Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Neafsey, Daniel E.; Galagan, James E.; Sharpton, Thomas J.; Taylor, John W. (BioMed Central Ltd, 2008-01)
    Background: Genome comparisons across deep phylogenetic divergences have revealed that spliceosomal intron gain and loss are common evolutionary events. However, because of the deep divergences involved in these comparisons, ...
  • Valastyan, Julie Suzanne; Lindquist, Susan (Company of Biologists, 2014-01)
    For a protein to function appropriately, it must first achieve its proper conformation and location within the crowded environment inside the cell. Multiple chaperone systems are required to fold proteins correctly. In ...
  • Duchemin, Jean-Bernard; Bomblies, Arne; Eltahir, Elfatih A. B. (BioMed Central, 2009-10)
    Background: Malaria transmission models commonly incorporate spatial environmental and climate variability for making regional predictions of disease risk. However, a mismatch of these models' typical spatial resolutions ...
  • Allen, Peter M.; Walker, Brian J.; Bawendi, Moungi G.; Bawendi, Moungi G. (Wiley Blackwell, 2009-12)
    The molecular mechanism of InP colloidal quantum dot (QD) syntheses was investigated by NMR spectroscopy. Unlike methods for monodisperse PbSe and CdSe, existing InP syntheses result in total depletion of molecular phosphorous ...
  • Benedek, George B.; Li, Huiyuan; Monien, Bernhard H.; Lomakin, Aleksey; Zemel, Reeve; Fradinger, Erica A.; Tan, Miao; Spring, Sean M.; Urbanc, Brigita; Xie, Cui-Wei; Bitan, Gal (American Chemical Society (ACS), 2010-08)
    Oligomeric forms of amyloid β-protein (Aβ) are key neurotoxins in Alzheimer’s disease (AD). Previously, we found that C-terminal fragments (CTFs) of Aβ42 interfered with assembly of full-length Aβ42 and inhibited Aβ42-induced ...
  • Zaborenko, Nikolay; Bedore, Matthew W.; Jamison, Timothy F.; Jensen, Klavs F. (American Chemical Society, 2011-01)
    A continuous-flow microreactor is applied for a kinetic study of a model β-amino alcohol formation by epoxide aminolysis. A large number of experiments are performed in a short time with minimal reagent consumption. The ...
  • Chang, Wei-chen; Dey, Mishtu; Liu, Pinghua; Mansoorabadi, Steven O.; Moon, Sung-Ju; Zhao, Zongbao K.; Drennan, Catherine L.; Liu, Hung-wen (Nature Publishing Group, 2013-04)
    (S)-2-hydroxypropylphosphonate ((S)-2-HPP) epoxidase (HppE) is a mononuclear non-haem-iron-dependent enzyme1, 2, 3 responsible for the final step in the biosynthesis of the clinically useful antibiotic fosfomycin4. Enzymes ...
  • Papa, Anne-Laure; Basu, Sudipta; Sengupta, Poulomi; Banerjee, Deboshri; Sengupta, Shiladitya; Harfouche, Rania (BioMed Central Ltd., 2012-09)
    Background: Pancreatic cancer remains the deadliest of all cancers, with a mortality rate of 91%. Gemcitabine is considered the gold chemotherapeutic standard, but only marginally improves life-span due to its chemical ...
  • Lippard, Stephen J.; Song, Woon Ju (American Chemical Society, 2011-05)
    Site-directed mutagenesis studies of a strictly conserved T201 residue in the active site of toluene/o-xylene monooxygenase hydroxylase (ToMOH) revealed that a single mutation can facilitate kinetic isolation of two ...
  • Chen, Jingyang; Ghorai, Manas K.; Kenney, Grace; Stubbe, JoAnne (Oxford University Press (OUP), 2008-05)
    The bleomycins (BLMs) are a family of natural glycopeptides used clinically as antitumor agents. In the presence of required cofactors (Fe[superscript 2+] and O[subscript 2]), BLM causes both single-stranded (ss) and ...
  • Strieter, Eric R.; Bhayana, Brijesh; Buchwald, Stephen Leffler (American Chemical Society (ACS), 2008-12)
    The copper-catalyzed N-arylation of amides, i.e., the Goldberg reaction, is an efficient method for the construction of products relevant to both industry and academic settings. Herein, we present mechanistic details ...
  • Kagey, Michael H.; Newman, Jamie J.; Bilodeau, Steve; Zhan, Ye; Orlando, David A.; van Berkum, Nynke L.; Ebmeier, Christopher C.; Goossens, Jesse; Rahl, Peter B.; Levine, Stuart S.; Taatjes, Dylan J.; Dekker, Job; Young, Richard A. (Nature Publishing Group, 2010-08)
    Transcription factors control cell-specific gene expression programs through interactions with diverse coactivators and the transcription apparatus. Gene activation may involve DNA loop formation between enhancer-bound ...
  • Finkelstein, Amy; Taubman, Sarah L.; Allen, Heidi L.; Wright, Bill J.; Baicker, Katherine (American Association for the Advancement of Science (AAAS), 2014-01)
    In 2008, Oregon initiated a limited expansion of a Medicaid program for uninsured, low-income adults, drawing names from a waiting list by lottery. This lottery created a rare opportunity to study the effects of Medicaid ...
  • Clifford, Gari D.; Blaya, Joaquin Andres; Hall-Clifford, Rachel; Fraser, Hamish S. (BioMed Central Ltd., 2008-06)
  • Romero, R.; Emanuel, Kerry Andrew (American Geophysical Union, 2013-06)
    Medicanes or “Mediterranean hurricanes” are extreme cyclonic windstorms morphologically and physically similar to tropical cyclones. Owing to their potential destructiveness on the islands and continental coastal zones, ...
  • Engelhardt, Gary V.; Gruber, Jonathan (American Economic Association, 2011-11)
    We examine the impact of the expansion of public prescription-drug insurance coverage from Medicare Part D and find evidence of substantial crowd-out. Using the 2002-2007 waves of the Medical Expenditure Panel Survey, we ...
  • D'Eramo, Francesco; Liu, Hong; Rajagopal, Krishna (IOP Publishing, 2011-11)
    The propagation of hard partons through the strongly interacting matter created in high-energy heavy-ion collisions involves widely separated scales. The methods of effective field theories can provide a factorized description ...
  • Oskooi, Ardavan; Roundy, David; Ibanescu, Mihai; Bermel, Peter A.; Joannopoulos, John D.; Johnson, Steven G. (Elsevier, 2009-11)
    This paper describes Meep, a popular free implementation of the finite-difference time-domain (FDTD) method for simulating electromagnetism. In particular, we focus on aspects of implementing a full-featured FDTD package ...
  • Chisholm, Jennifer; Hawley, R. Scott; Orr-Weaver, Terry L.; Whitfield, Zachary James (Public Library of Science, 2013-09)
    Oocytes are stockpiled with proteins and mRNA that are required to drive the initial mitotic divisions of embryogenesis. But are there proteins specific to meiosis whose levels must be decreased to begin embryogenesis ...
  • Lander, Eric S.; Berger, Michael F.; Hodis, Eran; Heffernan, Timothy P.; Deribe, Yonathan Lissanu; Lawrence, Michael S.; Protopopov, Alexei; Ivanova, Elena; Watson, Ian R.; Nickerson, Elizabeth; Ghosh, Papia; Zhang, Hailei; Zeid, Rhamy; Ren, Xiaojia; Cibulskis, Kristian; Sivachenko, Andrey Y.; Wagle, Nikhil; Sucker, Antje; Sougnez, Carrie; Onofrio, Robert (Nature Publishing Group, 2012-05)
    Melanoma is notable for its metastatic propensity, lethality in the advanced setting and association with ultraviolet exposure early in life. To obtain a comprehensive genomic view of melanoma in humans, we sequenced the ...
Open Access