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Browsing MIT Open Access Articles by Title

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  • Sundaram, S. K.; Woskov, Paul P. (Institute of Electrical and Electronics Engineers, 2009-11)
    Millimeter waves are ideally suited for sensing and diagnosing materials, devices, and processes that are broadly important to energy, environment, and national security. Thermal return reflection (TRR) techniques that ...
  • Kotani, Ai; Ha, Daon; Schotte, Diana; den Boer, Monique L.; Armstrong, Scott A.; Lodish, Harvey F. (Landes Bioscience, 2010-03)
    MLL-AF4 Acute Lymphocytic Leukemia has a poor prognosis, and the mechanisms by which these leukemias develop are not understood despite intensive research based on well-known concepts and methods. MicroRNAs (miRNAs) are a ...
  • Zhou, Kang; Zhou, Lihan; Lim, Qing 'En; Zou, Ruiyang; Stephanopoulos, Gregory; Too, Heng-Phon (BioMed Central Ltd, 2011-04)
    Background: Accurate interpretation of quantitative PCR (qPCR) data requires normalization using constitutively expressed reference genes. Ribosomal RNA is often used as a reference gene for transcriptional studies in E. ...
  • Wilkinson, Matthew B.; Dias, Caroline; Magida, Jane; Mazei-Robison, Michelle; Lobo, MaryKay; Kennedy, Pamela; Dietz, David; Covington, Herbert, III; Russo, Scott; Ghose, Subroto; Tamminga, Carol; Nestler, Eric J.; Neve, Rachael L. (Society for Neuroscience, 2011-06)
    Based on earlier gene expression and chromatin array data, we identified the protein, dishevelled (DVL)-2, as being regulated in the nucleus accumbens (NAc), a key brain reward region, in the mouse social defeat model of ...
  • Seidel, Hannah S.; Ailion, Michael; Li, Jialing; van Oudenaarden, Alexander; Rockman, Matthew V.; Kruglyak, Leonid (Public Library of Science, 2011-10-13)
    The evolutionary fate of an allele ordinarily depends on its contribution to host fitness. Occasionally, however, genetic elements arise that are able to gain a transmission advantage while simultaneously imposing a fitness ...
  • Buyukozturk, Oral; Yu, Tzu-Yang (Springer-Verlag, 2009)
    Repairing deteriorated concrete bridge piers using externally wrapped fiber reinforced polymer (FRP) composites have been proven as an effective approach. This technique has also been applied to low-rise building structures. ...
  • Lovoll, Marie; Wiik-Nielsen, Jannicke; Grove, Soren; Wiik-Nielsen, Christer R.; Kristoffersen, Anja B.; Faller, Randi; Poppe, Trygve; Jung, Joonil; Pedamallu, Chandra S.; Nederbragt, Alexander J.; Meyerson, Matthew L.; Rimstad, Espen; Tengs, Torstein (BioMed Central Ltd., 2010-11)
    Background Cardiomyopathy syndrome (CMS) is a severe disease affecting large farmed Atlantic salmon. Mortality often appears without prior clinical signs, typically shortly prior to slaughter. We recently reported the ...
  • Xu, Zhiguang; Youcef-Toumi, Kamal; Yoon, Soon Fatt (Institute of Electrical and Electronics Engineers (IEEE), 2009-11)
    This paper presents a special configuration of white-light scanning interferometer, in which the measured gap is not located in any interference arm of the interferometer, but acts as an amplitude-and-phase modulator of ...
  • Gonçalves, Geisa A. L.; Prazeres, Duarte M. F.; Monteiro, Gabriel A.; Prather, Kristala L. Jones (Springer-Verlag, 2012-08)
    The interest in plasmid DNA (pDNA) as a biopharmaceutical has been increasing over the last several years, especially after the approval of the first DNA vaccines. New pDNA production strains have been created by rationally ...
  • Hassan, Musa A.; Melo, Mariane Bandeira; Haas, Brian; Jensen, Kirk D. C.; Saeij, Jeroen (BioMed Central Ltd., 2012-12)
    Background: Accurate gene model predictions and annotation of alternative splicing events are imperative for genomic studies in organisms that contain genes with multiple exons. Currently most gene models for the intracellular ...
  • Haas, Brian J; Papanicolaou, Alexie; Yassour, Moran; Grabherr, Manfred; Blood, Philip D; Bowden, Joshua; Couger, Matthew Brian; Eccles, David; Li, Bo; Lieber, Matthias; MacManes, Matthew D; Ott, Michael; Orvis, Joshua; Pochet, Nathalie; Strozzi, Francesco; Weeks, Nathan; Westerman, Rick; William, Thomas; Dewey, Colin N; Henschel, Robert; LeDuc, Richard D; Friedman, Nir; Regev, Aviv (Nature Publishing Group, 2013-07)
    De novo assembly of RNA-seq data enables researchers to study transcriptomes without the need for a genome sequence; this approach can be usefully applied, for instance, in research on 'non-model organisms' of ecological ...
  • Khot, Subhash; Moshkovitz, Hadar Dana (Association for Computing Machinery, 2011-06)
    In this paper, we consider the problem of approximately solving a system of homogeneous linear equations over reals, where each equation contains at most three variables. Since the all-zero assignment always satisfies ...
  • Tsitsiklis, John N. (Elsevier, 2006-08)
    The unichain condition requires that every policy in an MDP result in a single ergodic class, and guarantees that the optimal average cost is independent of the initial state. We show that checking whether the unichain ...
  • Ahmadi, Amir Ali; Olshevsky, Alexander; Parrilo, Pablo A.; Tsitsiklis, John N. (Springer-Verlag, 2011-11)
    We show that unless P = NP, there exists no polynomial time (or even pseudo-polynomial time) algorithm that can decide whether a multivariate polynomial of degree four (or higher even degree) is globally convex. This solves ...
  • Jaenisch, Rudolf (Elsevier, 2012-12)
    This year’s Nobel Prize in Physiology or Medicine was awarded to John Gurdon and Shinya Yamanaka for solving key problems of biology. Their work provided fundamental insights into how an egg gives rise to a complex organism ...
  • Detmold, William; Orginos, Kostas (American Physical Society, 2013-06)
    We consider the problem of calculating the large number of Wick contractions necessary to compute states with the quantum numbers of many baryons in lattice QCD. We consider a constructive approach and a determinant-based ...
  • Poggio, M.; Mamin, H. J.; Degen, Christian; Sherwood, M. H.; Rugar, D. (American Physical Society, 2009-02)
    We demonstrate nuclear double resonance for nanometer-scale volumes of spins where random fluctuations rather than Boltzmann polarization dominate. When the Hartmann-Hahn condition is met in a cross-polarization experiment, ...
  • Dooley, Alison L.; Winslow, Monte Meier; Chiang, Derek Y.; Banerji, Shantanu; Stransky, Nicolas; Dayton, Talya Lucia; Snyder, Eric; Senna, Stephanie; Whittaker, Charles A.; Bronson, Roderick T.; Crowley, Denise G.; Barretina, Jordi; Garraway, Levi A.; Meyerson, Matthew L.; Jacks, Tyler E. (Cold Spring Harbor Laboratory Press in association with The Genetics Society, 2011-10)
    Small cell lung cancer (SCLC) is an aggressive cancer often diagnosed after it has metastasized. Despite the need to better understand this disease, SCLC remains poorly characterized at the molecular and genomic levels. ...
  • Russo, Scott J.; Wilkinson, Matthew B.; Mazei-Robison, Michelle S.; Dietz, David M.; Maze, Ian; Krishnan, Vaishnav; Rentha, William; Graham, Ami; Birnbaum, Shari G.; Green, Thomas A.; Robison, Bruce; Lesselyong, Alan; Perrotti, Linda I.; Bolaños, Carlos A.; Kumar, Arvind; Clark, Michael S.; Neumaier, John F.; Bhakar, Asha L.; Barker, Philip A.; Nestler, Eric J.; Neve, Rachael L. (Society for Neuroscience, 2009-03)
    Although chronic cocaine-induced changes in dendritic spines on nucleus accumbens (NAc) neurons have been correlated with behavioral sensitization, the molecular pathways governing these structural changes, and their ...
  • Gerardi, Craig; Cory, David G.; Buongiorno, Jacopo; Hu, Lin-Wen; McKrell, Thomas J. (American Institute of Physics, 2009-12)
    Layering of water molecules on the surface of alumina nanoparticles in an alumina/water nanofluid is studied using nuclear magnetic resonance (NMR). The data suggest that a thin ordered layer ( ∼ 1.4 nm) of water molecules ...
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