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Browsing MIT Open Access Articles by Title

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  • Discovery of 9-(6-aminopyridin-3-yl)-1-(3- (trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treatment of cancer 
    Kang, Seong A.; Sabatini, David M.; Liu, Qingsong; Wang, Jinhua; Thoreen, Carson C.; Hur, Wooyoung; Ahmed, Tausif; Gray, Nathanael S. (American Chemical Society (ACS), 2011-02)
    The mTOR mediated PI3K/AKT/mTOR signal transduction pathway has been demonstrated to play a key role in a broad spectrum of cancers. Starting from the mTOR selective inhibitor 1 (Torin1), a focused medicinal chemistry ...
  • Discovery Of A 552 Hz Burst Oscillation In The Low-Mass X-Ray Binary Exo 0748–676 
    Lin, Jinrong; Chakrabarty, Deepto; Galloway, Duncan K.; Hartman, Jacob M. (IOP Publishing, 2010-02)
    We report the detection of pulsations at 552 Hz in the rising phase of two type-I (thermonuclear) X-ray bursts observed from the accreting neutron star EXO 0748–676 in 2007 January and December, by the Rossi X-ray Timing ...
  • Discovery of a 693.5 S Period in the X-ray Binary 4u 1820−30: a Superhump Interpretation 
    Wang, Zhongxiang; Chakrabarty, Deepto (IOP Publishing, 2010-03)
    The X-ray source 4U 1820-30 in the globular cluster NGC 6624 is known as the most compact binary among the identified X-ray binaries (XRBs). Having an orbital period of 685.0 s, the source consists of a neutron star (NS) ...
  • DISCOVERY OF A CANDIDATE FOR THE COOLEST KNOWN BROWN DWARF 
    Luhman, K. L.; Bochanski, John J.; Burgasser, Adam J. (IOP Publishing, 2011-02)
    We have used multi-epoch images from the Infrared Array Camera on board the Spitzer Space Telescope to search for substellar companions to stars in the solar neighborhood based on common proper motions. Through this work, ...
  • DISCOVERY OF A COSMOLOGICAL, RELATIVISTIC OUTBURST VIA ITS RAPIDLY FADING OPTICAL EMISSION 
    Cenko, S. Bradley; Kulkarni, S. R.; Horesh, Assaf; Corsi, A.; Fox, Derek B.; Carpenter, John; Frail, Dale A.; Nugent, Peter E.; Perley, Daniel A.; Gruber, D.; Gal-Yam, Avishay; Groot, P.; Hallinan, G.; Ofek, Eran O.; Rau, Arne; MacLeod, Chelsea L.; Miller, Adam A.; Bloom, Joshua S.; Filippenko, Alexei V.; Kasliwal, Mansi M.; Law, Nicholas M.; Morgan, Adam N.; Polishook, David; Poznanski, Dovi; Quimby, Robert M.; Sesar, Branimir; Shen, Ken J.; Silverman, Jeffrey M.; Sternberg, Assaf (Institute of Physics/American Astronomical Society, 2013-06)
    We report the discovery by the Palomar Transient Factory (PTF) of the transient source PTF11agg, which is distinguished by three primary characteristics: (1) bright (R[subscript peak] = 18.3 mag), rapidly fading (ΔR = 4 ...
  • DISCOVERY OF A HIGHLY VARIABLE DIPPING ULTRALUMINOUS X-RAY SOURCE IN M94 
    Lin, Dacheng; Irwin, Jimmy A.; Webb, Natalie A.; Barret, Didier; Remillard, Ronald Alan (Institute of Physics/American Astronomical Society, 2013-12)
    We report the discovery of a new ultraluminous X-ray source (ULX) 2XMM J125048.6+410743 within the spiral galaxy M94. The source has been observed by ROSAT, Chandra, and XMM-Newton on several occasions, exhibiting as a ...
  • DISCOVERY OF AN ACCRETING MILLISECOND PULSAR IN THE ECLIPSING BINARY SYSTEM SWIFT J1749.4–2807 
    Altamirano, D.; Cavecchi, Y.; Patruno, A.; Watts, A.; Linares, Manuel Alegret; Degenaar, N.; Kalamkar, M.; van der Klis, M.; Rea, N.; Casella, P.; Armas Padilla, M.; Kaur, R.; Yang, Y. J.; Soleri, P.; Wijnands, R. (Institute of Physics/American Astronomical Society, 2011-01)
    We report on the discovery and the timing analysis of the first eclipsing accretion-powered millisecond X-ray pulsar (AMXP): SWIFT J1749.4-2807. The neutron star rotates at a frequency of ~517.9 Hz and is in a binary system ...
  • DISCOVERY OF AN UNUSUALLY BLUE L DWARF WITHIN 10 pc OF THE SUN 
    Burgasser, Adam J.; West, Andrew A.; Bochanski, John J.; Schmidt, Sarah J.; Hawley, Suzanne L. (American Astronomical Society, 2010-02)
    We report the discovery of an unusually blue L5 dwarf within 10 pc of the Sun from a search of Sloan Digital Sky Survey (SDSS) spectra. A spectrophotometric distance estimate of 8.0±1.6 pc places SDSS J141624.08+134826.7 among ...
  • DISCOVERY OF A SECOND TRANSIENT LOW-MASS X-RAY BINARY IN THE GLOBULAR CLUSTER NGC 6440 
    Heinke, C. O.; Altamirano, D.; Cohn, H. N.; Lugger, P. M.; Budac, S. A.; Servillat, M.; Linares, Manuel Alegret; Strohmayer, T. E.; Markwardt, Craig B.; Wijnands, R.; Swank, J. H.; Knigge, C.; Bailyn, Charles D.; Grindlay, Jonathan E. (Institute of Physics/American Astronomical Society, 2010-05)
    We have discovered a new transient low-mass X-ray binary, NGC 6440 X-2, with Chandra/ACIS, RXTE/PCA, and Swift/XRT observations of the globular cluster NGC 6440. The discovery outburst (2009 July 28-31) peaked at LX ~ 1.5 ...
  • Discovery of bisamide-heterocycles as inhibitors of scavenger receptor BI (SR-BI)-mediated lipid uptake 
    Dockendorff, Chris; Faloon, Patrick W.; Germain, Andrew; Youngsaye, Willmen; Nag, Partha P.; Bennion, Melissa; Dandapani, Sivaraman; Perez, José R.; Munoz, Benito; Palmer, Michelle A.; Schreiber, Stuart L.; Yu, Miao; Penman, Marsha L; Nieland, Thomas J; Krieger, Monty (Elsevier, 2015-04)
    A new series of potent inhibitors of cellular lipid uptake from HDL particles mediated by scavenger receptor, class B, type I (SR-BI) was identified. The series was identified via a high-throughput screen of the National ...
  • Discovery of directional and nondirectional pioneer transcription factors by modeling DNase profile magnitude and shape 
    Lewis, Sophia; van Hoff, John Peter; Karun, Vivek; Hashimoto, Tatsunori Benjamin; Sherwood, Richard I.; O'Donnell, Charles William; Barkal, Amira A.; Jaakkola, Tommi S.; Gifford, David K. (Nature Publishing Group, 2014-01)
    We describe protein interaction quantitation (PIQ), a computational method for modeling the magnitude and shape of genome-wide DNase I hypersensitivity profiles to identify transcription factor (TF) binding sites. Through ...
  • Discovery of eight z~6 quasars from Pan-STARRS1 
    Banados, E.; Venemans, B. P.; Morganson, E.; Decarli, R.; Walter, F.; Chambers, K. C.; Rix, H.-W.; Farina, E. P.; Fan, X.; Jiang, L.; McGreer, I.; De Rosa, G.; Weiss, A.; Price, P. A.; Morgan, Jeffrey S.; Burgett, William S.; Greiner, J.; Kaiser, Nick; Kudritzki, R.-P.; Magnier, Eugene A.; Metcalfe, N.; Stubbs, C. W.; Sweeney, W.; Tonry, J. L.; Wainscoat, R. J.; Waters, C.; Simcoe, Robert A. (IOP Publishing, 2014-06)
    High-redshift quasars are currently the only probes of the growth of supermassive black holes and potential tracers of structure evolution at early cosmic time. Here we present our candidate selection criteria from the ...
  • The Discovery of Ellipsoidal Variations in the Kepler Light Curve of Hat-P-7 
    Seager, Sara; Welsh, William F.; Orosz, Jerome A.; Fortney, Jonathan J.; Jenkins, Jon M.; Rowe, Jason F.; Koch, David; Borucki, William J. (IOP Publishing, 2010-03)
    We present an analysis of the early Kepler observations of the previously discovered transiting planet HAT-P-7b. The light curve shows the transit of the star, the occultation of the planet, and the orbit phase-dependent ...
  • Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure 
    Wang, Xinchen; Kellis, Manolis; Boyer, Laurie Ann (Public Library of Science, 2016-05)
    Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular ...
  • Discovery of Human sORF-Encoded Polypeptides (SEPs) in Cell Lines and Tissue 
    Ma, Jiao; Ward, Carl C.; Jungreis, Irwin; Slavoff, Sarah A.; Schwaid, Adam G.; Neveu, John; Budnik, Bogdan A.; Kellis, Manolis; Saghatelian, Alan (American Chemical Society (ACS), 2014-03)
    The existence of nonannotated protein-coding human short open reading frames (sORFs) has been revealed through the direct detection of their sORF-encoded polypeptide (SEP) products. The discovery of novel SEPs increases ...
  • Discovery of Novel Materials with Broad Resistance to Bacterial Attachment Using Combinatorial Polymer Microarrays 
    Hook, Andrew L.; Chang, Chien-Yi; Yang, Jing; Atkinson, Steve; Langer, Robert; Davies, Martyn C.; Williams, Paul; Alexander, Morgan R.; Anderson, Daniel Griffith (Wiley Blackwell, 2013-02)
    A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available ...
  • DISCOVERY OF THE CANDIDATE OFF-NUCLEAR ULTRASOFT HYPER-LUMINOUS X-RAY SOURCE 3XMM J141711.1+522541 
    Lin, Dacheng; Carrasco, Eleazar R.; Webb, Natalie A.; Irwin, Jimmy A.; Dupke, Renato; Romanowsky, Aaron J.; Ramirez-Ruiz, Enrico; Strader, Jay; Homan, Jeroen; Barret, Didier; Godet, Olivier (IOP Publishing, 2016-04)
    We report the discovery of an off-nuclear ultrasoft hyper-luminous X-ray source candidate 3XMM J141711.1+522541 in the inactive S0 galaxy SDSS J141711.07+522540.8 (z = 0.41827, d[subscript L] = 2.3 Gpc) in the Extended ...
  • DISCOVERY OF THE FIRST METHANOL (CH [subscript 3] OH) MASER IN THE ANDROMEDA GALAXY (M31) 
    Sjouwerman, Loránt O.; Murray, Claire E.; Pihlström, Ylva M.; Fish, Vincent L.; Araya, Esteban D. (IOP Publishing, 2010-11)
    We present the first detection of a 6.7 GHz Class II methanol (CH[subscript 3]OH) maser in the Andromeda galaxy (M31). The CH[subscript 3]OH maser was found in a VLA survey during the fall of 2009. We have confirmed the ...
  • DISCOVERY OF THE NEAR-INFRARED COUNTERPART TO THE LUMINOUS NEUTRON-STAR LOW-MASS X-RAY BINARY GX 3+1 
    van den Berg, Maureen; Homan, Jeroen; Fridriksson, Joel K.; Linares, Manuel Alegret (Institute of Physics/American Astronomical Society, 2014-09)
    Using the High Resolution Camera on board the Chandra X-ray Observatory, we have measured an accurate position for the bright persistent neutron star X-ray binary and atoll source GX 3+1. At a location that is consistent ...
  • DISCOVERY OF THE THIRD TRANSIENT X-RAY BINARY IN THE GALACTIC GLOBULAR CLUSTER TERZAN 5 
    Bahramian, Arash; Heinke, C. O.; Sivakoff, Gregory R.; Altamirano, Diego; Wijnands, Rudy; Homan, Jeroen; Linares, Manuel Alegret; Pooley, David; Degenaar, N.; Gladstone, Jeanette C. (IOP Publishing, 2013-12)
    We report and study the outburst of a new transient X-ray binary (XRB) in Terzan 5, the third detected in this globular cluster, Swift J174805.3-244637 or Terzan 5 X-3. We find clear spectral hardening in Swift/XRT data ...
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