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Browsing MIT Open Access Articles by Title

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  • Microquake seismic interferometry with SVD-enhanced Green's function recovery 
    Melo, Gabriela; Malcolm, Alison E. (Society of Exploration Geophysicists, 2011-05)
    The conditions under which seismic interferometry (SI) leads to the exact Green's function (GF) are rarely met in practice. As a result, we generally recover only estimates of the true GF. This raises the questions: How ...
  • MicroRNA-125b transforms myeloid cell lines by repressing multiple mRNA 
    Bousquet, Marina; Nguyen, Diu; Chen, Cynthia; Shields, Lauren; Lodish, Harvey F. (Ferrata Storti Foundation, 2012-06)
    Background: We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that ...
  • MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13 
    Sankaran, Vijay G.; Menne, Tobias F.; Scepanovic, Danilo; Vergilio, Jo-Anne; Ji, Peng; Kim, Jinkuk; Thiru, Prathapan; Orkin, Stuart H.; Lander, Eric S.; Lodish, Harvey F. (National Academy of Sciences (U.S.), 2011-01)
    Many human aneuploidy syndromes have unique phenotypic consequences, but in most instances it is unclear whether these phenotypes are attributable to alterations in the dosage of specific genes. In human trisomy 13, there ...
  • MicroRNA Destabilization Enables Dynamic Regulation of the miR-16 Family in Response to Cell-Cycle Changes 
    Rissland, Olivia S.; Hong, Sue-Jean; Bartel, David; Rissland, Olivia S. (Elsevier B.V., 2011-09)
    The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or downregulated in many types of cancers. Here, we report the ...
  • MicroRNA Functions in Stress Responses 
    Leung, Anthony K.L.; Sharp, Phillip A.; Leung, Anthony K. L. (Elsevier B.V., 2010-10)
    MicroRNAs (miRNAs) are a class of ~22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding ...
  • MicroRNA miR-125b causes leukemia 
    Bousquet, Marina; Harris, Marian H.; Zhou, Beiyan; Lodish, Harvey F. (National Academy of Sciences (U.S.), 2010-12)
    MicroRNA miR-125b has been implicated in several kinds of leukemia. The chromosomal translocation t(2;11)(p21;q23) found in patients with myelodysplasia and acute myeloid leukemia leads to an overexpression of miR-125b of ...
  • MicroRNAs can generate thresholds in target gene expression 
    Mukherji, Shankar; Ebert, Margaret S.; Zheng, Grace X. Y.; Sharp, Phillip A.; van Oudenaarden, Alexander; Tsang, John S. (Nature Publishing Group, 2011-08)
    MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner. We performed single-cell measurements using quantitative fluorescence microscopy and flow ...
  • MicroRNA signature of cis-platin resistant vs. cis-platin sensitive ovarian cancer cell lines 
    Kumar, Smriti R.; Kumar, Arooshi R.; Shah, Parag P.; Rai, Shesh N.; Panguluri, Siva K.; Kakar, Sham S. (BioMed Central Ltd., 2011-09)
    Background: Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide. According to the National Cancer Institute, ovarian cancer has the highest mortality rate among all the reproductive ...
  • MicroRNAs in adipogenesis and as therapeutic targets for obesity 
    Alexander, Ryan; Lodish, Harvey F.; Sun, Lei (Informa Healthcare, 2011-02)
    Introduction: Obesity and obesity-related disease have reached pandemic proportions and are prevalent even in developing countries. Adipose tissue is increasingly being recognized as a key regulator of whole-body energy ...
  • MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitment 
    Zhang, L.; Sankaran, V. G.; Lodish, Harvey F. (Nature Publishing Group, 2012-05)
    MicroRNAs (miRNAs) are a class of small regulatory noncoding RNAs that modulate the expression of their target genes through either mRNA degradation or inhibition of protein translation. In recent years, miRNAs have been ...
  • MicroRNAs: the primary cause or a determinant of progression in leukemia? 
    Bousquet, Marina; Lodish, Harvey F. (Expert Reviews, Ltd., 2011-04)
    Leukemia is a complex disease with many different types and subtypes caused by a huge diversity of genetic and epigenetic aberrations. Until recently, alterations of protein-coding genes were thought to be the sole cause ...
  • Microsaccade rate varies with subjective visibility during motion-i= blindness 
    Hsieh, Po-Jang; Tse, Peter U. (Public Library of Science, 2009-04)
    Motion-induced blindness (MIB) occurs when a dot embedded in a motion field subjectively vanishes. Here we report the first psychophysical data concerning effects of microsaccade/eyeblink rate upon perceptual switches ...
  • A Microsaccadic Rhythm Modulates Gamma-Band Synchronization and Behavior 
    Fries, Pascal; Womelsdorf, Thilo; Bosman, Conrado A.; Desimone, Robert (Society for Neuroscience, 2009-06)
    Rhythms occur both in neuronal activity and in behavior. Behavioral rhythms abound at frequencies at or below 10 Hz. Neuronal rhythms cover a very wide frequency range, and the phase of neuronal low-frequency rhythms ...
  • MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma 
    Sabatini, David M.; Wood, Kris C.; Konieczkowski, David J.; Johannessen, Cory M.; Boehm, Jesse S.; Tamayo, Pablo; Botvinnik, Olga B.; Mesirov, Jill P.; Hahn, William C.; Root, David E.; Garraway, Levi A. (American Association for the Advancement of Science (AAAS), 2012-05)
    Cell microarrays are a promising tool for performing large-scale functional genomic screening in mammalian cells at reasonable cost, but owing to technical limitations they have been restricted for use with a narrow range ...
  • Microscale structural model of Alzheimer Aβ(1-40) amyloid fibril 
    Paparcone, Raffaella; Buehler, Markus J. (American Institute of Physics (AIP), 2009-06)
    Amyloid fibril formation and characterization are crucial due to their association with severe degenerative disorders such as Alzheimer’s, type II diabetes, and Parkinson’s disease. Here we present an atomistic-based ...
  • Microscale Technologies for Tissue Engineering 
    Khademhosseini, Ali; Chung, Bong Geun (Institute of Electrical and Electronics Engineers, 2009-05)
    Microscale technologies are emerging as enabling tools for tissue engineering and biology. Here, we present our experience in developing microscale technologies to regulate cell-microenvironment interactions and generate ...
  • Microscopic mechanism of low thermal conductivity in lead telluride 
    Shiga, Takuma; Shiomi, Junichiro; Ma, Jie; Delaire, Olivier; Radzynski, Tomasz; Lusakowski, Andrzej; Esfarjani, Keivan; Chen, Gang (American Physical Society, 2012-04)
    The microscopic physics behind low-lattice thermal conductivity of single-crystal rock salt lead telluride (PbTe) is investigated. Mode-dependent phonon (normal and umklapp) scattering rates and their impact on thermal ...
  • Microscopic model of electric-field-noise heating in ion traps 
    Safavi-Naini, Arghavan; Rabl, P.; Weck, P. F.; Sadeghpour, H. R. (American Physical Society, 2011-08)
    Motional heating of ions in microfabricated traps is one of the open challenges hindering experimental realizations of large-scale quantum processing devices. Recently, a series of measurements of the heating rates in ...
  • Microscopic model versus systematic low-energy effective field theory for a doped quantum ferromagnet 
    Gerber, U.; Hofmann, C. P.; Kampfer, Florian; Wiese, U. J. (American Physical Society, 2010-02)
    We consider a microscopic model for a doped quantum ferromagnet as a test case for the systematic low-energy effective field theory for magnons and holes, which is constructed in complete analogy to the case of quantum ...
  • Microscopic picture of Co clustering in ZnO 
    Iusan, Diana; Kabir, Mohammad Mukul; Granas, Oscar; Eriksson, Olle; Sanyal, Biplab (American Physical Society, 2009-03)
    Density functional theory was applied to study the chemical and magnetic interactions between Co atoms doped in ZnO. It was found that the Co impurities tend to form nanoclusters and the interactions between these atoms ...
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