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Browsing MIT Open Access Articles by Title

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  • Greenstone, Michael; Hornbeck, Richard; Moretti, Enrico (University of Chicago Press, 2010-06)
    We quantify agglomeration spillovers by comparing changes in total factor productivity (TFP) among incumbent plants in “winning” counties that attracted a large manufacturing plant and “losing” counties that were the new ...
  • Miller, Miles Aaron; Feng, Xiao-Jiang; Li, Genyuan; Rabitz, Herschel A. (Public Library of Science, 2012-06)
    This work presents an adapted Random Sampling - High Dimensional Model Representation (RS-HDMR) algorithm for synergistically addressing three key problems in network biology: (1) identifying the structure of biological ...
  • Thaler, Jesse; Van Tilburg, Ken (Springer-Verlag, 2011-03)
    We introduce a new jet shape—N-subjettiness—designed to identify boosted hadronically-decaying objects like electroweak bosons and top quarks. Combined with a jet invariant mass cut, N-subjettiness is an effective ...
  • Oloritun, Rahman O.; Madan, Anmol; Khayal, Inas; Pentland, Alex Paul (Elsevier, 2013-06)
    Studies have suggested that propinquity; social, cultural, physical and psychological similarities are major factors in close friendship ties. These studies were subject to human recall of interactions with no details of ...
  • Pintilie, Grigore Dimitrie; Zhang, Junjie; Chiu, Wah; Gossard, David C. (Institute of Electrical and Electronics Engineers, 2009-04)
    Segmentation of density maps obtained using cryo-electron microscopy (cryo-EM) is a challenging task, and is typically accomplished by time-intensive interactive methods. The goal of segmentation is to identify the regions ...
  • Mitsos, Alexander; Melas, Ioannis N.; Siminelakis, Paraskeuas; Chairakaki, Aikaterini D.; Saez-Rodriguez, Julio; Alexopoulos, Leonidas G. (Public Library of Science, 2009-10)
    Understanding the mechanisms of cell function and drug action is a major endeavor in the pharmaceutical industry. Drug effects are governed by the intrinsic properties of the drug (i.e., selectivity and potency) and the ...
  • Yang, Ming; Chakraborty, Arup K.; Govern, Christopher C. (American Physical Society, 2012-01)
    In biochemical networks, identifying key proteins and protein-protein reactions that regulate fluctuation-driven transitions leading to pathological cellular function is an important challenge. Using large deviation theory, ...
  • Yang, Shun-Chieh; Chang, Su-Sen; Chen, Yu-Chian (Public Library of Science, 2011-12)
    The relationship between abnormal HER2 expression and cancer is important in cancer therapeutics. Formation and spread of cancer cells may be restricted by inhibiting HER2. We conducted ligand-based and structure-based ...
  • Guttman, Mitchell; Garber, Manuel; Clamp, Michele; Zody, Michael C.; Friedman, Nir; Xie, Xiaohui (Oxford University Press (OUP), 2009-06)
    Motivation: Comparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved sequences across species; ...
  • Andersen, Kristian G.; Shlyakhter, Ilya; Tabrizi, Shervin; Winnicki, Sarah; Yen, Angela; Park, Daniel J.; Griesemer, Dustin; Karlsson, Elinor K.; Wong, Sunny H.; Cabili, Moran; Adegbola, Richard A.; Bamezai, Rameshwar N.K.; Hill, Adrian V.S.; Vannberg, Fredrik O.; Rinn, John L.; Lander, Eric S.; Schaffner, Stephen F.; Sabeti, Pardis C.; Grossman, Sharon Rachel; Lander, Eric S. (Elsevier, 2013-02)
    Although several hundred regions of the human genome harbor signals of positive natural selection, few of the relevant adaptive traits and variants have been elucidated. Using full-genome sequence variation from the 1000 ...
  • Daly, Mark J.; Altshuler, David; Xavier, Ramnik J.; Sklar, Pamela; Purcell, Shaun M.; International Schizophrenia Consortium; Nguyen, Aylwin C. Y.; Scolnick, Edward Mark; Rossin, Elizabeth; Plenge, Robert M.; Raychaudhuri, Soumya (Public Library of Science, 2009-06)
    Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ...
  • Raychaudhuri, Soumya; Plenge, Robert M.; Rossin, Elizabeth; Ng, Aylwin C. Y.; Purcell, Shaun M.; Sklar, Pamela; Scolnick, Edward Mark; Xavier, Ramnik J.; Altshuler, David; Daly, Mark J. (Public Library of Science, 2009-06)
    Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ...
  • Ong, Shao-En; Schenone, Monica; Margolin, Adam A.; Li, Xiaoyu; Do, Kathy; Doud, Mary K.; Mani, D. R.; Kuai, Letian; Wang, Xiang; Wood, John L.; Tolliday, Nicola J.; Koehler, Angela N.; Marcaurelle, Lisa A.; Golub, Todd R.; Gould, Robert J.; Schreiber, Stuart L.; Carr, Steven A. (National Academy of Sciences, 2009-03)
    Most small-molecule probes and drugs alter cell circuitry by interacting with 1 or more proteins. A complete understanding of the interacting proteins and their associated protein complexes, whether the compounds are ...
  • von Hippel, Eric A.; von Krogh, Georg (2013-11-27)
    Problem-solving research, and formal problem-solving practice as well, begins with the assumption that a problem has been identified or formulated for solving. The problem-solving process then involves a search for a ...
  • Daniel, J. S.; Portmann, R. W.; Solomon, Susan; Murphy, D. M. (American Geophysical Union (AGU), 2012-07)
    [1] Weekly cycles in several meteorological parameters have been previously reported. Yet the extent to which these cycles are caused by anthropogenic activity remains unclear. Some of the complications associated with ...
  • Petersen, Roger D. (Oxford University Press, 2012-10)
    I wish to address both a substantive and a methodological issue in this chapter. Substantively, I will discuss the process of state disintegration and reconstruction. Here, I will draw on the experience of Eastern Europe ...
  • Van Maanen, John (Cambridge University Press, 2010-11)
    This chapter is about three highly intertwined concepts. The first concerns occupational communities and the work cultures they nourish. The second concerns the work identities that are valued (and devalued) in such ...
  • Haslanger, Sally (Springer Science + Business Media B.V., 2011)
    Introduction: Are sagging pants cool? Are cows food? Are women more submissive than men? Are blacks more criminal than whites? Taking the social world at face value, many people would be tempted to answer these questions ...
  • Schultz, David; Liskov, Barbara H. (Association for Computing Machinery (ACM), 2013-04)
    Numerous sensitive databases are breached every year due to bugs in applications. These applications typically handle data for many users, and consequently, they have access to large amounts of confidential information. This ...
  • Grodzinsky, Alan J.; Wheeler, Cameron A.; Jafarzadeh, Seyed R.; Rocke, David M. (Elsevier Ltd., 2009-02)
    Objective To determine changes in chondrocyte transcription of a range of anabolic, catabolic and signaling genes following simultaneous treatment of cartilage with Insulin-like growth factor-1 (IGF-1) and ramp-and-hold ...
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