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Browsing MIT Open Access Articles by Title

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  • Kim, Dohoon; Tsai, Li-Huei (New York Academy of Sciences, 2009-08)
    Aberrant cell cycle activity and DNA damage have been observed in neurons in association with various neurodegenerative conditions. While there is strong evidence for a causative role for these events in neurotoxicity, it ...
  • Jin, Bilian; Ernst, Jason; Tiedemann, Rochelle L.; Xu, Hongyan; Sureshchandra, Suhas; Kellis, Manolis; Dalton, Stephen; Liu, Chen; Choi, Jeong-Hyeon; Robertson, Keith D. (Elsevier, 2012-11)
    DNA methylation, mediated by the combined action of three DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B), is essential for mammalian development and is a major contributor to cellular transformation. To elucidate how ...
  • Bomblies, Arne; Laminou, Ibrahim M; Duchemin, Jean-Bernard; Yamana, Teresa K.; Eltahir, Elfatih A. B. (BioMed Central Ltd, 2013-08)
    Background: Individuals continuously exposed to malaria gradually acquire immunity that protects from severe disease and high levels of parasitization. Acquired immunity has been incorporated into numerous models of malaria ...
  • Moxley, Joel F.; Jewett, Michael C.; Antoniewicz, Maciek R.; Villas-Boas, Silas G.; Alper, Hal; Wheeler, Robert T.; Tong, Lily V.; Hinnebusch, Alan G.; Ideker, Trey; Nielsen, Jens; Stephanopoulos, Gregory (National Academy of Sciences, 2009-04)
    Genome sequencing dramatically increased our ability to understand cellular response to perturbation. Integrating system-wide measurements such as gene expression with networks of protein–protein interactions and transcription ...
  • Huang, Shao-shan Carol; Clarke, David C.; Gosline, Sara Jane Calafell; Labadorf, Adam; Chouinard, Candace R.; Gordon, William; Lauffenburger, Douglas A.; Fraenkel, Ernest (Public Library of Science, 2013-02)
    Cellular signal transduction generally involves cascades of post-translational protein modifications that rapidly catalyze changes in protein-DNA interactions and gene expression. High-throughput measurements are improving ...
  • Lambrecht, Bart M.; Myers, Stewart C. (John Wiley & Sons, Inc, 2012-10)
    We develop a dynamic agency model in which payout, investment, and financing decisions are made by managers who attempt to maximize the rents they take from the firm, subject to a capital market constraint. Managers smooth ...
  • Chen, Haogang; Mao, Yandong; Wang, Xi; Zhou, Dong; Zeldovich, Nickolai; Kaashoek, M. Frans (Association for Computing Machinery (ACM), 2011-07)
    Avoiding kernel vulnerabilities is critical to achieving security of many systems, because the kernel is often part of the trusted computing base. This paper evaluates the current state-of-the-art with respect to kernel ...
  • Duplantier, Bertrand; Sheffield, Scott Roger (Springer-Verlag, 2010-12)
    Consider a bounded planar domain D, an instance h of the Gaussian free field on D, with Dirichlet energy ... and a constant 0[less than or equal to]γ<2. The Liouville quantum gravity measure on D is the weak limit as ...
  • Peng, Zhangli; Dao, Ming; Suresh, Subra; Li, Xuejin; Pivkin, Igor V.; Karniadakis, George E. (National Academy of Sciences (U.S.), 2013-08)
    We study the biomechanical interactions between the lipid bilayer and the cytoskeleton in a red blood cell (RBC) by developing a general framework for mesoscopic simulations. We treated the lipid bilayer and the cytoskeleton ...
  • Chaparro, Jose P.; Bershteyn, A.; Riley, E. B.; Yao, R. S.; Zachariah, Roshini Sarah; Irvine, Darrell J. (Institute of Electrical and Electronics Engineers, 2009-05)
    The physicochemical context in which molecules are presented at the surfaces of microbes has tremendous implications for the immune response to vaccination. The spacing and mobility of molecules may control interactions ...
  • Ong, Ta-Chung; Clark, Lindsay; Teijido, Oscar; van der Wel, Patrick C. A.; Garces, Robert; Wagner, Gerhard; Rostovtseva, Tatiana K.; Eddy, Matthew Thomas; Griffin, Robert Guy (American Chemical Society (ACS), 2012-03)
    We employ a combination of [superscript 13]C/[superscript 15]N magic angle spinning (MAS) NMR and [superscript 2]H NMR to study the structural and functional consequences of different membrane environments on VDAC1 and, ...
  • Love, Kevin T.; Mahon, Kerry P.; Levins, Christopher G.; Whitehead, Kathryn Ann; Querbes, William; Dorkin, J. Robert; Qin, June; Cantley, William; Qin, Liu Liang; Racie, Timothy; Frank-Kamenetsky, Maria; Yip, Ka; Alvarez, Rene; Sah, Dinah W. Y.; de Fougerolles, Antonin; Fitzgerald, Kevin; Koteliansky, Victor; Akinc, Akin; Langer, Robert; Anderson, Daniel G. (National Academy of Sciences, 2010-02)
    Significant effort has been applied to discover and develop vehicles which can guide small interfering RNAs (siRNA) through the many barriers guarding the interior of target cells. While studies have demonstrated the ...
  • Miljkovic, Nenad; Enright, Ryan; Maroo, Shalabh C.; Cho, H. Jeremy; Wang, Evelyn N. (ASME International, 2011-04)
    Environmental scanning electron microscope (ESEM) images of water evaporation from superhydrophilic and superhydrophobic nanostructured surfaces are presented. The nanostructured surfaces consiste of an array of equidistant ...
  • Miljkovic, Nenad; Enright, Ryan; Wang, Evelyn N. (ASME International, 2012-06)
    False color environmental scanning electron microscope (ESEM) images of water freezing on smooth (θe ≈ 120°) and nanostructured (l ~ 50 nm, θe ≈ 170 - 180°) hydrophobic surfaces are presented. To obtain the freezing dynamics ...
  • Wang, Jiang; Vayanos, Dimitri (Oxford University Press, 2011-11)
    We analyze how asymmetric information and imperfect competition affect liquidity and asset prices. Our model has three periods: Agents are identical in the first, become heterogeneous and trade in the second, and consume ...
  • Guerrieri, Veronica; Lorenzoni, Guido (Econometric Society, 2009-12)
    In this paper, we build a model where the presence of liquidity constraints tends to magnify the economy's response to aggregate shocks. We consider a decentralized model of trade, where agents may use money or credit to ...
  • Amat, Miguel A.; Rutledge, Gregory C. (American Institute of Physics, 2010-03)
    A molecular dynamics study is presented to assess the performance of a united-atom model in the prediction of liquid-vapor interfacial properties for short-chain perfluoroalkanes and their alkane counterparts. In particular, ...
  • Fedynyshyn, Theodore H.; Krohn, Keith E.; Goodman, Russell B.; Kingsborough, Richard P. (The International Society for Optical Engineering, 2009-03)
    We have developed a processing method that significantly reduces the number of steps necessary to yield a surface that directs block copolymer assembly. This methodology employs a single resistless lithography step that ...
  • Krohn, Keith E.; Goodman, Russell B.; Kingsborough, Richard P.; Fedynyshyn, Theodore H. (The International Society for Optical Engineering, 2009-03)
    We have developed a processing method that significantly reduces the number of steps necessary to yield a surface that directs block copolymer assembly. This methodology employs a single resistless lithography step that ...
  • Graham, Peter W.; Ismail, Ahmed; Saraswat, Prashant; Rajendran, Surjeet (American Physical Society, 2010-03)
    We present a simple solution to the little hierarchy problem in the minimal supersymmetric standard model: a vectorlike fourth generation. With O(1) Yukawa couplings for the new quarks, the Higgs mass can naturally be ...
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