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Browsing MIT Open Access Articles by Title

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  • McCarren, Jay; Becker, Jamie William; Repeta, Daniel J.; Shi, Yanmei; Young, Curtis Robert, III; Malmstrom, Rex R.; Chisholm, Sallie (Penny); DeLong, Edward (National Academy of Sciences, 2010-08)
    Marine dissolved organic matter (DOM) contains as much carbon as the Earth's atmosphere, and represents a critical component of the global carbon cycle. To better define microbial processes and activities associated with ...
  • Faust, Karoline; Sathirapongsasuti, Jarupon; Izard, Jacques; Segata, Nicola; Gevers, Dirk; Raes, Jeroen; Huttenhower, Curtis (Public Library of Science, 2012-01)
    The healthy microbiota show remarkable variability within and among individuals. In addition to external exposures, ecological relationships (both oppositional and symbiotic) between microbial inhabitants are important ...
  • Kourtesi, Christina; Ball, Anthony R.; Huang, Ying-Ying; Jachak, Sanjay M.; Vera, D. Mariano A.; Khondkar, Proma; Gibbons, Simon; Hamblin, Michael R.; Tegos, George P. (Bentham Science, 2013-03)
    Conventional antimicrobials are increasingly ineffective due to the emergence of multidrug-resistance among pathogenic microorganisms. The need to overcome these deficiencies has triggered exploration for novel and ...
  • Stewart, Frank J.; Ulloa, Osvaldo; DeLong, Edward (Society for Applied Microbiology and Blackwell Publishing Ltd, 2012-01)
    Simultaneous characterization of taxonomic composition, metabolic gene content and gene expression in marine oxygen minimum zones (OMZs) has potential to broaden perspectives on the microbial and biogeochemical dynamics ...
  • Ulloa, Osvaldo; Canfield, Donald E.; DeLong, Edward; Letelier, Ricardo M.; Stewart, Frank J. (National Academy of Sciences (U.S.), 2012-09)
    Vast expanses of oxygen-deficient and nitrite-rich water define the major oxygen minimum zones (OMZs) of the global ocean. They support diverse microbial communities that influence the nitrogen economy of the oceans, ...
  • Poutahidis, Theofilos; Kleinewietfeld, Markus; Levkovich, Tatiana; Bhela, Siddheshvar; Chatzigiagkos, Antonis; Hafler, David A.; Alm, Eric J.; Erdman, Susan E.; Varian, Bernard; Ibrahim, Yassin; Lakritz, Jessica; Kearney, Sean Michael; Smillie, Chris Scott; Perrotta, Allison Rose (Public Library of Science, 2013-07)
    A recent epidemiological study showed that eating ‘fast food’ items such as potato chips increased likelihood of obesity, whereas eating yogurt prevented age-associated weight gain in humans. It was demonstrated previously ...
  • Poutahidis, Theofilos; Levkovich, Tatiana; Qi, Peimin; Chatzigiagkos, Antonis; Alm, Eric J.; Erdman, Susan E.; Kearney, Sean Michael; Varian, Bernard; Lakritz, Jessica; Ibrahim, Yassin (Public Library of Science, 2013-10)
    Wound healing capability is inextricably linked with diverse aspects of physical fitness ranging from recovery after minor injuries and surgery to diabetes and some types of cancer. Impact of the microbiome upon the mammalian ...
  • Luo, Ying; Qiu, Cheng-Wei; Liang, Xian-jiao; Li, Kai-ming; Zhang, Qun (Institute of Electrical and Electronics Engineers, 2010-04)
    The micro-Doppler (m-D) effect induced by the rotating parts or vibrations of the target provides a new approach for target recognition. To obtain high range resolution for the extraction of the fine m-D signatures of an ...
  • March, Sandra; Hui, Elliot E.; Underhill, Gregory; Khetani, Salman; Bhatia, Sangeeta N. (Wiley Blackwell, 2009-05)
    Liver sinusoidal endothelial cells (LSECs) differ, both structurally and functionally, from endothelial cells (ECs) lining blood vessels of other tissues. For example, in contrast to other ECs, LSECs possess fenestrations, ...
  • Umesh, Vaibhavi; Rape, Andrew D.; Ulrich, Theresa A.; Kumar, Sanjay (Public Library of Science, 2014-07)
    The aggressive and rapidly lethal brain tumor glioblastoma (GBM) is associated with profound tissue stiffening and genomic lesions in key members of the epidermal growth factor receptor (EGFR) pathway. Previous studies ...
  • Bow, Hansen; Pivkin, Igor V.; Diez Silva, Monica; Goldfless, Stephen Jacob; Dao, Ming; Niles, Jacquin; Suresh, Subra; Han, Jongyoon (Royal Society of Chemistry, 2011-02)
    Malaria resulting from Plasmodium falciparum infection is a major cause of human suffering and mortality. Red blood cell (RBC) deformability plays a major role in the pathogenesis of malaria. Here we introduce an automated ...
  • Gassend, Blaise; Velasquez-Garcia, Luis Fernando; Akinwande, Akintunde Ibitayo; Martinez-Sanchez, Manuel (Institute of Electrical and Electronics Engineers, 2009-06)
    This paper reports the design, fabrication, and experimental characterization of a fully microfabricated planar array of externally fed electrospray emitters that produces heavy molecular ions from the ionic liquids ...
  • Waits, Christopher Mike; McCarthy, Matthew; Ghodssi, Reza (Institute of Electrical and Electronics Engineers (IEEE), 2010-02)
    The development of a microfabricated turbopump that is capable of delivering liquid fuel with the flow rates and pressures required for portable power generation is reported. The device is composed of a spiral-groove viscous ...
  • Herskind, Peter F.; Wang, Shannon Xuanyue; Shi, Molu; Ge, Yufei; Cetina, Marko; Chuang, Isaac L. (Optical Society of America, 2011-08)
    A novel approach to optics integration in ion traps is demonstrated based on a surface electrode ion trap that is microfabricated on top of a dielectric mirror. Additional optical losses due to fabrication are found to be ...
  • Timotijevic, B.; Lockhart, R.; Stanley, R.; Luetzelschwab, M.; Zamkotsian, F.; Lanzoni, P.; Noell, W.; Tormen, M.; Canonica, Michael D. (Elsevier, 2012)
    We have fabricated and characterized a Fully Programmable Micro-Diffraction Grating (FPMDG) with 64 silicon micro-mirrors for spectral shaping in the visible and near-infrared wavelength range. The FPMDG arrays of 50 μm ...
  • Shin, Yoojin; Han, Sewoon; Jeon, Jessie S; Yamamoto, Kyoko; Zervantonakis, Ioannis K; Sudo, Ryo; Kamm, Roger Dale; Chung, Seok; Jeon, Jessie S.; Zervantonakis, Ioannis K. (Nature Publishing Group, 2012-06)
    This protocol describes a simple but robust microfluidic assay combining three-dimensional (3D) and two-dimensional (2D) cell culture. The microfluidic platform comprises hydrogel-incorporating chambers between surface-accessible ...
  • Lauffenburger, Douglas A.; Lee, Jeong Hoon; Han, Jongyoon; Cosgrove, Benjamin D. (American Chemical Society, 2009-07)
    In this paper, we reported a simple, disposable PDMS micro/nanofluidic preconcentration chip for in vitro concentration-enhanced cell kinase assays. Utilizing the preconcentration (electrokinetic trapping) directly from ...
  • Hou, Han Wei; Bhagat, Ali Asgar S.; Lee, Wong Cheng; Huang, Sha; Han, Jongyoon; Lim, Chwee Teck (MDPI AG, 2011-07)
    Blood, a complex biological fluid, comprises 45% cellular components suspended in protein rich plasma. These different hematologic components perform distinct functions in vivo and thus the ability to efficiently fractionate ...
  • Zervantonakis, Ioannis K.; Kothapalli, Chandrasekhar R.; Chung, Seok; Sudo, Ryo; Kamm, Roger Dale (American Institute of Physics (AIP), 2011-03)
    Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment ...
  • Matsudaira, Paul T.; Ryu, Sangjin; Thorsen, Todd A.; Nagai, M; Fujita, H (Institute of Electrical and Electronics Engineers, 2009-06)
    We demonstrate a microfluidic device to control the motion of Vorticella convallaria by changing solution. Floating cells of V. convallaria were injected and cultured inside the device. Approximately 35 cells of V. convallaria ...
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