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Browsing MIT Open Access Articles by Title

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  • Lippard, Stephen J.; Song, Woon Ju (American Chemical Society, 2011-05)
    Site-directed mutagenesis studies of a strictly conserved T201 residue in the active site of toluene/o-xylene monooxygenase hydroxylase (ToMOH) revealed that a single mutation can facilitate kinetic isolation of two ...
  • Chen, Jingyang; Ghorai, Manas K.; Kenney, Grace; Stubbe, JoAnne (Oxford University Press (OUP), 2008-05)
    The bleomycins (BLMs) are a family of natural glycopeptides used clinically as antitumor agents. In the presence of required cofactors (Fe[superscript 2+] and O[subscript 2]), BLM causes both single-stranded (ss) and ...
  • Strieter, Eric R.; Bhayana, Brijesh; Buchwald, Stephen Leffler (American Chemical Society (ACS), 2008-12)
    The copper-catalyzed N-arylation of amides, i.e., the Goldberg reaction, is an efficient method for the construction of products relevant to both industry and academic settings. Herein, we present mechanistic details ...
  • Kagey, Michael H.; Newman, Jamie J.; Bilodeau, Steve; Zhan, Ye; Orlando, David A.; van Berkum, Nynke L.; Ebmeier, Christopher C.; Goossens, Jesse; Rahl, Peter B.; Levine, Stuart S.; Taatjes, Dylan J.; Dekker, Job; Young, Richard A. (Nature Publishing Group, 2010-08)
    Transcription factors control cell-specific gene expression programs through interactions with diverse coactivators and the transcription apparatus. Gene activation may involve DNA loop formation between enhancer-bound ...
  • Finkelstein, Amy; Taubman, Sarah L.; Allen, Heidi L.; Wright, Bill J.; Baicker, Katherine (American Association for the Advancement of Science (AAAS), 2014-01)
    In 2008, Oregon initiated a limited expansion of a Medicaid program for uninsured, low-income adults, drawing names from a waiting list by lottery. This lottery created a rare opportunity to study the effects of Medicaid ...
  • Clifford, Gari D.; Blaya, Joaquin Andres; Hall-Clifford, Rachel; Fraser, Hamish S. (BioMed Central Ltd., 2008-06)
  • Romero, R.; Emanuel, Kerry Andrew (American Geophysical Union, 2013-06)
    Medicanes or “Mediterranean hurricanes” are extreme cyclonic windstorms morphologically and physically similar to tropical cyclones. Owing to their potential destructiveness on the islands and continental coastal zones, ...
  • Engelhardt, Gary V.; Gruber, Jonathan (American Economic Association, 2011-11)
    We examine the impact of the expansion of public prescription-drug insurance coverage from Medicare Part D and find evidence of substantial crowd-out. Using the 2002-2007 waves of the Medical Expenditure Panel Survey, we ...
  • D'Eramo, Francesco; Liu, Hong; Rajagopal, Krishna (IOP Publishing, 2011-11)
    The propagation of hard partons through the strongly interacting matter created in high-energy heavy-ion collisions involves widely separated scales. The methods of effective field theories can provide a factorized description ...
  • Oskooi, Ardavan; Roundy, David; Ibanescu, Mihai; Bermel, Peter A.; Joannopoulos, John D.; Johnson, Steven G. (Elsevier, 2009-11)
    This paper describes Meep, a popular free implementation of the finite-difference time-domain (FDTD) method for simulating electromagnetism. In particular, we focus on aspects of implementing a full-featured FDTD package ...
  • Miller, Matthew P.; Unal, Elcin; Brar, Gloria A.; Amon, Angelika B. (eLife Sciences Publications, Ltd., 2012-12)
    During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain ...
  • Chisholm, Jennifer; Hawley, R. Scott; Orr-Weaver, Terry L.; Whitfield, Zachary James (Public Library of Science, 2013-09)
    Oocytes are stockpiled with proteins and mRNA that are required to drive the initial mitotic divisions of embryogenesis. But are there proteins specific to meiosis whose levels must be decreased to begin embryogenesis ...
  • Lander, Eric S.; Berger, Michael F.; Hodis, Eran; Heffernan, Timothy P.; Deribe, Yonathan Lissanu; Lawrence, Michael S.; Protopopov, Alexei; Ivanova, Elena; Watson, Ian R.; Nickerson, Elizabeth; Ghosh, Papia; Zhang, Hailei; Zeid, Rhamy; Ren, Xiaojia; Cibulskis, Kristian; Sivachenko, Andrey Y.; Wagle, Nikhil; Sucker, Antje; Sougnez, Carrie; Onofrio, Robert (Nature Publishing Group, 2012-05)
    Melanoma is notable for its metastatic propensity, lethality in the advanced setting and association with ultraviolet exposure early in life. To obtain a comprehensive genomic view of melanoma in humans, we sequenced the ...
  • Gregg, Patricia M.; Behn, M. D.; Lin, J.; Grove, Timothy L. (American Geophysical Union (AGU), 2009-11)
    We examine mantle melting, fractional crystallization, and melt extraction beneath fast slipping, segmented oceanic transform fault systems. Three-dimensional mantle flow and thermal structures are calculated using a ...
  • Till, Christy B.; Grove, Timothy L.; Krawczynski, Michael J. (American Geophysical Union (AGU), 2012-06)
    Here we develop a lherzolite melting model and explore the effects of variations in mantle composition, pressure, temperature, and H[subscript 2]O content on melt composition. New experiments and a compilation of experimental ...
  • Choi, Philip S.; Zakhary, Lisa; Choi, Wen-Yee; Caron, Sophie; Alvarez-Saavedra, Ezequiel; Miska, Eric A.; McManus, Mike; Harfe, Brian; Giraldez, Antonio J.; Horvitz, H. Robert; Schier, Alexander F.; Dulac, Catherine (Elsevier B.V., 2008-01)
    MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs ...
  • Leksa, Nina Carolina; Schwartz, Thomas (Landes Bioscience, 2010-07)
    The nuclear pore complex (NPC) regulates all traffic between the cytoplasm and the nucleus. It is a large protein assembly composed of multiple copies of ~30 nucleoporins (nups). Structural studies of the NPC have been ...
  • Lis, Mieszko; Shim, Keun Sup; Cho, Myong Hyon; Devadas, Srinivas (Institute of Electrical and Electronics Engineers (IEEE), 2011-11)
    As we enter an era of exascale multicores, the question of efficiently supporting a shared memory model has become of paramount importance. On the one hand, programmers demand the convenience of coherent shared memory; on ...
  • Shepherd, Jason Dennis (Frontiers Research Foundation, 2012-04)
    Experience shapes and molds the brain throughout life.These changes in neuronal circuits are produced by a myriad of molecular and cellular processes. Simplistically, circuits are modified through changes in neurotransmitter ...
  • Qin, Qi; Reno, John L.; Hu, Qing (Optical Society of America, 2011-02)
    We demonstrate continuous tuning of a terahertz quantum cascade wire laser over a broad range of ~ 330 GHz ( ~ 8.6% of the 3.85 THz center frequency) with single-mode operation. Tuning is achieved with a narrow laser ridge ...
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