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Browsing MIT Open Access Articles by Title

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  • Finkelstein, Amy; Brown, Jeffrey R. (American Economic Association, 2011-01)
    Long-term care expenditures constitute one of the largest uninsured financial risks facing the elderly in the United States and thus play a central role in determining the retirement security of elderly Americans. In this ...
  • Ploegh, Hidde; Tafesse, Fikadu G.; Sanyal, Sumana; Ashour, Joseph; Guimaraes, Carla P.; Hermansson, Martin; Somerharju, Pentti (National Academy of Sciences (U.S.), 2013-04)
    Cells genetically deficient in sphingomyelin synthase-1 (SGMS1) or blocked in their synthesis pharmacologically through exposure to a serine palmitoyltransferase inhibitor (myriocin) show strongly reduced surface display ...
  • Meyers, Carol A.; Schulz, Andreas S. (Elsevier Science, 2009-03)
    The integer equal flow problem is an NP-hard network flow problem, in which all arcs in given sets R1,…,R[subscript ℓ] must carry equal flow. We show that this problem is effectively inapproximable, even if the cardinality ...
  • Demaine, Erik D.; Fekete, Sándor P.; Rote, Günter; Schweer, Nils; Schymura, Daria; Zelke, Mariano (Elsevier B.V., 2010-09)
    An n-town, n[is an element of]N , is a group of n buildings, each occupying a distinct position on a 2-dimensional integer grid. If we measure the distance between two buildings along the axis-parallel street grid, then ...
  • Orlin, James B.; Punnen, Abraham P.; Schulz, Andreas S. (Springer Science + Business Media B.V., 2009-01)
    We show that if one can find the optimal value of an integer linear programming problem in polynomial time, then one can find an optimal solution in polynomial time. We also present a proper generalization to (general) ...
  • Todadri, Senthil; Levin, Michael (American Physical Society, 2013-01)
    A simple physical realization of an integer quantum Hall state of interacting two dimensional bosons is provided. This is an example of a symmetry-protected topological (SPT) phase which is a generalization of the concept ...
  • Perron, J. Taylor; Royden, Leigh H. (Wiley Blackwell, 2012-08)
    Bedrock river profiles are often interpreted with the aid of slope–area analysis, but noisy topographic data make such interpretations challenging. We present an alternative approach based on an integration of the steady-state ...
  • Crounse, B. C.; Wannamaker, E. J.; Adams, E. Eric (American Society of Civil Engineers (ASCE), 2007-01)
    The writers present a one-dimensional integral model to describe multiphase plumes discharged to quiescent stratified receiving waters. The model includes an empirical submodel for detrainment, and the capability to include ...
  • Byun, Hyunil; Pudo, Dominik; Frolov, Sergey; Hanjani, Amir; Shmulovich, Joseph; Ippen, Erich P.; Kärtner, Franz X. (Institute of Electrical and Electronics Engineers (IEEE), 2010-07)
    An integrated passively mode-locked 2-GHz waveguide laser generating 285-fs pulses is demonstrated. It is based on a 500-MHz repetition rate laser integrated together with a pulse interleaver on a 45×50 mm silica waveguide chip.
  • Monier, Erwan; Scott, Jeffery R.; Sokolov, Andrei P.; Forest, Chris E.; Schlosser, Adam (Copernicus GmbH, 2013-12)
    This paper describes a computationally efficient framework for uncertainty studies in global and regional climate change. In this framework, the Massachusetts Institute of Technology (MIT) Integrated Global System Model ...
  • Selva Valero, Daniel; Crawley, Edward F. (Institute of Electrical and Electronics Engineers, 2010-04)
    When designing Earth observation missions, it is essential to take into account the programmatic context. Considering individual missions as part of a whole enables overall program optimization, which may bring important ...
  • Martin, Collin H.; Wu, Danyi; Prather, Kristala L. Jones (American Society for Microbiology, 2010-01)
    Enzymes are powerful biocatalysts capable of performing specific chemical transformations under mild conditions, yet as catalysts they remain subject to the laws of thermodynamics, namely, that they cannot catalyze chemical ...
  • Wang, Han; Yu, Lili; Lee, Yi-Hsien; Shi, Yumeng; Hsu, Allen; Chin, Matthew L.; Li, Lain-Jong; Dubey, Madan; Kong, Jing; Palacios, Tomas (American Chemical Society, 2012-09)
    Two-dimensional (2D) materials, such as molybdenum disulfide (MoS2), have been shown to exhibit excellent electrical and optical properties. The semiconducting nature of MoS2 allows it to overcome the shortcomings of ...
  • Watanabe, Hideo; Francis, Joshua M.; Woo, Michele S.; Etemad, Banafsheh; Lin, Wenchu; Fries, Daniel F.; Peng, Shouyong; Snyder, Eric; Tata, Purushothama Rao; Izzo, Francesca; Schinzel, Anna C.; Cho, Jeonghee; Hammerman, Peter S.; Verhaak, Roel G.; Hahn, William C.; Rajagopal, Jayaraj; Jacks, Tyler E.; Meyerson, Matthew (Cold Spring Harbor Laboratory Press, 2013-01)
    The NKX2-1 transcription factor, a regulator of normal lung development, is the most significantly amplified gene in human lung adenocarcinoma. To study the transcriptional impact of NKX2-1 amplification, we generated an ...
  • Joughin, Brian A.; Naegle, Kristen Marie; Huang, Paul H.; Yaffe, Michael B.; Lauffenburger, Douglas A.; White, Forest M. (Royal Society of Chemistry, 2008-10)
    Glioblastoma (GBM, WHO grade IV) is an aggressively proliferative and invasive brain tumor that carries a poor clinical prognosis with a median survival of 9 to 12 months. In a prior phosphoproteomic study performed in the ...
  • Carlson, Scott Moore; White, Forest M.; Lahesmaa-Korpinen, Anna-Maria; Hautaniemi, Sampsa (Wiley Blackwell, 2010-09)
    MS/MS is a widely used method for proteome-wide analysis of protein expression and PTMs. The thousands of MS/MS spectra produced from a single experiment pose a major challenge for downstream analysis. Standard programs, ...
  • Altshuler, Robert Charles; Ernst, Jason; Kellis, Manolis; Kheradpour, Pouya; Ward, Lucas D.; Eaton, Matthew Lucas; Hendrix, David A.; Jungreis, Irwin; Lin, Michael F.; Washietl, Stefan (Nature Publishing Group, 2012-09)
    The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of ...
  • Lander, Eric S.; Meyerson, Matthew L. (Nature Publishing Group, 2011-06)
    A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, ...
  • Lander, Eric S.; Park, Peter J. (Nature Publishing Group, 2013-05)
    We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ~25% of high-grade endometrioid ...
  • Salvesen, H. B.; Carter, Scott Lambert; Mannelqvist, M.; Dutt, Amit; Getz, Gad; Stefansson, I. M.; Raeder, M. B.; Sos, M. L.; Engelsen, I. B.; Trovik, J.; Wik, E.; Greulich, Heidi; Bo, T. H.; Jonassen, I.; Thomas, R. K.; Zander, T.; Garraway, Levi A.; Oyan, A. M.; Sellers, W. R.; Kalland, K. H.; Meyerson, Matthew L.; Akslen, L. A.; Beroukhim, Rameen (National Academy of Sciences, 2009-03)
    Although 75% of endometrial cancers are treated at an early stage, 15% to 20% of these recur. We performed an integrated analysis of genome-wide expression and copy-number data for primary endometrial carcinomas with ...
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