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Browsing MIT Open Access Articles by Title

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  • Beatty, Anne; Liao, Scott; Weber, Joseph P. (Elsevier, 2011-12)
    We investigate delegated monitoring by examining the determinants and effects of including cross-acceleration provisions in public debt contracts. We find that cross-acceleration provision use depends on borrowers' going ...
  • Hohnloser, Stefan H.; Ikeda, Takanori; Cohen, Richard J. (Elsevier, 2008-10)
    Background: Microvolt T-wave alternans (MTWA) testing in many studies has proven to be a highly accurate predictor of ventricular tachyarrhythmic events (VTEs) in patients with risk factors for sudden cardiac death (SCD) ...
  • Morten, Christopher J.; Byers, Jeffery A.; Jamison, Timothy F. (American Chemical Society (ACS), 2011-01)
    A detailed kinetic study of the endo-selective epoxide-opening cascade reaction of a diepoxy alcohol in neutral water was undertaken using 1H NMR spectroscopy. The observation of monoepoxide intermediates resulting from ...
  • Dewey, Dan; Dwarkadas, V. V.; Haberl, F.; Sturm, R.; Canizares, Claude R. (IOP Publishing, 2012-05)
    Observations of SN 1987A by the Chandra High Energy Transmission Grating (HETG) in 1999 and the XMM-Newton Reflection Grating Spectrometer (RGS) in 2003 show very broad (v-b) lines with a full width at half-maximum (FWHM) ...
  • Landau, Dan A.; Carter, Scott L.; Stojanov, Petar; McKenna, Aaron; Stevenson, Kristen; Lawrence, Michael S.; Sougnez, Carrie; Stewart, Chip; Sivachenko, Andrey; Wang, Lili; Wan, Youzhong; Zhang, Wandi; Shukla, Sachet A.; Vartanov, Alexander; Fernandes, Stacey M.; Saksena, Gordon; Cibulskis, Kristian; Tesar, Bethany; Gabriel, Stacey B.; Hacohen, Nir; Meyerson, Matthew L.; Lander, Eric S.; Neuberg, Donna S.; Brown, Jennifer R.; Getz, Gad; Wu, Catherine J. (Elsevier, 2013-02)
    Clonal evolution is a key feature of cancer progression and relapse. We studied intratumoral heterogeneity in 149 chronic lymphocytic leukemia (CLL) cases by integrating whole-exome sequence and copy number to measure the ...
  • Jumlongras, Dolrudee; Lachke, Salil A.; O’Connell, Daniel J.; Aboukhalil, Anton; Li, Xiao; Choe, Sung E.; Ho, Joshua W. K.; Turbe-Doan, Annick; Robertson, Erin A.; Olsen, Bjorn R.; Bulyk, Martha L.; Amendt, Brad A.; Maas, Richard L. (Public Library of Science, 2012-06)
    To elucidate the transcriptional regulation of Bmp4 expression during organogenesis, we used phylogenetic footprinting and transgenic reporter analyses to identify Bmp4 cis-regulatory modules (CRMs). These analyses identified ...
  • Means, Terry K.; Mylonakis, Eleftherios; Tampakakis, Emmanouil; Colvin, Richard A.; Seung, Edward; Puckett, Lindsay; Tai, Melissa F.; Stewart, Cameron R.; Pukkila-Worley, Read; Hickman, Suzanne E.; Moore, Kathryn J.; Calderwood, Stephen B.; Hacohen, Nir; Luster, Andrew D.; El Khoury, Joseph (Rockefeller University Press, 2009-03)
    Receptors involved in innate immunity to fungal pathogens have not been fully elucidated. We show that the Caenorhabditis elegans receptors CED-1 and C03F11.3, and their mammalian orthologues, the scavenger receptors SCARF1 ...
  • O'Reilly, Una-May; Medard, Muriel; Traskov, Danail; Kim, Minkyu (2009-06)
    Whereas the theory and application of optimal network coding are well studied for the single-session multicast scenario, there is no known optimal network coding strategy for a more general connection problem where there ...
  • Butler, Thomas Charles; Benayoun, Marc; Wallace, Edward; van Drongelen, Wim; Goldenfeld, Nigel; Cowan, Jack (National Academy of Sciences of the United States of America, 2011-12)
    In the cat or primate primary visual cortex (V1), normal vision corresponds to a state where neural excitation patterns are driven by external visual stimuli. A spectacular failure mode of V1 occurs when such patterns are ...
  • Tsankov, Alexander M.; Yanagisawa, Yoshimi; Rhind, Nicholas; Regev, Aviv; Rando, Oliver J. (Cold Spring Harbor Laboratory Press, 2011-09)
    The packaging of eukaryotic genomes into nuclesomes plays critical roles in chromatin organization and gene regulation. Studies in Saccharomyces cerevisiae indicate that nucleosome occupancy is partially encoded by intrinsic ...
  • Washietl, Stefan; Kellis, Manolis; Garber, Manuel (Cold Spring Harbor Laboratory Press, 2014-01)
    Long intergenic noncoding RNAs (lincRNAs) play diverse regulatory roles in human development and disease, but little is known about their evolutionary history and constraint. Here, we characterize human lincRNA expression ...
  • Merkin, Jason Jay; Russell, Caitlin; Chen, Ping; Burge, Christopher B. (American Association for the Advancement of Science (AAAS), 2012-12)
    Most mammalian genes produce multiple distinct messenger RNAs through alternative splicing, but the extent of splicing conservation is not clear. To assess tissue-specific transcriptome variation across mammals, we sequenced ...
  • Li, Aming; Broom, Mark; Du, Jinming; Wang, Long (American Physical Society, 2016-02)
    The evolution of populations is influenced by many factors, and the simple classical models have been developed in a number of important ways. Both population structure and multiplayer interactions have been shown to ...
  • Plunkett, Jevon; Doniger, Scott; Orabona, Guilherme; Morgan, Thomas; Haataja, Ritva; Hallman, Mikko; Puttonen, Hilkka; Menon, Ramkumar; Kuczynski, Edward; Norwitz, Errol; Snegovskikh, Victoria; Palotie, Aarno; Peltonen, Leena; Fellman, Vineta; DeFranco, Emily A.; Chaudhari, Bimal P.; McGregor, Tracy L.; McElroy, Jude J.; Oetjens, Matthew T.; Teramo, Kari; Borecki, Ingrid; Fay, Justin C.; Muglia, Louis J. (Public Library of Science, 2011-04)
    Coordination of fetal maturation with birth timing is essential for mammalian reproduction. In humans, preterm birth is a disorder of profound global health significance. The signals initiating parturition in humans have ...
  • Brennan, Thomas J.; Lo, Andrew W. (Public Library of Science, 2012-11)
    Background: Most economic theories are based on the premise that individuals maximize their own self-interest and correctly incorporate the structure of their environment into all decisions, thanks to human intelligence. ...
  • Weng, Jing-Ke (Wiley Blackwell, 2014-03)
    As sessile organisms, land plants have exploited their metabolic systems to produce a panoply of structurally and functionally diverse natural chemicals and polymers to adapt to challenging ecosystems. Many of these core ...
  • Thompson, Dawn A.; Roy, Sushmita; Chan, Michelle Mei Wah; Styczynsky, Mark P.; Pfiffner, Jenna; French, Courtney; Socha, Amanda; Thielke, Anne; Napolitano, Sara; Muller, Paul; Kellis, Manolis; Konieczka, Jay; Wapinski, Ilan; Regev, Aviv (eLife Sciences Publications, Ltd, 2013-06)
    Divergence in gene regulation can play a major role in evolution. Here, we used a phylogenetic framework to measure mRNA profiles in 15 yeast species from the phylum Ascomycota and reconstruct the evolution of their modular ...
  • Yang, Lei; Damkiaer, Soren; Molin, Soren; Jelsbak, Lars (National Academy of Sciences (U.S.), 2013-04)
    The genetic basis of bacterial adaptation to a natural environment has been investigated in a highly successful Pseudomonas aeruginosa lineage (DK2) that evolved within the airways of patients with cystic fibrosis (CF) for ...
  • Wu, Yi-Chieh; Rasmussen, Matthew D.; Kellis, Manolis (Oxford University Press (OUP), 2011-09)
    Although the possibility of gene evolution by domain rearrangements has long been appreciated, current methods for reconstructing and systematically analyzing gene family evolution are limited to events such as duplication, ...
  • Wu, Yi-Chieh; Rasmussen, Matthew D.; Kellis, Manolis (Oxford University Press (OUP), 2011-09)
    Although the possibility of gene evolution by domain rearrangements has long been appreciated, current methods for reconstructing and systematically analyzing gene family evolution are limited to events such as duplication, ...
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