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Browsing MIT Open Access Articles by Title

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  • Goodman, Joel I.; Herman, Matthew; Miller, Benjamin A.; Bond, Bradley N. (Institute of Electrical and Electronics Engineers, 2009-07)
    In this paper we present a simple closed-form solution to the Wiener-Hammerstein (W-H) identification problem. The identification process occurs in the log-frequency domain where magnitudes and phases are separable. We ...
  • Borodin, Alexei; Corwin, Ivan; Remenik, Daniel (Springer-Verlag, 2013-07)
    We prove that under n[superscript 1/3] scaling, the limiting distribution as n → ∞ of the free energy of Seppalainen’s log-Gamma discrete directed polymer is GUE Tracy-Widom. The main technical innovation we provide is a ...
  • Mikaelian, Tsoline; Rhodes, Donna H.; Nightingale, Deborah J.; Hastings, Daniel E. (Institute of Electrical and Electronics Engineers, 2011-01)
    Complex systems are subject to uncertainties that may lead to suboptimal performance or even catastrophic failure if unmanaged. Uncertainties may be managed through real options that provide a decision maker with the right, ...
  • Morris, Melody Kay; Saez-Rodriguez, Julio; Sorger, Peter K.; Lauffenburger, Douglas A. (American Chemical Society, 2010-03)
    Computational models are increasingly used to analyze the operation of complex biochemical networks, including those involved in cell signaling networks. Here we review recent advances in applying logic-based modeling to ...
  • Kim, Tae-Woo; Kim, Dae-Hyun; del Alamo, Jesus A. (Institute of Electrical and Electronics Engineers (IEEE), 2010-07)
    We have experimentally investigated the trade-offs involved in thinning down the channel of III-V FETs with the ultimate goal of enhancing the electrostatic integrity and scalability of these devices. To do so, we have ...
  • Jiang, Ming; Zhang, Haoran; Pfeifer, Blaine A. (MyJoVE Corporation, 2013-01)
    The heterologous production of complex natural products is an approach designed to address current limitations and future possibilities. It is particularly useful for those compounds which possess therapeutic value but ...
  • Guarente, Leonard Pershing (Elsevier, 2011-08)
    Protein acetylation now rivals phosphorylation in frequency of occurrence but is incompletely understood. A picture is presented in which protein acetylation is linked to available energy via the NAD-dependent deacetylases. ...
  • Sorger, Peter K.; Alexopoulos, Leonidas G.; Saez-Rodriguez, Julio; Klamt, Steffen; Samaga, Regina (Public Library of Science, 2009-08)
    The epidermal growth factor receptor (EGFR) signaling pathway is probably the best-studied receptor system in mammalian cells, and it also has become a popular example for employing mathematical modeling to cellular signaling ...
  • Le, Long Bao; Joo, Changhee; Shroff, Ness B.; Modiano, Eytan H. (Association for Computing Machinery (ACM), 2010-09)
    We investigate the performance of longest-queue-first (LQF) scheduling (i.e., greedy maximal scheduling) for wireless networks under the SINR interference model. This interference model takes network geometry and the ...
  • Lin, Qian; Van Camp, Mackenzie Anne; Zhang, Hao; Jelenkovic, Branislav; Vuletic, Vladan (Optical Society of America, 2012-05)
    We report on a simple, compact, and robust 780 nm distributed Bragg reflector laser with subkilohertz intrinsic linewidth. An external cavity with optical path length of 3.6 m, implemented with an optical fiber, reduces ...
  • Kochan, Thomas Anton; Lipsky, David B.; NewHart, Mary; Benson, Alan M. (New York State School of Industrial and Labor Relations, 2010-01)
    The authors examine debates about the effects of mandatory interest arbitration on police and firefighters in New York State under the Taylor Law from 1974 to 2007. Comparing experience with interest arbitration in the ...
  • Balewski, Jan T.; Betancourt, Michael Joseph; Corliss, Ross Cameron; Hays-Wehle, J. P.; Leight, William Axel; Redwine, Robert P.; Seele, J.; van Nieuwenhuizen, Gerrit Jan; Steadman, Stephen G.; Surrow, Bernd (American Physical Society, 2012-08)
    We report STAR measurements of the longitudinal double-spin asymmetry A[subscript LL], the transverse single-spin asymmetry A[subscript N], and the transverse double-spin asymmetries A[subscript Σ] and [subscript ATT] for ...
  • Peltonen, Leena; Smith, Erin N.; Chen, Wei; Kahonen, Mika; Kettunen, Johannes; Lehtimaki, Terho; Raitakari, Olli T.; Salem, Rany M.; Schork, Nicholas J.; Shaw, Marian; Srinivasan, Sathanur R.; Topol, Eric J.; Viikari, Jorma S.; Berenson, Gerald S.; Murray, Sarah S. (2010-09)
    Cardiovascular disease (CVD) is the leading cause of death worldwide. Recent genome-wide association (GWA) studies have pinpointed many loci associated with CVD risk factors in adults. It is unclear, however, if these loci ...
  • Kohane, Isaac; Mandl, Kenneth D.; Reis, Ben Y. (British Medical Association, 2009-05)
    Objective To determine whether longitudinal data in patients’ historical records, commonly available in electronic health record systems, can be used to predict a patient’s future risk of receiving a diagnosis of ...
  • Devauchelle, O.; Petroff, A. P.; Lobkovsky, Alexander E.; Rothman, Daniel H. (Cambridge University Press, 2010-12)
    We propose a simple theory for the longitudinal profile of channels incised by groundwater flow. The aquifer surrounding the stream is represented in two dimensions through Darcy's law and the Dupuit approximation. The ...
  • Vosoughi, Soroush; Roy, Deb K. (Speech Prosody Special Interest Group (SProSIG), 2012-05)
    We investigate the role of prosody in child-directed speech of three English speaking adults using data collected for the Human Speechome Project, an ecologically valid, longitudinal corpus collected from the home of a ...
  • Tsunematsu, Tomomi; Tabuchi, Sawako; Tanaka, Kenji F.; Tominaga, Makoto; Yamanaka, Akihiro; Boyden, Edward Stuart (Elsevier, 2013-05)
    Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. Recent optogenetic studies revealed that the activation or inhibition of orexin neuronal activity affects the probability of ...
  • Nam, Jin-Wu; Bartel, David (Cold Spring Harbor Laboratory Press, 2012-06)
    Thousands of long non-coding RNAs (lncRNAs) have been found in vertebrate animals, a few of which have known biological roles. To better understand the genomics and features of lncRNAs in invertebrates, we used available ...
  • Sun, Lei; Goff, Loyal Andrew; Alexander, Ryan K.; Lo, Kinyui Alice; Yuan, Bingbing B.; Kellis, Manolis; Lodish, Harvey F.; Trapnell, Cole; Hacisuleyman, Ezgi; Sauvageau, Martin; Tazon-Vega, Barbara; Kelley, David R.; Hendrickson, David G.; Rinn, John L. (National Academy of Sciences (U.S.), 2013-02)
    The prevalence of obesity has led to a surge of interest in understanding the detailed mechanisms underlying adipocyte development. Many protein-coding genes, mRNAs, and microRNAs have been implicated in adipocyte development, ...
  • Aichholzer, Oswin; Bremner, David; Demaine, Erik D.; Meijer, Henk; Sacristán, Vera; Soss, Michael (Elsevier, 2003-05)
    It is widely accepted that (1) the natural or folded state of proteins is a global energy minimum, and (2) in most cases proteins fold to a unique state determined by their amino acid sequence. The H-P (hydrophobic-hydrophilic) ...
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