fei; Rohde, Christopher Benjamin; Yanik, Mehmet Fatih (Society of Photo-optical Instrumentation Engineers, 2009-02)
    In recent years, the advantages of using small invertebrate animals as model systems for human disease have become increasingly apparent and have resulted in three Nobel Prizes in medicine or chemistry during the last six ...
  • Cox, David D.; Pinto, Nicolas; Doukhan, David; DiCarlo, James (Public Library of Science, 2009-11)
    While many models of biological object recognition share a common set of ‘‘broad-stroke’’ properties, the performance of any one model depends strongly on the choice of parameters in a particular instantiation of that ...
  • Pinto, Nicolas; Doukhan, David; DiCarlo, James; Cox, David D. (Public Library of Science, 2009-11)
    While many models of biological object recognition share a common set of “broad-stroke” properties, the performance of any one model depends strongly on the choice of parameters in a particular instantiation of that ...
  • Armiento, R.; Kozinsky, B.; Hautier, G.; Fornari, M.; Ceder, Gerbrand (American Physical Society, 2014-04)
    We screen a large chemical space of perovskite alloys for systems with optimal properties to accommodate a morphotropic phase boundary (MPB) in their composition-temperature phase diagram, a crucial feature for high ...
  • Steinmeyer, Joseph Daly; Yanik, Mehmet Fatih (Public Library of Science, 2012-04)
    The complexity of neurons and neuronal circuits in brain tissue requires the genetic manipulation, labeling, and tracking of single cells. However, current methods for manipulating cells in brain tissue are limited to ...
  • Kim, Daekeun; So, Peter T. C. (Society of Photo-optical Instrumentation Engineers, 2010-02)
    Two-photon excitation microfabrication has been shown to be useful in the field of photonics and biomedicine. It generates 3D microstructures and provides sub-diffraction fabrication resolution. Nevertheless, laser direct ...
  • Alver, Burak Han; Ballintijn, Maarten; Busza, Wit; Decowski, Michael P.; Gulbrandsen, K.; Henderson, C.; Kane, J. L.; Kulinich, Piotr; Li, Wei; Loizides, Constantin; Reed, C.; Roland, Christof E.; Roland, Gunther M.; Stephans, George S. F.; Vale, C.; van Nieuwenhuizen, Gerrit Jan; Vaurynovich, Siarhei S.; Verdier, Robin; Veres, Gabor; Wenger, Edward Allen; Wyslouch, Boleslaw (American Physical Society, 2010-02)
    A measurement of two-particle correlations with a high transverse momentum trigger particle (p[subscript T][superscript trig]>2.5  GeV/c) is presented for Au+Au collisions at √sNN=200   GeV over the uniquely broad ...
  • Speck, Jared R.; Strain, Robert M. (Springer-Verlag, 2011-02)
    We study the local-in-time hydrodynamic limit of the relativistic Boltzmann equation using a Hilbert expansion. More specifically, we prove the existence of local solutions to the relativistic Boltzmann equation that are ...
  • Abbott, Timothy G.; Abel, Zachary Ryan; Charlton, David; Demaine, Erik D.; Demaine, Martin L.; Kominers, Scott Duke (Springer-Verlag, 2012-01)
    We prove that any finite collection of polygons of equal area has a common hinged dissection. That is, for any such collection of polygons there exists a chain of polygons hinged at vertices that can be folded in the ...
  • Tonegawa, Susumu; Nakashiba, Toshiaki; Buhl, Derek L.; McHugh, Thomas J. (Cell Press, 2009-06)
    A widely held memory consolidation theory posits that memory of events and space is initially stored in the hippocampus (HPC) in a time-limited manner and is consolidated in the neocortex for permanent storage. Although ...
  • Kitamura, Takashi; Okubo-suzuki, Reiko; Takashima, Noriko; Murayama, Akiko; Hino, Toshiaki; Nishizono, Hirofumi; Kida, Satoshi; Inokuchi, Kaoru (BioMed Central Ltd, 2012-02)
    Background: During permanent memory formation, recall of acquired place memories initially depends on the hippocampus and eventually become hippocampus-independent with time. It has been suggested that the quality of ...
  • Neve, Rachael L.; Xia, Yan; Portugal, George S.; Fakira, Amanda K.; Melyan, Zara; Lee, H. Thomas; Russo, Scott J.; Liu, Jie; Morón, Jose A. (Society for Neuroscience, 2011-11)
    Glutamatergic systems, including AMPA receptors (AMPARs), are involved in opiate-induced neuronal and behavioral plasticity, although the mechanisms underlying these effects are not fully understood. In the present study, ...
  • Lamar, John Michael; Stern, Patrick; Liu, Hui; Schindler, Jeffrey W.; Jiang, Zhigang; Hynes, Richard O. (National Academy of Sciences (U.S.), 2012-09)
    The transcriptional coactivator Yes-associated protein (YAP) is a major regulator of organ size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue types if its activity is increased ...
  • Yang, Linfeng; Zhang, Jing; Ho, Bow; Ding, Jeak Ling (Public Library of Science, 2011-05)
    Background: M-ficolin, a pathogen recognition molecule in the innate immune system, binds sugar residues including N-acetyl-D-glucosamine (GlcNAc), which is displayed on invading microbes and on apoptotic cells. The cis ...
  • Vu, Quang Hieu; Ooi, Beng Chin; Rinard, Martin C.; Tan, Kian-Lee (Institute of Electrical and Electronics Engineers, 2009-04)
    Over the past few years, peer-to-peer (P2P) systems have rapidly grown in popularity and have become a dominant means for sharing resources. In these systems, load balancing is a key challenge because nodes are often ...
  • Yildirim, Ferah; Ji, Shengbo; Kronenberg, Golo; Barco, Angel; Olivares, Roman; Benito, Eva; Dirnagl, Ulrich; Gertz, Karen; Endres, Matthias; Harms, Christoph; Meisel, Andreas (Public Library of Science, 2014-04)
    Epigenetic transcriptional regulation by histone acetylation depends on the balance between histone acetyltransferase (HAT) and deacetylase activities (HDAC). Inhibition of HDAC activity provides neuroprotection, indicating ...
  • Ji, Peng; Yeh, Victor; Ramirez, Tzutzuy; Murata-Hori, Maki; Lodish, Harvey F. (Ferrata Storti Foundation, 2010-09)
    Background: During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of ...
  • Cheng, Albert W.; Creyghton, Menno P.; Welstead, G. Grant; Kooistra, Tristan G.; Carey, Bryce W.; Steine, Eveline J.; Hanna, Jacob; Lodato, Michael A.; Frampton, Garrett M.; Sharp, Phillip A.; Boyer, Laurie; Young, Richard A.; Jaenisch, Rudolf (National Academy of Sciences (U.S.), 2010-11)
    Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. These regulatory events at enhancers ...
  • Heintzman, Nathaniel D.; Hon, Gary C.; Hawkins, R. David; Kheradpour, Pouya; Stark, Alexander; Harp, Lindsey F.; Ye, Zhen; Lee, Leonard K.; Stuart, Rhona K.; Ching, Christina W.; Ching, Keith A.; Antosiewicz-Bourget, Jessica E.; Liu, Hui; Zhang, Xinmin; Green, Roland D.; Lobanenkov, Victor V.; Stewart, Ron; Thomson, James A.; Crawford, Gregory E.; Kellis, Manolis; Ren, Bing (Nature Publishing Group, 2009-03)
    The human body is composed of diverse cell types with distinct functions. Although it is known that lineage specification depends on cell-specific gene expression, which in turn is driven by promoters, enhancers, insulators ...
  • Monier, Erwan; Schlosser, Adam; Sokolov, Andrei P. (Copernicus GmbH, 2013-05)
    Both historical and idealized climate model experiments are performed with a variety of Earth system models of intermediate complexity (EMICs) as part of a community contribution to the Intergovernmental Panel on Climate ...
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