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Browsing MIT Open Access Articles by Title

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  • Cheeseman, Iain McPherson; Welburn, Julie P. I.; Grishchuk, Ekaterina L.; Backer, Chelsea B.; Wilson-Kubalek, Elizabeth M.; Yates III, John R. (Cell Press, 2009-03)
    Mitotic chromosome segregation requires that kinetochores attach to microtubule polymers and harness microtubule dynamics to drive chromosome movement. In budding yeast, the Dam1 complex couples kinetochores with microtubule ...
  • Krishnaswamy, Pavitra; Brown, Emery N.; Herr, Hugh M. (Public Library of Science, 2011-03)
    A common feature in biological neuromuscular systems is the redundancy in joint actuation. Understanding how these redundancies are resolved in typical joint movements has been a long-standing problem in biomechanics, ...
  • Gevers, Dirk (Public Library of Science, 2012-08)
    The Human Microbiome Project (HMP) [1],[2] is a concept that was long in the making. After the Human Genome Project, interest grew in sequencing the “other genome" of microbes carried in and on the human body [3],[4]. ...
  • Roubelakis, Maria G.; Zotos, Pantelis; Papachristoudis, Georgios; Michalopoulos, Ioannis; Pappa, Kalliopi I.; Anagnou, Nicholas P.; Kossida, Sophia (BioMed Central Ltd., 2009-06)
    microRNAs (miRNAs) are single-stranded RNA molecules of about 20–23 nucleotides length found in a wide variety of organisms. miRNAs regulate gene expression, by interacting with target mRNAs at specific sites in order to ...
  • Roubelakis, Maria G.; Zotos, Pantelis; Papachristoudis, Georgios; Michalopoulos, Ioannis; Pappa, Kalliopi I.; Anagnou, Nicholas P.; Kossida, Sophia (BioMed Central Ltd., 2009-06)
    Background: microRNAs (miRNAs) are single-stranded RNA molecules of about 20–23 nucleotides length found in a wide variety of organisms. miRNAs regulate gene expression, by interacting with target mRNAs at specific sites ...
  • Chen, Qingfeng; Amaladoss, Anburaj; Ye, Weijian; Liu, Min; Dummler, Sara; Kong, Fang; Wong, Lan Hiong; Loo, Hooi Linn; Loh, Eva; Tan, Shu Qi; Tan, Thiam Chye; Chang, Kenneth T. E.; Dao, Ming; Suresh, Subra; Preiser, Peter R.; Chen, Jianzhu (National Academy of Sciences (U.S.), 2014-01)
    Immunodeficient mouse–human chimeras provide a powerful approach to study host-specific pathogens, such as Plasmodium falciparum that causes human malaria. Supplementation of immunodeficient mice with human RBCs supports ...
  • Helmreich, Stefan (Paradigm Publishers, 2010-12)
    Nineteenth-century Americans and Europeans envisaged the ocean as a sublime space, at once frightening and inviting. Romantic poets such as Byron and Shelley celebrated the sea as a seductive substance with which we ...
  • Hospodsky, Denina; Qian, Jing; Nazaroff, William W.; Yamamoto, Naomichi; Bibby, Kyle; Rismani-Yazdi, Hamid; Peccia, Jordan (Public Library of Science, 2012-04)
    Exposure to specific airborne bacteria indoors is linked to infectious and noninfectious adverse health outcomes. However, the sources and origins of bacteria suspended in indoor air are not well understood. This study ...
  • Demidova-Rice, Tatiana N.; Wolf, Lindsey; Deckenback, Jeffry; Hamblin, Michael R.; Herman, Ira M. (Public Library of Science, 2012-02)
    Previous work in our laboratory has described several pro-angiogenic short peptides derived from endothelial extracellular matrices degraded by bacterial collagenase. Here we tested whether these peptides could stimulate ...
  • Marcus, Adam; Wu, Eugene; Madden, Samuel R.; Miller, Robert C. (VLDB Endowment, 2011-09)
    Crowdsourcing markets like Amazon's Mechanical Turk (MTurk) make it possible to task people with small jobs, such as labeling images or looking up phone numbers, via a programmatic interface. MTurk tasks for processing ...
  • Nikolaidis, Stefanos; Shah, Julie A. (Institute of Electrical and Electronics Engineers, 2013-03)
    We design and evaluate human-robot cross-training, a strategy widely used and validated for effective human team training. Cross-training is an interactive planning method in which a human and a robot iteratively switch ...
  • Ritvo, Harriet (American Academy of Arts and Sciences, 2009-06)
    “When I use a word,” says Humpty Dumpty in Through the Looking Glass, “it means just what I choose it to mean– neither more nor less.” Alice demurs on several grounds, appealing first to contrary popular consensus–“But ...
  • Xu, Weihong; Seok, Junhee; Mindrinos, Michael N.; Schweitzer, Anthony C.; Jiang, Hui; Wilhelmy, Julie; Clark, Tyson A.; Kapur, Karen; Xing, Yi; Faham, Malek; Storey, John D.; Moldawer, Lyle L.; Maier, Ronald V.; Tompkins, Ronald G.; Wong, Wing Hung; Davis, Ronald W.; Xiao, Wenzhong; Inflammation and Host Response to Injury Large-Scale Collaborative Research Program (National Academy of Sciences (U.S.), 2011-03)
    A 6.9 million-feature oligonucleotide array of the human transcriptome [Glue Grant human transcriptome (GG-H array)] has been developed for high-throughput and cost-effective analyses in clinical studies. This array allows ...
  • Knee, Kelly M.; Sergeeva, Oksana Andrei; King, Jonathan Alan (Springer-Verlag Berlin Heidelberg, 2012-08)
    Archaeal and eukaryotic cytosols contain group II chaperonins, which have a double-barrel structure and fold proteins inside a cavity in an ATP-dependent manner. The most complex of the chaperonins, the eukaryotic TCP-1 ...
  • Begley, Ulrike; Sosa, Maria Soledad; Avivar-Valderas, Alvaro; Patil, Ashish; Endres, Lauren; Estrada, Yeriel; Chan, Clement T.Y.; Su, Dan; Dedon, Peter C.; Aguirre-Ghiso, Julio A.; Begley, Thomas (Wiley Blackwell, 2013-04)
    Emerging evidence points to aberrant regulation of translation as a driver of cell transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators ...
  • Maier-Hein, Lena; Walsh, Conor James; Seitel, Alexander; Hanumara, Nevan Clancy; Shepard, Jo-Anne; Franz, A. M.; Pianka, F.; Muller, Sascha A.; Schmied, Bruno; Slocum, Alexander H.; Gupta, Rajiv; Meinzer, Hans-Peter (Society of Photo-optical Instrumentation Engineers, 2009-03)
    Computed tomography (CT) guided percutaneous punctures of the liver for cancer diagnosis and therapy (e.g. tumor biopsy, radiofrequency ablation) are well-established procedures in clinical routine. One of the main challenges ...
  • Schlicht, Erik J.; Shimojo, Shinsuke; Camerer, Colin F.; Nakayama, Ken; Battaglia, Peter W. (Public Library of Science, 2010-07)
    Research in competitive games has exclusively focused on how opponent models are developed through previous outcomes and how peoples' decisions relate to normative predictions. Little is known about how rapid impressions ...
  • Endo, Ken; Herr, Hugh M. (Institute of Electrical and Electronics Engineers, 2009-12)
    In this paper, we present an under-actuated model of human walking, comprising only a soleus muscle and flexion/extension monoarticular hip muscles. The remaining muscle groups of the human leg are modeled using quasi-passive, ...
  • Taylor, Frank E. (Springer-Verlag, 2012-07)
    Results are presented of a search for new particles decaying to large numbers of jets in association with missing transverse momentum, using 4.7 fb[superscript −1] of pp collision data at √s = 7 TeV collected by the ATLAS ...
  • Weiss, Kurt R.; Kimura, Yoko; Lee, Wyan-Ching Mimi; Littleton, J. Troy (Genetics Society of America, The, 2011-11)
    Huntington’s disease is a neurodegenerative disorder resulting from expansion of a polyglutamine tract in the Huntingtin protein. Mutant Huntingtin forms intracellular aggregates within neurons, although it is unclear ...
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