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Browsing MIT Open Access Articles by Title

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  • Chiaverini, John; Sage, Jeremy M. (American Physical Society, 2014-01)
    We present measurements of trapped-ion motional-state heating rates in niobium and gold surface-electrode ion traps over a range of trap-electrode temperatures from approximately 4 K to room temperature (295 K) in a single ...
  • Gibbons, Robert (Annual Reviews, 2010-03)
    When economists have considered organizations, much attention has focused on the boundary of the firm, rather than its internal structures and processes. In contrast, this review sketches three approaches to the economic ...
  • Gibbons, Robert S. (Annual Reviews, 2010-03)
    When economists have considered organizations, much attention has focused on the boundary of the firm, rather than its internal structures and processes. In contrast, this review sketches three approaches to the economic ...
  • Weinberg, David E.; Nakanishi, Kotaro; Patel, Dinshaw J.; Bartel, David; Weinberg, David E. (Elsevier B.V., 2011-07)
    The Dicer ribonuclease III (RNase III) enzymes process long double-stranded RNA (dsRNA) into small interfering RNAs (siRNAs) that direct RNA interference. Here, we describe the structure and activity of a catalytically ...
  • Hernandez Rivera, Javier; McDuff, Daniel Jonathan; Fletcher, Richard Ribon; Picard, Rosalind W. (IEEE Computer Society, 2013-03)
    We present a novel sensor system and interface that enables an individual to capture and reflect on their daily activities. The wearable system gathers both physiological responses and visual context through the use of a ...
  • Artin, Erin; Wang, Jun; Lohman, Gregory J. S.; Yokoyama, Kenichi; Yu, Guixue; Bar, Galit; Stubbe, JoAnne; Griffin, Robert Guy (American Chemical Society (ACS), 2009-11)
    Gemcitabine 5′-diphosphate (F[subscript 2]CDP) is a potent inhibitor of ribonucleotide reductases (RNRs), enzymes that convert nucleotides (NDPs) to deoxynucleotides and are essential for DNA replication and repair. The ...
  • Musolino, Nicholas; Trout, Bernhardt L. (American Institute of Physics (AIP), 2013-04)
    The process of water's evaporation at its liquid/air interface has proven challenging to study experimentally and, because it constitutes a rare event on molecular time scales, presents a challenge for computer simulations ...
  • Delbanco, Tom; Ahern, David K.; Walker, Jan; Le, Lan Xuan (Springer New York, 2009-05)
    BACKGROUND: In designing electronic personal health records (PHRs) and related health technologies, lay perspectives are rarely solicited, and we know little about what individuals want and need. OBJECTIVE: To learn how ...
  • Gai, Claudia S.; Lu, Jingnan; Brigham, Christopher J.; de Carvalho Bernardi, Amanda; Sinskey, Anthony J. (Springer, 2014-01)
    Carbonic anhydrase (CA) enzymes catalyze the interconversion of CO2 and bicarbonate. These enzymes play important roles in cellular metabolism, CO2 transport, ion transport, and internal pH regulation. Understanding the ...
  • Summons, Roger Everett; Bernhard, Joan M.; Edgcomb, Virginia P.; Visscher, Pieter T.; McIntyre-Wressnig, Anna; Bouxsein, Mary L.; Louis, Leeann; Jeglinski, Marleen (National Academy of Sciences (U.S.), 2013-05)
    Microbialites, which are organosedimentary structures formed by microbial communities through binding and trapping and/or in situ precipitation, have a wide array of distinctive morphologies and long geologic record. The ...
  • Yu, Ming; Riva, Laura; Schindler, Yocheved; Moran, Tyler B.; Cheng, Yong; Yu, Duonan; Hardison, Ross; Weiss, Mitchell J.; Orkin, Stuart H.; Bernstein, Bradley E.; Fraenkel, Ernest; Cantor, Alan B. (Elsevier, 2009-11)
    The transcription factor GATA-1 is required for terminal erythroid maturation and functions as an activator or repressor depending on gene context. Yet its in vivo site selectivity and ability to distinguish between ...
  • Bochevarov, Arteum D.; Li, Jianing; Song, Woon Ju; Friesner, Richard A.; Lippard, Stephen J. (American Chemical Society (ACS), 2010-11)
    The methane and toluene monooxygenase hydroxylases (MMOH and TMOH, respectively) have almost identical active sites, yet the physical and chemical properties of their oxygenated intermediates, designated P*, H[subscript ...
  • London, Nir; Keating, Amy E.; Schueler-Furman, Ora; Gulla, Stefano (American Chemical Society (ACS), 2012-06)
    Interactions between Bcl-2-like proteins and BH3 domains play a key role in the regulation of apoptosis. Despite the overall structural similarity of their interaction with helical BH3 domains, Bcl-2-like proteins exhibit ...
  • Cranford, Steven Wayne; Buehler, Markus J. (Institute of Physics, 2010-07)
    Carbon nanotube sheets or films, also known as 'buckypaper', have been proposed for use in actuating, structural and filtration systems, based in part on their unique and robust mechanical properties. Computational modeling ...
  • Weaver, James C.; Burns, Stephen K.; Smith, Kyle Christopher; Esser, Axel Thomas; Gowrishankar, Thiruvallur R. (Institute of Electrical and Electronics Engineers, 2009-11)
    We use a system model of a cell and approximate magnitudes of electrical incapacitation (EI) device waveforms to estimate conditions that lead to responses with or without electroporation (EP) of cell membranes near ...
  • Nyein, Michelle K.; Jason, Amanda M.; Yu, Li; Pita, Claudio M.; Joannopoulos, John D.; Moore, David F.; Radovitzky, Raul (National Academy of Sciences, 2010-11)
    Blast-induced traumatic brain injury is the most prevalent military injury in Iraq and Afghanistan, yet little is known about the mechanical effects of blasts on the human head, and still less is known about how personal ...
  • Koo, Andrew; Nordsletten, David; Umeton, Renato; Yankama, Beracah; Ayyadurai, Shiva; Dewey, C. Forbes; Garcia-Cardena, Guillermo; Dewey, C. Forbes (Elsevier, 2013-05)
    Nitric oxide (NO) produced by vascular endothelial cells is a potent vasodilator and an antiinflammatory mediator. Regulating production of endothelial-derived NO is a complex undertaking, involving multiple signaling and ...
  • Danino, Tal; Volfson, Dmitri; Bhatia, Sangeeta N.; Tsimring, Lev; Hasty, Jeff (Public Library of Science, 2011-05)
    Cells organize in complex three-dimensional patterns by interacting with proteins along with the surrounding extracellular matrix. This organization provides the mechanical and chemical cues that ultimately influence a ...
  • Cziczo, Daniel James; Baumgardner, D.; Avallone, L.; Bansemer, A.; Borrmann, S,; Brown, P.; Bundke, U.; Chuang, P. Y,; Field, P. (American Meteorological Society, 2012-02)
    A meeting of 31 international experts on in situ measurements from aircraft was held to identify unresolved questions concerning ice formation and evolution in ice clouds, assess the current state of instrumentation that ...
  • Lu, Yi-chun; Crumlin, Ethan J.; Veith, Gabriel M.; Harding, Jonathon R.; Mutoro, Eva; Baggetto, Loic; Dudney, Nancy J.; Liu, Zhi; Shao-Horn, Yang (Nature Publishing Group, 2012-10)
    The lack of fundamental understanding of the oxygen reduction and oxygen evolution in nonaqueous electrolytes significantly hinders the development of rechargeable lithium-air batteries. Here we employ a solid-state ...
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