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Browsing MIT Open Access Articles by Title

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  • Wilson, Justin J.; Lippard, Stephen J. (American Chemical Society (ACS), 2012-05)
    Five cationic platinum(II) complexes of general formula, [Pt(NH[subscript 3])[subscript 2](β-diketonate)]X are reported, where X is a noncoordinating anion and β-diketonate = acetylacetonate (acac), 1,1,1,-trifluoroacetylacetonate ...
  • Matthews, Jonathan; Chang, Philip H.; Niroui, Farnaz; Severgnini, Mariano; Whitehead, Kathryn Ann; Dorkin, Joseph Robert; Anderson, Daniel Griffith (American Chemical Society (ACS), 2012-07)
    A significant challenge in the development of clinically viable siRNA delivery systems is a lack of in vitro–in vivo translatability: many delivery vehicles that are initially promising in cell culture do not retain efficacy ...
  • Park, Young K.; Tu, Ting-Yuan; Lim, Sei Hien; Clement, Ivan J. M.; Yang, Se Y.; Kamm, Roger Dale (Springer-Verlag, 2013-12)
    This paper presents in vitro microvascular network formation within 3D gel scaffolds made from different concentrations of type-I collagen, fibrin, or a mixture of collagen and fibrin, using a simple microfluidic platform. ...
  • Jeon, Jessie S.; Zervantonakis, Ioannis; Chung, Seok; Kamm, Roger Dale (Public Library of Science, 2013-02)
    Tumor cells that disseminate from the primary tumor and survive the vascular system can eventually extravasate across the endothelium to metastasize at a secondary site. In this study, we developed a microfluidic system ...
  • Soldatow, Valerie Y.; LeCluyse, Edward L.; Griffith, Linda G.; Rusyn, Ivan (Royal Society of Chemistry, 2013)
    Over the years, various liver-derived in vitro model systems have been developed to enable investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices, isolated microsomes, perfused liver, ...
  • Artzi, Natalie; Oliva, Nuria; Puron, Cristina; Shitreet, Sagi; bon Ramos, Adriana; Artzi, Shay; Groothuis, Adam; Sahagian, Gary; Edelman, Elazer R. (Nature Publishing Group, 2011-08)
    The design of erodible biomaterials relies on the ability to program the in vivo retention time, which necessitates real-time monitoring of erosion. However, in vivo performance cannot always be predicted by traditional ...
  • Gill, Thomas J.; Li, Guoan; Hosseini, Ali (Springer Japan, 2009-06)
    Background: The knowledge of in vivo anterior cruciate ligament (ACL) deformation is fundamental for understanding ACL injury mechanisms and for improving surgical reconstruction of the injured ACL. This study investigated ...
  • Iverson, Nicole M.; Barone, Paul W.; Shandell, Mia; Trudel, Laura J.; Sen, Selda; Sen, Fatih; Ivanov, Vsevolod; Atolia, Esha; Farias, Edgardo; McNicholas, Thomas P.; Reuel, Nigel; Parry, Nicola M. A.; Wogan, Gerald N.; Strano, Michael S. (Nature Publishing Group, 2013-11)
    Single-walled carbon nanotubes are particularly attractive for biomedical applications, because they exhibit a fluorescent signal in a spectral region where there is minimal interference from biological media. Although ...
  • Chen, Yi; Hunter, Ian (Institute of Electrical and Electronics Engineers, 2009-11)
    This paper describes an indentometer device used to identify the linear dynamic and nonlinear properties of skin and underlying tissue using an in vivo test. The device uses a Lorentz force actuator to apply a dynamic force ...
  • Zhou, Penghui; Shaffer, Donald R.; Alvarez Arias, Diana A.; Nakazaki, Yukoh; Pos, Wouter; Torres, Alexis J.; Cremasco, Viviana; Dougan, Stephanie K.; Cowley, Glenn S.; Elpek, Kutlu; Brogdon, Jennifer; Lamb, John; Turley, Shannon J.; Ploegh, Hidde; Root, David E.; Love, J. Christopher; Dranoff, Glenn; Hacohen, Nir; Cantor, Harvey; Wucherpfennig, Kai W. (Nature Publishing Group, 2014-01)
    Recent clinical trials showed that targeting of inhibitory receptors on T cells induces durable responses in a subset of cancer patients, despite advanced disease. However, the regulatory switches controlling T-cell function ...
  • Danino, Tal; Lo, Justin H.; Prindle, Arthur; Hasty, Jeff; Bhatia, Sangeeta N. (American Chemical Society (ACS), 2012-09)
    The engineering of bacteria to controllably deliver therapeutics is an attractive application for synthetic biology. While most synthetic gene networks have been explored within microbes, there is a need for further ...
  • Massimini, Daniel Frank; Boyer, Patrick J.; Papannagari, Ramprasad; Gill, Thomas J.; Warner, Jon P.; Li, Guoan (Biomed Central Ltd., 2012-06)
    Study Design: Basic Science. To investigate humeral head translations and glenohumeral ligament elongation with a dual fluoroscopic imaging system. Background: The glenohumeral ligaments are partially responsible for ...
  • Lee, Taekwan; Zhang, Xiao-an; Dhar, Shanta; Faas, Henryk; Lippard, Stephen J.; Jasanoff, Alan Pradip (Elsevier B.V., 2010-06)
    Magnetic resonance imaging (MRI) with molecular probes offers the potential to monitor physiological parameters with comparatively high spatial and temporal resolution in living subjects. For detection of intracellular ...
  • Lee, Taekwan; Zhang, Xiao-an; Dhar, Shanta; Faas, Henryk; Lippard, Stephen J.; Jasanoff, Alan Pradip (Elsevier, 2010-06)
    Magnetic resonance imaging (MRI) with molecular probes offers the potential to monitor physiological parameters with comparatively high spatial and temporal resolution in living subjects. For detection of intracellular ...
  • Penman, Sheldon; Hoffman, Robert M.; Fujiwara, Toshiyoshi; Tanaka, Noriaki; Urata, Yasuo; Hayashi, Katsuhiro; Zhao, Ming; Kishimoto, Hiroyuki (United States National Academy of Sciences, 2009-08)
    Cancer surgery requires the complete and precise identification of malignant tissue margins including the smallest disseminated lesions. Internal green fluorescent protein (GFP) fluorescence can intensely illuminate even ...
  • Yan, Jie; Kang, Yuzhan; Xu, Shuoyu; Ong, Lee-Ling S.; Zhuo, Shuangmu; Bunte, Ralph M; Chen, Nanguang; Wanless, Ian R.; Yu, Hanry; Asada, Harry; So, Peter T. C. (SPIE, 2014-11)
    Microcirculation lesion is a common symptom of chronic liver diseases in the form of vasculature deformation and circulation alteration. In acute to chronic liver diseases such as biliary atresia, microcirculation lesion ...
  • Wyatt, John L.; Mendoza, Oscar D.; Kelly, Shawn K.; Doyle, Patrick S.; Shire, Douglas B.; Gingerich, Marcus D.; Chen, Jinghua; Cogan, Stuart F.; Drohan, William A.; Theogarajan, Luke; Rizzo, Joseph F. (SPIE, 2010-02)
    This presentation concerns the engineering development of the Boston visual prosthesis for restoring useful vision to patients blind with degenerative retinal disease. A miniaturized, hermetically-encased, 15-channel ...
  • Sidor, Michelle M.; Davidson, Thomas J.; Warden, Melissa R.; Diesseroth, Karl; McClung, Colleen A.; Tye, Kay (MyJoVE Corporation, 2015-01)
    The ability to probe defined neural circuits in awake, freely-moving animals with cell-type specificity, spatial precision, and high temporal resolution has been a long sought tool for neuroscientists in the systems-level ...
  • Chan, Juliana Maria; Rhee, June-Wha; Drum, Chester L.; Bronson, Roderick T.; Golomb, Gershon; Langer, Robert; Farokhzad, Omid C. (National Academy of Sciences, 2011-11)
    Following recent successes with percutaneous coronary intervention (PCI) for treating coronary artery disease (CAD), many challenges remain. In particular, mechanical injury from the procedure results in extensive endothelial ...
  • Wirth, Dyann; Daily, Johanna; Winzeler, Elizabeth; Mesirov, Jill P.; Regev, Aviv (National Academy of Sciences, 2009-07)
    Lemieux et al. (1) describe a reanalysis of our in vivo Plasmodium falciparum patient samples (2), supporting many of our conclusions (exclusive presence of rings, lack of distinct asexual phases in the clusters, a relation ...
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