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Browsing MIT Open Access Articles by Title

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  • Shan, Jing; Ross, Nathan T; Logan, David J; Thomas, David; Duncan, Stephen A; North, Trista E; Goessling, Wolfram; Carpenter, Anne E; Schwartz, Robert; Bhatia, Sangeeta N. (2013-06)
    Cell-based therapies hold the potential to alleviate the growing burden of liver diseases. Such therapies require human hepatocytes, which, within the stromal context of the liver, are capable of many rounds of replication. ...
  • Barthelme, Dominik; Sauer, Robert T. (American Association for the Advancement of Science, 2012-07)
    Proteasomes are the major energy-dependent proteolytic machines in the eukaryotic and archaeal domains of life. To execute protein degradation, the 20S core peptidase combines with the AAA+ ring of the 19S regulatory ...
  • Regev, Aviv (Nature Publishing Group, 2013-04)
    The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. Here, the ...
  • Eyford, Brett A.; Ahmad, Rushdy; Enyaru, John C.; Carr, Steven A.; Pearson, Terry W. (Public Library of Science, 2013-08)
    Control of human African sleeping sickness, caused by subspecies of the protozoan parasite Trypanosoma brucei, is based on preventing transmission by elimination of the tsetse vector and by active diagnostic screening and ...
  • Balewski, Jan T.; Betancourt, M. J.; Corliss, Ross; Hays-Wehle, James Prewitt; Leight, William Axel; Milner, Richard G.; Redwine, Robert P; Seele, J.; Steadman, Stephen G.; Surrow, Bernd; van Nieuwenhuizen, G.; Walker, M. (American Physical Society, 2012-02)
    We report transverse momentum (pT≤15  GeV/c) spectra of π[superscript ±], K[superscript ±], p, p̅ , K[subscript S][superscript 0], and ρ[superscript 0] at midrapidity in p+p and Au+Au collisions at √sNN=200  GeV. Perturbative ...
  • Surrow, Bernd; Balewski, Jan T.; Betancourt, Michael Joseph; Hays-Wehle, James Prewitt; Hoffman, A. M.; Jones, Christopher LaDon; Kocoloski, Adam Philip; Leight, William Axel; Milner, Richard G.; Redwine, Robert P.; Sakuma, Tai; Seele, Joseph Patrick; Stephans, George S. F.; van Nieuwenhuizen, Gerrit Jan; Walker, M.; Corliss, Ross Cameron (American Physical Society, 2010-02)
    We present the first measurements of identified hadron production, azimuthal anisotropy, and pion interferometry from Au+Au collisions below the nominal injection energy at the BNL Relativistic Heavy-Ion Collider (RHIC) ...
  • Greenstone, Michael; Hornbeck, Richard; Moretti, Enrico (University of Chicago Press, 2010-06)
    We quantify agglomeration spillovers by comparing changes in total factor productivity (TFP) among incumbent plants in “winning” counties that attracted a large manufacturing plant and “losing” counties that were the new ...
  • Miller, Miles Aaron; Feng, Xiao-Jiang; Li, Genyuan; Rabitz, Herschel A. (Public Library of Science, 2012-06)
    This work presents an adapted Random Sampling - High Dimensional Model Representation (RS-HDMR) algorithm for synergistically addressing three key problems in network biology: (1) identifying the structure of biological ...
  • Thaler, Jesse; Van Tilburg, Ken (Springer-Verlag, 2011-03)
    We introduce a new jet shape—N-subjettiness—designed to identify boosted hadronically-decaying objects like electroweak bosons and top quarks. Combined with a jet invariant mass cut, N-subjettiness is an effective ...
  • Oloritun, Rahman O.; Madan, Anmol; Khayal, Inas; Pentland, Alex Paul (Elsevier, 2013-06)
    Studies have suggested that propinquity; social, cultural, physical and psychological similarities are major factors in close friendship ties. These studies were subject to human recall of interactions with no details of ...
  • Pintilie, Grigore Dimitrie; Zhang, Junjie; Chiu, Wah; Gossard, David C. (Institute of Electrical and Electronics Engineers, 2009-04)
    Segmentation of density maps obtained using cryo-electron microscopy (cryo-EM) is a challenging task, and is typically accomplished by time-intensive interactive methods. The goal of segmentation is to identify the regions ...
  • Mitsos, Alexander; Melas, Ioannis N.; Siminelakis, Paraskeuas; Chairakaki, Aikaterini D.; Saez-Rodriguez, Julio; Alexopoulos, Leonidas G. (Public Library of Science, 2009-10)
    Understanding the mechanisms of cell function and drug action is a major endeavor in the pharmaceutical industry. Drug effects are governed by the intrinsic properties of the drug (i.e., selectivity and potency) and the ...
  • Yang, Ming; Chakraborty, Arup K.; Govern, Christopher C. (American Physical Society, 2012-01)
    In biochemical networks, identifying key proteins and protein-protein reactions that regulate fluctuation-driven transitions leading to pathological cellular function is an important challenge. Using large deviation theory, ...
  • Yang, Shun-Chieh; Chang, Su-Sen; Chen, Yu-Chian (Public Library of Science, 2011-12)
    The relationship between abnormal HER2 expression and cancer is important in cancer therapeutics. Formation and spread of cancer cells may be restricted by inhibiting HER2. We conducted ligand-based and structure-based ...
  • Guttman, Mitchell; Garber, Manuel; Clamp, Michele; Zody, Michael C.; Friedman, Nir; Xie, Xiaohui (Oxford University Press (OUP), 2009-06)
    Motivation: Comparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved sequences across species; ...
  • Andersen, Kristian G.; Shlyakhter, Ilya; Tabrizi, Shervin; Winnicki, Sarah; Yen, Angela; Park, Daniel J.; Griesemer, Dustin; Karlsson, Elinor K.; Wong, Sunny H.; Cabili, Moran; Adegbola, Richard A.; Bamezai, Rameshwar N.K.; Hill, Adrian V.S.; Vannberg, Fredrik O.; Rinn, John L.; Lander, Eric S.; Schaffner, Stephen F.; Sabeti, Pardis C.; Grossman, Sharon Rachel; Lander, Eric S. (Elsevier, 2013-02)
    Although several hundred regions of the human genome harbor signals of positive natural selection, few of the relevant adaptive traits and variants have been elucidated. Using full-genome sequence variation from the 1000 ...
  • Daly, Mark J.; Altshuler, David; Xavier, Ramnik J.; Sklar, Pamela; Purcell, Shaun M.; International Schizophrenia Consortium; Nguyen, Aylwin C. Y.; Scolnick, Edward Mark; Rossin, Elizabeth; Plenge, Robert M.; Raychaudhuri, Soumya (Public Library of Science, 2009-06)
    Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ...
  • Raychaudhuri, Soumya; Plenge, Robert M.; Rossin, Elizabeth; Ng, Aylwin C. Y.; Purcell, Shaun M.; Sklar, Pamela; Scolnick, Edward Mark; Xavier, Ramnik J.; Altshuler, David; Daly, Mark J. (Public Library of Science, 2009-06)
    Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ...
  • Ong, Shao-En; Schenone, Monica; Margolin, Adam A.; Li, Xiaoyu; Do, Kathy; Doud, Mary K.; Mani, D. R.; Kuai, Letian; Wang, Xiang; Wood, John L.; Tolliday, Nicola J.; Koehler, Angela N.; Marcaurelle, Lisa A.; Golub, Todd R.; Gould, Robert J.; Schreiber, Stuart L.; Carr, Steven A. (National Academy of Sciences, 2009-03)
    Most small-molecule probes and drugs alter cell circuitry by interacting with 1 or more proteins. A complete understanding of the interacting proteins and their associated protein complexes, whether the compounds are ...
  • von Hippel, Eric A.; von Krogh, Georg (2013-11-27)
    Problem-solving research, and formal problem-solving practice as well, begins with the assumption that a problem has been identified or formulated for solving. The problem-solving process then involves a search for a ...
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