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Browsing MIT Open Access Articles by Title

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  • Samson, Leona D.; Kisby, Glen E.; Olivas, A.; Park, T.; Churchwell, Mona; Doerge, Daniel R.; Gerson, S. L.; Turker, M. S. (Elsevier Pub. Co., 2009-01)
    Neurons of the developing brain are especially vulnerable to environmental agents that damage DNA (i.e., genotoxicants), but the mechanism is poorly understood. The focus of the present study is to demonstrate that DNA ...
  • Lan, Yuk Yuen; Bouley, Richard; Rooney, Michael S.; Hacohen, Nir; Londono, Diana; Rooney, Michael S. (Elsevier, 2014-10)
    Deficiencies in DNA-degrading nucleases lead to accumulation of self DNA and induction of autoimmunity in mice and in monogenic and polygenic human diseases. However, the sources of DNA and the mechanisms that trigger ...
  • Xiao, Zeyu; Ji, Changwei; Shi, Jinjun; Frieder, Jillian; Wu, Jun; Farokhzad, Omid C.; Pridgen, Eric Michael; Shi, JinJun (Wiley Blackwell, 2012-10)
    Targeted cancer therapy: Inspired by the ability of DNA hybridization, a targeted near-infrared (NIR) light-responsive delivery system has been developed through simple DNA self-assembly (see picture; PEG=polyethylene ...
  • Slomovic, Shimyn; Collins, James J. (Nature Publishing Group, 2015-09)
    We generated synthetic protein components that can detect specific DNA sequences and subsequently trigger a desired intracellular response. These modular sensors exploit the programmability of zinc-finger DNA recognition ...
  • Charoensawan, Varodom; Janga, Sarath Chandra; Bulyk, Martha L.; Babu, M. Madan; Teichmann, Sarah A. (Elsevier, 2012-07)
    Transcription factors (TFs) and histone octamers are two abundant classes of DNA binding proteins that coordinate the transcriptional program in cells. Detailed studies of individual TFs have shown that TFs bind to ...
  • Hsu, Patrick; Scott, David Arthur; Weinstein, Joshua; Ran, F. Ann; Konermann, Silvana M.; Agarwala, Vineeta; Li, Yinqing; Fine, Eli J.; Wu, Xavier; Shalem, Ophir; Cradick, Thomas J.; Marraffini, Luciano A.; Bao, Gang; Zhang, Feng (Nature Publishing Group, 2013-09)
    The Streptococcus pyogenes Cas9 (SpCas9) nuclease can be efficiently targeted to genomic loci by means of single-guide RNAs (sgRNAs) to enable genome editing1, 2, 3, 4, 5, 6, 7, 8, 9, 10. Here, we characterize SpCas9 ...
  • Li, Cheri Yingjie; Wood, David K.; Hsu, Caroline M.; Bhatia, Sangeeta N. (Royal Society of Chemistry, The, 2011-07)
    Patterning multiple cell types is a critical step for engineering functional tissues, but few methods provide three-dimensional positioning at the cellular length scale. Here, we present a “bottom-up” approach for fabricating ...
  • Patel, Suraj J.; Yarmush, Martin; King, Kevin R.; Casali, Monica (United States National Academy of Sciences, 2009-05)
    Cells respond to infection by sensing pathogens and communicating danger signals to noninfected neighbors; however, little is known about this complex spatiotemporal process. Here we show that activation of the innate ...
  • Bajaj, Vikram S.; Mak-Jurkauskas, Melody L.; Belenky, Marina; Herzfeld, Judith; Griffin, Robert Guy (Elsevier, 2009-09)
    We describe a new approach to multiple [superscript 13]C–[superscript 15]N distance measurements in uniformly labeled solids, frequency-selective (FS) TEDOR. The method shares features with FS-REDOR and ZF- and BASE-TEDOR, ...
  • Ravera, Enrico; Corzilius, Bjorn; Michaelis, Vladimir K.; Luchinat, Claudio; Griffin, Robert Guy; Bertini, Ivano (American Chemical Society (ACS), 2014-03)
    Protein sedimentation sans cryoprotection is a new approach to magic angle spinning (MAS) and dynamic nuclear polarization (DNP) nuclear magnetic resonance (NMR) spectroscopy of proteins. It increases the sensitivity of ...
  • Caviezel, D.; Chatzikyriakou, Despoina; Buongiorno, Jacopo; Lakehal, Djamel (Elsevier, 2015-03)
    Direct Numerical Simulations (DNS) and Large Eddy Simulations (LES) were performed for fully-developed turbulent flow in channels with smooth walls and walls featuring hemispherical roughness elements at shear Reynolds ...
  • Janssen, Erin; Tohme, Mira; Hedayat, Mona; Leick, Marion; Ramesh, Narayanaswamy; Massaad, Michel J.; Ullas, Sumana; Azcutia, Veronica; Goodnow, Christopher C.; Randall, Katrina L.; Qiao, Qi; Wu, Hao; Al-Herz, Waleed; Cox, Dianne; Hartwig, John; Luscinskas, Francis W.; Geha, Raif S.; Kumari, Sudha; Irvine, Darrell J (American Society for Clinical Investigation, 2016-09)
    Wiskott-Aldrich syndrome (WAS) is associated with mutations in the WAS protein (WASp), which plays a critical role in the initiation of T cell receptor–driven (TCR-driven) actin polymerization. The clinical phenotype of ...
  • Maier, Pauline (Omohundro Institute of Early American History and Culture, 2011-01)
    Start with the almost 250-page cumulative index in Volume XXIII of The Documentary History of the Ratification of the Constitution, or DHRC, the last of five volumes on ratification in New York. Predictably, it includes ...
  • Ruthmann, Stephen; Tseng, Tiffany; Yang, Maria (2014-08)
    Web-based documentation platforms afford lightweight and visually rich mechanisms for designers to share documentation online, yet present challenges regarding representation, particularly for collaborative teams. This ...
  • Ho, Joseph; Witkin, Andre J.; Liu, Jonathan Jaoshin; Chen, Yueli; Fujimoto, James G.; Schuman, Joel S.; Duker, Jay S. (Elsevier, 2010-11)
    Purpose To describe the features of intraretinal retinal pigment epithelium (RPE) migration documented on a prototype spectral-domain, high-speed, ultrahigh-resolution optical coherence tomography (OCT) device in a group ...
  • Suri, Tavneet; Jack, William; Stoker, Thomas Martin (National Academy of Sciences (U.S.), 2011-09)
    The birth and explosive growth of mobile money in Kenya has provided economists with an opportunity to study the evolution and impact of a new financial system. Mobile money is an innovation that allows individuals to ...
  • Guth, Alan; Hertzberg, Mark Peter; Prescod-Weinstein, Chanda (American Physical Society, 2015-11)
    Recently there has been significant interest in the claim that dark matter axions gravitationally thermalize and form a Bose-Einstein condensate with a cosmologically long-range correlation. This has potential consequences ...
  • Zhu, Haoxiang (Oxford University Press, 2013-12)
    Dark pools are equity trading systems that do not publicly display orders. Dark pools offer potential price improvements but do not guarantee execution. Informed traders tend to trade in the same direction, crowd on the ...
  • Moen, Phyllis; Fan, Wen; Lee, Shi-Rong; Almeida, David; Kossek, Ellen Ernst; Buxton, Orfeu M.; Kelly, Erin L. (Sage Publications, 2016-01)
    This study tests a central theoretical assumption of stress process and job strain models, namely that increases in employees’ control and support at work should promote well-being. To do so, we use a group-randomized field ...
  • Kohane, Isaac; Lee, Kyungjoon; Brownstein, John S.; Mills, Richard G. (Public Library of Science, 2010-12)
    Background It has been shown that large interdisciplinary teams working across geography are more likely to be impactful. We asked whether the physical proximity of collaborators remained a strong predictor of the ...
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