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Browsing MIT Open Access Articles by Title

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  • Sarkar, Sovan; Carroll, Bernadette; Buganim, Yosef; Maetzel, Dorothea; Ng, Alex H.M.; Cassady, John P.; Cohen, Malkiel A.; Chakraborty, Souvik; Wang, Haoyi; Spooner, Eric; Ploegh, Hidde; Gsponer, Joerg; Korolchuk, Viktor I.; Jaenisch, Rudolf (Elsevier, 2013-11)
    Autophagy dysfunction has been implicated in misfolded protein accumulation and cellular toxicity in several diseases. Whether alterations in autophagy also contribute to the pathology of lipid-storage disorders is not ...
  • Woods, Stephanie E.; Leonard, Monika R.; Hayden, Joshua A.; Brophy, Megan Brunjes; Bernert, Kara R.; Lavoie, Brigitte; Muthupalani, Sureshkumar; Whary, Mark T.; Mawe, Gary M.; Nolan, Elizabeth M.; Carey, Martin C.; Fox, James G. (American Physiological Society, 2014-12)
    “Black” pigment gallstones form in sterile gallbladder bile in the presence of excess bilirubin conjugates (“hyperbilirubinbilia”) from ineffective erythropoiesis, hemolysis, or induced enterohepatic cycling (EHC) of ...
  • Lazzara, Matthew J.; Lane, Keara M.; Chan, Richard; Jasper, Paul J.; Yaffe, Michael B.; Sorger, Peter K.; Jacks, Tyler E.; Neel, Benjamin G.; Lauffenburger, Douglas A. (American Association for Cancer Research, 2010-04)
    Most non–small cell lung cancers (NSCLC) display elevated expression of epidermal growth factor receptor (EGFR), but response to EGFR kinase inhibitors is predominantly limited to NSCLC harboring EGFR-activating mutations. ...
  • Speed, Nicole; Saunders, Christine; Davis, Adeola R.; Owens, W. Anthony; Matthies, Heinrich J. G.; Saadat, Sanaz; Kennedy, Jack P.; Vaughan, Roxanne A.; Neve, Rachael L.; Lindsley, Craig W.; Russo, Scott J.; Daws, Lynette C.; Niswender, Kevin D.; Galli, Aurelio (Public Library of Science, 2011-09)
    The prevalence of obesity has increased dramatically worldwide. The obesity epidemic begs for novel concepts and therapeutic targets that cohesively address “food-abuse” disorders. We demonstrate a molecular link between ...
  • Bonocora, Richard P.; Abel, Ethan V.; Shub, David A.; Zeng, Qinglu (Proceedings of the National Academy of Sciences (PNAS), 2011-09)
    Since its initial description more than two decades ago, the ribosome bypass (or “hop”) sequence of phage T4 stands out as a uniquely extreme example of programmed translational frameshifting. The gene for a DNA topoisomerase ...
  • Hartzell, Samantha R.; Seneff, Stephanie (MDPI AG, 2012-10)
    Autism is a brain disorder involving social, memory, and learning deficits, that normally develops prenatally or early in childhood. Frustratingly, many research dollars have as yet failed to identify the cause of autism. ...
  • Moran, Joseph M.; Young, Liane L.; Saxe, Rebecca R.; Lee, Su Mei; O'Young, Daniel; Mavros, Penelope L.; Gabrieli, John D. E. (Proceedings of the National Academy of Sciences (PNAS), 2011-02)
    High-functioning autism (ASD) is characterized by real-life difficulties in social interaction; however, these individuals often succeed on laboratory tests that require an understanding of another person's beliefs and ...
  • Li, C. K.; Seguin, Fredrick Hampton; Frenje, Johan A.; Rosenberg, Michael Jonathan; Rinderknecht, Hans George; Zylstra, Alex Bennett; Petrasso, Richard D.; Amendt, P. A.; Landen, O. L.; Mackinnon, A. J.; Town, R. P. J.; Wilks, S. C.; Betti, R.; Meyerhofer, D. D.; Soures, J. M. (American Physical Society, 2012-01)
    This Letter reports the first time-gated proton radiography of the spatial structure and temporal evolution of how the fill gas compresses the wall blowoff, inhibits plasma jet formation, and impedes plasma stagnation in ...
  • Near, Joseph Paul; Jackson, Daniel (Springer, 2010-02)
    We extend the Alloy language with the standard imperative constructs; we show the mix of declarative and imperative constructs to be useful in modeling dynamic systems. We present a translation from our extended language ...
  • Park, Soonae; Kim, Byung-Yeon; Jang, Wonchang; Nam, Kyung-min (Springer-Verlag, 2014-03)
    We examine the labor market’s bias against small and medium-sized enterprises focusing on the Seoul Digital Industrial Complex case. We adopt Heckman’s approach to control selection bias, and use primary data from questionnaire ...
  • Artzi, Natalie; Conde, Joao; Oliva Jorge, Nuria (National Academy of Sciences (U.S.), 2015-03)
    Multidrug resistance (MDR) in cancer cells is a substantial limitation to the success of chemotherapy. Here, we describe facile means to overcome resistance by silencing the multidrug resistance protein 1 (MRP1), before ...
  • Elman, Noel; Ho Duc, Hong Linh; Cima, Michael J. (Springer Netherlands, 2009-01)
    We introduce the first implantable drug delivery system based on MEMS (Micro-Electro-Mechanical-Systems) technology specifically designed as a platform for treatment in ambulatory emergency care. The device is named ...
  • Jonas, Oliver H.; Landry, Heather M.; Fuller, Jason E.; Cima, Michael J.; Langer, Robert; Santini, John T., Jr.; Baselga, Jose; Tepper, Robert I. (American Association for the Advancement of Science (AAAS), 2015-04)
    Current anticancer chemotherapy relies on a limited set of in vitro or indirect prognostic markers of tumor response to available drugs. A more accurate analysis of drug sensitivity would involve studying tumor response ...
  • Lee, Jungwoo; Li, Matthew; Milwid, Jack; Dunham, Joshua; Vinegoni, Claudio; Gorbatov, Rostic; Iwamoto, Yoshiko; Wang, Fangjing; Shen, Keyue; Hatfield, Kimberley; Enger, Marianne; Shafiee, Sahba; McCormack, Emmet; Ebert, Benjamin L.; Weissleder, Ralph; Yarmush, Martin L.; Parekkadan, Biju (Public Library of Science, 2012-11)
    The environments that harbor hematopoietic stem and progenitor cells are critical to explore for a better understanding of hematopoiesis during health and disease. These compartments often are inaccessible for controlled ...
  • Vydrov, Oleg A.; Van Voorhis, Troy (American Institute of Physics, 2010-04)
    Recently we developed a nonlocal van der Waals density functional (VV09) that has a simple and well-behaved analytic form. In this article, we report a self-consistent implementation of VV09 with an atom-centered basis ...
  • Van Kleek, Max G.; Perttunen, Mikko; Lassila, Ora; Riekki, Jukka (Institute of Electrical and Electronics Engineers, 2009-06)
    Auditory contexts are recognized from mixtures of sounds from mobile userspsila everyday environments. We describe our implementation of auditory context recognition for mobile devices. In our system we use a set of support ...
  • Vuletic, Vladan; Schleier-Smith, Monika Helene; Leroux, Ian Daniel (American Physical Society, 2010-02)
    We squeeze unconditionally the collective spin of a dilute ensemble of laser-cooled superscript 87]Rb atoms using their interaction with a driven optical resonator. The shape and size of the resulting spin uncertainty ...
  • Cappellaro, Paola (Springer-Verlag, 2014)
    Nuclear spin systems and magnetic resonance techniques have provided a fertile platform for experimental investigation of quantum state transfer in spin chains. From the first observation of polarization transfer, predating ...
  • Vijayaraghavan, Muralidaran; Ng, Man Cheuk; King, Myron D.; Khan, Asif Imtiaz; Fleming, Kermin Elliott; Dave, Nirav H.; Agarwal, Abhinav (Institute of Electrical and Electronics Engineers, 2009-08)
    The 2009 MEMOCODE Hardware/Software Co-Design Contest assignment was the implementation of a cartesian-to-polar matrix interpolator. We discuss our hardware and software design submissions.
  • Hillger, Jason J.; Timmerman, Chayil S.; Ramakrishnan, Balasubramanian; Laffely, Andrew; Yao, Huan (Institute of Electrical and Electronics Engineers, 2010-01)
    For ease of implementation, communications systems have been steadily converted to digital implementations. FPGA technologies and high-quality, high-speed DACs have enabled this trend. While this is commonly done for modern ...
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