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Browsing MIT Open Access Articles by Title

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  • Shi, Jiahai; Kundrat, Lenka; Pishesha, Novalia; Bilate, Angelina M.; Theile, Christopher S.; Maruyama, Takeshi; Dougan, Stephanie K.; Ploegh, Hidde; Lodish, Harvey F. (National Academy of Sciences (U.S.), 2014-06)
    We developed modified RBCs to serve as carriers for systemic delivery of a wide array of payloads. These RBCs contain modified proteins on their plasma membrane, which can be labeled in a sortase-catalyzed reaction under ...
  • Barbero, Roberto Juan; Carnelli, Lino; Simon, Anna; Kao, Albert; Monforte, Alessandra d'Arminio; Riccò, Moreno; Bianchi, Daniele; Belcher, Angela M. (Royal Society of Chemistry, 2013)
    In this work, a biologically catalysed CO2 mineralization process for the capture of CO2 from point sources was designed, constructed at a laboratory scale, and, using standard chemical process scale-up protocols, was ...
  • Nielsen, David R.; Yoon, Sang-Hwal; Yuan, Clara J.; Prather, Kristala L. Jones (John Wiley & Sons, Inc., 2010-01)
    The functional reconstruction of acetoin and meso-2,3-butanediol (meso-2,3-BD) biosynthetic pathways in Escherichia coli have been explored systematically. Pathway construction involved the in vivo screening of prospective ...
  • Ryu, Min-Hyung; Kang, In-Hye; Nelson, Mathew D.; Jensen, Tricia M.; Lyuksyutova, Anna I.; Siltberg-Liberles, Jessica; Raizen, David M.; Gomelsky, Mark (National Academy of Sciences (U.S.), 2014-06)
    Bacteriophytochromes sense light in the near-infrared window, the spectral region where absorption by mammalian tissues is minimal, and their chromophore, biliverdin IXα, is naturally present in animal cells. These properties ...
  • Belmont, Brian Joshua; Niles, Jacquin (American Chemical Society, 2010-06)
    The importance and pervasiveness of naturally occurring regulation of RNA function in biology is increasingly being recognized. A common mechanism uses inducible protein−RNA interactions to shape diverse aspects of cellular ...
  • Lam, Felix H.; Ghaderi, Adel; Fink, Gerald R.; Stephanopoulos, Gregory (American Association for the Advancement of Science (AAAS), 2014-10)
    Ethanol toxicity in the yeast Saccharomyces cerevisiae limits titer and productivity in the industrial production of transportation bioethanol. We show that strengthening the opposing potassium and proton electrochemical ...
  • Nielsen, David R.; Leonard, Effendi; Yoon, Sang-Hwal; Tseng, Hsien-chung; Yuan, Clara J.; Prather, Kristala L. Jones (Elsevier B.V., 2009-05)
    Alternative microbial hosts have been engineered as biocatalysts for butanol biosynthesis. The butanol synthetic pathway of Clostridium acetobutylicum was first re-constructed in Escherichia coli to establish a baseline ...
  • Potter, Andrew Cole; Lee, Patrick A. (American Physical Society, 2011-05)
    We compare topological insulator materials and Rashba-coupled surfaces as candidates for engineering p+ip superconductivity. Specifically, in each type of material we examine (1) the limitations to inducing superconductivity ...
  • Renugopalakrishnan, Venkatesan; Barbiellini, Bernardo; King, Chris; Molinari, Michael; Mochalov, Konstantin; Sukhanova, Alyona; Nabiev, Igor; Fojan, Peter; Tuller, Harry L.; Chin, Michael; Somasundaran, Ponisseril; Ramakrishna, Seeram; Padros, Esteve (American Chemical Society (ACS), 2014-05)
    We present a route toward a radical improvement in solar cell efficiency using resonant energy transfer and sensitization of semiconductor metal oxides with a light-harvesting quantum dot (QD)/bacteriorhodopsin (bR) layer ...
  • Vanhoutte, Michiel; Singh, Vivek; Hu, Juejun; Cai, Yan; Michel, Jurgen; Kimerling, Lionel C.; Lin, Pao Tai; Patel, Neil Sunil; Camacho-Aguilera, Rodolfo Ernesto; Agarwal, Anuradha Murthy (Optical Society of America, 2012-01)
    Broadband and anisotropic light emission from rare-earth doped tellurite thin films is demonstrated using Er[superscript 3+]-TeO[subscript 2] photonic crystals (PhCs). By adjusting the PhC parameters, photoluminescent light ...
  • Wang, Yana; Irvine, Darrell J. (Elsevier, 2011-04)
    Spatial and temporal concentration gradients of chemoattractants direct many biological processes, especially the guidance of immune cells to tissue sites during homeostasis and responses to infection. Such gradients are ...
  • Bowring, J. F.; McLean, Noah Morgan; Bowring, Samuel A. (American Geophysical Union (AGU), 2011-06)
    In the past decade, major advancements in precision and accuracy of U-Pb geochronology, which stem from improved sample pretreatment and refined measurement techniques, have revealed previously unresolvable discrepancies ...
  • Zhang, Haoran; Li, Zhengjun; Stephanopoulos, Gregory; Pereira, Brian J. (BioMed Central Ltd., 2015-09)
    Background cis, cis-Muconic acid is an important chemical that can be biosynthesized from simple substrates in engineered microorganisms. Recently, it has been shown that engineering microbial cocultures is an emerging ...
  • Dhamankar, Himanshu; Tarasova, Yekaterina; Martin, Collin H.; Prather, Kristala L. Jones (Elsevier, 2014-06)
    3-hydroxy-γ-butyrolactone (3HBL) is a versatile chiral synthon, deemed a top value-added chemical from biomass by the DOE. We recently reported the first biosynthetic pathway towards 3HBL and its hydrolyzed form, ...
  • Barthelmes, Katja; Reynolds, Anne M.; Peisach, Ezra; Jonker, Hendrik R. A.; DeNunzio, Nicholas J.; Allen, Karen N.; Imperiali, Barbara; Schwalbe, Harald (American Chemical Society, 2010-12)
    Lanthanide-binding tags (LBTs) are valuable tools for investigation of protein structure, function, and dynamics by NMR spectroscopy, X-ray crystallography, and luminescence studies. We have inserted LBTs into three different ...
  • Jeng, Lily; Olsen, Bjorn R.; Spector, Myron (Mary Ann Liebert, 2010-06)
    Although there is widespread recognition of the importance of angiogenesis in tissue repair, there is little work on the inhibition of angiogenesis in the context of tissue engineering of naturally avascular tissues, like ...
  • Lippow, Shaun M.; Moon, Tae Seok; Basu, Subhayu; Yoon, Sang-Hwal; Li, Xiazhen; Chapman, Brad A.; Robison, Keith; Lipovšek, Daša; Prather, Kristala L. Jones (Elsevier, 2010-12)
    Engineered biosynthetic pathways have the potential to produce high-value molecules from inexpensive feedstocks, but a key limitation is engineering enzymes with high activity and specificity for new reactions. Here, we ...
  • Zhang, Haoran; Li, Zhengjun; Stephanopoulos, Gregory; Pereira, Brian J. (National Academy of Sciences (U.S.), 2015-07)
    Engineering microbial consortia to express complex biosynthetic pathways efficiently for the production of valuable compounds is a promising approach for metabolic engineering and synthetic biology. Here, we report the ...
  • Dai, Shou-Huang; Maity, Debaprasad; Zhang, Yun-Long; Chen, Jiunn-Wei (American Physical Society, 2016-10)
    By introducing interacting scalar fields, we tried to engineer physically motivated holographic phase diagrams which may be interesting in the context of various known condensed matter systems. We introduce an additional ...
  • Drake, Adam; Chen, Jianzhu; Chen, Qingfeng (Nature Publishing Group, 2012-05)
    Humanized mice are immunodeficient animals engrafted with human hematopoietic stem cells that give rise to various lineages of human blood cells throughout the life of the mouse. This article reviews recent advances in the ...
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