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Browsing MIT Open Access Articles by Title

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  • Lander, Eric S.; Chapman, Michael A.; Lawrence, Michael S.; Keats, Jonathan J.; Cibulskis, Kristian; Sougnez, Carrie; Schinzel, Anna C.; Harview, Christina L.; Brunet, Jean-Philippe; Ahmann, Gregory J.; Adli, Mazhar; Anderson, Kenneth C.; Ardlie, Kristin G.; Auclair, Daniel; Baker, Angela; Bergsagel, P. Leif; Bernstein, Bradley E.; Drier, Yotam; Fonseca, Rafael; Gabriel, Stacey B. (Nature Publishing Group, 2011-03)
    Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs. ...
  • Labelle, Myriam; Hynes, Richard O. (American Association for Cancer Research, 2012-11)
    Tumor cells transit from the primary tumor via the blood circulation to form metastases in distant organs. During this process, tumor cells encounter a number of environmental challenges and stimuli that profoundly impact ...
  • Blanchard, Olivier Jean; Das, Mitali; Faruqee, Hamid (Brookings Institution Press, 2010-06)
    To understand the diverse impact of the crisis across emerging market countries, we explore the role of two shocks—the collapse in trade and the sharp decline in financial flows—in the transmission of the crisis from ...
  • Massachusetts Institute of Technology. Department of Biology; Broad Institute of MIT and Harvard; Lander, Eric S.; Lander, Eric S. (Nature Publishing Group, 2011-02)
    The sequence of the human genome has dramatically accelerated biomedical research. Here I explore its impact, in the decade since its publication, on our understanding of the biological functions encoded in the genome, on ...
  • Kaur, Gurneet; Cappellaro, Paola (IOP Publishing, 2012-08)
    Linear chains of spins acting as quantum wires are a promising approach for achieving scalable quantum information processors. Nuclear spins in apatite crystals provide an ideal test bed for the experimental study of quantum ...
  • Smith, David Edmund; Zuber, Maria; Neumann, Gregory A.; Lemoine, Frank G.; Mazarico, Erwan; Torrence, Mark H.; McGarry, Jan F.; Rowlands, David D.; Head III, James W.; Duxbury, Thomas H.; Aharonson, Oded; Lucey, Paul G.; Robinson, Mark S.; Barnouin, Olivier S.; Cavanaugh, John F.; Sun, Xiaoli; Liiva, Peter; Mao, Dan-dan; Smith, James C.; Bartels, Arlin E. (American Geophysical Union, 2010-09)
    As of June 19, 2010, the Lunar Orbiter Laser Altimeter, an instrument on the Lunar Reconnaissance Orbiter, has collected over 2.0 × 109 measurements of elevation that collectively represent the highest resolution global ...
  • Cowan, Ray Franklin; Dujmic, Denis; Sciolla, Gabriella (American Physical Society, 2012-06)
    We study the process e[superscript +] e-→π[superscript +]π[superscript -]π[superscript +] π[superscript -], with a photon emitted from the initial-state electron or positron, using 454.3  fb-1 of data collected with the ...
  • Kohane, Daniel S.; Fink, Gerald R.; Langer, Robert; Hudson, Sarah (Elsevier, 2009-11)
    Invasive fungal infections can be devastating, particularly in immunocompromised patients, and difficult to treat with systemic drugs. Furthermore, systemic administration of those medications can have severe side effects. ...
  • Kim, Tae-Woo; del Alamo, Jesus A. (Institute of Electrical and Electronics Engineers (IEEE), 2011-08)
    We have experimentally extracted the virtual-source electron injection velocity in InAs HEMTs with a 5 nm thick channel. For long gate lengths, these devices exhibit noticeably worse injection velocity than thicker channel ...
  • Miller, Robert C.; Chou, Victoria H.; Bernstein, Michael S.; Little, Danny Greg; Van Kleek, Max G.; Karger, David R.; schraefel, mc (Association for Computing Machinery, 2008)
    We present Inky, a command line for shortcut access to common web tasks. Inky aims to capture the efficiency benefits of typed commands while mitigating their usability problems. Inky commands have little or no new ...
  • Yanik, Mehmet Fatih; Angel, Matthew (Matthew M.) (Public Library of Science, 2010-07)
    Background Generating autologous pluripotent stem cells for therapeutic applications will require the development of efficient DNA-free reprogramming techniques. Transfecting cells with in vitro-transcribed, protein-encoding ...
  • Agarwal, Niket; Jha, Niraj K.; Peh, Li-Shiuan (Association for Computing Machinery, 2009-12)
    With transistor miniaturization leading to an abundance of on-chip resources and uniprocessor designs providing diminishing returns, the industry has moved beyond single-core microprocessors and embraced the many-core wave. ...
  • Besharov, Douglas J.; Williams, Heidi L. (John Wiley & Sons, Inc, 2012-06)
    Innovation inducement prizes have been used for centuries. In the United States, a recent federal policy change—the America COMPETES Reauthorization Act of 2010—clarified and simplified a path by which all federal agencies ...
  • Yang, Hong; Wang, Wei (Institute of Electrical and Electronics Engineers (IEEE), 2009-07)
    The strategy of exempting bus from other traffic through exclusive bus lanes (XBL) is prevalent. Rather than just deploying the XBL system, in this study, a new innovative dynamic bus lane (DBL) operation system which is ...
  • Gertler, Frank; Nakatsu, Fubito; Perera, Rushika M.; Lucast, Louise; Zoncu, Roberto; Domin, Jan; Toomre, Derek; De Camilli, Pietro (Rockefeller University Press, 2010-08)
    Phosphatidylinositol (PI) 4,5-bisphosphate (PI(4,5)P[subscript 2]) and its phosphorylated product PI 3,4,5-triphosphate (PI(3,4,5)P[subscript 3]) are two major phosphoinositides concentrated at the plasma membrane. Their ...
  • McGlinn, Edwina; Yekta, Soraya; Mansfield, Jennifer H.; Soutschek, Jürgen; Tabina, Clifford J.; Bartel, David (National Academy of Sciences, 2009-11)
    Patterning of the vertebrate axial skeleton requires precise spatial and temporal control of Hox gene expression during embryonic development. MicroRNAs (miRNAs) are recently described modulators of gene activity, and ...
  • McGreevy, John (American Physical Society, 2010-10)
    A Viewpoint on: Holographic Metals and the Fractionalized Fermi Liquid - Subir Sachdev - Phys. Rev. Lett. 105, 151602 (2010) – Published October 04, 2010
  • Sontag, Eduardo D.; Wang, Yuan; Megretski, Alexandre (Institute of Electrical and Electronics Engineers, 2009-02)
    This paper asks what classes of input signals are sufficient in order to completely identify the input/output behavior of generic bilinear systems. The main results are that step inputs are not sufficient, nor are single ...
  • Lauffenburger, Douglas A.; Chen, William W.; Schoeberl, Birgit; Jasper, Paul J.; Nielsen, Ulrik B.; Niepel, Mario; Sorger, Peter K. (Nature Publishing Group, 2009-01)
    The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis. Nonetheless, it remains poorly understood ...
  • Angrist, Joshua; Dynarski, Susan M.; Kane, Thomas J.; Pathak, Parag; Walters, Christopher Ross (American Economic Association, 2010-05)
    The charter school landscape includes a variety of organizational models and a few national franchises. The nation’s largest network of charter schools is the Knowledge is Power Program (KIPP), with 80 schools operating ...
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