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Browsing MIT Open Access Articles by Title

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  • Gregg, Patricia M.; Behn, M. D.; Lin, J.; Grove, Timothy L. (American Geophysical Union (AGU), 2009-11)
    We examine mantle melting, fractional crystallization, and melt extraction beneath fast slipping, segmented oceanic transform fault systems. Three-dimensional mantle flow and thermal structures are calculated using a ...
  • Till, Christy B.; Grove, Timothy L.; Krawczynski, Michael J. (American Geophysical Union (AGU), 2012-06)
    Here we develop a lherzolite melting model and explore the effects of variations in mantle composition, pressure, temperature, and H[subscript 2]O content on melt composition. New experiments and a compilation of experimental ...
  • Choi, Philip S.; Zakhary, Lisa; Choi, Wen-Yee; Caron, Sophie; Alvarez-Saavedra, Ezequiel; Miska, Eric A.; McManus, Mike; Harfe, Brian; Giraldez, Antonio J.; Horvitz, H. Robert; Schier, Alexander F.; Dulac, Catherine (Elsevier B.V., 2008-01)
    MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs ...
  • Leksa, Nina Carolina; Schwartz, Thomas (Landes Bioscience, 2010-07)
    The nuclear pore complex (NPC) regulates all traffic between the cytoplasm and the nucleus. It is a large protein assembly composed of multiple copies of ~30 nucleoporins (nups). Structural studies of the NPC have been ...
  • Lis, Mieszko; Shim, Keun Sup; Cho, Myong Hyon; Devadas, Srinivas (Institute of Electrical and Electronics Engineers (IEEE), 2011-11)
    As we enter an era of exascale multicores, the question of efficiently supporting a shared memory model has become of paramount importance. On the one hand, programmers demand the convenience of coherent shared memory; on ...
  • Shepherd, Jason Dennis (Frontiers Research Foundation, 2012-04)
    Experience shapes and molds the brain throughout life.These changes in neuronal circuits are produced by a myriad of molecular and cellular processes. Simplistically, circuits are modified through changes in neurotransmitter ...
  • Qin, Qi; Reno, John L.; Hu, Qing (Optical Society of America, 2011-02)
    We demonstrate continuous tuning of a terahertz quantum cascade wire laser over a broad range of ~ 330 GHz ( ~ 8.6% of the 3.85 THz center frequency) with single-mode operation. Tuning is achieved with a narrow laser ridge ...
  • Hunter, Seth Edward; Maes, Patricia; Scott, Stacey; Kaufman, Henry (Association for Computing Machinery, 2011-05)
    This paper presents the design, implementation, and evaluation of an interactive tabletop system that supports co-located meeting capture and asynchronous search and review of past meetings. The goal of the project is to ...
  • Gupton, Stephanie L.; Riquelme, Daisy Noelia; Hughes-Alford, Shannon Kay; Tadros, Jenny; Rudina, Shireen S.; Hynes, Richard O.; Lauffenburger, Douglas A.; Gertler, Frank B. (Rockefeller University Press, The, 2012-08)
    Mena is an Ena/VASP family actin regulator with roles in cell migration, chemotaxis, cell–cell adhesion, tumor cell invasion, and metastasis. Although enriched in focal adhesions, Mena has no established function within ...
  • Roussos, Evanthia T.; Wang, Yarong; Wyckoff, Jeffrey B.; Sellers, Rani S.; Wang, Weigang; Li, Jiufeng; Pollard, Jeffrey W.; Gertler, Frank; Condeelis, John S. (BioMed Central Ltd., 2010-11)
    Introduction The actin binding protein Mammalian enabled (Mena), has been implicated in the metastatic progression of solid tumors in humans. Mena expression level in primary tumors is correlated with metastasis in ...
  • Philippar, Ulrike; Roussos, Evanthia T.; Oser, Matthew; Yamaguchi, Hideki; Kim, Hyung-Do; Giampieri, Silvia; Wang, Yarong; Goswami, Sumanta; Wyckoff, Jeffrey B.; Lauffenburger, Douglas A.; Sahai, Erik; Condeelis, John S.; Gertler, Frank (Elsevier, 2008-12)
    The spread of cancer during metastatic disease requires that tumor cells subvert normal regulatory networks governing cell motility to invade surrounding tissues and migrate toward blood and lymphatic vessels. Enabled ...
  • Roussos, Evanthia T.; Goswami, Sumanta; Balsamo, Michele; Wang, Yarong; Stobezki, Robert; Adler, Esther; Robinson, Brian D.; Jones, Joan G.; Condeelis, John S.; Oktay, Maja H.; Gertler, Frank (Springer-Verlag, 2011-04)
    Mena, an actin regulatory protein, functions at the convergence of motility pathways that drive breast cancer cell invasion and migration in vivo. The tumor microenvironment spontaneously induces both increased expression ...
  • Gates, Monte A; Witke, Walter; Macklis, Jeffrey D; Kwiatkowski, David; Soriano, Philippe; Lanier, Lorene M.; Menzies, A. Sheila; Wehman, Ann M.; Gertler, Frank (Elsevier, 1999-02)
    Mammalian enabled (Mena) is a member of a protein family thought to link signal transduction pathways to localized remodeling of the actin cytoskeleton. Mena binds directly to Profilin, an actin-binding protein that modulates ...
  • Bonatti, Alessandro (American Economic Association, 2011-08)
    We analyze the design of dynamic menus to sell experience goods. The quality of the product is initially unknown, and the total quantity sold in each period determines the amount of information in the market. We characterize ...
  • Lamborg, Carl; Bowman, Katilin; Hammerschmidt, Chad; Gilmour, Cindy; Munson, Kathleen; Tseng, Chun-Mao; Selin, Noelle Eckley (Oceanography Society, 2014-03)
    The toxic metal mercury is present only at trace levels in the ocean, but it accumulates in fish at concentrations high enough to pose a threat to human and environmental health. Human activity has dramatically altered the ...
  • Pilawa-Podgurski, Robert C. N.; Perreault, David J. (Institute of Electrical and Electronics Engineers (IEEE), 2012-05)
    In this paper, we introduce a merged two-stage dc-dc power converter for low-voltage power delivery. By separating the transformation and regulation function of a dc-dc power converter into two stages, both large voltage ...
  • Lin, Ying-Tsong; Newhall, Arthur E.; Duda, Timothy F.; Lermusiaux, Pierre F. J.; Haley, Patrick J. (Institute of Electrical and Electronics Engineers, 2010-10)
    In this paper, a method for merging partial overlapping time series of ocean profiles into a single time series of profiles using empirical orthogonal function (EOF) decomposition with the objective analysis is presented. ...
  • Drake, Adam; Chen, Qingfeng; Dong, Di; Leskov, Ilya; Fragoso, Maria F.; Li, Yan; Iliopoulou, Bettina P.; Hwang, William; Lodish, Harvey F.; Chen, Jianzhu (Mary Ann Liebert, 2010-12)
    Clinical and preclinical applications of human hematopoietic stem cells (HSCs) are often limited by scarcity of cells. Expanding human HSCs to increase their numbers while maintaining their stem cell properties has therefore ...
  • Aloupis, Greg; Demaine, Erik D.; Demaine, Martin L.; Iacono, John; Dujmovic, Vida (Springer-Verlag, 2012)
    The minimum feature size of a planar straight-line graph is the minimum distance between a vertex and a nonincident edge. When such a graph is partitioned into a mesh, the degradation is the ratio of original to final ...
  • Amaro, J. E.; Barbaro, M. B.; Caballero, J. A.; Maieron, C.; Udias, J. M.; Donnelly, T. William (American Physical Society, 2010-01)
    The effects of meson-exchange currents (MEC) are computed for the one-particle one-hole transverse response function for finite nuclei at high momentum transfers q in the region of the quasi-elastic peak. A semirelativistic ...
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