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Browsing MIT Open Access Articles by Title

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  • Vieux (Kloss), Ellen; Wohlever, Matthew Lee; Chen, James Z.; Sauer, Robert T.; Baker, Tania (National Academy of Sciences (U.S.), 2013-05)
    Lon is an ATPase associated with cellular activities (AAA+) protease that controls cell division in response to stress and also degrades misfolded and damaged proteins. Subunits of Lon are known to assemble into ring-shaped ...
  • Triantafyllou, Christina; Brown, Emery N.; Whitfield-Gabrieli, Susan; Scholz, Jonathan; Saxe, Rebecca R. (Public Library of Science, 2009-03)
    In functional magnetic resonance imaging (fMRI) studies, a cortical region in the right temporo-parietal junction (RTPJ) is recruited when participants read stories about people's thoughts (‘Theory of Mind’). Both fMRI and ...
  • Gantz, Stephanie C.; Robinson, Brooks G.; Buck, David C.; Bunzow, James R.; Neve, Rachael L.; Williams, John T.; Neve, Kim A. (eLife Sciences Publications, Ltd., 2015-08)
    D2 autoreceptors regulate dopamine release throughout the brain. Two isoforms of the D2 receptor, D2S and D2L, are expressed in midbrain dopamine neurons. Differential roles of these isoforms as autoreceptors are poorly ...
  • Kim, Seokhee; Sauer, Robert T. (Cold Spring Harbor Laboratory Press, 2014-04)
    Intracellular proteases combat proteotoxic stress by degrading damaged proteins, but their activity must be carefully controlled to maintain cellular fitness. The activity of Escherichia coli DegP, a highly conserved ...
  • Golarai, Golijeh; Ghahremani, Dara G.; Eberhardt, Jennifer L.; Gabrieli, John D. E. (Frontiers Research Foundation, 2015-11)
    Several regions of the human brain respond more strongly to faces than to other visual stimuli, such as regions in the amygdala (AMG), superior temporal sulcus (STS), and the fusiform face area (FFA). It is unclear if these ...
  • McLaughlin, Nathan; Foster, Kelly A.; Edbauer, Dieter; Phillips, Marnie A.; Bolton, Andrew Donald; Constantine-Paton, Martha; Sheng, Morgan Hwa-Tze (Society for Neuroscience, 2010-02)
    NMDA receptors (NMDARs) are critical mediators of activity-dependent synaptic plasticity, but the differential roles of NR2A- versus NR2B-containing NMDARs have been controversial. Here, we investigate the roles of NR2A ...
  • Goard, Michael; Pho, Gerald N; Woodson, Jonathan; Sur, Mriganka (eLife Sciences Publications, Ltd., 2016-08)
    Mapping specific sensory features to future motor actions is a crucial capability of mammalian nervous systems. We investigated the role of visual (V1), posterior parietal (PPC), and frontal motor (fMC) cortices for ...
  • Sun, Chen; Kitamura, Takashi; Yamamoto, Jun; Martin, Jared; Kitch, Lacey J.; Schnitzer, Mark J.; Tonegawa, Susumu; Pignatelli di Spinazzola, Michele (National Academy of Sciences (U.S.), 2015-07)
    Entorhinal–hippocampal circuits in the mammalian brain are crucial for an animal’s spatial and episodic experience, but the neural basis for different spatial computations remain unknown. Medial entorhinal cortex layer II ...
  • Conlon, David; Fox, Jacob; Gasarch, William; Harris, David G.; Ulrich, Douglas; Zbarsky, Samuel (Society for Industrial and Applied Mathematics, 2015-03)
    Suppose that a and d are positive integers with a ≥ 2. Let h[subscript a,d](n) be the largest integer t such that any set of n points in R[superscript d] contains a subset of t points for which all the nonzero volumes of ...
  • Lusztig, George (American Mathematical Society (AMS), 2014-08)
    We define and study a correspondence between the set of distinguished G[superscript 0]-conjugacy classes in a fixed connected component of a reductive group G (with G[superscript 0] almost simple) and the set of (twisted) ...
  • Haslanger, Sally (Muse - Johns Hopkins University Press, 2015-03)
    Recent work on social injustice has focused on implicit bias as an important factor in explaining persistent injustice in spite of achievements on civil rights. In this paper, I argue that because of its individualism, ...
  • Yang, Yu; Yao, Hongwei; Hong, Mei (American Chemical Society (ACS), 2015-03)
    Nonlamellar lipid membranes are frequently induced by proteins that fuse, bend, and cut membranes. Understanding the mechanism of action of these proteins requires the elucidation of the membrane morphologies that they ...
  • Gordan, Raluca; Hartemink, Alexander J.; Bulyk, Martha L. (Cold Spring Harbor Laboratory Press, 2009-08)
    Transcriptional regulation is largely enacted by transcription factors (TFs) binding DNA. Large numbers of TF binding motifs have been revealed by ChIP-chip experiments followed by computational DNA motif discovery. However, ...
  • Aral, Sinan; Sundararajan, Arun; Muchnik, Lev (National Academy of Sciences, 2009-12)
    Node characteristics and behaviors are often correlated with the structure of social networks over time. While evidence of this type of assortative mixing and temporal clustering of behaviors among linked nodes is used to ...
  • Rieder, Harald E.; Polvani, Lorenzo M.; Solomon, Susan (American Geophysical Union (AGU), 2014-04)
    Whether stratospheric cooling due to increases in well-mixed greenhouse gases (WMGHG) could increase the depletion of Arctic stratospheric ozone has been the subject of scientific and public attention for decades. Here we ...
  • Gallagher, Gillian; Coon Burgess, Jessica Louise (Springer Science + Business Media B.V., 2009-08)
    This paper argues that long-distance assimilations between consonants come in two varieties: Total identity, which arises via a non-local relation between the interacting segments; and partial identity, which results from ...
  • Pottschmidt, K.; Miyasaka, Hiromasa; Bhalerao, V.; Bachetti, M.; Boggs, S. E.; Christensen, F. E.; Craig, W. W.; Hailey, C. J.; Harrison, F. A.; Kennea, Jamie A.; Rahoui, F.; Stern, D.; Tendulkar, S. P.; Tomsick, J. A.; Walton, D. J.; Wilms, J.; Zhang, W. W.; Furst, F.; Grinberg, Victoria (IOP Publishing, 2015-06)
    We present spectral analysis of Nuclear Spectroscopic Telescope Array and Swift observations of Cep X-4 during its outburst in 2014. We observed the source once during the peak of the outburst and once during the decay, ...
  • Gargallo-Peiró, Abel; Sarrate, Josep; Roca Navarro, Francisco Javier; Peraire, Jaime (Springer London, 2014-07)
    A procedure to quantify the distortion (quality) of a high-order mesh composed of curved tetrahedral elements is presented. The proposed technique has two main applications. First, it can be used to check the validity and ...
  • Park, Stephen K. (Society of Exploration Geophysicists, 1985-05)
    Distortions of magnetotelluric fields caused by threedimensional (3-D) structures can be severe and are not predictable using one-dimensional or two-dimensional modeling. I used a 3-D modeling algorithm based upon an ...
  • Norman-Haignere, Samuel Victor; McDermott, Joshua H. (Elsevier, 2016-01)
    Nonlinearities in the cochlea can introduce audio frequencies that are not present in the sound signal entering the ear. Known as distortion products (DPs), these added frequencies complicate the interpretation of auditory ...
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