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Browsing MIT Open Access Articles by Title

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  • Vahey, Michael D.; Quiros Pesudo, Laia; Svensson, J. Peter; Samson, Leona D.; Voldman, Joel (Royal Society of Chemistry, 2013-04)
    Methods to analyze the intrinsic physical properties of cells – for example, size, density, rigidity, or electrical properties – are an active area of interest in the microfluidics community. Although the physical properties ...
  • Haggarty, Stephen; Norton, Stephanie; Samara, Chrysanthi; Gilleland, Cody Lee; Rohde, Christopher Benjamin; Yanik, Mehmet Fatih (Institute of Electrical and Electronics Engineers, 2009-11)
    Compound screening is a powerful tool to identify new therapeutic targets, drug leads, and elucidate the fundamental mechanisms of biological processes. We report here the results of the first in vivo small-molecule screens ...
  • Blagovic, Katarina; Kim, Lily Y.; Voldman, Joel (Public Library of Science, 2011-08)
    Background Autocrine & paracrine signaling are widespread both in vivo and in vitro, and are particularly important in embryonic stem cell (ESC) pluripotency and lineage commitment. Although autocrine signaling via ...
  • Li, Ran; Polacheck, William Joseph; Uzel, Sebastien GM; Kamm, Roger Dale (Royal Society of Chemistry, The, 2013-04)
    Mechanotransduction has been a topic of considerable interest since early studies demonstrated a link between mechanical force and biological response. Until recently, studies of fundamental phenomena were based either on ...
  • Chung, Seok; Sudo, Ryo; Vickerman, Vernella Velonie V.; Zervantonakis, Ioannis; Kamm, Roger Dale (Springer-Verlag/Biomedical Engineering Society, 2010-01)
    Recent advances in microfluidic technologies have opened the door for creating more realistic in vitro cell culture methods that replicate many aspects of the true in vivo microenvironment. These new designs (i) provide ...
  • Wen, Jian; Albrecht, Jacob W.; Jensen, Klavs F. (John Wiley & Sons, Inc., 2010-04)
    A preparative scale free-flow IEF device is developed and characterized with the aim of addressing needs of molecular biologists working with protein samples on the milligrams and milliliters scale. A triangular-shape ...
  • Wen, Jian; Wilker, Erik W.; Yaffe, Michael B.; Jensen, Klavs F. (American Chemical Society (ACS), 2010-01)
    Isoelectric focusing (IEF) is the first step for two-dimensional (2D) gel electrophoresis and plays an important role in sample purification for proteomics. However, biases in protein size and pI resolution, as well as ...
  • Hou, Han Wei; Gan, Hiong Yap; Bhagat, Ali Asgar S.; Li, Leon Daliang; Lim, Chwee Teck; Han, Jongyoon (American Institute of Physics, 2012-05)
    Sepsis is an adverse systemic inflammatory response caused by microbial infection in blood. This paper reports a simple microfluidic approach for intrinsic, non-specific removal of both microbes and inflammatory cellular ...
  • Langer, Robert; Valencia, Pedro Miguel; Farokhzad, Omid C.; Karnik, Rohit N.; Langer, Robert (Nature Publishing Group, 2012-10)
    Using nanoparticles for therapy and imaging holds tremendous promise for the treatment of major diseases such as cancer. However, their translation into the clinic has been slow because it remains difficult to produce ...
  • Johnson, Micah K.; Cole, Forrester; Raj, Alvin; Adelson, Edward H. (Association for Computing Machinery (ACM), 2011-07)
    We describe a system for capturing microscopic surface geometry. The system extends the retrographic sensor [Johnson and Adelson 2009] to the microscopic domain, demonstrating spatial resolution as small as 2 microns. In ...
  • Zeineldin, H. H.; Kirtley, James L., Jr. (Institute of Electrical and Electronics Engineers (IEEE), 2009-10)
    Distribution systems are experiencing increasing penetration of distributed generation (DG). One attractive option is to use the available DG capacity during utility outages by forming planned micro-grids. Load sharing ...
  • Cetina, Marko; Grier, Andrew T.; Vuletic, Vladan (American Physical Society, 2012-12)
    We present, and derive analytic expressions for, a fundamental limit to the sympathetic cooling of ions in radio-frequency traps using cold atoms. The limit arises from the work done by the trap electric field during a ...
  • Chen, Gang; Peterson, G. P. “Bud”; Li, Chen; Wang, Moran (Hindawi Pub. Corp., 2010-03)
    As a result of serious concerns about climate change, high oil prices, and peak oil, energy has become one of the most important issues of our time. Renewable energy and energy-saving technologies are potentially crucial ...
  • Verma, Naveen; Shoeb, Ali H.; Bohorquez, Jose L.; Dawson, Joel L.; Guttag, John V.; Chandrakasan, Anantha P. (Institute of Electrical and Electronics Engineers (IEEE), 2010-04)
    This paper presents a low-power SoC that performs EEG acquisition and feature extraction required for continuous detection of seizure onset in epilepsy patients. The SoC corresponds to one EEG channel, and, depending on ...
  • Verma, Naveen; Shoeb, Ali H.; Chandrakasan, Anantha P.; Guttag, John V. (Institute of Electrical and Electronics Engineers, 2009-08)
    Continuous on-scalp EEG monitoring provides a non-invasive means to detect the onset of seizures in epilepsy patients, but cables from the scalp pose a severe strangulation hazard during convulsions. Since the power of ...
  • Sarpeshkar, Rahul; Fay, Leon; Misra, Vinith (Institute of Electrical and Electronics Engineers, 2009-09)
    We introduce an electrocardiogram (EKG) preamplifier with a power consumption of 2.8 muW, 8.1 muV[subscript rms] input-referred noise, and a common-mode rejection ratio of 90 dB. Compared to previously reported work, this ...
  • Denison, Timothy; Panken, Eric; Carlson, Dave; Shoeb, Ali H. (Institute of Electrical and Electronics Engineers, 2009-11)
    Implantable neurostimulators for the treatment of epilepsy that are capable of sensing seizures can enable novel therapeutic applications. However, detecting seizures is challenging due to significant intracranial EEG ...
  • Shoeb, Ali H.; Carlson, Dave; Panken, Eric; Denison, Timothy (Institute of Electrical and Electronics Engineers, 2009-11)
    Implantable neurostimulators for the treatment of epilepsy that are capable of sensing seizures can enable novel therapeutic applications. However, detecting seizures is challenging due to significant intracranial EEG ...
  • Melo, Gabriela; Malcolm, Alison E. (Society of Exploration Geophysicists, 2011-05)
    The conditions under which seismic interferometry (SI) leads to the exact Green's function (GF) are rarely met in practice. As a result, we generally recover only estimates of the true GF. This raises the questions: How ...
  • Bousquet, Marina; Nguyen, Diu; Chen, Cynthia; Shields, Lauren; Lodish, Harvey F. (Ferrata Storti Foundation, 2012-06)
    Background: We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that ...
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