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Browsing MIT Open Access Articles by Title

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  • Niu, Nifang; Schaid, Daniel J; Abo, Ryan P; Kalari, Krishna; Fridley, Brooke L; Feng, Qiping; Jenkins, Gregory; Batzler, Anthony; Brisbin, Abra G; Cunningham, Julie M; Li, Liang; Sun, Zhifu; Yang, Ping; Wang, Liewei (BioMed Central Ltd., 2012-09)
    Background: Taxane is one of the first line treatments of lung cancer. In order to identify novel single nucleotide polymorphisms (SNPs) that might contribute to taxane response, we performed a genome-wide association study ...
  • Hassan, Musa A.; Butty, Vincent; Jensen, Kirk D. C.; Saeij, Jeroen (Cold Spring Harbor Laboratory Press, 2013-11)
    Alternative splicing and mRNA editing are known to contribute to transcriptome diversity. Although alternative splicing is pervasive and contributes to a variety of pathologies, including cancer, the genetic context for ...
  • Yang, Ninghan; Farrell, Andrew; Lu, Diana; Julien, Lindsay; Marth, Gabor T; Gubbels, Marc-Jan; Roberts, Wendy Niedelman; Melo, Mariane Bandeira; Saeij, Jeroen (BioMed Central Ltd, 2013-07)
    Background: Toxoplasma gondii has a largely clonal population in North America and Europe, with types I, II and III clonal lineages accounting for the majority of strains isolated from patients. RH, a particular type I ...
  • Kurreeman, Fina; Liao, Katherine; Chibnik, Lori; Hickey, Brendan; Stahl, Eli; Gainer, Vivian; Li, Gang; Bry, Lynn; Mahan, Scott; Ardlie, Kristin; Thomson, Brian; Szolovits, Peter; Churchill, Susanne; Murphy, Shawn N.; Cai, Tianxi; Raychaudhuri, Soumya; Kohane, Isaac; Karlson, Elizabeth; Plenge, Robert M. (Elsevier B.V., 2011-01)
    Discovering and following up on genetic associations with complex phenotypes require large patient cohorts. This is particularly true for patient cohorts of diverse ancestry and clinically relevant subsets of disease. The ...
  • Moser, Felix; Broers, Nicolette J.; Hartmans, Sybe; Tamsir, Alvin; Kerkman, Richard; Roubos, Johannes A.; Bovenberg, Roel; Voigt, Christopher A. (American Chemical Society (ACS), 2012-10)
    Synthetic genetic programs promise to enable novel applications in industrial processes. For such applications, the genetic circuits that compose programs will require fidelity in varying and complex environments. In this ...
  • Prindle, Arthur; Selimkhanov, Jangir; Danino, Tal; Samayoa, Phillip; Goldber, Anna; Bhatia, Sangeeta N.; Hasty, Jeff (American Chemical Society (ACS), 2012-08)
    Synthetic biology has rapidly progressed over the past decade and is now positioned to impact important problems in health and energy. In the clinical arena, the field has thus far focused primarily on the use of bacteria ...
  • Peltonen, Leena; Elliott, Paul; McCarthy, Mark I.; Jarvelin, Marjo-Riitta; Widen, Elisabeth; Sovio, Ulla; Bennett, Amanda J.; Millwood, Iona Y.; Molitor, John; O'Reilly, Paul F.; Timpson, Nicholas J.; Kaakinen, Marika; Laitinen, Jaana; Haukka, Jari; Pillas, Demetris; Tzoulaki, Ioanna; Molitor, Jassy; Hoggart, Clive; Coin, Lachlan J. M.; Whittaker, John; Pouta, Anneli; Hartikaninen, Anna-Liisa; Freimer, Nelson B. (Public Library of Science, 2009-03)
    Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height ...
  • Schnall-Levin, Michael; Berger, Bonnie; Bergwitz, Clemens; Wee, Mark J.; Sinha, Sumi; Huang, Joanne; DeRobertis, Charles; Mensah, Lawrence B.; Cohen, Jonathan; Friedman, Adam; Kulkarni, Meghana; Hu, Yanhui; Vinayagam, Arunachalam; Perkins, Lizabeth A.; Mohr, Stephanie E.; Perrimon, Norbert (Public Library of Science, 2013-03)
    Phosphate is required for many important cellular processes and having too little phosphate or too much can cause disease and reduce life span in humans. However, the mechanisms underlying homeostatic control of extracellular ...
  • Kelly, Libusha; Ding, Huiming; Huang, Katherine H.; Osburne, Marcia; Chisholm, Sallie (Penny) (Nature Publishing Group, 2013-05)
    Viruses that infect marine cyanobacteria–cyanophages–often carry genes with orthologs in their cyanobacterial hosts, and the frequency of these genes can vary with habitat. To explore habitat-influenced genomic diversity ...
  • Hockemeyer, Dirk; Wang, Haoyi; Kiani, Samira; Lai, Christine S.; Gao, Qing; Cassady, John P.; Cost, Gregory J.; Zhang, Lei; Santiago, Yolanda; Miller, Jeffrey C.; Zeitler, Bryan; Zeitler, Bryan; Cherone, Jennifer M.; Meng, Xiangdong; Hinkley, Sarah J.; Rebar, Edward J.; Gregory, Philip D.; Urnov, Fyodor D.; Jaenisch, Rudolf (Nature Publishing Group, 2011-07)
    Targeted genetic engineering of human pluripotent cells is a prerequisite for exploiting their full potential. Such genetic manipulations can be achieved using site-specific nucleases. Here we engineered transcription ...
  • Yang, Fan; Cho, Seung Woo; Son, Sun Mi; Bogatyrev, Said R.; Singh, Deepika; Green, Jordan; Mei, Ying; Park, Sohyun; Bhang, Suk Ho; Kim, Byung-Soo; Langer, Robert; Anderson, Daniel G. (National Academy of Sciences, 2010-02)
    Stem cells hold great potential as cell-based therapies to promote vascularization and tissue regeneration. However, the use of stem cells alone to promote angiogenesis remains limited because of insufficient expression ...
  • Moorjani, Priya; Thangaraj, Kumarasamy; Patterson, Nick; Lipson, Mark; Loh, Po-Ru; Govindaraj, Periyasamy; Berger, Bonnie; Reich, David; Singh, Lalji (Elsevier, 2013-08)
    Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) ...
  • Lander, Eric S. (Nature Publishing Group, 2013-01)
    Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. To determine the spectrum of somatic mutation ...
  • Strauss, Bernard S.; Strauss, Jacob A. (United States National Academy of Sciences, 2009-09)
    Both biological and social scientists have recently commented on the supposed greater variability of males in IQ tests and in mathematical achievement (1). Missing from these discussions is any consideration of possible ...
  • Proia, Theresa A.; Keller, Patricia J.; Klebba, Ina; Jones, Ainsley D.; Sedic, Maja; Gilmore, Hannah; Tung, Nadine; Naber, Stephen P.; Schnitt, Stuart; Gupta, Piyush; Lander, Eric S.; Kuperwasser, Charlotte (Elsevier, 2011-02)
    Women with inherited mutations in the BRCA1 gene have increased risk of developing breast cancer but also exhibit a predisposition for the development of aggressive basal-like breast tumors. We report here that breast ...
  • Pickrell, Joseph K.; Patterson, Nick; Barbieri, Chiara; Berthold, Falko; Gerlach, Linda; Güldemann, Tom; Kure, Blesswell; Mpoloka, Sununguko Wata; Nakagawa, Hirosi; Naumann, Christfried; Lipson, Mark; Loh, Po-Ru; Lachance, Joseph; Mountain, Joanna; Bustamante, Carlos D.; Berger, Bonnie; Tishkoff, Sarah A.; Henn, Brenna M.; Stoneking, Mark; Reich, David; Pakendorf, Brigitte (Nature Publishing Group, 2012-10)
    Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships are poorly understood. Here, ...
  • Moon, Tae Seok; Lou, Chunbo; Tamsir, Alvin; Stanton, Brynne Christine; Voigt, Christopher A. (Nature Publishing Group, 2012-10)
    Genetic programs function to integrate environmental sensors, implement signal processing algorithms and control expression dynamics[1]. These programs consist of integrated genetic circuits that individually implement ...
  • Soukas, Alexander A.; Carr, Christopher E.; Ruvkun, Gary (Public Library of Science, 2013-10)
    Lysosomes are membrane-bound organelles that contain acid hydrolases that degrade cellular proteins, lipids, nucleic acids, and oligosaccharides, and are important for cellular maintenance and protection against age-related ...
  • Burrage, Lindsay C.; Baskin-Hill, Annie E.; Sinasac, David S.; Singer, Jonathan B.; Croniger, Colleen M.; Kirby, Andrew; Kulbokas, E. J.; Daly, Mark J.; Lander, Eric S.; Broman, Karl W.; Nadeau, Joseph H. (Springer-Verlag, 2010-02)
    Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-Chr[superscript A/J]/NaJ panel of chromosome ...
  • Wang, Tim; Wei, Jenny J.; Sabatini, David M.; Lander, Eric S. (American Association for the Advancement of Science (AAAS), 2013-12)
    The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 system for genome editing has greatly expanded the toolbox for mammalian genetics, enabling the rapid generation of isogenic cell lines ...
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