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Browsing MIT Open Access Articles by Title

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  • Reinke, Aaron Wade; Grigoryan, Gevorg; Keating, Amy E. (American Chemical Society, 2010-03)
    Basic-region leucine-zipper transcription factors (bZIPs) contain a segment rich in basic amino acids that can bind DNA, followed by a leucine zipper that can interact with other leucine zippers to form coiled-coil homo- ...
  • Emerling, B. M.; Benes, C. H.; Poulogiannis, G.; Courtney, K.; Liu, H.; Choo-Wing, R.; Bellinger, G.; Tsukazawa, K. S.; Brown, V.; Signoretti, S.; Soltoff, S. P.; Cantley, L. C.; Bell, Eric L. (National Academy of Sciences (U.S.), 2013-02)
    CUB domain-containing protein 1 (CDCP1) is a transmembrane protein that is highly expressed in stem cells and frequently overexpressed and tyrosine-phosphorylated in cancer. CDCP1 promotes cancer cell metastasis. However, ...
  • Kheradpour, Pouya; Bristow, Christopher A.; Mag Washietl, Stefan; Ay, Ferhat; Jungreis, Irwin; Marbach, Daniel; Sealfon, Rachel Sima; Will, Sebastian; Berger, Bonnie; Kellis, Manolis; Roy, Sushmita; Ernst, Jason; Lin, Michael F.; Meyer, Patrick E.; Di Stefano, Luisa; Candeias, Rogerio; Nordman, Jared; Orr-Weaver, Terry L. (American Association for the Advancement of Science (AAAS), 2010-12)
    To gain insight into how genomic information is translated into cellular and developmental programs, the Drosophila model organism Encyclopedia of DNA Elements (modENCODE) project is comprehensively mapping transcripts, ...
  • Vaysse, Amaury; Ratnakumar, Abhirami; Derrien, Thomas; Axelsson, Erik; Pielberg, Gerli Rosengren; Fall, Tove; Seppälä, Eija H.; Hansen, Mark S. T.; Lawley, Cindy T.; Bannasch, Danika; Vilà, Carles; Lohi, Hannes; Galibert, Francis; Fredholm, Merete; Häggström, Jens; Hedhammar, Åke; André, Catherine; Hitte, Christophe; Webster, Matthew T.; Sigurdsson, Snaevar; Karlsson, Elinor K.; Lindblad-Toh, Kerstin (Public Library of Science, 2011-10)
    The extraordinary phenotypic diversity of dog breeds has been sculpted by a unique population history accompanied by selection for novel and desirable traits. Here we perform a comprehensive analysis using multiple test ...
  • Liu, Fa; Park, Jung-Eun; Qian, Wen-Jian; Scharow, Andrej; Berg, Thorsten; Yaffe, Michael B.; Lee, Kyung S.; Burke, Terrence R.; Lim, Daniel Cham-Chin (American Chemical Society (ACS), 2012-01)
    In an effort to develop improved binding antagonists of the polo-like kinase 1 (Plk1) polo-box domain (PBD), we optimized interactions of the known high affinity 5-mer peptide PLHSpT using oxime-based post solid-phase ...
  • Guimaraes, Carla P.; Carette, Jan E.; Varadarajan, Malini; Antos, John; Popp, Maximilian W.; Spooner, Eric; Brummelkamp, Thijn R.; Ploegh, Hidde (Rockefeller University Press, 2011-10)
    We describe a novel labeling strategy to site-specifically attach fluorophores, biotin, and proteins to the C terminus of the A1 subunit (CTA1) of cholera toxin (CTx) in an otherwise correctly assembled and active CTx ...
  • McCombie, D. B.; Asada, Harry; Reisner, Andrew T.; Hahn, Jin-Oh; Hojman, H. M. (Institute of Electrical and Electronics Engineers, 2009-12)
    This paper presents a novel method to identify the cardiovascular (CV) system using two distinct peripheral blood pressure (BP) signals. The method can characterize the distinct arterial path dynamics that shape each of ...
  • Rosasco, Lorenzo Andrea; Fardin, Paolo; Cornero, Andrea; Barla, Annalisa; Mosci, Sofia; Acquaviva, Massimo; Gambini, Claudio; Verri, Alessandro; Varesio, Luigi (Hindawi, 2010-04)
    Hypoxia is a condition of low oxygen tension occurring in the tumor and negatively correlated with the progression of the disease. We studied the gene expression profiles of nine neuroblastoma cell lines grown under hypoxic ...
  • Svensson, J. Peter; Fry, Rebecca C.; Wang, Emma; Somoza, Luis A.; Samson, Leona D. (Public Library of Science, 2012-05)
    Studies in Saccharomyces cerevisiae show that many proteins influence cellular survival upon exposure to DNA damaging agents. We hypothesized that human orthologs of these S. cerevisiae proteins would also be required for ...
  • Chan, Clement T. Y.; Chionh, Yok Hian; Ho, Chia-Hua; Lim, Kok Seong; Babu, I. Ramesh; Ang, Emily; Wenwei, Lin; Alonso, Sylvie; Dedon, Peter C. (MDPI AG, 2011-06)
    There are more than 100 different ribonucleoside structures incorporated as post-transcriptional modifications, mainly in tRNA and rRNA of both prokaryotes and eukaryotes, and emerging evidence suggests that these modifications ...
  • Yang, Shun-Chieh; Chang, Su-Sen; Chen, Hsin-Yi; Chen, Yu-Chian (Public Library of Science, 2011-10)
    Overexpression of epidermal growth factor receptor (EGFR) has been associated with cancer. Targeted inhibition of the EGFR pathway has been shown to limit proliferation of cancerous cells. Hence, we employed Traditional ...
  • Wang, Hongxin; Mitra, Devrani; Tinberg, Christine E.; Do, Loi Hung; Jenney, Francis E., Jr.; Adams, Michael W. W.; Cramer, Stephen P.; Lippard, Stephen J. (American Chemical Society (ACS), 2010-04)
    We have applied [superscript 57]Fe nuclear resonance vibrational spectroscopy (NRVS) to identify protein-bound dinitrosyl iron complexes. Intense NRVS peaks due to vibrations of the N−Fe−N unit can be observed between 500 ...
  • Michalek, Diana; Balakrishnan, Hamsa (Eurocontrol, 2009-06)
    Convective weather is responsible for large delays and widespread disruptions in the U.S. National Airspace System (NAS), especially during summer months when travel demand is high. This has been the motivation for Air ...
  • Balakrishnan, Hamsa; Pfeil, Diana Michalek (Institute for Operations Research and the Management Sciences (INFORMS), 2011-06)
    Convective weather is responsible for large delays and widespread disruptions in the U.S. National Airspace System, especially during summer. Traffic flow management algorithms require reliable forecasts of route blockage ...
  • Shan, Jing; Ross, Nathan T; Logan, David J; Thomas, David; Duncan, Stephen A; North, Trista E; Goessling, Wolfram; Carpenter, Anne E; Schwartz, Robert; Bhatia, Sangeeta N. (2013-06)
    Cell-based therapies hold the potential to alleviate the growing burden of liver diseases. Such therapies require human hepatocytes, which, within the stromal context of the liver, are capable of many rounds of replication. ...
  • Barthelme, Dominik; Sauer, Robert T. (American Association for the Advancement of Science, 2012-07)
    Proteasomes are the major energy-dependent proteolytic machines in the eukaryotic and archaeal domains of life. To execute protein degradation, the 20S core peptidase combines with the AAA+ ring of the 19S regulatory ...
  • Regev, Aviv (Nature Publishing Group, 2013-04)
    The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. Here, the ...
  • Eyford, Brett A.; Ahmad, Rushdy; Enyaru, John C.; Carr, Steven A.; Pearson, Terry W. (Public Library of Science, 2013-08)
    Control of human African sleeping sickness, caused by subspecies of the protozoan parasite Trypanosoma brucei, is based on preventing transmission by elimination of the tsetse vector and by active diagnostic screening and ...
  • Balewski, Jan T.; Betancourt, M. J.; Corliss, Ross; Hays-Wehle, James Prewitt; Leight, William Axel; Milner, Richard G.; Redwine, Robert P; Seele, J.; Steadman, Stephen G.; Surrow, Bernd; van Nieuwenhuizen, G.; Walker, M. (American Physical Society, 2012-02)
    We report transverse momentum (pT≤15  GeV/c) spectra of π[superscript ±], K[superscript ±], p, p̅ , K[subscript S][superscript 0], and ρ[superscript 0] at midrapidity in p+p and Au+Au collisions at √sNN=200  GeV. Perturbative ...
  • Surrow, Bernd; Balewski, Jan T.; Betancourt, Michael Joseph; Hays-Wehle, James Prewitt; Hoffman, A. M.; Jones, Christopher LaDon; Kocoloski, Adam Philip; Leight, William Axel; Milner, Richard G.; Redwine, Robert P.; Sakuma, Tai; Seele, Joseph Patrick; Stephans, George S. F.; van Nieuwenhuizen, Gerrit Jan; Walker, M.; Corliss, Ross Cameron (American Physical Society, 2010-02)
    We present the first measurements of identified hadron production, azimuthal anisotropy, and pion interferometry from Au+Au collisions below the nominal injection energy at the BNL Relativistic Heavy-Ion Collider (RHIC) ...
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