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Browsing MIT Open Access Articles by Title

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  • Schnall-Levin, Michael; Berger, Bonnie; Bergwitz, Clemens; Wee, Mark J.; Sinha, Sumi; Huang, Joanne; DeRobertis, Charles; Mensah, Lawrence B.; Cohen, Jonathan; Friedman, Adam; Kulkarni, Meghana; Hu, Yanhui; Vinayagam, Arunachalam; Perkins, Lizabeth A.; Mohr, Stephanie E.; Perrimon, Norbert (Public Library of Science, 2013-03)
    Phosphate is required for many important cellular processes and having too little phosphate or too much can cause disease and reduce life span in humans. However, the mechanisms underlying homeostatic control of extracellular ...
  • Kelly, Libusha; Ding, Huiming; Huang, Katherine H.; Osburne, Marcia; Chisholm, Sallie (Penny) (Nature Publishing Group, 2013-05)
    Viruses that infect marine cyanobacteria–cyanophages–often carry genes with orthologs in their cyanobacterial hosts, and the frequency of these genes can vary with habitat. To explore habitat-influenced genomic diversity ...
  • Elbaz, Johann; Yin, Peng; Voigt, Christopher A. (Nature Publishing Group, 2016-04)
    The field of DNA nanotechnology has harnessed the programmability of DNA base pairing to direct single-stranded DNAs (ssDNAs) to assemble into desired 3D structures. Here, we show the ability to express ssDNAs in Escherichia ...
  • Hockemeyer, Dirk; Wang, Haoyi; Kiani, Samira; Lai, Christine S.; Gao, Qing; Cassady, John P.; Cost, Gregory J.; Zhang, Lei; Santiago, Yolanda; Miller, Jeffrey C.; Zeitler, Bryan; Cherone, Jennifer Michelle; Meng, Xiangdong; Hinkley, Sarah J.; Rebar, Edward J.; Gregory, Philip D.; Urnov, Fyodor D.; Jaenisch, Rudolf (Nature Publishing Group, 2011-07)
    Targeted genetic engineering of human pluripotent cells is a prerequisite for exploiting their full potential. Such genetic manipulations can be achieved using site-specific nucleases. Here we engineered transcription ...
  • Yang, Fan; Cho, Seung Woo; Son, Sun Mi; Bogatyrev, Said R.; Singh, Deepika; Green, Jordan J.; Mei, Ying; Park, Sohyun; Bhang, Suk Ho; Kim, Byung-Soo; Langer, Robert; Anderson, Daniel G. (National Academy of Sciences, 2010-02)
    Stem cells hold great potential as cell-based therapies to promote vascularization and tissue regeneration. However, the use of stem cells alone to promote angiogenesis remains limited because of insufficient expression ...
  • Moorjani, Priya; Thangaraj, Kumarasamy; Patterson, Nick; Lipson, Mark; Loh, Po-Ru; Govindaraj, Periyasamy; Berger, Bonnie; Reich, David; Singh, Lalji (Elsevier, 2013-08)
    Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; and Ancestral South Indians (ASI) ...
  • Ke, Hangjun; Lewis, Ian A.; Morrisey, Joanne M.; McLean, Kyle J.; Painter, Heather J.; Mather, Michael W.; Jacobs-Lorena, Marcelo; Vaidya, Akhil B.; Maddur Ganesan, Suresh; Llinas, Manuel (Elsevier, 2015-04)
    New antimalarial drugs are urgently needed to control drug-resistant forms of the malaria parasite Plasmodium falciparum. Mitochondrial electron transport is the target of both existing and new antimalarials. Herein, we ...
  • Lander, Eric S. (Nature Publishing Group, 2013-01)
    Neuroblastoma is a malignancy of the developing sympathetic nervous system that often presents with widespread metastatic disease, resulting in survival rates of less than 50%. To determine the spectrum of somatic mutation ...
  • Strauss, Bernard S.; Strauss, Jacob A. (United States National Academy of Sciences, 2009-09)
    Both biological and social scientists have recently commented on the supposed greater variability of males in IQ tests and in mathematical achievement (1). Missing from these discussions is any consideration of possible ...
  • Proia, Theresa A.; Keller, Patricia J.; Klebba, Ina; Jones, Ainsley D.; Sedic, Maja; Gilmore, Hannah; Tung, Nadine; Naber, Stephen P.; Schnitt, Stuart; Gupta, Piyush; Lander, Eric S.; Kuperwasser, Charlotte (Elsevier, 2011-02)
    Women with inherited mutations in the BRCA1 gene have increased risk of developing breast cancer but also exhibit a predisposition for the development of aggressive basal-like breast tumors. We report here that breast ...
  • Pickrell, Joseph K.; Patterson, Nick; Barbieri, Chiara; Berthold, Falko; Gerlach, Linda; Güldemann, Tom; Kure, Blesswell; Mpoloka, Sununguko Wata; Nakagawa, Hirosi; Naumann, Christfried; Lipson, Mark; Loh, Po-Ru; Lachance, Joseph; Mountain, Joanna; Bustamante, Carlos D.; Berger, Bonnie; Tishkoff, Sarah A.; Henn, Brenna M.; Stoneking, Mark; Reich, David; Pakendorf, Brigitte (Nature Publishing Group, 2012-10)
    Southern and eastern African populations that speak non-Bantu languages with click consonants are known to harbour some of the most ancient genetic lineages in humans, but their relationships are poorly understood. Here, ...
  • Moon, Tae Seok; Lou, Chunbo; Tamsir, Alvin; Stanton, Brynne Christine; Voigt, Christopher A. (Nature Publishing Group, 2012-10)
    Genetic programs function to integrate environmental sensors, implement signal processing algorithms and control expression dynamics[1]. These programs consist of integrated genetic circuits that individually implement ...
  • Soukas, Alexander A.; Carr, Christopher E.; Ruvkun, Gary (Public Library of Science, 2013-10)
    Lysosomes are membrane-bound organelles that contain acid hydrolases that degrade cellular proteins, lipids, nucleic acids, and oligosaccharides, and are important for cellular maintenance and protection against age-related ...
  • Burrage, Lindsay C.; Baskin-Hill, Annie E.; Sinasac, David S.; Singer, Jonathan B.; Croniger, Colleen M.; Kirby, Andrew; Kulbokas, E. J.; Daly, Mark J.; Lander, Eric S.; Broman, Karl W.; Nadeau, Joseph H. (Springer-Verlag, 2010-02)
    Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-Chr[superscript A/J]/NaJ panel of chromosome ...
  • Wang, Tim; Wei, Jenny J.; Sabatini, David M.; Lander, Eric S. (American Association for the Advancement of Science (AAAS), 2013-12)
    The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 system for genome editing has greatly expanded the toolbox for mammalian genetics, enabling the rapid generation of isogenic cell lines ...
  • Moser, Felix; Horwitz, Andrew; Chen, Jacinto; Lim, Wendell A.; Voigt, Christopher A. (American Chemical Society (ACS), 2013-09)
    Methylating chemicals are common in industry and agriculture and are often toxic, partly due to their propensity to methylate DNA. The Escherichia coli Ada protein detects methylating compounds by sensing aberrant methyl ...
  • Lesch, Bluma J.; Page, David C. (Nature Publishing Group, 2012-10)
    The germ line represents a continuous cellular link between generations and between species, but the germ cells themselves develop in a specialized, organism-specific context. The model organisms Caenorhabditis elegans, ...
  • Chen, Chi-Hua; Fiecas, Mark; Gutierrez, E. D.; Panizzon, Matthew S.; Eyler, Lisa T.; Vuoksimaa, Eero; Thompson, Wesley K.; Fennema-Notestine, Christine; Hagler, Donald J., Jr.; Jernigan, Terry L.; Neale, Michael C.; Franz, Carol E.; Lyons, Michael J.; Fischl, Bruce; Tsuang, Ming T.; Dale, Anders M.; Kremen, William S. (National Academy of Sciences (U.S.), 2013-10)
    Animal data show that cortical development is initially patterned by genetic gradients largely along three orthogonal axes. We previously reported differences in genetic influences on cortical surface area along an ...
  • Cesarini, David Alexander; Dawes, Christopher T.; Johannesson, Magnus; Lichtenstein, Paul; Wallace, Bjorn (MIT Press, 2009-05)
    In this paper, we use the classical twin design to provide estimates of genetic and environmental influences on experimentally elicited preferences for risk and giving. Using standardmethods from behavior genetics, we ...
  • Abdullah, Syahril; Wendy-Yeo, Wai Yeng; Hosseinkhani, Hossein; Hosseinkhani, Mohsen; Masrawa, Ehab; Ramasamy, Rajesh; Rosli, Rozita; Rahman, Sabariah A.; Domb, Abraham J. (Hindawi Publishing Corporation, 2010)
    A novel cationic polymer, dextran-spermine (D-SPM), has been found to mediate gene expression in a wide variety of cell lines and in vivo through systemic delivery. Here, we extended the observations by determining the ...
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