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Browsing MIT Open Access Articles by Title

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  • Khademhosseini, Ali; Peppas, Nicholas A. (Wiley Blackwell, 2013-01)
    Many advances in the healthcare industry have been enabled by innovations in materials science and engineering. Materials science has revolutionized medicine in a range of applications from the implantable stents for ...
  • Murtuza, Bari; Nichol, Jason W.; Khademhosseini, Ali (Mary Ann Liebert, Inc., 2009-12)
    Advances in stem cell (SC) biology have greatly enhanced our understanding of SC self-renewal and differentiation. Both embryonic and adult SCs can be differentiated into a great variety of tissue cell types, including ...
  • Harley, Brendan A. C.; Kim, Hyung-Do; Zaman, Muhammad H.; Yannas, Ioannis V.; Lauffenburger, Douglas A.; Gibson, Lorna (Elsevier B.V. for the Biophysical Society, 2008-10)
    Cell migration plays a critical role in a wide variety of physiological and pathological phenomena as well as in scaffold-based tissue engineering. Cell migration behavior is known to be governed by biochemical stimuli and ...
  • Miska, Eric A; Alvarez-Saavedra, Ezequiel; Yoshii, Akira; Sestan, Nenad; Rakic, Pasko; Constantine-Paton, Martha; Horvitz, H. Robert; Townsend, Matthew R. (BioMed Central Ltd, 2004-08)
    Background: MicroRNAs are a large new class of tiny regulatory RNAs found in nematodes, plants, insects and mammals. MicroRNAs are thought to act as post-transcriptional modulators of gene expression. In invertebrates ...
  • Li, Wei; Lee, Samuel; Ma, Minglin; Kim, Soo Min; Guye, Patrick; Pancoast, James R.; Weiss, Ron; Lee, Richard T.; Hammond, Paula T.; Anderson, Daniel Griffith (Nature Publishing Group, 2013-10)
    Diabetes is caused by the loss or dysfunction of insulin-secreting β-cells in the pancreas. β-cells reduce their mass and lose insulin-producing ability in vitro, likely due to insufficient cell-cell and cell-extracellular ...
  • Dehal, Paramvir S.; Joachimiak, Marcin P.; Price, Morgan N.; Bates, John T.; Baumohl, Jason K.; Chivian, Dylan; Friedland, Greg D.; Huang, Katherine H.; Keller, Keith; Novichkov, Pavel S.; Dubchak, Inna L.; Alm, Eric J.; Arkin, Adam P. (Oxford University Press, 2009-11)
    Since 2003, MicrobesOnline (http://www.microbesonline.org) has been providing a community resource for comparative and functional genome analysis. The portal includes over 1000 complete genomes of bacteria, archaea and ...
  • Marcos; Seymour, Justin R.; Luhar, Mitul; Durham, William M.; Mitchell, James G.; Mackee, Andreas; Stocker, Roman (National Academy of Sciences (U.S.), 2011-02)
    The growth of microbial cultures in the laboratory often is assessed informally with a quick flick of the wrist: dense suspensions of microorganisms produce translucent “swirls” when agitated. Here, we rationalize the ...
  • Dhamankar, Himanshu Hemant; Prather, Kristala L. Jones (Elsevier B.V., 2011-08)
    The dwindling nature of petroleum and other fossil reserves has provided impetus towards microbial synthesis of fuels and value added chemicals from biomass-derived sugars as a renewable resource. Microbes have naturally ...
  • McCarren, Jay; Becker, Jamie William; Repeta, Daniel J.; Shi, Yanmei; Young, Curtis Robert, III; Malmstrom, Rex R.; Chisholm, Sallie (Penny); DeLong, Edward (National Academy of Sciences, 2010-08)
    Marine dissolved organic matter (DOM) contains as much carbon as the Earth's atmosphere, and represents a critical component of the global carbon cycle. To better define microbial processes and activities associated with ...
  • Faust, Karoline; Sathirapongsasuti, Jarupon; Izard, Jacques; Segata, Nicola; Gevers, Dirk; Raes, Jeroen; Huttenhower, Curtis (Public Library of Science, 2012-01)
    The healthy microbiota show remarkable variability within and among individuals. In addition to external exposures, ecological relationships (both oppositional and symbiotic) between microbial inhabitants are important ...
  • Kourtesi, Christina; Ball, Anthony R.; Huang, Ying-Ying; Jachak, Sanjay M.; Vera, D. Mariano A.; Khondkar, Proma; Gibbons, Simon; Hamblin, Michael R.; Tegos, George P. (Bentham Science, 2013-03)
    Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-resistance among pathogenic microorganisms. The need to overcome these deficiencies has triggered exploration for novel and ...
  • Stewart, Frank J.; Ulloa, Osvaldo; DeLong, Edward (Society for Applied Microbiology and Blackwell Publishing Ltd, 2012-01)
    Simultaneous characterization of taxonomic composition, metabolic gene content and gene expression in marine oxygen minimum zones (OMZs) has potential to broaden perspectives on the microbial and biogeochemical dynamics ...
  • Ulloa, Osvaldo; Canfield, Donald E.; DeLong, Edward; Letelier, Ricardo M.; Stewart, Frank J. (National Academy of Sciences (U.S.), 2012-09)
    Vast expanses of oxygen-deficient and nitrite-rich water define the major oxygen minimum zones (OMZs) of the global ocean. They support diverse microbial communities that influence the nitrogen economy of the oceans, ...
  • Poutahidis, Theofilos; Kleinewietfeld, Markus; Levkovich, Tatiana; Bhela, Siddheshvar; Chatzigiagkos, Antonis; Hafler, David A.; Alm, Eric J.; Erdman, Susan E.; Varian, Bernard; Ibrahim, Yassin; Lakritz, Jessica; Kearney, Sean Michael; Smillie, Chris Scott; Perrotta, Allison Rose (Public Library of Science, 2013-07)
    A recent epidemiological study showed that eating ‘fast food’ items such as potato chips increased likelihood of obesity, whereas eating yogurt prevented age-associated weight gain in humans. It was demonstrated previously ...
  • Poutahidis, Theofilos; Levkovich, Tatiana; Qi, Peimin; Chatzigiagkos, Antonis; Alm, Eric J.; Erdman, Susan E.; Kearney, Sean Michael; Varian, Bernard; Lakritz, Jessica; Ibrahim, Yassin (Public Library of Science, 2013-10)
    Wound healing capability is inextricably linked with diverse aspects of physical fitness ranging from recovery after minor injuries and surgery to diabetes and some types of cancer. Impact of the microbiome upon the mammalian ...
  • Luo, Ying; Qiu, Cheng-Wei; Liang, Xian-jiao; Li, Kai-ming; Zhang, Qun (Institute of Electrical and Electronics Engineers, 2010-04)
    The micro-Doppler (m-D) effect induced by the rotating parts or vibrations of the target provides a new approach for target recognition. To obtain high range resolution for the extraction of the fine m-D signatures of an ...
  • March, Sandra; Hui, Elliot E.; Underhill, Gregory; Khetani, Salman; Bhatia, Sangeeta N. (Wiley Blackwell, 2009-05)
    Liver sinusoidal endothelial cells (LSECs) differ, both structurally and functionally, from endothelial cells (ECs) lining blood vessels of other tissues. For example, in contrast to other ECs, LSECs possess fenestrations, ...
  • Bow, Hansen; Pivkin, Igor V.; Diez Silva, Monica; Goldfless, Stephen Jacob; Dao, Ming; Niles, Jacquin; Suresh, Subra; Han, Jongyoon (Royal Society of Chemistry, 2011-02)
    Malaria resulting from Plasmodium falciparum infection is a major cause of human suffering and mortality. Red blood cell (RBC) deformability plays a major role in the pathogenesis of malaria. Here we introduce an automated ...
  • Gassend, Blaise; Velasquez-Garcia, Luis Fernando; Akinwande, Akintunde Ibitayo; Martinez-Sanchez, Manuel (Institute of Electrical and Electronics Engineers, 2009-06)
    This paper reports the design, fabrication, and experimental characterization of a fully microfabricated planar array of externally fed electrospray emitters that produces heavy molecular ions from the ionic liquids ...
  • Waits, Christopher Mike; McCarthy, Matthew; Ghodssi, Reza (Institute of Electrical and Electronics Engineers (IEEE), 2010-02)
    The development of a microfabricated turbopump that is capable of delivering liquid fuel with the flow rates and pressures required for portable power generation is reported. The device is composed of a spiral-groove viscous ...
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