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Browsing MIT Open Access Articles by Title

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  • Buti, Ludovico; Spooner, Eric; Van der Veen, Annemarthe G.; Rappuoli, Rino; Covacci, Antonello; Ploegh, Hidde (National Academy of Sciences, 2011-05)
    Type I strains of Helicobacter pylori (Hp) possess a pathogenicity island, cag, that encodes the effector protein cytotoxin-associated gene A (CagA) and a type four secretion system. After translocation into the host cell, ...
  • Burns, Monika; Muthupalani, Sureshkumar; Ge, Zhongming; Wang, Timothy C.; Cunningham, Catriona; Ennis, Kathleen; Georgieff, Michael; Fox, James G.; Bakthavatchalu, Vasu (Public Library of Science, 2015-11)
    Iron deficiency anemia (IDA) affects > 500 million people worldwide, and is linked to impaired cognitive development and function in children. Helicobacter pylori, a class 1 carcinogen, infects about half of the world’s ...
  • Peterson, Anthony J.; Menheniott, Trevelyan R.; O'Connor, Louise; Walduck, Anna K.; Fox, James G.; Kawakami, Kazuyuki; Minamoto, Toshinari; Ong, Eng Kok; Wang, Timothy C.; Judd, Louise M.; Giraud, Andrew S. (Elsevier, 2010-08)
    Background & Aims Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in the stomach. Tff1 deficiency results in gastric cancer, whereas Tff2 deficiency increases gastric inflammation. TFF2 expression ...
  • So, Peter T. C.; Bansil, Rama; Erramilli, Shyamsunder; McKinley, Gareth H.; Ewoldt, Randy H.; Kelly, Ciaran P.; Ghiran, Ionita; Keates, Sarah; Afdhal, Nezam H.; Turner, Bradley S.; Celli, Jonathan P. (United States National Academy of Sciences, 2009-08)
    The ulcer-causing gastric pathogen Helicobacter pylori is the only bacterium known to colonize the harsh acidic environment of the human stomach. H. pylori survives in acidic conditions by producing urease, which catalyzes ...
  • Bernstein, Jacob; Breiner, Christine Elaine (Walter de Gruyter, 2011-03)
    We show that for an embedded minimal disk in R[superscript 3], near points of large curvature the surface is bi-Lipschitz with a piece of a helicoid. Additionally, a simplified proof of the uniqueness of the helicoid is provided.
  • Burlaga, L. F.; Ness, N. F.; Decker, R. B.; Krimigis, S. M.; Richardson, John D. (IOP Publishing, 2016-02)
    We discuss magnetic field and plasma observations of the heliosheath made by Voyager 2 (V2) during 2012, when V2 was observing the effects of increasing solar activity following the solar minimum in 2009. The average ...
  • Fuselier, S. A.; Allegrini, F.; Bzowski, M.; Funsten, H. O.; Ghielmetti, A. G.; Gloeckler, G.; Heirtzler, D.; Janzen, Paul H.; Kubiak, M. A.; Kucharek, Harald; McComas, David J.; Mobius, Eberhard; Moore, T. E.; Petrinec, S. M.; Quinn, M.; Reisenfeld, D.; Saul, L. A.; Scheer, J. A.; Schwadron, N.; Trattner, K. J.; Wurz, P.; Vanderspek, Roland K. (IOP Publishing, 2012-06)
    Since 2008 December, the Interstellar Boundary Explorer (IBEX) has been making detailed observations of neutrals from the boundaries of the heliosphere using two neutral atom cameras with overlapping energy ranges. The ...
  • Narayan, G. Prakash; Lienhard, John H.; Zubair, Syed M.; McGovern, Ronan Killian (ASME International, 2011-11)
    A promising technology for small scale seawater desalination is the humidification dehumidification (HDH) system. This technology has been widely investigated in recent years. Since existing HDH systems have very high ...
  • Hu, Renyu; Seager, Sara; Yung, Yuk L. (IOP Publishing, 2015-06)
    Warm Neptune- and sub-Neptune-sized exoplanets in orbits smaller than Mercury's are thought to have experienced extensive atmospheric evolution. Here we propose that a potential outcome of this atmospheric evolution is the ...
  • Wu, Kevin; Kamil, Shoaib; Ragan-Kelley, Jonathan; Paris, Sylvain; Zhao, Qin; Mendis, Thirimadura C. Yasend; Bosboom, Jeffrey William; Amarasinghe, Saman P. (Association for Computing Machinery (ACM), 2015-06)
    Highly optimized programs are prone to bit rot, where performance quickly becomes suboptimal in the face of new hardware and compiler techniques. In this paper we show how to automatically lift performance-critical stencil ...
  • Ashenberg, Orr; Keating, Amy E.; Laub, Michael T. (Elsevier, 2013-01)
    Bacteria frequently use two-component signal transduction pathways to sense and respond to environmental and intracellular stimuli. Upon receipt of a stimulus, a homodimeric sensor histidine kinase autophosphorylates and ...
  • Oelker, Abigail M.; Morey, Shannon M.; Griffith, Linda G.; Hammond, Paula T. (Royal Society of Chemistry, 2012-09)
    As a platform for investigating the individual effects of substrate stiffness, permeability, and ligand density on cellular behavior, we developed a set of hydrogels with stiffness tuned by polymer backbone rigidity, ...
  • Whary, Mark T.; Muthupalani, Sureshkumar; Ge, Zhongming; Feng, Yan; Lofgren, Jennifer L.; Shi, Hai Ning; Taylor, Nancy S.; Correa, Pelayo; Versalovic, James; Wang, Timothy C.; Fox, James G. (Elsevier, 2014-02)
    Higher prevalence of helminth infections in Helicobacter pylori infected children was suggested to potentially lower the life-time risk for gastric adenocarcinoma. In rodent models, helminth co-infection does not reduce ...
  • Agrawal, Kunal; Leiserson, Charles E.; Sukha, Jim (Association for Computing Machinery / ACM Special Interest Group on Programming Languages., 2010-01)
    Helper locks allow programs with large parallel critical sections, called parallel regions, to execute more efficiently by enlisting processors that might otherwise be waiting on the helper lock to aid in the execution ...
  • Ullman, Tomer David; Tenenbaum, Joshua B.; Baker, Christopher Lawrence; Macindoe, Owen; Evans, Owain Rhys; Goodman, Noah D. (Neural Information Processing Systems Foundation, 2009-12)
    Everyday social interactions are heavily influenced by our snap judgments about others’ goals. Even young infants can infer the goals of intentional agents from observing how they interact with objects and other agents ...
  • Hensley, Scott E.; Das, Suman R.; Bailey, Adam L.; Schmidt, Loren M.; Hickman, Heather D.; Bennink, Jack R.; Yewdell, Jonathan W.; Jayaraman, Akila; Viswanathan, Karthik; Raman, Rahul; Sasisekharan, Ram (American Association for the Advancement of Science, 2009-10)
    Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza vaccine. Neutralizing ...
  • Chen, Hsieh; Angerer, Jennifer I.; Napoleone, Marina; Reininger, Armin J.; Schneider, Stefan W.; Wixforth, Achim; Schneider, Matthias F.; Alexander-Katz, Alfredo (American Institute of Physics (AIP), 2013-12)
    Primary hemostasis and blood clotting is known to be influenced by the red blood cell volume fraction (hematocrit) in blood. Depressed or elevated levels of red blood cells can lead to vascular perfusion problems ranging ...
  • Mukaigawa, Yasuhiro; Tagawa, Seiichi; Kim, Jaewon; Raskar, Ramesh; Matsushita, Yasuyuki; Yagi, Yasushi (Springer, 2010-11)
    We propose a new imaging method called hemispherical confocal imaging to clearly visualize a particular depth in a 3-D scene. The key optical component is a turtleback reflector which is a specially designed polyhedral ...
  • Benevento, Emilia; Djebbari, Abdelghani; Cecere, Renzo; Kadem, Lyes; Keshavarz Motamed, Zahra (Public Library of Science, 2015-04)
    Aortic valve bypass (AVB) has been shown to be a viable solution for patients with severe aortic stenosis (AS). Under this circumstance, the left ventricle (LV) has a double outlet. The objective was to develop a mathematical ...
  • Weinberg, Eli J.; Mack, Peter J.; Shoen, Frederick J.; Garcia-Cardena, Guillermo; Kaazempur Mofrad, Mohammad R. (Springer Science + Business Media B.V., 2010-01)
    The regulation of valvular endothelial phenotypes by the hemodynamic environments of the human aortic valve is poorly understood. The nodular lesions of calcific aortic stenosis (CAS) develop predominantly beneath the ...
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