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Browsing MIT Open Access Articles by Title

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  • Distal chromatin structure influences local nucleosome positions and gene expression 
    Jansen, An; van der Zande, Elisa; Meert, Wim; Fink, Gerald R.; Verstrepen, Kevin J. (Oxford University Press (OUP), 2012-01)
    The positions of nucleosomes across the genome influence several cellular processes, including gene transcription. However, our understanding of the factors dictating where nucleosomes are located and how this affects gene ...
  • Distal transport of dissolved hydrothermal iron in the deep South Pacific Ocean 
    Fitzsimmons, Jessica N.; Boyle, Edward A.; Jenkins, William J. (National Academy of Sciences (U.S.), 2014-11)
    Until recently, hydrothermal vents were not considered to be an important source to the marine dissolved Fe (dFe) inventory because hydrothermal Fe was believed to precipitate quantitatively near the vent site. Based on ...
  • Distance and Political Boundaries: Estimating Border Effects under Inequality Constraints 
    Borraz, Fernando; Zipitria, Leandro; Cavallo, Alberto F.; Rigobon, Roberto (John Wiley & Sons, 2015-04)
    The ‘border effects’ literature finds that political boundaries have a large impact on relative prices across locations. In this paper, we show that the standard empirical specification suffers from selection bias and ...
  • The distance geometry of music 
    Demaine, Erik D.; Gomez-Martin, Francisco; Meijer, Henk; Rappaport, David; Taslakian, Perouz; Winograd, Terry; Wood, David R.; Toussaint, Godfried (Elsevier, 2008-12)
    We demonstrate relationships between the classic Euclidean algorithm and many other fields of study, particularly in the context of music and distance geometry. Specifically, we show how the structure of the Euclidean ...
  • Distance scaling of electric-field noise in a surface-electrode ion trap 
    Sedlacek, Jonathon; Greene, Amy L; Stuart, J. Scott; McConnell, Robert P.; Bruzewicz, Colin D.; Sage, Jeremy M.; Chiaverini, John (American Physical Society, 2018-02)
    We investigate anomalous ion-motional heating, a limitation to multiqubit quantum-logic gate fidelity in trapped-ion systems, as a function of ion-electrode separation. Using a multizone surface-electrode trap in which ...
  • Distant cis-regulatory elements in human skeletal muscle differentiation 
    McCord, Rachel P.; Zhou, Vicky W.; Yuh, Tiffany; Bulyk, Martha L. (Elsevier, 2011-08)
    Identifying gene regulatory elements and their target genes in human cells remains a significant challenge. Despite increasing evidence of physical interactions between distant regulatory elements and gene promoters in ...
  • A distant trophoblast-specific enhancer controls HLA-G expression at the maternal–fetal interface 
    Ferreira, Leonardo M. R.; Meissner, Torsten B.; Mikkelsen, Tarjei S.; Mallard, William; O’Donnell, Charles W.; Tilburgs, Tamara; Gomes, Hannah A. B.; Camahort, Raymond; Sherwood, Richard I.; Rinn, John L.; Cowan, Chad A.; Strominger, Jack L.; Gifford, David K (National Academy of Sciences (U.S.), 2016-04)
    HLA-G, a nonclassical HLA molecule uniquely expressed in the placenta, is a central component of fetus-induced immune tolerance during pregnancy. The tissue-specific expression of HLA-G, however, remains poorly understood. ...
  • DistFlow ODE: Modeling, analyzing and controlling long distribution feeder 
    Wang, Danhua; Turitsyn, Konstantin; Chertkov, Michael (Institute of Electrical and Electronics Engineers, 2012-12)
    We consider a linear feeder connecting multiple distributed loads and generators to the sub-station. Voltage is controlled directly at the sub-station, however, voltage down the line shifts up or down, in particular depending ...
  • Distilling clinically interpretable information from data collected on next-generation wearable sensors 
    Haslam, Bryan Todd; Gordhandas, Ankit; Ricciardi, Catherine; Verghese, George C.; Heldt, Thomas (2011-08)
    Medical electronic systems are generating ever larger data sets from a variety of sensors and devices. Such systems are also being packaged in wearable designs for easy and broad use. The large volume of data and the ...
  • Distinct and Predictive Histone Lysine Acetylation Patterns at Promoters, Enhancers, and Gene Bodies 
    Rajagopal, Nisha; Kellis, Manolis; Ernst, Jason; Ray, Pradipta; Wu, Jie; Zhang, Michael; Ren, Bing (Genetics Society of America, 2014-08)
    In eukaryotic cells, histone lysines are frequently acetylated. However, unlike modifications such as methylations, histone acetylation modifications are often considered redundant. As such, the functional roles of distinct ...
  • Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses 
    Kapeli, Katannya; Pratt, Gabriel A.; Vu, Anthony Q.; Hutt, Kasey R.; Martinez, Fernando J.; Sundararaman, Balaji; Batra, Ranjan; Huelga, Stephanie C.; Chun, Seung J.; Liang, Tiffany Y.; Chang, Jeremy; Donohue, John P.; Shiue, Lily; Zhang, Jiayu; Zhu, Haining; Cambi, Franca; Kasarskis, Edward; Hoon, Shawn; Ares Jr., Manuel; Ravits, John; Rigo, Frank; Yeo, Gene W.; Freese, Peter Dale; Lambert, Nicole; Burge, Christopher B (Nature Publishing Group, 2016-07)
    The RNA-binding protein (RBP) TAF15 is implicated in amyotrophic lateral sclerosis (ALS). To compare TAF15 function to that of two ALS-associated RBPs, FUS and TDP-43, we integrate CLIP-seq and RNA Bind-N-Seq technologies, ...
  • Distinct Cortical Pathways for Music and Speech Revealed by Hypothesis-Free Voxel Decomposition 
    Norman-Haignere, Samuel Victor; Kanwisher, Nancy; McDermott, Joshua H. (Elsevier/Cell Press, 2015-12)
    The organization of human auditory cortex remains unresolved, due in part to the small stimulus sets common to fMRI studies and the overlap of neural populations within voxels. To address these challenges, we measured fMRI ...
  • Distinct Distance Estimates and Low Degree Polynomial Partitioning 
    Guth, Lawrence (Springer US, 2014-12)
    We give a shorter proof of a slightly weaker version of a theorem from Guth and Katz (Ann Math 181:155–190, 2015): we prove that if L is a set of L lines in R[superscript 3] with at most L[superscript 1/2] lines in any ...
  • Distinct distributed patterns of neural activity are associated with two languages in the bilingual brain 
    Xu, Min; Chang, Chun Qi; Tan, Li Hai; Baldauf, Daniel; Desimone, Robert (American Association for the Advancement of Science (AAAS), 2017-07)
    A large body of previous neuroimaging studies suggests that multiple languages are processed and organized in a single neuroanatomical system in the bilingual brain, although differential activation may be seen in some ...
  • Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel 
    Archary, D; Seaton, K E; Passmore, J S; Werner, L; Deal, A; Yates, N L; Bergin, P; Liebenberg, L J; Samsunder, N; Mureithi, M W; Altfeld, M; Garrett, N; Abdool Karim, Q; Abdool Karim, S S; Morris, L; Tomaras, G D; Dunphy, Laura J.; Arnold, Kelly Benedict; Lauffenburger, Douglas A (Nature Publishing Group, 2016-01)
    The impact of topical antiretrovirals for pre-exposure prophylaxis on humoral responses following HIV infection is unknown. Using a binding antibody multiplex assay, we investigated HIV-specific IgG and IgA responses to ...
  • Distinct Interfacial Fluorescence in Oil-in-Water Emulsions via Exciton Migration of Conjugated Polymers 
    Koo, Byungjin; Swager, Timothy M (Wiley Blackwell, 2017-08)
    Commercial dyes are extensively utilized to stain specific phases for the visualization applications in emulsions and bioimaging. In general, dyes emit only one specific fluorescence signal and thus, in order to stain ...
  • A DISTINCTIVE DISK-JET COUPLING IN THE SEYFERT-1 ACTIVE GALACTIC NUCLEUS NGC 4051 
    King, A. L.; Miller, J. M.; Cackett, E. M.; Fabian, Andrew C.; Markoff, Sera B.; Rupen, M.; Reynolds, M. T.; Nowak, Michael A.; Gultekin, K. (IOP Publishing, 2010-02)
    We report on the results of a simultaneous monitoring campaign employing eight Chandra X-ray (0.5-10 keV) and six Very Large Array/Extended Very Large Array (8.4 GHz) radio observations of NGC 4051 over seven months. ...
  • Distinct Neural Circuits Control Rhythm Inhibition and Spitting by the Myogenic Pharynx of C. elegans 
    Bhatla, Nikhil; Droste, Rita; Sando, Steven Robert; Huang, Anne; Horvitz, Howard Robert (Elsevier, 2015-07)
    Neural circuits have long been known to modulate myogenic muscles such as the heart, yet a mechanistic understanding at the cellular and molecular levels remains limited. We studied how light inhibits pumping of the ...
  • Distinct Organization and Regulation of the Outer Kinetochore KMN Network Downstream of CENP-C and CENP-T 
    Rago, Florencia; Gascoigne, Karen E.; Cheeseman, Iain M (Elsevier, 2015-02)
    The kinetochore provides a vital connection between chromosomes and spindle microtubules [1 and 2]. Defining the molecular architecture of the core kinetochore components is critical for understanding the mechanisms by ...
  • Distinct Patterns of Expression and Evolution of Intronless and Intron-Containing Mammalian Genes 
    Shabalina, Svetlana A.; Ogurtsov, Aleksey Y.; Spiridonov, Alexey Nikolaevich; Novichkov, Pavel S.; Spiridonov, Nikolay A.; Koonin, Eugene V. (Oxford University Press on behalf of the Society for Molecular Biology and Evolution, 2010-04)
    Comparison of expression levels and breadth and evolutionary rates of intronless and intron-containing mammalian genes shows that intronless genes are expressed at lower levels, tend to be tissue specific, and evolve ...
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