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Browsing MIT Open Access Articles by Title

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  • Cheeseman, Iain McPherson (Springer-Verlag, 2013-04)
    The first centromeric protein identified in any species was CENP-A, a divergent member of the histone H3 family that was recognised by autoantibodies from patients with scleroderma-spectrum disease. It has recently been ...
  • Chryssostomidis, Chryssostomos; Chalfant, Julie; Vargas, J. V. C.; Souza, J. A.; Hovsapian, R.; Ordonez, J. C.; Chiocchio, T. (Association for Computing Machinery (ACM), 2011)
    This work presents a fast visualization and thermal simulation tool developed as part of the Electric Ship Research and Development Consortium (ESRDC) funded by the Office of Naval Research (ONR) that is capable of providing ...
  • Barresi, Michael J. F.; Burton, Sean; Dipietrantonio, Kristina; Amsterdam, Adam; Hopkins, Nancy H.; Karlstrom, Rolf O. (Wiley Blackwell (John Wiley & Sons), 2010-08)
    The formation of the central nervous system depends on the coordinated development of neural and glial cell types that arise from a common precursor. Using an existing group of zebrafish mutants generated by viral insertion, ...
  • Thiaville, Patrick C.; El Yacoubi, Basma; Thiaville, Jennifer J.; Deutsch, Chris; Iwata-Reuyl, Dirk; Bacusmo, Jo Marie; Armengaud, Jean; Bessho, Yoshitaka; Wetzel, Collin; Cao, Xiaoyu; Limbach, Patrick A.; de Crécy-Lagard, Valérie; Koehrer, Caroline; Rajbhandary, Uttam L (Wiley Blackwell, 2015-09)
    Threonylcarbamoyladenosine (t[superscript 6]A) is a modified nucleoside universally conserved in tRNAs in all three kingdoms of life. The recently discovered genes for t6A synthesis, including tsaC and tsaD, are essential ...
  • Yoon, Bong-June; Smith, Gordon B.; Heynen, Arnold J.; Neve, Rachael L.; Bear, Mark (National Academy of Sciences, 2009-06)
    The classic example of experience-dependent cortical plasticity is the ocular dominance (OD) shift in visual cortex after monocular deprivation (MD). The experimental model of homosynaptic long-term depression (LTD) was ...
  • Richardson, Claire Elissa; Kooistra, Tristan G.; Kim, Dennis H. (Nature Publishing Group, 2010-02)
    The detection and compensatory response to the accumulation of unfolded proteins in the endoplasmic reticulum (ER), termed the unfolded protein response (UPR), represents a conserved cellular homeostatic mechanism with ...
  • Scobie, Kimberly N.; Damez-Werno, Diane; Sun, HaoSheng; Shao, NingYi; Gancarz, Amy; Panganiban, Clarisse H.; Dias, Caroline; Koo, Ja Wook; Caiafa, Paola; Kaufman, Lewis; Neve, Rachael L.; Dietz, David M.; Shen, Li; Nestler, Eric J. (National Academy of Sciences (U.S.), 2014-02)
    Many of the long-term effects of cocaine on the brain’s reward circuitry have been shown to be mediated by alterations in gene expression. Several chromatin modifications, including histone acetylation and methylation, ...
  • Ferguson, Deveroux; Koo, Ja Wook; Feng, Jian; Heller, Elizabeth; Rabkin, Jacqui; Heshmati, Mitra; Renthal, William; Neve, Rachael L.; Liu, Xiaochuan; Shao, Ningyi; Sartorelli, Vittorio; Shen, Li; Nestler, Eric J. (Society for Neuroscience, 2013-10)
    Sirtuins (SIRTs), class III histone deacetylases, are well characterized for their control of cellular physiology in peripheral tissues, but their influence in brain under normal and pathological conditions remains poorly ...
  • Freinkman, Elizaveta; Wang, Tim; Chen, Walter W.; Abu-Remaileh, Monther; Sabatini, David; Birsoy, Kivanc (Elsevier, 2015-07)
    The mitochondrial electron transport chain (ETC) enables many metabolic processes, but why its inhibition suppresses cell proliferation is unclear. It is also not well understood why pyruvate supplementation allows cells ...
  • Pulina, Maria V.; Hou, Shuan-Yu; Mittal, Ashok; Julich, Dorthe; Whittaker, Charlie A.; Holley, Scott A.; Hynes, Richard O.; Astrof, Sophie; Whittaker, Charles A. (Elsevier, 2011-04)
    Studies in Xenopus laevis suggested that cell-extracellular matrix (ECM) interactions regulate the development of the left–right axis of asymmetry; however, the identities of ECM components and their receptors important ...
  • De Sole, Alberto; Kac, Victor (Springer-Verlag, 2012-04)
    In our recent paper “The variational Poisson cohomology” (2011) we computed the dimension of the variational Poisson cohomology H[subscript K](V) for any quasiconstant coefficient ℓ × ℓ matrix differential operator K of ...
  • Gonzalez-Andrades, Miguel; Alonso-Pastor, Luis; Cruzat, Andrea; Dohlman, Claes H.; Mauris, Jerome; Argueso, Pablo (Nature Publishing Group, 2016-01)
    The repair of wounds through collective movement of epithelial cells is a fundamental process in multicellular organisms. In stratified epithelia such as the cornea and skin, healing occurs in three steps that include a ...
  • Farhi, Emmanuel; Werning, Ivan (American Economic Association, 2013-05)
    We develop a theory of optimal estate taxation in a model where bequest inequality is driven by differences in parental altruism. We show that a wide range of results are possible, from positive taxes to subsidies. The ...
  • Langton, Rae (Wiley Periodicals, Inc., 2009-12)
  • Wright, Len; Chinowsky, Paul; Jones, Russell; Streeter, Richard; Mayotte, Jean-Marc; Powell, Anthony; Jantarasami, Lesley; Perkins, William; Smith, Joel B.; Strzepek, Kenneth (Springer Netherlands, 2012-02)
    We assessed the potential impacts of increased river flooding from climate change on bridges in the continental United States. Daily precipitation statistics from four climate models and three greenhouse gas (GHG) emissions ...
  • Forget, Gael; Maze, Guillaume O.; Buckley, Martha Weaver; Marshall, John C. (American Meteorological Society, 2010-07)
    The seasonal cycle in the volume and formation rate of Eighteen Degree Water (EDW) in the North Atlantic is quantified over the 3-yr period from 2004 to 2006. The EDW layer is defined as all waters that have a temperature ...
  • Hausmann, Ute; Czaja, Arnaud; Marshall, John C (American Meteorological Society, 2016-01)
    Sea surface temperature (SST) air–sea feedback strengths and associated decay time scales in the Southern Ocean (SO) are estimated from observations and reanalysis datasets of SST, air–sea heat fluxes, and ocean mixed layer ...
  • Schmitt, Raymond W.; Schanze, Julian Johannes (American Meteorological Society, 2013-04)
    Owing to the larger thermal expansion coefficient at higher temperatures, more buoyancy is put into the ocean by heating than is removed by cooling at low temperatures. The authors show that, even with globally balanced ...
  • Tewelde, Yodit; Perron, J. Taylor; Miller, Scott; Ford, Peter Gerald; Black, Benjamin Alexander (American Geophysical Union (AGU), 2013-10)
    Titan has few impact craters, suggesting that its surface is geologically young. Titan's surface also has abundant landforms interpreted to be fluvial networks. Here we evaluate whether fluvial erosion has caused significant ...
  • Raymond, Peter A.; Bohlen, W. Frank; Howard-Strobel, Mary M.; Collins, James Robert (Springer-Verlag, 2012-10)
    Biogeochemical cycles in estuaries are regulated by a diverse set of physical and biological variables that operate over a variety of time scales. Using in situ optical sensors, we conducted a high-frequency time-series ...
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