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Browsing MIT Open Access Articles by Title

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  • Kapur, Arnav; Marwah, Kshitij; Alterovitz, Gil (BioMed Central, 2016-06)
    Background An exponential growth of high-throughput biological information and data has occurred in the past decade, supported by technologies, such as microarrays and RNA-Seq. Most data generated using such methods are ...
  • Berger, Bonnie; Palmer, Nathan Patrick; Schmid, Patrick Raphael; Kohane, Isaac (BioMed Central Ltd, 2012-08)
    Abstract Background Understanding the fundamental mechanisms of tumorigenesis remains one of the most pressing problems in modern biology. To this end, stem-like cells with tumor-initiating potential have become a central ...
  • Regev, Aviv; Immunological Genome Project Consortium (Nature Publishing Group, 2012-09)
    We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were selectively ...
  • Boissonneault, Katie; Henningsen, Brooks M.; Bates, Stephen S.; Robertson, Deborah L.; Milton, Sean; Pelletier, Jerry; Hogan, Deborah A.; Housman, David E. (Biomed Central Ltd., 2013-11)
    Background: Pseudo-nitzschia multiseries Hasle (Hasle) (Ps-n) is distinctive among the ecologically important marine diatoms because it produces the neurotoxin domoic acid. Although the biology of Ps-n has been investigated ...
  • Wang, Meng C.; Oakley, Holly D.; Carr, Christopher E.; Sowa, Jessica N.; Ruvkun, Gary (Public Library of Science, 2014-12)
    Reproductive senescence is a hallmark of aging. The molecular mechanisms regulating reproductive senescence and its association with the aging of somatic cells remain poorly understood. From a full genome RNA interference ...
  • Spidlen, Josef; Barsky, Aaron; Breuer, Karin; Carr, Peter; Nazaire, Marc-Danie; Hill, Barbara; Qian, Yu; Liefeld, Ted; Reich, Michael; Wilkinson, Peter; Scheuermann, Richard H.; Sekaly, Rafick-Pierre; Brinkman, Ryan R.; Mesirov, Jill P. (BioMed Central Ltd, 2013-07)
    Background: Traditional flow cytometry data analysis is largely based on interactive and time consuming analysis of series two dimensional representations of up to 20 dimensional data. Recent technological advances have ...
  • Adida, Ben; Kohane, Isaac (BioMed Central Ltd, 2006-04)
    Background: Patient genomic data are rapidly becoming part of clinical decision making. Within a few years, full genome expression profiling and genotyping will be affordable enough to perform on every individual. The ...
  • Brown, Emery N.; Purdon, Patrick Lee; Van Dort, Christa (Annual Reviews, 2011-07)
    Placing a patient in a state of general anesthesia is crucial for safely and humanely performing most surgical and many nonsurgical procedures. How anesthetic drugs create the state of general anesthesia is considered a ...
  • Schiff, Nicholas D.; Brown, Emery N.; Lydic, Emily K. (New England Journal of Medicine, 2010-12)
    In the United States, nearly 60,000 patients per day receive general anesthesia for surgery.1 General anesthesia is a drug-induced, reversible condition that includes specific behavioral and physiological traits — ...
  • Brown, Emery N.; Lydic, Ralph; Schiff, Nicholas D. (New England Journal of Medicine, 2010-12)
    In the United States, nearly 60,000 patients per day receive general anesthesia for surgery.1 General anesthesia is a drug-induced, reversible condition that includes specific behavioral and physiological traits — ...
  • Kim, Justin; Movassaghi, Mohammad (American Chemical Society, 2010-09)
    A highly stereoselective and systematic strategy for the introduction of polysulfides in the synthesis of epipolythiodiketopiperazines is described. We report the first total synthesis of dimeric epitri- and epitetrathio ...
  • Braatz, Richard D.; Chen, Kejia; Vaidyanathan, Ramakrishnan; Seebauer, Edmund G. (American Institute of Physics (AIP), 2010-01)
    In many solids, diffusion of foreign atoms takes place primarily through highly mobile intermediate species that periodically exchange with atoms in the crystalline lattice. The governing reaction-diffusion equations include ...
  • Berger, Carola; Gainer, J. S.; Hewett, J. L.; Lillie, B.; Rizzo, T. G. (American Physical Society, 2009-11)
    We present the first detailed, large-scale study of the minimal supersymmetric standard model (MSSM) at the √s=500  GeV International Linear Collider (ILC), including full standard model backgrounds and detector simulation. ...
  • Mittal, Shashi; Schulz, Andreas S. (Institute for Operations Research and the Management Sciences (INFORMS), 2013-02)
    In this paper, we present a general framework for designing approximation schemes for combinatorial optimization problems in which the objective function is a combination of more than one function. Examples of such problems ...
  • Tulabandhula, Theja; Rudin, Cynthia (Springer Science+Business Media, 2014-12)
    In this paper, we consider a supervised learning setting where side knowledge is provided about the labels of unlabeled examples. The side knowledge has the effect of reducing the hypothesis space, leading to tighter ...
  • He, Xuhua; Lusztig, George (American Mathematical Society, 2012-01)
    Let G be a semisimple group over an algebraically closed field. Steinberg has associated to a Coxeter element w of minimal length r a subvariety V of G isomorphic to an affine space of dimension r which meets the regular ...
  • Demaine, Erik D.; Lubiw, Anna (Springer-Verlag, 2012)
    We present a new method for unfolding a convex polyhedron into one piece without overlap, based on shortest paths to a convex curve on the polyhedron. Our “sun unfoldings” encompass source unfolding from a point, source ...
  • Kedlaya, Kiran S.; Shao, Xuancheng (American Mathematical Society, 2009-01)
    In this paper, we present some generalizations of Gowers’s result about product-free subsets of groups. For any group G of order n, a subset A of G is said to be product-free if there is no solution of the equation ab = ...
  • Wang, Yinan (Springer-Verlag, 2015-07)
    We develop the generalized Cartan Calculus for the groups G = SL(2,R) × R[superscript +],SL(5,R) and SO(5, 5). They are the underlying algebraic structures of d = 9, 7, 6 exceptional field theory, respectively. These ...
  • Hwang, J. George; Lehn, Peter W.; Winkelnkemper, Manfred (Institute of Electrical and Electronics Engineers (IEEE), 2010-10)
    Within power systems, high-power pulsewidth-modulated ac-dc converters are used in flexible ac transmission systems controllers and for interfacing renewable energy sources to the grid. These converters traditionally ...
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