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Browsing MIT Open Access Articles by Title

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  • Menolascina, Filippo; Fiore, Gianfranco; Orabona, Emanuele; De Stefano, Luca; Ferry, Mike; Hasty, Jeff; di Bernardo, Mario; di Bernardo, Diego (Public Library of Science, 2014-05)
    We describe an innovative experimental and computational approach to control the expression of a protein in a population of yeast cells. We designed a simple control algorithm to automatically regulate the administration ...
  • Ho, Emily E.; Dubrovsky, Esther; Gertler, Frank; Meacham, Meacham; Hemann, Michael (Nature Publishing Group, 2009-09)
    Mouse models have markedly improved our understanding of cancer development and tumor biology. However, these models have shown limited efficacy as tractable systems for unbiased genetic experimentation. Here, we report ...
  • Forest, Craig R.; Kodandaramaiah, Suhasa Bangalo; Boyden, Edward Stuart (Wiley Blackwell, 2013-07)
    Robotic and automation technologies have played a huge role in in vitro biological science, having proved critical for scientific endeavors such as genome sequencing and high-throughput screening. Robotic and automation ...
  • Lau, Ken S.; Lauffenburger, Douglas A.; Juchheim, Alwin M.; Cavaliere, Kimberly R.; Philips, Sarah R.; Haigis, Kevin M. (American Association for the Advancement of Science (AAAS), 2011-03)
    Cellular responses to external stimuli depend on dynamic features of multipathway network signaling; thus, cell behavior is influenced in a complex manner by the environment and by intrinsic properties. Methods of multivariate ...
  • Zheng, Yiran; Stephan, Matthias T.; Gai, S. Annie; Abraham, Wuhbet; Shearer, Adrianne; Irvine, Darrell J.; Zheng, Yiran (Elsevier, 2013-06)
    In adoptive cell therapy (ACT), autologous tumor-specific T-cells isolated from cancer patients are activated and expanded ex vivo, then infused back into the individual to eliminate metastatic tumors. A major limitation ...
  • Malka, Roy; Manalis, Scott R.; Higgins, John M.; Feijo Delgado, Francisco Feijo (Public Library of Science, 2014-10)
    Human red blood cells (RBCs) lose ~30% of their volume and ~20% of their hemoglobin (Hb) content during their ~100-day lifespan in the bloodstream. These observations are well-documented, but the mechanisms for these volume ...
  • Agrawal, Rohit; Musiker, Gregg; Sotirov, Vladimir; Wei, Fan (Electronic Journal of Combinatorics, 2013-09)
    We elaborate upon a bijection discovered by Cools, Draisma, Payne, and Robeva (2012) between the set of rectangular standard Young tableaux and the set of equivalence classes of chip configurations on certain metric graphs ...
  • Scarcelli, Giuliano; Kim, Pilhan; Yun, Seok Hyun (Andy) (Elsevier, 2011-09)
    The biophysical and biomechanical properties of the crystalline lens (e.g., viscoelasticity) have long been implicated in accommodation and vision problems, such as presbyopia and cataracts. However, it has been difficult ...
  • Mateo, Celine; Avermann, Michael; Gentet, Luc J.; Zhang, Feng; Deisseroth, Karl; Petersen, Carl C.H. (Elsevier, 2011-09)
    Background Synaptic interactions between excitatory and inhibitory neocortical neurons are important for mammalian sensory perception. Synaptic transmission between identified neurons within neocortical microcircuits has ...
  • Lamata, L.; Leibrant, David R.; Chuang, Isaac L.; Cirac, J. I.; Lukin, M. D.; Vuletic, Vladan; Yelin, S. F. (American Physical Society, 2011-07)
    A new approach for the realization of a quantum interface between single photons and single ions in an ion crystal is proposed and analyzed. In our approach the coupling between a single photon and a single ion is enhanced ...
  • Zastrow, Jordan; Oey, M. S.; Veilleux, Sylvain; Martin, Crystal L.; McDonald, Michael A. (IOP Publishing, 2011-10)
    There are few observational constraints on how the escape of ionizing photons from starburst galaxies depends on galactic parameters. Here we report on the first major detection of an ionization cone in NGC 5253, a nearby ...
  • Schulz, Norbert S.; Canizares, Claude R.; Lee, Julia C.; Sako, Masao (IOP Publishing, 2001-12)
    We present a first analysis of a high-resolution X-ray spectrum of the ionized stellar wind of Vela X-1 during eclipse. The data were obtained with the High-Energy Transmission Grating Spectrometer on board the Chandra ...
  • Landreman, Matt; Fulop, T. (American Physical Society, 2013-07)
    Runaway ions can be produced in plasmas with large electric fields, where the accelerating electric force is augmented by the low mean ionic charge due to the imbalance between the number of electrons and ions. Here we ...
  • Rosenberg, M. J.; Hoffman, N. M.; Kagan, G.; Amendt, P.; Bellei, C.; Wilks, S.; Delettrez, J.; Glebov, V. Yu.; Stoeckl, C.; Sangster, T. C.; Meyerhofer, D. D.; Nikroo, A.; Rinderknecht, Hans George; Li, Chikang; Zylstra, Alex Bennett; Sio, Hong Weng; Frenje, Johan A.; Gatu Johnson, Maria; Seguin, Fredrick Hampton; Petrasso, Richard D. (American Physical Society, 2015-01)
    Anomalous reduction of the fusion yields by 50% and anomalous scaling of the burn-averaged ion temperatures with the ion-species fraction has been observed for the first time in D[superscript 3]He-filled shock-driven ...
  • Gardikis, Georgios; Xilouris, George; Montpetit, Marie-Jose; Vanelli-Coralli, Alessandro; Negru, Daniel (Hindawi Publishing Corporation, 2010-12)
    The vision of the Internet of the Future for service ubiquity dictates that end users should be able to access services—mostly media-oriented ones—at any time from a variety of networks, including mobile, broadband, and ...
  • Tierney, Patrick L.; Koretsky, Alan P.; Walters, Judith R.; Leopold, David A.; Yu, David; Chuang, Kai-Hsiang; Conroy, Richard S.; Bergstrom, Debra A.; Pelled, Galit (United States National Academy of Sciences, 2009-08)
    In the weeks following unilateral peripheral nerve injury, the deprived primary somatosensory cortex (SI) responds to stimulation of the ipsilateral intact limb as demonstrated by functional magnetic resonance imaging ...
  • Montpetit, Marie-Jose (Institute of Electrical and Electronics Engineers, 2009-08)
    This keynote address wants to establish the current status of IPTV and define how it will evolve with the new ubiquity of Internet video and smartphones with Web access. In particular, the discussion centers on how IPTV ...
  • Fischer, Michael M. J. (Berg Publishers, 2009-03)
    Twelve cartoons, published in the Danish newspaper Jyllands-Posten in September 2005, nine cartoons published in the Tehran newspaperIran in May 2006, and two hundred eighty-two cartoons curated in Tehran in September 2006 ...
  • Hur, Kyu Yeon; So, Jae-Seon; Frank-Kamenetsky, Maria; Fitzgerald, Kevin; Koteliansky, Victor; Iwawaki, Takao; Lee, Ann-Hwee; Ruda, Vera; Glimcher, Laurie H. (Rockefeller University Press, The, 2012-01)
    The mammalian stress sensor IRE1α plays a central role in the unfolded protein, or endoplasmic reticulum (ER), stress response by activating its downstream transcription factor XBP1 via an unconventional splicing mechanism. ...
  • Emtage, Lesley; Aziz-Zaman, Sonya; Padovan-Merhar, Olivia; Horvitz, H. Robert; Fang-Yen, Christopher; Ringstad, Niels (Society for Neuroscience, 2012-11)
    To identify molecular mechanisms that function in G-protein signaling, we have performed molecular genetic studies of a simple behavior of the nematode Caenorhabditis elegans, egg laying, which is driven by a pair of ...
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