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Browsing MIT Open Access Articles by Title

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  • Umesh, Vaibhavi; Rape, Andrew D.; Ulrich, Theresa A.; Kumar, Sanjay (Public Library of Science, 2014-07)
    The aggressive and rapidly lethal brain tumor glioblastoma (GBM) is associated with profound tissue stiffening and genomic lesions in key members of the epidermal growth factor receptor (EGFR) pathway. Previous studies ...
  • Bow, Hansen; Pivkin, Igor V.; Diez Silva, Monica; Goldfless, Stephen Jacob; Dao, Ming; Niles, Jacquin; Suresh, Subra; Han, Jongyoon (Royal Society of Chemistry, 2011-02)
    Malaria resulting from Plasmodium falciparum infection is a major cause of human suffering and mortality. Red blood cell (RBC) deformability plays a major role in the pathogenesis of malaria. Here we introduce an automated ...
  • Gassend, Blaise; Velasquez-Garcia, Luis Fernando; Akinwande, Akintunde Ibitayo; Martinez-Sanchez, Manuel (Institute of Electrical and Electronics Engineers, 2009-06)
    This paper reports the design, fabrication, and experimental characterization of a fully microfabricated planar array of externally fed electrospray emitters that produces heavy molecular ions from the ionic liquids ...
  • Waits, Christopher Mike; McCarthy, Matthew; Ghodssi, Reza (Institute of Electrical and Electronics Engineers (IEEE), 2010-02)
    The development of a microfabricated turbopump that is capable of delivering liquid fuel with the flow rates and pressures required for portable power generation is reported. The device is composed of a spiral-groove viscous ...
  • Herskind, Peter F.; Wang, Shannon Xuanyue; Shi, Molu; Ge, Yufei; Cetina, Marko; Chuang, Isaac L. (Optical Society of America, 2011-08)
    A novel approach to optics integration in ion traps is demonstrated based on a surface electrode ion trap that is microfabricated on top of a dielectric mirror. Additional optical losses due to fabrication are found to be ...
  • Timotijevic, B.; Lockhart, R.; Stanley, R.; Luetzelschwab, M.; Zamkotsian, F.; Lanzoni, P.; Noell, W.; Tormen, M.; Canonica, Michael D. (Elsevier, 2012)
    We have fabricated and characterized a Fully Programmable Micro-Diffraction Grating (FPMDG) with 64 silicon micro-mirrors for spectral shaping in the visible and near-infrared wavelength range. The FPMDG arrays of 50 μm ...
  • Shin, Yoojin; Han, Sewoon; Jeon, Jessie S; Yamamoto, Kyoko; Zervantonakis, Ioannis K; Sudo, Ryo; Kamm, Roger Dale; Chung, Seok; Jeon, Jessie S.; Zervantonakis, Ioannis K. (Nature Publishing Group, 2012-06)
    This protocol describes a simple but robust microfluidic assay combining three-dimensional (3D) and two-dimensional (2D) cell culture. The microfluidic platform comprises hydrogel-incorporating chambers between surface-accessible ...
  • Lauffenburger, Douglas A.; Lee, Jeong Hoon; Han, Jongyoon; Cosgrove, Benjamin D. (American Chemical Society, 2009-07)
    In this paper, we reported a simple, disposable PDMS micro/nanofluidic preconcentration chip for in vitro concentration-enhanced cell kinase assays. Utilizing the preconcentration (electrokinetic trapping) directly from ...
  • Hou, Han Wei; Bhagat, Ali Asgar S.; Lee, Wong Cheng; Huang, Sha; Han, Jongyoon; Lim, Chwee Teck (MDPI AG, 2011-07)
    Blood, a complex biological fluid, comprises 45% cellular components suspended in protein rich plasma. These different hematologic components perform distinct functions in vivo and thus the ability to efficiently fractionate ...
  • Zervantonakis, Ioannis K.; Kothapalli, Chandrasekhar R.; Chung, Seok; Sudo, Ryo; Kamm, Roger Dale (American Institute of Physics (AIP), 2011-03)
    Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment ...
  • Matsudaira, Paul T.; Ryu, Sangjin; Thorsen, Todd A.; Nagai, M; Fujita, H (Institute of Electrical and Electronics Engineers, 2009-06)
    We demonstrate a microfluidic device to control the motion of Vorticella convallaria by changing solution. Floating cells of V. convallaria were injected and cultured inside the device. Approximately 35 cells of V. convallaria ...
  • Lewis, Christina L.; Lin, Yan; Yang, Cuixian; Manocchi, Amy K.; Yuet, Kai P.; Doyle, Patrick S.; Yi, Hyunmin (American Chemical Society, 2010-08)
    We demonstrate rapid microfluidic fabrication of hybrid microparticles composed of functionalized viral nanotemplates directly embedded in polymeric hydrogels. Specifically, genetically modified tobacco mosaic virus (TMV) ...
  • Vahey, Michael D.; Quiros Pesudo, Laia; Svensson, J. Peter; Samson, Leona D.; Voldman, Joel (Royal Society of Chemistry, 2013-04)
    Methods to analyze the intrinsic physical properties of cells – for example, size, density, rigidity, or electrical properties – are an active area of interest in the microfluidics community. Although the physical properties ...
  • Haggarty, Stephen; Norton, Stephanie; Samara, Chrysanthi; Gilleland, Cody Lee; Rohde, Christopher Benjamin; Yanik, Mehmet Fatih (Institute of Electrical and Electronics Engineers, 2009-11)
    Compound screening is a powerful tool to identify new therapeutic targets, drug leads, and elucidate the fundamental mechanisms of biological processes. We report here the results of the first in vivo small-molecule screens ...
  • Blagovic, Katarina; Kim, Lily Y.; Voldman, Joel (Public Library of Science, 2011-08)
    Background Autocrine & paracrine signaling are widespread both in vivo and in vitro, and are particularly important in embryonic stem cell (ESC) pluripotency and lineage commitment. Although autocrine signaling via ...
  • Li, Ran; Polacheck, William Joseph; Uzel, Sebastien GM; Kamm, Roger Dale (Royal Society of Chemistry, The, 2013-04)
    Mechanotransduction has been a topic of considerable interest since early studies demonstrated a link between mechanical force and biological response. Until recently, studies of fundamental phenomena were based either on ...
  • Chung, Seok; Sudo, Ryo; Vickerman, Vernella Velonie V.; Zervantonakis, Ioannis; Kamm, Roger Dale (Springer-Verlag/Biomedical Engineering Society, 2010-01)
    Recent advances in microfluidic technologies have opened the door for creating more realistic in vitro cell culture methods that replicate many aspects of the true in vivo microenvironment. These new designs (i) provide ...
  • Wen, Jian; Albrecht, Jacob W.; Jensen, Klavs F. (John Wiley & Sons, Inc., 2010-04)
    A preparative scale free-flow IEF device is developed and characterized with the aim of addressing needs of molecular biologists working with protein samples on the milligrams and milliliters scale. A triangular-shape ...
  • Wen, Jian; Wilker, Erik W.; Yaffe, Michael B.; Jensen, Klavs F. (American Chemical Society (ACS), 2010-01)
    Isoelectric focusing (IEF) is the first step for two-dimensional (2D) gel electrophoresis and plays an important role in sample purification for proteomics. However, biases in protein size and pI resolution, as well as ...
  • Hou, Han Wei; Gan, Hiong Yap; Bhagat, Ali Asgar S.; Li, Leon Daliang; Lim, Chwee Teck; Han, Jongyoon (American Institute of Physics, 2012-05)
    Sepsis is an adverse systemic inflammatory response caused by microbial infection in blood. This paper reports a simple microfluidic approach for intrinsic, non-specific removal of both microbes and inflammatory cellular ...
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