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Browsing MIT Open Access Articles by Title

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  • Fujiwara, Yuji; Sun, Jianwei; Fu, Gregory C. (Royal Society of Chemistry, The, 2011-08)
    An effective phosphine-catalyzed method was developed for the enantioselective addition of aryl thiols to the γ position of allenoates, thereby providing ready access to aryl alkyl sulfides in very good ee. The array of ...
  • Zhu, Shaolin; Buchwald, Stephen Leffler (American Chemical Society (ACS), 2014-10)
    Enantioselective synthesis of β-chiral amines has been achieved via copper-catalyzed hydroamination of 1,1-disubstituted alkenes with hydroxylamine esters in the presence of a hydrosilane. This mild process affords a range ...
  • Zhu, Rong; Buchwald, Stephen Leffler (Wiley Blackwell, 2013-10)
    Something radical: An efficient enantioselective oxytrifluoromethylation of alkenes has been developed using a copper catalyst system. Mechanistic studies are consistent with a metal-catalyzed redox radical addition mechanism ...
  • Lee, Sarah Yunmi; Neufeind, Stefan; Fu, Gregory C. (American Chemical Society (ACS), 2014-06)
    The catalytic asymmetric synthesis of alkyl fluorides, particularly α-fluorocarbonyl compounds, has been the focus of substantial effort in recent years. While significant progress has been described in the formation of ...
  • Shen, Xiaoqiang; Jones, Gavin O.; Watson, Donald A.; Bhayana, Brijesh; Buchwald, Stephen Leffler (American Chemical Society (ACS), 2010-07)
    We report efficient syntheses of axially chiral biaryl amides in yields ranging from 80−92%, and with enantioselectivity in the range 88−94% ee employing an asymmetric Suzuki−Miyaura process with Pd(OAc)[subscript 2] and ...
  • Niljianskul, Nootaree; Zhu, Shaolin; Buchwald, Stephen Leffler (Wiley Blackwell, 2014-12)
    The synthesis of α-aminosilanes by a highly enantio- and regioselective copper-catalyzed hydroamination of vinylsilanes is reported. The system employs Cu-DTBM-SEGPHOS as the catalyst, diethoxymethylsilane as the stoichiometric ...
  • Movassaghi, Mohammad; Piersanti, Giovanni; Piizzi, Grazia; Siegel, Dustin Scott (American Chemical Society, 2009-11)
    We report our full account of the enantioselective total synthesis of (−)-acylfulvene (1) and (−)-irofulven (2), which features metathesis reactions for the rapid assembly of the molecular framework of these antitumor ...
  • Kwiatkowski, Adam V.; Rubinson, Douglas A.; Dent, Erik W.; Edward van Veen, J.; Leslie, Jonathan D.; Zhang, Jiangyang; Mebane, Leslie Marie; Philippar, Ulrike; Pinheiro, Elaine M.; Burds, Aurora A.; Bronson, Roderick T.; Mori, Susumu; Gertler, Frank; Fassler, Reinhard (Elsevier, 2007-11)
    Mammalian cortical development involves neuronal migration and neuritogenesis; this latter process forms the structural precursors to axons and dendrites. Elucidating the pathways that regulate the cytoskeleton to drive ...
  • Goh, Keow Lin; Cai, Li; Cepko, Constance L.; Gertler, Frank (Elsevier, 2002-04)
    Development of the multilayered cerebral cortex involves extensive regulated migration of neurons arising from the deeper germinative layers of the mammalian brain [1]. The anatomy and formation of the cortical layers has ...
  • Barzik, Melanie; McClain, Leslie Marie; Gupton, Stephanie L.; Gertler, Frank (American Society for Cell Biology, 2014-07)
    Filopodia are long plasma membrane extensions involved in the formation of adhesive, contractile, and protrusive actin-based structures in spreading and migrating cells. Whether filopodia formed by different molecular ...
  • Mobine, Hector R.; Engelmayr, George C.; Moussazadeh, Nelson; Anwar, Tayyba R.; Freed, Lisa E.; Edelman, Elazer R. (Mary Ann Liebert, Inc., 2009-07)
    Pheochromocytomas are widely believed to induce cardiomyopathy via hypersecretion of catecholamines, including norepinephrine (NE). NE can have direct cardiomyocyte toxicity and/or can stimulate myocardial remodeling ...
  • Suntharalingam, Kogularamanan; Lippard, Stephen J.; Zheng, Yaorong; Johnstone, Timothy (Royal Society of Chemistry, The, 2014-11)
    This report presents a novel strategy that facilitates delivery of multiple, specific payloads of Pt(IV) prodrugs using a well-defined supramolecular system. This delivery system comprises a hexanuclear Pt(II) cage that ...
  • Yarnall, Timothy M.; Abouraddy, Ayman F.; Di Giuseppe, Giovanni; Saleh, Bahaa E. A.; Teich, Malvin C. (American Physical Society, 2012-06)
    Advancing quantum information processing is predicated on the preparation of ever-larger multiqubit states. Photonic realizations of such states may be achieved by increasing the number of photons populating the state or ...
  • Khan, Sheraz; Lefevre, Julien; Baillet, Sylvain; Michmizos, Konstantinos; Ganesan, Santosh; Kitzbichler, Manfred G.; Zetino, Manuel; Hamalainen, Matti S.; Papadelis, Christos; Kenet, Tal (Frontiers Research Foundation, 2014-05)
    Distributed cortical solutions of magnetoencephalography (MEG) and electroencephalography (EEG) exhibit complex spatial and temporal dynamics. The extraction of patterns of interest and dynamic features from these cortical ...
  • Stamoulis, Catherine; Richardson, Andrew G. (Springer Science + Business Media B.V., 2010-02)
    Local field potentials (LFPs) measure aggregate neural activity resulting from the coordinated firing of neurons within a local network. We hypothesized that state parameters associated with the underlying brain dynamics ...
  • Van Leemput, Koen (Institute of Electrical and Electronics Engineers, 2009-06)
    This paper addresses the problem of creating probabilistic brain atlases from manually labeled training data. Probabilistic atlases are typically constructed by counting the relative frequency of occurrence of labels in ...
  • Pipa, Gordon; Lewis, Laura D.; Nikolić, Danko; Williams, Ziv; Brown, Emery N.; Haslinger, Robert Heinz (MIT Press, 2013-08)
    Although the existence of correlated spiking between neurons in a population is well known, the role such correlations play in encoding stimuli is not. We address this question by constructing pattern-based encoding models ...
  • Tucker, Catherine Elizabeth; Miller, Amalia R. (Wiley Blackwell, 2011-05)
    Fast-paced IT advances have made it increasingly possible and useful for firms to collect data on their customers on an unprecedented scale. One downside of this is that firms can experience negative publicity and financial ...
  • Ritvo, Harriet (American Association for the Advancement of Science, 2009-03)
  • Nicholson, Anna L.; Olivetti, Elsa A.; Gregory, Jeremy; Field, Frank R.; Kirchain, Randolph E., Jr. (Institute of Electrical and Electronics Engineers, 2009-07)
    Materials selection decisions exhibit great influence on the environmental performance of firms through their impact on processing technology, product form, and supply chain configuration. Consequently, materials dictate ...
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