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Browsing MIT Open Access Articles by Title

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  • Kitamura, Takashi; Okubo-suzuki, Reiko; Takashima, Noriko; Murayama, Akiko; Hino, Toshiaki; Nishizono, Hirofumi; Kida, Satoshi; Inokuchi, Kaoru (BioMed Central Ltd, 2012-02)
    Background: During permanent memory formation, recall of acquired place memories initially depends on the hippocampus and eventually become hippocampus-independent with time. It has been suggested that the quality of ...
  • Neve, Rachael L.; Xia, Yan; Portugal, George S.; Fakira, Amanda K.; Melyan, Zara; Lee, H. Thomas; Russo, Scott J.; Liu, Jie; Morón, Jose A. (Society for Neuroscience, 2011-11)
    Glutamatergic systems, including AMPA receptors (AMPARs), are involved in opiate-induced neuronal and behavioral plasticity, although the mechanisms underlying these effects are not fully understood. In the present study, ...
  • Lamar, John Michael; Stern, Patrick; Liu, Hui; Schindler, Jeffrey W.; Jiang, Zhigang; Hynes, Richard O. (National Academy of Sciences (U.S.), 2012-09)
    The transcriptional coactivator Yes-associated protein (YAP) is a major regulator of organ size and proliferation in vertebrates. As such, YAP can act as an oncogene in several tissue types if its activity is increased ...
  • West, Andrew A.; Garcia-Appadoo, Diego A.; Dalcanton, Julianne J.; Disney, Mike J.; Rockosi, Constance M.; Ivezic, Zeljko (IOP Publishing, 2009-07)
    We utilize color information for an H I-selected sample of 195 galaxies to explore the star formation histories and physical conditions that produce the observed colors. We show that the H I selection creates a significant ...
  • West, Andrew A.; Garcia-Appadoo, Diego A.; J. Dalcanton, Julianne; Disney, Mike J.; Rockosi, Constance M.; Bentz, Misty C.; Brinkmann, J.; Ivezic, Zeljko (IOP Publishing, 2009-12)
    We present the optical data for 195 H I-selected galaxies that fall within both the Sloan Digital Sky Survey (SDSS) and the Parkes Equatorial Survey (ES). The photometric quantities have been independently recomputed for ...
  • Yang, Linfeng; Zhang, Jing; Ho, Bow; Ding, Jeak Ling (Public Library of Science, 2011-05)
    Background: M-ficolin, a pathogen recognition molecule in the innate immune system, binds sugar residues including N-acetyl-D-glucosamine (GlcNAc), which is displayed on invading microbes and on apoptotic cells. The cis ...
  • Vu, Quang Hieu; Ooi, Beng Chin; Rinard, Martin C.; Tan, Kian-Lee (Institute of Electrical and Electronics Engineers, 2009-04)
    Over the past few years, peer-to-peer (P2P) systems have rapidly grown in popularity and have become a dominant means for sharing resources. In these systems, load balancing is a key challenge because nodes are often ...
  • Yildirim, Ferah; Ji, Shengbo; Kronenberg, Golo; Barco, Angel; Olivares, Roman; Benito, Eva; Dirnagl, Ulrich; Gertz, Karen; Endres, Matthias; Harms, Christoph; Meisel, Andreas (Public Library of Science, 2014-04)
    Epigenetic transcriptional regulation by histone acetylation depends on the balance between histone acetyltransferase (HAT) and deacetylase activities (HDAC). Inhibition of HDAC activity provides neuroprotection, indicating ...
  • Ji, Peng; Yeh, Victor; Ramirez, Tzutzuy; Murata-Hori, Maki; Lodish, Harvey F. (Ferrata Storti Foundation, 2010-09)
    Background: During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of ...
  • Taniguchi, Makoto; Carreira, Maria B.; Smith, Laura N.; Zirlin, Benjamin C.; Neve, Rachael L.; Cowan, Christopher W.; Neve, Rachael L. (Elsevier, 2012-01)
    Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient ...
  • Jones, Richard Bradley; O'Connor, Rachel; Mueller, Stefanie; Foley, Maria Hottelet; Szeto, Gregory Lee; Karel, Dan; Lichterfeld, Mathias; Kovacs, Colin; Ostrowski, Mario A.; Trocha, Alicja; Irvine, Darrell J.; Walker, Bruce D. (Public Library of Science, 2014-08)
    Resting memory CD4[superscript +] T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis), such as suberanilohydroxamic acid (SAHA), romidepsin, ...
  • Zwaans, Bernadette M.M.; Silberman, Dafne M.; Goren, Alon; Zhong, Lei; Ram, Oren; Truelove, Jessica; Guimaraes, Alexander R.; Toiber, Debra; Cosentino, Claudia; Greenson, Joel K.; MacDonald, Alasdair I.; McGlynn, Liane; Maxwell, Fraser; Edwards, Joanne; Giacosa, Sofia; Guccione, Ernesto; Weissleder, Ralph; Bernstein, Bradley E.; Regev, Aviv; Shiels, Paul G.; Lombard, David B.; Mostoslavsky, Raul; Sebastian, Carlos; Gymrek, Melissa A.; Bernstein, Bradley E. (Elsevier, 2012-12)
    Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here, we identify SIRT6 as a ...
  • Cheng, Albert W.; Creyghton, Menno P.; Welstead, G. Grant; Kooistra, Tristan G.; Carey, Bryce W.; Steine, Eveline J.; Hanna, Jacob; Lodato, Michael A.; Frampton, Garrett M.; Sharp, Phillip A.; Boyer, Laurie; Young, Richard A.; Jaenisch, Rudolf (National Academy of Sciences (U.S.), 2010-11)
    Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. These regulatory events at enhancers ...
  • Heintzman, Nathaniel D.; Hon, Gary C.; Hawkins, R. David; Kheradpour, Pouya; Stark, Alexander; Harp, Lindsey F.; Ye, Zhen; Lee, Leonard K.; Stuart, Rhona K.; Ching, Christina W.; Ching, Keith A.; Antosiewicz-Bourget, Jessica E.; Liu, Hui; Zhang, Xinmin; Green, Roland D.; Lobanenkov, Victor V.; Stewart, Ron; Thomson, James A.; Crawford, Gregory E.; Kellis, Manolis; Ren, Bing (Nature Publishing Group, 2009-03)
    The human body is composed of diverse cell types with distinct functions. Although it is known that lineage specification depends on cell-specific gene expression, which in turn is driven by promoters, enhancers, insulators ...
  • Monier, Erwan; Schlosser, Adam; Sokolov, Andrei P. (Copernicus GmbH, 2013-05)
    Both historical and idealized climate model experiments are performed with a variety of Earth system models of intermediate complexity (EMICs) as part of a community contribution to the Intergovernmental Panel on Climate ...
  • Mahlstein, Irina; Gent, Peter R.; Solomon, Susan (American Geophysical Union (AGU), 2013-06)
    In contrast to Arctic sea ice, average Antarctic sea ice area is not retreating but has slowly increased since satellite measurements began in 1979. While most climate models from the Coupled Model Intercomparison Project ...
  • McCants, Anne E. C. (M.I.T. Press, 2009)
  • Cavicchi, Elizabeth (Springer-Verlag, 2008-08)
    Two students, meeting together with a teacher, redid historical experiments. Unlike conventional instruction where science topics and practices often fragment, they experienced interrelatedness among phenomena, participants’ ...
  • Win, Moe Z.; Dardari, Davide; Molisch, A. F.; Wiesbeck, W.; Zhang, Jinyun (Institute of Electrical and Electronics Engineers, 2009-03)
    This mathematical modeling method for wireless networks is designed to take into account propagation effects and interference from unwanted transmissions.
  • Rigby, Matthew; Muhle, J.; Miller, B. R.; Prinn, Ronald G.; Krummel, P. B.; Steele, L. P.; Fraser, P. J.; Salameh, P. K.; Harth, C. M.; Weiss, R. F.; Greally, B. R.; O'Doherty, S.; Simmonds, P. G.; Vollmer, M. K.; Reimann, S.; Kim, J.; Kim, K.-R.; Wang, H. J.; Olivier, J. G. J.; Dlugokencky, E. J.; Dutton, G. S.; Hall, B. D.; Elkins, J. W. (European Geosciences Union / Copernicus, 2010-11)
    We present atmospheric sulfur hexafluoride (SF6)[SF subscript 6] mole fractions and emissions estimates from the 1970s to 2008. Measurements were made of archived air samples starting from 1973 in the Northern Hemisphere ...
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