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Browsing MIT Open Access Articles by Title

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  • Wendler, Petra; Shorter, James; Snead, David; Plisson, Celia; Clare, Daniel K.; Saibil, Helen R.; Lindquist, Susan (Elsevier, 2009-04)
    The protein-remodeling machine Hsp104 dissolves amorphous aggregates as well as ordered amyloid assemblies such as yeast prions. Force generation originates from a tandem AAA+ (ATPases associated with various cellular ...
  • Kim, Yong Baek; Paramekanti, Arun; Senthil, Todadri; Podolsky, Daniel (American Physical Society, 2009-05)
    We study a bandwidth controlled Mott metal-insulator transition (MIT) from a Fermi-liquid metal to a quantum spin-liquid insulator in three dimensions. Using a slave rotor approach including gauge fluctuations, we obtain ...
  • Zhang, Qing; Menon, Rajasree; Wang, Hong; Bardeesy, Nabeel; Dinulescu, Daniela; Kucherlapati, Raju; Politi, Katerina; Aebersold, Ruedi; Jacks, Tyler E.; Deutsch, Eric W.; Pitteri, Sharon J.; Faca, Vitor M.; Newcomb, Lisa F.; DePinho, Ronald A.; Hung, Kenneth E.; Omenn, Gilbert S.; States, David J.; Hanash, Samir M. (BioMed Central Ltd, 2008-06)
    We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of 13,779 distinct peptides have ...
  • Ringgaard, Simon; van Zon, Jeroen Sebastiaan; Howard, Martin; Gerdes, Kenn (National Academy of Sciences, 2009-11)
    Bacterial plasmids encode partitioning (par) loci that confer stable plasmid inheritance. We showed previously that, in the presence of ParB and parC encoded by the par2 locus of plasmid pB171, ParA formed cytoskeletal-like ...
  • Edwards, Dylan J; Dipietro, Laura; Demirtas-Tatlidede, Asli; Medeiros, Ana H; Thickbroom, Gary W; Mastaglia, Francis L; Pascual-Leone, Alvaro; Krebs, Hermano Igo (BioMed Central Ltd, 2014-03)
    Background: A peripheral nerve stimulus can enhance or suppress the evoked response to transcranial magnetic stimulation (TMS) depending on the latency of the preceding peripheral nerve stimulation (PNS) pulse. Similarly, ...
  • Lemon, Katherine P.; Grossman, Alan D. (Elsevier, 2000-12)
    We found that DNA is replicated at a central stationary polymerase, and each replicated region moves away from the replisome. In Bacillus subtilis, DNA polymerase is predominantly located at or near midcell. When replication ...
  • Hainmueller, Jens; Eggers, Andrew C. (Cambridge University Press, 2009-10)
    Many recent studies show that firms profit from connections to influential politicians, but less is known about how much politicians financially benefit from wielding political influence. We estimate the returns to serving ...
  • Atanasijevic, Tatjana; Zhang, Xiao-an; Lippard, Stephen J.; Jasanoff, Alan Pradip (American Chemical Society, 2010-03)
    We introduce a mechanism for ion sensing by MRI in which analytes compete with paramagnetic ions for binding to polydentate chelating agents. Displacement of the paramagnetic ions results in alteration of solvent interaction ...
  • McKinley, Gareth H.; Zimoch, Pawel Jerzy; Hosoi, Anette E. (American Physical Society, 2013-07)
    Using discontinuously rate thickening suspensions (DRTS) as a model system, we show that beads-on-a-string morphologies can arise as a result of external viscous drag acting during capillary-driven breakup of a non-Newtonian ...
  • Hoque, Mohammed Ehsan; Picard, Rosalind W.; McDuff, Daniel Jonathan; Hoque, Mohammed Ehasanul (Institute of Electrical and Electronics Engineers (IEEE), 2012-04)
    We create two experimental situations to elicit two affective states: frustration, and delight. In the first experiment, participants were asked to recall situations while expressing either delight or frustration, while ...
  • Williams, Michael (American Physical Society, 2013-05)
    Using pp collision data corresponding to an integrated luminosity of 1.0  fb[superscript -1] and collected by LHCb in 2011 at a center-of-mass energy of 7 TeV, we report the measurement of direct CP violation in Bs0→K[superscript ...
  • Wetzstein, Gordon; Raskar, Ramesh; Heidrich, Wolfgang (Institute of Electrical and Electronics Engineers (IEEE), 2011-04)
    We introduce a new approach to capturing refraction in transparent media, which we call Light Field Background Oriented Schlieren Photography (LFBOS). By optically coding the locations and directions of light rays emerging ...
  • Chen, Ying; Schuh, Christopher A.; Ueland, Stian Melhus (Wiley Blackwell, 2012-03)
    Copper-based shape memory alloys (SMAs) exhibit excellent shape memory properties in single crystalline form. However, when they are polycrystalline, their shape memory properties are severely compromised by brittle fracture ...
  • Taylor, Frank E. (American Physical Society, 2013-06)
    A search for resonant diboson production using a data sample corresponding to 4.7  fb[superscript -1] of integrated luminosity collected by the ATLAS experiment at the Large Hadron Collider in pp collisions at √s=7  TeV ...
  • Lange, Julian; Skaletsky, Helen; Bell, George W.; Page, David C. (Oxford University Press (OUP), 2007-10)
    Y chromosome deletions arise frequently in human populations, where they cause sex reversal and Turner syndrome and predispose individuals to infertility and germ cell cancer. Knowledge of the nucleotide sequence of the ...
  • Efeyan, Alejo; Sabatini, David M. (Elsevier, 2009-04)
    The mammalian target of rapamycin (mTOR) is a master regulator of cell growth and division that responds to a variety of stimuli, including nutrient, energy, and growth factors. In the last years, a significant number of ...
  • Sabatini, David M.; Laplante, Mathieu (National Academy of Sciences, 2010-02)
    Insulin resistance, which is defined as the inability of insulin to promote efficient glucose uptake by peripheral tissues, is a metabolic condition associated with obesity, type 2 diabetes, dyslipidemia, and cardiovascular ...
  • Yilmaz, Omer H.; Katajisto, Pekka; Lamming, Dudley W.; Gultekin, Yetis; Bauer-Rowe, Khristian E.; Sengupta, Shomit; Birsoy, Kivanc; Dursun, Abdulmetin; Yilmaz, V. Onur; Selig, Martin; Nielson, G. Petur; Mino-Kenudson, Mari; Zuckerberg, Lawrence; Bahn, Atul; Deshpande, Vikram; Sabatini, David M. (Nature Publishing Group, 2012-05)
    How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment ...
  • Cervantes, Christopher L.; Lim, Daniel Cham-Chin; Yaffe, Michael B.; Sabatini, David M.; Kang, Seong A.; Pacold, Michael E.; Lou, Hua Jane; Ottina, Kathleen; Gray, Nathanael S.; Turk, Benjamin E. (American Association for the Advancement of Science (AAAS), 2013-07)
    The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) protein kinase promotes growth and is the target of rapamycin, a clinically useful drug that also prolongs life span in model organisms. A persistent mystery ...
  • Kang, Seong A.; Pacold, Michael E.; Cervantes, Christopher L.; Lim, Daniel Cham-Chin; Ottina, Kathleen; Yaffe, Michael B.; Sabatini, David M.; Lou, Hua Jane; Gray, Nathanael S.; Turk, Benjamin E. (American Association for the Advancement of Science (AAAS), 2013-07)
    The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) protein kinase promotes growth and is the target of rapamycin, a clinically useful drug that also prolongs life span in model organisms. A persistent mystery ...
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