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Browsing MIT Open Access Articles by Title

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  • Lin, Michael F.; Kellis, Manolis (Cold Spring Harbor Laboratory Press, 2012-09)
    The GENCODE Consortium aims to identify all gene features in the human genome using a combination of computational analysis, manual annotation, and experimental validation. Since the first public release of this annotation ...
  • Ellison, Glenn; Swanson, Ashley Terese (American Economic Association, 2010)
    This paper uses a new data source, American Mathematics Competitions, to examine the gender gap among high school students at very high achievement levels. The data bring out several new facts. There is a large gender gap ...
  • Fernandez, Roberto; Friedrich, Colette (Regents of the University of California, 2011-03)
    We document gender sorting of candidates into gender-typed jobs at the point of initial application to a company. At this step of the hiring process, the firm has implemented a policy whereby organizational screeners’ ...
  • Tang, Yun-Chi; Amon, Angelika B. (Elsevier, 2013-01)
    Changes in DNA copy number, whether confined to specific genes or affecting whole chromosomes, have been identified as causes of diseases and developmental abnormalities and as sources of adaptive potential. Here, we discuss ...
  • Lodato, Simona; Zuccaro, Emanuela; Chen, Hsu-Hsin; Yuan, Wen; Meleski, Alyssa; Takahashi, Emi; Mahony, Shaun; Gifford, David K; Arlotta, Paola; Molyneaux, Bradley J.; Goff, Loyal A.; Rinn, John L.; Gifford, David K. (Nature Publishing Group, 2014-07)
    The neocortex contains an unparalleled diversity of neuronal subtypes, each defined by distinct traits that are developmentally acquired under the control of subtype-specific and pan-neuronal genes. The regulatory logic ...
  • Regev, Aviv; Wapinski, Ilan; Pfiffner, Jenna; French, Courtney; Socha, Amanda; Thompson, Dawn Anne (National Academy of Sciences (U.S.), 2010-03)
    Coexpression of genes within a functional module can be conserved at great evolutionary distances, whereas the associated regulatory mechanisms can substantially diverge. For example, ribosomal protein (RP) genes are tightly ...
  • Prilutsky, Daria; Kho, Alvin T.; Palmer, Nathan Patrick; Bhakar, Asha L.; Smedemark-Margulies, Niklas; Kong, Sek Won; Margulies, David M.; Bear, Mark F.; Kohane, Isaac S.; Kohane, Isaac S. (BioMed Central, 2015-12)
    Background Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes ...
  • Cheung, Vincent Chi-Kwan; DeBoer, Caroline; Hanson, Elizabeth; Tunesi, Marta; D'Onofrio, Mara; Arisi, Ivan; Brandi, Rossella; Cattaneo, Antonino; Goosens, Ki Ann (Public Library of Science, 2013-04)
    The primary motor cortex (M1) supports motor skill learning, yet little is known about the genes that contribute to motor cortical plasticity. Such knowledge could identify candidate molecules whose targeting might enable ...
  • Nakanishi, Nagayasu; Camara, Anthony C.; Yuan, David C.; Jacobs, David K.; Gold, David (Public Library of Science, 2015-07)
    In Bilateria, Pax6, Six, Eya and Dach families of transcription factors underlie the development and evolution of morphologically and phyletically distinct eyes, including the compound eyes in Drosophila and the camera-type ...
  • Kapur, Arnav; Marwah, Kshitij; Alterovitz, Gil (BioMed Central, 2016-06)
    Background An exponential growth of high-throughput biological information and data has occurred in the past decade, supported by technologies, such as microarrays and RNA-Seq. Most data generated using such methods are ...
  • Berger, Bonnie; Palmer, Nathan Patrick; Schmid, Patrick Raphael; Kohane, Isaac (BioMed Central Ltd, 2012-08)
    Abstract Background Understanding the fundamental mechanisms of tumorigenesis remains one of the most pressing problems in modern biology. To this end, stem-like cells with tumor-initiating potential have become a central ...
  • Regev, Aviv; Immunological Genome Project Consortium (Nature Publishing Group, 2012-09)
    We assessed gene expression in tissue macrophages from various mouse organs. The diversity in gene expression among different populations of macrophages was considerable. Only a few hundred mRNA transcripts were selectively ...
  • Boissonneault, Katie; Henningsen, Brooks M.; Bates, Stephen S.; Robertson, Deborah L.; Milton, Sean; Pelletier, Jerry; Hogan, Deborah A.; Housman, David E. (Biomed Central Ltd., 2013-11)
    Background: Pseudo-nitzschia multiseries Hasle (Hasle) (Ps-n) is distinctive among the ecologically important marine diatoms because it produces the neurotoxin domoic acid. Although the biology of Ps-n has been investigated ...
  • Wang, Meng C.; Oakley, Holly D.; Carr, Christopher E.; Sowa, Jessica N.; Ruvkun, Gary (Public Library of Science, 2014-12)
    Reproductive senescence is a hallmark of aging. The molecular mechanisms regulating reproductive senescence and its association with the aging of somatic cells remain poorly understood. From a full genome RNA interference ...
  • Spidlen, Josef; Barsky, Aaron; Breuer, Karin; Carr, Peter; Nazaire, Marc-Danie; Hill, Barbara; Qian, Yu; Liefeld, Ted; Reich, Michael; Wilkinson, Peter; Scheuermann, Richard H.; Sekaly, Rafick-Pierre; Brinkman, Ryan R.; Mesirov, Jill P. (BioMed Central Ltd, 2013-07)
    Background: Traditional flow cytometry data analysis is largely based on interactive and time consuming analysis of series two dimensional representations of up to 20 dimensional data. Recent technological advances have ...
  • Adida, Ben; Kohane, Isaac (BioMed Central Ltd, 2006-04)
    Background: Patient genomic data are rapidly becoming part of clinical decision making. Within a few years, full genome expression profiling and genotyping will be affordable enough to perform on every individual. The ...
  • Brown, Emery N.; Purdon, Patrick Lee; Van Dort, Christa (Annual Reviews, 2011-07)
    Placing a patient in a state of general anesthesia is crucial for safely and humanely performing most surgical and many nonsurgical procedures. How anesthetic drugs create the state of general anesthesia is considered a ...
  • Schiff, Nicholas D.; Brown, Emery N.; Lydic, Emily K. (New England Journal of Medicine, 2010-12)
    In the United States, nearly 60,000 patients per day receive general anesthesia for surgery.1 General anesthesia is a drug-induced, reversible condition that includes specific behavioral and physiological traits — ...
  • Brown, Emery N.; Lydic, Ralph; Schiff, Nicholas D. (New England Journal of Medicine, 2010-12)
    In the United States, nearly 60,000 patients per day receive general anesthesia for surgery.1 General anesthesia is a drug-induced, reversible condition that includes specific behavioral and physiological traits — ...
  • Kim, Justin; Movassaghi, Mohammad (American Chemical Society, 2010-09)
    A highly stereoselective and systematic strategy for the introduction of polysulfides in the synthesis of epipolythiodiketopiperazines is described. We report the first total synthesis of dimeric epitri- and epitetrathio ...
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