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Browsing MIT Open Access Articles by Title

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  • Gupton, Stephanie L.; Riquelme, Daisy Noelia; Hughes-Alford, Shannon Kay; Tadros, Jenny; Rudina, Shireen S.; Hynes, Richard O.; Lauffenburger, Douglas A.; Gertler, Frank B. (Rockefeller University Press, The, 2012-08)
    Mena is an Ena/VASP family actin regulator with roles in cell migration, chemotaxis, cell–cell adhesion, tumor cell invasion, and metastasis. Although enriched in focal adhesions, Mena has no established function within ...
  • Roussos, Evanthia T.; Wang, Yarong; Wyckoff, Jeffrey B.; Sellers, Rani S.; Wang, Weigang; Li, Jiufeng; Pollard, Jeffrey W.; Gertler, Frank; Condeelis, John S. (BioMed Central Ltd., 2010-11)
    Introduction The actin binding protein Mammalian enabled (Mena), has been implicated in the metastatic progression of solid tumors in humans. Mena expression level in primary tumors is correlated with metastasis in ...
  • Philippar, Ulrike; Roussos, Evanthia T.; Oser, Matthew; Yamaguchi, Hideki; Kim, Hyung-Do; Giampieri, Silvia; Wang, Yarong; Goswami, Sumanta; Wyckoff, Jeffrey B.; Lauffenburger, Douglas A.; Sahai, Erik; Condeelis, John S.; Gertler, Frank (Elsevier, 2008-12)
    The spread of cancer during metastatic disease requires that tumor cells subvert normal regulatory networks governing cell motility to invade surrounding tissues and migrate toward blood and lymphatic vessels. Enabled ...
  • Roussos, Evanthia T.; Goswami, Sumanta; Balsamo, Michele; Wang, Yarong; Stobezki, Robert; Adler, Esther; Robinson, Brian D.; Jones, Joan G.; Condeelis, John S.; Oktay, Maja H.; Gertler, Frank (Springer-Verlag, 2011-04)
    Mena, an actin regulatory protein, functions at the convergence of motility pathways that drive breast cancer cell invasion and migration in vivo. The tumor microenvironment spontaneously induces both increased expression ...
  • Gates, Monte A; Witke, Walter; Macklis, Jeffrey D; Kwiatkowski, David; Soriano, Philippe; Lanier, Lorene M.; Menzies, A. Sheila; Wehman, Ann M.; Gertler, Frank (Elsevier, 1999-02)
    Mammalian enabled (Mena) is a member of a protein family thought to link signal transduction pathways to localized remodeling of the actin cytoskeleton. Mena binds directly to Profilin, an actin-binding protein that modulates ...
  • Bonatti, Alessandro (American Economic Association, 2011-08)
    We analyze the design of dynamic menus to sell experience goods. The quality of the product is initially unknown, and the total quantity sold in each period determines the amount of information in the market. We characterize ...
  • Lamborg, Carl; Bowman, Katilin; Hammerschmidt, Chad; Gilmour, Cindy; Munson, Kathleen; Tseng, Chun-Mao; Selin, Noelle Eckley (Oceanography Society, 2014-03)
    The toxic metal mercury is present only at trace levels in the ocean, but it accumulates in fish at concentrations high enough to pose a threat to human and environmental health. Human activity has dramatically altered the ...
  • Pilawa-Podgurski, Robert C. N.; Perreault, David J. (Institute of Electrical and Electronics Engineers (IEEE), 2012-05)
    In this paper, we introduce a merged two-stage dc-dc power converter for low-voltage power delivery. By separating the transformation and regulation function of a dc-dc power converter into two stages, both large voltage ...
  • Lin, Ying-Tsong; Newhall, Arthur E.; Duda, Timothy F.; Lermusiaux, Pierre F. J.; Haley, Patrick J. (Institute of Electrical and Electronics Engineers, 2010-10)
    In this paper, a method for merging partial overlapping time series of ocean profiles into a single time series of profiles using empirical orthogonal function (EOF) decomposition with the objective analysis is presented. ...
  • Drake, Adam; Chen, Qingfeng; Dong, Di; Leskov, Ilya; Fragoso, Maria F.; Li, Yan; Iliopoulou, Bettina P.; Hwang, William; Lodish, Harvey F.; Chen, Jianzhu (Mary Ann Liebert, 2010-12)
    Clinical and preclinical applications of human hematopoietic stem cells (HSCs) are often limited by scarcity of cells. Expanding human HSCs to increase their numbers while maintaining their stem cell properties has therefore ...
  • Aloupis, Greg; Demaine, Erik D.; Demaine, Martin L.; Iacono, John; Dujmovic, Vida (Springer-Verlag, 2012)
    The minimum feature size of a planar straight-line graph is the minimum distance between a vertex and a nonincident edge. When such a graph is partitioned into a mesh, the degradation is the ratio of original to final ...
  • Amaro, J. E.; Barbaro, M. B.; Caballero, J. A.; Maieron, C.; Udias, J. M.; Donnelly, T. William (American Physical Society, 2010-01)
    The effects of meson-exchange currents (MEC) are computed for the one-particle one-hole transverse response function for finite nuclei at high momentum transfers q in the region of the quasi-elastic peak. A semirelativistic ...
  • Amaro, J. E.; Barbaro, M. B.; Caballero, J. A.; Donnelly, T. William (American Physical Society, 2012-04)
    We evaluate quasielastic double-differential antineutrino cross sections obtained in a phenomenological model based on the superscaling behavior of electron scattering data and estimate the contribution of the vector ...
  • Faulkner, Thomas; Liu, Hong (Elsevier, 2009-02)
    We show that open strings living on a D-brane which lies outside an AdS black hole We show that open strings living on a D-brane which lies outside an AdS black hole can tunnel into the black hole through worldsheet ...
  • Homer, Eric R.; Schuh, Christopher A. (Elsevier, 2009-03)
    A new mesoscale modeling technique for the thermo-mechanical behavior of metallic glasses is proposed. The modeling framework considers the shear transformation zone (STZ) as the fundamental unit of deformation, and ...
  • Sanghavi, Sujay; Shah, Devavrat; Willsky, Alan S. (2009-10)
    In this paper, we investigate the use of message-passing algorithms for the problem of finding the max-weight independent set (MWIS) in a graph. First, we study the performance of the classical loopy max-product belief ...
  • Giaccone, Paolo; Shah, Devavrat (Institute of Electrical and Electronics Engineers (IEEE), 2010-09)
    In the recent years, message-passing paradigm has emerged as a canonical algorithmic solution to solve networkwide problems by means of minimal local information exchange, across variety of disciplines. The primary purpose ...
  • Willsky, Alan S.; Kreidl, Olivier Patrick (Institute of Electrical and Electronics Engineers, 2010-01)
    Motivated by distributed inference applications in unreliable communication networks, we adapt the popular (sum-product) belief propagation (BP) algorithm under the constraint of discrete-valued messages. We show that, in ...
  • Johnson, Catherine L.; Purucker, Michael E.; Korth, Haje; Anderson, Brian J.; Winslow, Reka M.; Al Asad, Manar M. H.; Slavin, James A.; Alexeev, Igor. I.; Phillips, Roger J.; Zuber, Maria; Solomon, Sean C. (American Geophysical Union, 2012-12)
    We present a baseline, time-averaged model for Mercury's magnetosphere, derived from MESSENGER Magnetometer data from 24 March to 12 December 2011, comprising the spacecraft's first three Mercury years in orbit around the ...
  • Ueda, Satoshi; Fors, Brett P.; Ali, Siraj Z.; Buchwald, Stephen Leffler (American Chemical Society (ACS), 2012-02)
    A new biarylphosphine ligand, Me[subscript 3](OMe)tBuXPhos (L3), was designed as a surrogate for Me[subscript 4]tBuXPhos (L1). The Me[subscript 3](OMe)tBuXPhos could be prepared in a chromatography-free manner from inexpensive ...
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