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Browsing MIT Open Access Articles by Title

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  • Buti, Ludovico; Spooner, Eric; Van der Veen, Annemarthe G.; Rappuoli, Rino; Covacci, Antonello; Ploegh, Hidde (National Academy of Sciences, 2011-05)
    Type I strains of Helicobacter pylori (Hp) possess a pathogenicity island, cag, that encodes the effector protein cytotoxin-associated gene A (CagA) and a type four secretion system. After translocation into the host cell, ...
  • So, Peter T. C.; Bansil, Rama; Erramilli, Shyamsunder; McKinley, Gareth H.; Ewoldt, Randy H.; Kelly, Ciaran P.; Ghiran, Ionita; Keates, Sarah; Afdhal, Nezam H.; Turner, Bradley S.; Celli, Jonathan P. (United States National Academy of Sciences, 2009-08)
    The ulcer-causing gastric pathogen Helicobacter pylori is the only bacterium known to colonize the harsh acidic environment of the human stomach. H. pylori survives in acidic conditions by producing urease, which catalyzes ...
  • Fuselier, S. A.; Allegrini, F.; Bzowski, M.; Funsten, H. O.; Ghielmetti, A. G.; Gloeckler, G.; Heirtzler, D.; Janzen, P.; Kubiak, M.; Kucharek, H.; McComas, D. J.; Möbius, E.; Moore, T. E.; Petrinec, S. M.; Quinn, M.; Reisenfeld, D.; Saul, L. A.; Scheer, J. A.; Schwadron, N.; Trattner, K. J.; Wurz, P.; Vanderspek, Roland K. (IOP Publishing, 2012-06)
    Since 2008 December, the Interstellar Boundary Explorer (IBEX) has been making detailed observations of neutrals from the boundaries of the heliosphere using two neutral atom cameras with overlapping energy ranges. The ...
  • Oelker, Abigail M.; Morey, Shannon M.; Griffith, Linda G.; Hammond, Paula T. (Royal Society of Chemistry, 2012-09)
    As a platform for investigating the individual effects of substrate stiffness, permeability, and ligand density on cellular behavior, we developed a set of hydrogels with stiffness tuned by polymer backbone rigidity, ...
  • Agrawal, Kunal; Leiserson, Charles E.; Sukha, Jim (Association for Computing Machinery / ACM Special Interest Group on Programming Languages., 2010-01)
    Helper locks allow programs with large parallel critical sections, called parallel regions, to execute more efficiently by enlisting processors that might otherwise be waiting on the helper lock to aid in the execution ...
  • Ullman, Tomer David; Tenenbaum, Joshua B.; Baker, Christopher Lawrence; Macindoe, Owen; Evans, Owain Rhys; Goodman, Noah D. (Neural Information Processing Systems Foundation, 2009-12)
    Everyday social interactions are heavily influenced by our snap judgments about others’ goals. Even young infants can infer the goals of intentional agents from observing how they interact with objects and other agents ...
  • Hensley, Scott E.; Das, Suman R.; Bailey, Adam L.; Schmidt, Loren M.; Hickman, Heather D.; Bennink, Jack R.; Yewdell, Jonathan W.; Jayaraman, Akila; Viswanathan, Karthik; Raman, Rahul; Sasisekharan, Ram (American Association for the Advancement of Science, 2009-10)
    Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza vaccine. Neutralizing ...
  • Mukaigawa, Yasuhiro; Tagawa, Seiichi; Kim, Jaewon; Raskar, Ramesh; Matsushita, Yasuyuki; Yagi, Yasushi (Springer, 2010-11)
    We propose a new imaging method called hemispherical confocal imaging to clearly visualize a particular depth in a 3-D scene. The key optical component is a turtleback reflector which is a specially designed polyhedral ...
  • Benevento, Emilia; Djebbari, Abdelghani; Cecere, Renzo; Kadem, Lyes; Keshavarz Motamed, Zahra (Public Library of Science, 2015-04)
    Aortic valve bypass (AVB) has been shown to be a viable solution for patients with severe aortic stenosis (AS). Under this circumstance, the left ventricle (LV) has a double outlet. The objective was to develop a mathematical ...
  • Weinberg, Eli J.; Mack, Peter J.; Shoen, Frederick J.; García-Cardeña, Guillermo; Kaazempur Mofrad, Mohammad R. (Springer Science + Business Media B.V., 2010-01)
    The regulation of valvular endothelial phenotypes by the hemodynamic environments of the human aortic valve is poorly understood. The nodular lesions of calcific aortic stenosis (CAS) develop predominantly beneath the ...
  • Baker, Aaron B.; Gibson, William J.; Kolachalama, Vijaya B.; Golomb, Mordechai; Indolfi, Laura; Spruell, Christopher; Zcharia, Eyal; Vlodavsky, Israel; Edelman, Elazer R. (Elsevier, 2012-04)
    Objectives The purpose of this study was to examine the role of heparanase in controlling thrombosis following vascular injury or endovascular stenting. Background The use of endovascular stents are a common clinical ...
  • Giantsos-Adams, Kristina M.; Koo, Andrew Jia-An; Song, Sukhyun; Sakai, Jiro; Sankaran, Jagadish; Shin, Jennifer H.; Garcia-Cardena, Guillermo; Dewey, C. Forbes (Springer-Verlag, 2013-02)
    The local hemodynamic shear stress waveforms present in an artery dictate the endothelial cell phenotype. The observed decrease of the apical glycocalyx layer on the endothelium in atheroprone regions of the circulation ...
  • Shriver, Zachary H.; Capila, Ishan; Venkataraman, Ganesh; Sasisekharan, Ram (Springer-Verlag Berlin Heidelberg, 2012)
    The structural microheterogeneity of heparin and heparan sulfate is one of the major reasons for the multifunctionality exhibited by this class of molecules. In a physiological context, these molecules primarily exert their ...
  • Prince, Robin N.; Schreiter, Eric R.; Zou, Peng; Wiley, H. Steven; Ting, Alice Y.; Lee, Richard T.; Lauffenburger, Douglas A. (Company of Biologists, The, 2010-06)
    Heparin-binding EGF-like growth factor (HB-EGF) is a ligand for EGF receptor (EGFR) and possesses the ability to signal in juxtacrine, autocrine and/or paracrine mode, with these alternatives being governed by the degree ...
  • Shriver, Zachary H.; Sasisekharan, Ram (Nature Publishing Group, 2013-07)
    Heparin is an anionic polysaccharide that has tremendous clinical importance as an anticoagulant. Several dyes have been developed that can detect heparin, and the latest example — named Mallard Blue — has now been shown ...
  • Narmada, Balakrishnan Chakrapani; Kang, Yuzhan; Venkatraman, Lakshmi; Peng, Qiwen; Sakban, Rashidah Binte; Nugraha, Bramasta; Jiang, Xuan; Bunte, Ralph M.; So, Peter T.C.; Tucker-Kellogg, Lisa; Mao, Hai-Quan; Yu, Hanry; So, Peter T. C. (Mary Ann Liebert, 2013-03)
    Liver fibrosis generates fibrotic foci with abundant activated hepatic stellate cells and excessive collagen deposition juxtaposed with healthy regions. Targeted delivery of antifibrotic therapeutics to hepatic stellate ...
  • Bandyopadhyay, Sarmistha; Friedman, Robin Carl; Marquez, Rebecca T.; Keck, Kathy; Kong, Benjamin; Icardi, Michael S.; Brown, Kyle E.; Burge, Christopher B.; Schmidt, Warren N.; Wang, Yulei; McCaffrey, Anton P. (Oxford University Press, 2011-01)
    Background. Chronic hepatitis C virus (HCV)–induced liver fibrosis involves upregulation of transforming growth factor (TGF)–β and subsequent hepatic stellate cell (HSC) activation. MicroRNAs (miRNAs) regulate HCV infection ...
  • Huang, Tao; Wang, Junjie; Cai, Yu-Dong; Yu, Hanry; Chou, Kuo-Chen (Public Library of Science, 2012-04)
    Hepatitis C virus (HCV) is a main risk factor for liver cirrhosis and hepatocellular carcinoma, particularly to those patients with chronic liver disease or injury. The similar etiology leads to a high correlation of the ...
  • Kinsy, Michel A.; Pellauer, Michael; Devadas, Srinivas (Association for Computing Machinery (ACM), 2013-02)
    This paper presents Heracles, an open-source, functional, parameterized, synthesizable multicore system toolkit. Such a multi/many-core design platform is a powerful and versatile research and teaching tool for architectural ...
  • Tanji, Haruka; Simon, Jonathan; Ghosh, Saikat; Bloom, Benjamin; Vuletic, Vladan (Royal Swedish Academy of Sciences, 2009-07)
    We describe the mapping of quantum states between single photons and an atomic ensemble. In particular, we demonstrate a heralded quantum memory based on the mapping of a photon polarization state onto a single collective-spin ...
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