Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Wang, Han; Yu, Lili; Lee, Yi-Hsien; Shi, Yumeng; Hsu, Allen; Chin, Matthew L.; Li, Lain-Jong; Dubey, Madan; Kong, Jing; Palacios, Tomas (American Chemical Society, 2012-09)
    Two-dimensional (2D) materials, such as molybdenum disulfide (MoS2), have been shown to exhibit excellent electrical and optical properties. The semiconducting nature of MoS2 allows it to overcome the shortcomings of ...
  • Watanabe, Hideo; Francis, Joshua M.; Woo, Michele S.; Etemad, Banafsheh; Lin, Wenchu; Fries, Daniel F.; Peng, Shouyong; Snyder, Eric; Tata, Purushothama Rao; Izzo, Francesca; Schinzel, Anna C.; Cho, Jeonghee; Hammerman, Peter S.; Verhaak, Roel G.; Hahn, William C.; Rajagopal, Jayaraj; Jacks, Tyler E.; Meyerson, Matthew (Cold Spring Harbor Laboratory Press, 2013-01)
    The NKX2-1 transcription factor, a regulator of normal lung development, is the most significantly amplified gene in human lung adenocarcinoma. To study the transcriptional impact of NKX2-1 amplification, we generated an ...
  • Joughin, Brian A.; Naegle, Kristen Marie; Huang, Paul H.; Yaffe, Michael B.; Lauffenburger, Douglas A.; White, Forest M. (Royal Society of Chemistry, 2008-10)
    Glioblastoma (GBM, WHO grade IV) is an aggressively proliferative and invasive brain tumor that carries a poor clinical prognosis with a median survival of 9 to 12 months. In a prior phosphoproteomic study performed in the ...
  • Carlson, Scott Moore; White, Forest M.; Lahesmaa-Korpinen, Anna-Maria; Hautaniemi, Sampsa (Wiley Blackwell, 2010-09)
    MS/MS is a widely used method for proteome-wide analysis of protein expression and PTMs. The thousands of MS/MS spectra produced from a single experiment pose a major challenge for downstream analysis. Standard programs, ...
  • Altshuler, Robert Charles; Ernst, Jason; Kellis, Manolis; Kheradpour, Pouya; Ward, Lucas D.; Eaton, Matthew Lucas; Hendrix, David A.; Jungreis, Irwin; Lin, Michael F.; Washietl, Stefan (Nature Publishing Group, 2012-09)
    The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of ...
  • Lander, Eric S.; Meyerson, Matthew L. (Nature Publishing Group, 2011-06)
    A catalogue of molecular aberrations that cause ovarian cancer is critical for developing and deploying therapies that will improve patients’ lives. The Cancer Genome Atlas project has analysed messenger RNA expression, ...
  • Lander, Eric S.; Park, Peter J. (Nature Publishing Group, 2013-05)
    We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ~25% of high-grade endometrioid ...
  • Salvesen, H. B.; Carter, Scott Lambert; Mannelqvist, M.; Dutt, Amit; Getz, Gad; Stefansson, I. M.; Raeder, M. B.; Sos, M. L.; Engelsen, I. B.; Trovik, J.; Wik, E.; Greulich, Heidi; Bo, T. H.; Jonassen, I.; Thomas, R. K.; Zander, T.; Garraway, Levi A.; Oyan, A. M.; Sellers, W. R.; Kalland, K. H.; Meyerson, Matthew L.; Akslen, L. A.; Beroukhim, Rameen (National Academy of Sciences, 2009-03)
    Although 75% of endometrial cancers are treated at an early stage, 15% to 20% of these recur. We performed an integrated analysis of genome-wide expression and copy-number data for primary endometrial carcinomas with ...
  • Shmulovich, J.; Hanjani, A.; Frolov, S.; Kaertner, Franz X.; Pudo, Dominik; Byun, Hyunil; Ippen, Erich P. (Institute of Electrical and Electronics Engineers, 2009-05)
    An integrated passively mode-locked waveguide laser generating 440-fs pulses at 394-MHz repetition rate is demonstrated on an 18 mm times 44 mm silica waveguide chip. The laser self-starts, and uses a saturable Bragg ...
  • Altshuler, David; Lander, Eric S. (Nature Publishing Group, 2012-10)
    By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe the genomes ...
  • Wei, X.n.; Han, B.c.; Zhang, J.x.; Liu, X.h.; Tan, C.y.; Jiang, Y.y.; Low, Boon Chuan; Chen, Yu Zong; Tidor, Bruce (BioMed Central Ltd, 2011-07)
    Background: Endothelial permeability is involved in injury, inflammation, diabetes and cancer. It is partly regulated by the thrombin-, histamine-, and VEGF-mediated myosin-light-chain (MLC) activation pathways. While these ...
  • Dextras, Philip; Burg, Thomas P.; Manalis, Scott R. (American Chemical Society, 2009-05)
    Measurements of the mass and surface charge of microparticles are employed in the characterization of many types of colloidal dispersions. The suspended microchannel resonator (SMR) is capable of measuring individual ...
  • Shi, Yanmei; Tyson, Gene W.; Eppley, John Marmaduke; DeLong, Edward (Nature Publishing Group, 2010-12)
    As part of an ongoing survey of microbial community gene expression in the ocean, we sequenced and compared ~38 Mbp of community transcriptomes and ~157 Mbp of community genomes from four bacterioplankton samples, along a ...
  • Cohan, Lucy E.; Miller, David W. (Society of Photo-Optical Instrumentation Engineers, 2011-06)
    Lightweight, active, silicon carbide mirrors have the potential to enable larger primary aperture, space-based optical systems, hence improving the resolution and sensitivity of such systems. However, due to the lack of ...
  • Cohan, Lucy E.; Miller, David W. (The International Society for Optical Engineering, 2008-07)
    The future of space telescopes lies in large, lightweight, segmented aperture systems. Segmented apertures eliminate manufacturability and launch vehicle fairing diameter as apertures size constraints. Low areal density, ...
  • de Weck, Olivier L.; Grogan, Paul Thomas (Institute of Electrical and Electronics Engineers (IEEE), 2013-04)
    Design of future hard infrastructure must consider emergent behaviors from cross-system interdependencies. Understanding these interdependencies is challenging due to high levels of integration in high-performance systems ...
  • Mahony, Shaun; Edwards, Matthew Douglas; Mazzoni, Esteban O.; Sherwood, Richard I.; Kakumanu, Akshay; Morrison, Carolyn A.; Wichterle, Hynek; Gifford, David K. (Public Library of Science, 2014-03)
    Regulatory proteins can bind to different sets of genomic targets in various cell types or conditions. To reliably characterize such condition-specific regulatory binding we introduce MultiGPS, an integrated machine learning ...
  • Olipitz, Werner; Shuga, Joe; Pang, Bo; Mcfaline, Jose L.; Lonkar, Pallavi; Thomas, Aline; Mutamba, James T.; Greenberger, Joel S.; Samson, Leona D.; Dedon, Peter C.; Yanch, Jacquelyn C.; Engelward, Bevin P.; Wiktor-Brown, Dominika (National Center for Biotechnology Information, 2012-04)
    Background: In the event of a nuclear accident, people are exposed to elevated levels of continuous low dose-rate radiation. Nevertheless, most of the literature describes the biological effects of acute radiation. Objectives: ...
  • Fraenkel, Ernest; Lauffenburger, Douglas A.; Wilson, Jennifer Lynn; Hemann, Michael (Elsevier, 2013-08)
    RNA-interference (RNAi) studies hold great promise for functional investigation of the significance of genetic variations and mutations, as well as potential synthetic lethalities, for understanding and treatment of cancer, ...
  • Lee, Hsiang-Chieh; Zhou, Chao; Cohen, David W.; Mondelblatt, Amy E.; Wang, Yihong; Aguirre, Aaron D.; Shen, Dejun; Sheikine, Yuri; Fujimoto, James G.; Connolly, James L.; Fujimoto, James G (Elsevier B.V., 2012-02)
    Materials and Methods A total of 35 renal specimens from 19 patients, consisting of 12 normal tissues and 23 tumors (16 clear cell renal cell carcinomas, 5 papillary renal cell carcinomas and 2 oncocytomas) were imaged ...
Open Access