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Browsing MIT Open Access Articles by Title

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  • GENCODE: The reference human genome annotation for The ENCODE Project 
    Lin, Michael F.; Kellis, Manolis (Cold Spring Harbor Laboratory Press, 2012-09)
    The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and experimental validation. Since the first public release of this annotation ...
  • The Gender Gap in Secondary School Mathematics at High Achievement Levels: Evidence from the American Mathematics Competitions 
    Ellison, Glenn; Swanson, Ashley Terese (American Economic Association, 2010)
    This paper uses a new data source, American Mathematics Competitions, to examine the gender gap among high school students at very high achievement levels. The data bring out several new facts. There is a large gender gap ...
  • Gender Sorting at the Application Interface 
    Fernandez, Roberto; Friedrich, Colette (Regents of the University of California, 2011-03)
    We document gender sorting of candidates into gender-typed jobs at the point of initial application to a company. At this step of the hiring process, the firm has implemented a policy whereby organizational screeners’ ...
  • Gene Copy-Number Alterations: A Cost-Benefit Analysis 
    Tang, Yun-Chi; Amon, Angelika B. (Elsevier, 2013-01)
    Changes in DNA copy number, whether confined to specific genes or affecting whole chromosomes, have been identified as causes of diseases and developmental abnormalities and as sources of adaptive potential. Here, we discuss ...
  • Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons 
    Lodato, Simona; Zuccaro, Emanuela; Chen, Hsu-Hsin; Yuan, Wen; Meleski, Alyssa; Takahashi, Emi; Mahony, Shaun; Gifford, David K; Arlotta, Paola; Molyneaux, Bradley J.; Goff, Loyal A.; Rinn, John L.; Gifford, David K. (Nature Publishing Group, 2014-07)
    The neocortex contains an unparalleled diversity of neuronal subtypes, each defined by distinct traits that are developmentally acquired under the control of subtype-specific and pan-neuronal genes. The regulatory logic ...
  • Gene duplication and the evolution of ribosomal protein gene regulation in yeast 
    Regev, Aviv; Wapinski, Ilan; Pfiffner, Jenna; French, Courtney; Socha, Amanda; Thompson, Dawn Anne (National Academy of Sciences (U.S.), 2010-03)
    Coexpression of genes within a functional module can be conserved at great evolutionary distances, whereas the associated regulatory mechanisms can substantially diverge. For example, ribosomal protein (RP) genes are tightly ...
  • Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures 
    Prilutsky, Daria; Kho, Alvin T.; Palmer, Nathan Patrick; Bhakar, Asha L.; Smedemark-Margulies, Niklas; Kong, Sek Won; Margulies, David M.; Bear, Mark F.; Kohane, Isaac S.; Kohane, Isaac S. (BioMed Central, 2015-12)
    Background Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes ...
  • Gene Expression Changes in the Motor Cortex Mediating Motor Skill Learning 
    Cheung, Vincent Chi-Kwan; DeBoer, Caroline; Hanson, Elizabeth; Tunesi, Marta; D'Onofrio, Mara; Arisi, Ivan; Brandi, Rossella; Cattaneo, Antonino; Goosens, Ki Ann (Public Library of Science, 2013-04)
    The primary motor cortex (M1) supports motor skill learning, yet little is known about the genes that contribute to motor cortical plasticity. Such knowledge could identify candidate molecules whose targeting might enable ...
  • Gene Expression Data from the Moon Jelly, Aurelia, Provide Insights into the Evolution of the Combinatorial Code Controlling Animal Sense Organ Development 
    Nakanishi, Nagayasu; Camara, Anthony C.; Yuan, David C.; Jacobs, David K.; Gold, David (Public Library of Science, 2015-07)
    In Bilateria, Pax6, Six, Eya and Dach families of transcription factors underlie the development and evolution of morphologically and phyletically distinct eyes, including the compound eyes in Drosophila and the camera-type ...
  • Gene expression prediction using low-rank matrix completion 
    Kapur, Arnav; Marwah, Kshitij; Alterovitz, Gil (BioMed Central, 2016-06)
    Background An exponential growth of high-throughput biological information and data has occurred in the past decade, supported by technologies, such as microarrays and RNA-Seq. Most data generated using such methods are ...
  • A gene expression profile of stem cell pluripotentiality and differentiation is conserved across diverse solid and hematopoietic cancers 
    Berger, Bonnie; Palmer, Nathan Patrick; Schmid, Patrick Raphael; Kohane, Isaac (BioMed Central Ltd, 2012-08)
    Abstract Background Understanding the fundamental mechanisms of tumorigenesis remains one of the most pressing problems in modern biology. To this end, stem-like cells with tumor-initiating potential have become a central ...
  • Gene expression profiles and transcriptional regulatory pathways underlying mouse tissue macrophage identity and diversity 
    Regev, Aviv; Immunological Genome Project Consortium (Nature Publishing Group, 2012-09)
    We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were selectively ...
  • Gene expression studies for the analysis of domoic acid production in the marine diatom Pseudo-nitzschia multiseries 
    Boissonneault, Katie; Henningsen, Brooks M.; Bates, Stephen S.; Robertson, Deborah L.; Milton, Sean; Pelletier, Jerry; Hogan, Deborah A.; Housman, David E. (Biomed Central Ltd., 2013-11)
    Background: Pseudo-nitzschia multiseries Hasle (Hasle) (Ps-n) is distinctive among the ecologically important marine diatoms because it produces the neurotoxin domoic acid. Although the biology of Ps-n has been investigated ...
  • Gene Pathways That Delay Caenorhabditis elegans Reproductive Senescence 
    Wang, Meng C.; Oakley, Holly D.; Carr, Christopher E.; Sowa, Jessica N.; Ruvkun, Gary (Public Library of Science, 2014-12)
    Reproductive senescence is a hallmark of aging. The molecular mechanisms regulating reproductive senescence and its association with the aging of somatic cells remain poorly understood. From a full genome RNA interference ...
  • GenePattern flow cytometry suite 
    Spidlen, Josef; Barsky, Aaron; Breuer, Karin; Carr, Peter; Nazaire, Marc-Danie; Hill, Barbara; Qian, Yu; Liefeld, Ted; Reich, Michael; Wilkinson, Peter; Scheuermann, Richard H.; Sekaly, Rafick-Pierre; Brinkman, Ryan R.; Mesirov, Jill P. (BioMed Central Ltd, 2013-07)
    Background: Traditional flow cytometry data analysis is largely based on interactive and time consuming analysis of series two dimensional representations of up to 20 dimensional data. Recent technological advances have ...
  • GenePING: secure, scalable management of personal genomic data 
    Adida, Ben; Kohane, Isaac (BioMed Central Ltd, 2006-04)
    Background: Patient genomic data are rapidly becoming part of clinical decision making. Within a few years, full genome expression profiling and genotyping will be affordable enough to perform on every individual. The ...
  • General Anesthesia and Altered States of Arousal: A Systems Neuroscience Analysis 
    Brown, Emery N.; Purdon, Patrick Lee; Van Dort, Christa (Annual Reviews, 2011-07)
    Placing a patient in a state of general anesthesia is crucial for safely and humanely performing most surgical and many nonsurgical procedures. How anesthetic drugs create the state of general anesthesia is considered a ...
  • General anesthesia, sleep and coma 
    Schiff, Nicholas D.; Brown, Emery N.; Lydic, Emily K. (New England Journal of Medicine, 2010-12)
    In the United States, nearly 60,000 patients per day receive general anesthesia for surgery.1 General anesthesia is a drug-induced, reversible condition that includes specific behavioral and physiological traits — ...
  • General anesthesia, sleep, and coma 
    Brown, Emery N.; Lydic, Ralph; Schiff, Nicholas D. (New England Journal of Medicine, 2010-12)
    In the United States, nearly 60,000 patients per day receive general anesthesia for surgery.1 General anesthesia is a drug-induced, reversible condition that includes specific behavioral and physiological traits — ...
  • General Approach to Epipolythiodiketopiperazine Alkaloids: Total Synthesis of (+)-Chaetocins A, C and (+)-12,12'- Dideoxychetracin A 
    Kim, Justin; Movassaghi, Mohammad (American Chemical Society, 2010-09)
    A highly stereoselective and systematic strategy for the introduction of polysulfides in the synthesis of epipolythiodiketopiperazines is described. We report the first total synthesis of dimeric epitri- and epitetrathio ...
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