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Browsing MIT Open Access Articles by Title

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  • Su, Xingfang; Fricke, Jennifer; Kavanagh, Daniel G.; Irvine, Darrell J. (American Chemical Society, 2011-06)
    Biodegradable core−shell structured nanoparticles with a poly(β-amino ester) (PBAE) core enveloped by a phospholipid bilayer shell were developed for in vivo mRNA delivery with a view toward delivery of mRNA-based vaccines. ...
  • Wilson, Justin J.; Lippard, Stephen J. (American Chemical Society (ACS), 2012-05)
    Five cationic platinum(II) complexes of general formula, [Pt(NH[subscript 3])[subscript 2](β-diketonate)]X are reported, where X is a noncoordinating anion and β-diketonate = acetylacetonate (acac), 1,1,1,-trifluoroacetylacetonate ...
  • Jeon, Jessie S.; Zervantonakis, Ioannis; Chung, Seok; Kamm, Roger Dale (Public Library of Science, 2013-02)
    Tumor cells that disseminate from the primary tumor and survive the vascular system can eventually extravasate across the endothelium to metastasize at a secondary site. In this study, we developed a microfluidic system ...
  • Artzi, Natalie; Oliva, Nuria; Puron, Cristina; Shitreet, Sagi; bon Ramos, Adriana; Artzi, Shay; Groothuis, Adam; Sahagian, Gary; Edelman, Elazer R. (Nature Publishing Group, 2011-08)
    The design of erodible biomaterials relies on the ability to program the in vivo retention time, which necessitates real-time monitoring of erosion. However, in vivo performance cannot always be predicted by traditional ...
  • Gill, Thomas J.; Li, Guoan; Hosseini, Ali (Springer Japan, 2009-06)
    Background: The knowledge of in vivo anterior cruciate ligament (ACL) deformation is fundamental for understanding ACL injury mechanisms and for improving surgical reconstruction of the injured ACL. This study investigated ...
  • Chen, Yi; Hunter, Ian (Institute of Electrical and Electronics Engineers, 2009-11)
    This paper describes an indentometer device used to identify the linear dynamic and nonlinear properties of skin and underlying tissue using an in vivo test. The device uses a Lorentz force actuator to apply a dynamic force ...
  • Danino, Tal; Lo, Justin H.; Prindle, Arthur; Hasty, Jeff; Bhatia, Sangeeta N. (American Chemical Society (ACS), 2012-09)
    The engineering of bacteria to controllably deliver therapeutics is an attractive application for synthetic biology. While most synthetic gene networks have been explored within microbes, there is a need for further ...
  • Massimini, Daniel Frank; Boyer, Patrick J.; Papannagari, Ramprasad; Gill, Thomas J.; Warner, Jon P.; Li, Guoan (Biomed Central Ltd., 2012-06)
    Study Design: Basic Science. To investigate humeral head translations and glenohumeral ligament elongation with a dual fluoroscopic imaging system. Background: The glenohumeral ligaments are partially responsible for ...
  • Lee, Taekwan; Zhang, Xiao-an; Dhar, Shanta; Faas, Henryk; Lippard, Stephen J.; Jasanoff, Alan Pradip (Elsevier B.V., 2010-06)
    Magnetic resonance imaging (MRI) with molecular probes offers the potential to monitor physiological parameters with comparatively high spatial and temporal resolution in living subjects. For detection of intracellular ...
  • Lee, Taekwan; Zhang, Xiao-an; Dhar, Shanta; Faas, Henryk; Lippard, Stephen J.; Jasanoff, Alan Pradip (Elsevier, 2010-06)
    Magnetic resonance imaging (MRI) with molecular probes offers the potential to monitor physiological parameters with comparatively high spatial and temporal resolution in living subjects. For detection of intracellular ...
  • Penman, Sheldon; Hoffman, Robert M.; Fujiwara, Toshiyoshi; Tanaka, Noriaki; Urata, Yasuo; Hayashi, Katsuhiro; Zhao, Ming; Kishimoto, Hiroyuki (United States National Academy of Sciences, 2009-08)
    Cancer surgery requires the complete and precise identification of malignant tissue margins including the smallest disseminated lesions. Internal green fluorescent protein (GFP) fluorescence can intensely illuminate even ...
  • Wyatt, John L.; Mendoza, Oscar D.; Kelly, Shawn K.; Doyle, Patrick S.; Shire, Douglas B.; Gingerich, Marcus D.; Chen, Jinghua; Cogan, Stuart F.; Drohan, William A.; Theogarajan, Luke; Rizzo, Joseph F. (SPIE, 2010-02)
    This presentation concerns the engineering development of the Boston visual prosthesis for restoring useful vision to patients blind with degenerative retinal disease. A miniaturized, hermetically-encased, 15-channel ...
  • Chan, Juliana Maria; Rhee, June-Wha; Drum, Chester L.; Bronson, Roderick T.; Golomb, Gershon; Langer, Robert; Farokhzad, Omid C. (National Academy of Sciences, 2011-11)
    Following recent successes with percutaneous coronary intervention (PCI) for treating coronary artery disease (CAD), many challenges remain. In particular, mechanical injury from the procedure results in extensive endothelial ...
  • Wirth, Dyann; Daily, Johanna; Winzeler, Elizabeth; Mesirov, Jill P.; Regev, Aviv (National Academy of Sciences, 2009-07)
    Lemieux et al. (1) describe a reanalysis of our in vivo Plasmodium falciparum patient samples (2), supporting many of our conclusions (exclusive presence of rings, lack of distinct asexual phases in the clusters, a relation ...
  • Motz, Jason T.; Fitzmaurice, Maryann; Miller, Arnold; Gandhi, Saumil J.; Haka, Abigail S.; Galindo, Luis H.; Kramer, John R.; Feld, Michael S.; Dasari, Ramachandra Rao (SPIE, 2006-04)
    The rupture of vulnerable atherosclerotic plaque accounts for the majority of clinically significant acute cardiovascular events. Because stability of these culprit lesions is directly related to chemical and morphological ...
  • Ho, Emily E.; Dubrovsky, Esther; Gertler, Frank; Meacham, Meacham; Hemann, Michael (Nature Publishing Group, 2009-09)
    Mouse models have markedly improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic experimentation. Here, we report ...
  • Lamata, L.; Leibrant, David R.; Chuang, Isaac L.; Cirac, J. I.; Lukin, M. D.; Vuletic, Vladan; Yelin, S. F. (American Physical Society, 2011-07)
    A new approach for the realization of a quantum interface between single photons and single ions in an ion crystal is proposed and analyzed. In our approach the coupling between a single photon and a single ion is enhanced ...
  • Schulz, Norbert S.; Canizares, Claude R.; Lee, Julia C.; Sako, Masao (IOP Publishing, 2001-12)
    We present a first analysis of a high-resolution X-ray spectrum of the ionized stellar wind of Vela X-1 during eclipse. The data were obtained with the High-Energy Transmission Grating Spectrometer on board the Chandra ...
  • Landreman, Matt; Fulop, T. (American Physical Society, 2013-07)
    Runaway ions can be produced in plasmas with large electric fields, where the accelerating electric force is augmented by the low mean ionic charge due to the imbalance between the number of electrons and ions. Here we ...
  • Gardikis, Georgios; Xilouris, George; Montpetit, Marie-Jose; Vanelli-Coralli, Alessandro; Negru, Daniel (Hindawi Publishing Corporation, 2010-12)
    The vision of the Internet of the Future for service ubiquity dictates that end users should be able to access services—mostly media-oriented ones—at any time from a variety of networks, including mobile, broadband, and ...
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