Browsing MIT Open Access Articles by Title
Now showing items 737-756 of 55765
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Activation of the p53 Transcriptional Program Sensitizes Cancer Cells to Cdk7 Inhibitors
(Elsevier, 2017-10)Cdk7, the CDK-activating kinase and transcription factor IIH component, is a target of inhibitors that kill cancer cells by exploiting tumor-specific transcriptional dependencies. However, whereas selective inhibition of ... -
Activation of the Yeast Hippo Pathway by Phosphorylation-Dependent Assembly of Signaling Complexes
(American Association for the Advancement of Science (AAAS), 2013-04)Scaffold-assisted signaling cascades guide cellular decision-making. In budding yeast, one such signal transduction pathway called the mitotic exit network (MEN) governs the transition from mitosis to the G1 phase of the ... -
Activation of tolerogenic dendritic cells in the tumor draining lymph CD8+ T cells engineered to express CD40 ligand
(The American Association of Immunologists, 2010-03)Tolerogenic dendritic cells in the tumor microenvironment can inhibit the generation and maintenance of robust antitumor T cell responses. In this study, we investigated the effects of local delivery of CD40L by tumor-reactive ... -
Active 2D materials for on-chip nanophotonics and quantum optics
(Walter de Gruyter, 2017-03)Two-dimensional materials have emerged as promising candidates to augment existing optical networks for metrology, sensing, and telecommunication, both in the classical and quantum mechanical regimes. Here, we review the ... -
Active aerodynamic drag reduction on morphable cylinders
(American Physical Society, 2017-12)We study a mechanism for active aerodynamic drag reduction on morphable grooved cylinders, whose topography can be modified pneumatically. Our design is inspired by the morphology of the Saguaro cactus (Carnegiea gigantea), ... -
Active and Passive Tuning of Ultranarrow Resonances in Polaritonic Nanoantennas
(Wiley, 2022-03)Optical nanoantennas are of great importance for photonic devices and spectroscopy due to their capability of squeezing light at the nanoscale and enhancing light-matter interactions. Among them, nanoantennas made of polar ... -
Active and weakening MJO events in the Maritime Continent
(Springer Berlin Heidelberg, 2021-03-05)Abstract To better understand the Madden–Julian Oscillation (MJO) in the Maritime Continent (MC), events from 1980 to 2019 were classified as active or weakening according to propagation characteristics and ... -
Active Asteroid (6478) Gault: A Blue Q-type Surface below the Dust?
(American Astronomical Society, 2019-08)We present near-infrared spectroscopy of the sporadically active asteroid (6478)Gault collected on the 3 m NASA/Infrared Telescope Facility observatory in late 2019 March/early April. Long-exposure imaging with the 0.5 m ... -
Active Asteroid (6478) Gault: A Blue Q-type Surface below the Dust?
© 2019. The American Astronomical Society. All rights reserved.. We present near-infrared spectroscopy of the sporadically active asteroid (6478)Gault collected on the 3 m NASA/Infrared Telescope Facility observatory in ... -
Active black holes: Relevant plasma structures, regimes and processes involving all phase space
(American Institute of Physics (AIP), 2011-03)The presented theory is motivated by the growing body of experimental information on the characteristics, connected with relevant spectral, time, and space resolutions, of the radiation emission from objects considered as ... -
Active boundary annotation using random MAP perturbations
(PLMR, 2014-04)We address the problem of efficiently annotating labels of objects when they are structured. Often the distribution over labels can be described using a joint potential function over the labels for which sampling is provably ... -
Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains
(Cold Spring Harbor Laboratory Press, 2015-10)Recent advances enabled by the Hi-C technique have unraveled many principles of chromosomal folding that were subsequently linked to disease and gene regulation. In particular, Hi-C revealed that chromosomes of animals are ... -
Active Clothing Material Perception Using Tactile Sensing and Deep Learning
(Institute of Electrical and Electronics Engineers (IEEE), 2018-09)Humans represent and discriminate the objects in the same category using their properties, and an intelligent robot should be able to do the same. In this paper, we build a robot system that can autonomously perceive the ... -
Active control of arousal by a locus coeruleus GABAergic circuit
(Springer Nature, 2019)© 2019, The Author(The Author(s), under exclusive licence to Springer Nature America, Inc. Arousal responses linked to locus coeruleus noradrenergic (LC-NA) activity affect cognition. However, the mechanisms that control ... -
Active control of arousal by a locus coeruleus GABAergic circuit
(Springer Nature, 2019)© 2019, The Author(The Author(s), under exclusive licence to Springer Nature America, Inc. Arousal responses linked to locus coeruleus noradrenergic (LC-NA) activity affect cognition. However, the mechanisms that control ... -
Active control of viscous fingering using electric fields
(Springer Science and Business Media LLC, 2019-09)Viscous fingering is a widely observed phenomenon, in which finger-like instabilities occur at the interface of two fluids, whenever a less viscous phase displaces a more viscous phase. This instability is notoriously ... -
Active dendritic integration and mixed neocortical network representations during an adaptive sensing behavior
(Springer Nature, 2018)© 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations ... -
Active dendritic integration and mixed neocortical network representations during an adaptive sensing behavior
(Springer Nature, 2018)© 2018, The Author(s), under exclusive licence to Springer Nature America, Inc. Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations ... -
Active Denial: Redesigning Japan's Response to China's Military Challenge
(MIT Press, 2018-05)The growth of Chinese military power poses significant challenges to Japan. China's military spending, which was half that of Japan's in 1996, is now three and a half times as large. Japan has taken a range of measures to ... -
An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase
(American Chemical Society (ACS), 2010-01)Escherichia coli class Ib ribonucleotide reductase (RNR) converts nucleoside 5′-diphosphates to deoxynucleoside 5′-diphosphates and is expressed under iron-limited and oxidative stress conditions. This RNR is composed of ...
