Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Hosseini, Vahid; Ahadian, Samad; Ostrovidov, Serge; Camci-Unal, Gulden; Chen, Song; Kaji, Hirokazu; Ramalingam, Murugan; Khademhosseini, Ali (Mary Ann Liebert, Inc., 2012-09)
    To engineer tissue-like structures, cells must organize themselves into three-dimensional (3D) networks that mimic the native tissue microarchitecture. Microfabricated hydrogel substrates provide a potentially useful ...
  • Brigham, Christopher J.; Sinskey, Anthony J.; Song, Yuyang; Matsumoto, Ken’ichiro; Yamada, Miwa; Gohda, Aoi; Taguchi, Seiichi (Springer-Verlag, 2011-11)
    The first biosynthetic system for lactate (LA)-based polyesters was previously created in recombinant Escherichia coli (Taguchi et al. 2008). Here, we have begun efforts to upgrade the prototype polymer production system ...
  • Schneider, Martin W; Yamano, Takashi; Nishimasu, Hiroshi; Nureki, Osamu; Crosetto, Nicola; Gao, Linyi; Cox, David Benjamin Turitz; Yan, Winston Xia; Manteiga, John Colonnese; Zhang, Feng (Nature Publishing Group, 2017-06)
    The RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells. However, the utility of the commonly used Acidaminococcus sp. BV3L6 Cpf1 (AsCpf1) and Lachnospiraceae bacterium ND2006 Cpf1 ...
  • Bilate, Angelina M.; Huang, Nai-Jia; Li, Zeyang; Li, Hojun; Patterson, Heide C.; Dougan, Stephanie K.; Maruyama, Takeshi; Pishesha, Novalia; Wibowo, Marsha C; Dhesycka, Rhogerry; Bousbaine, Djenet; Lodish, Harvey F; Ploegh, Hidde (National Academy of Sciences (U.S.), 2017-03)
    Current therapies for autoimmune diseases rely on traditional immunosuppressive medications that expose patients to an increased risk of opportunistic infections and other complications. Immunoregulatory interventions that ...
  • Mata-Fink, Jordi; Hanson, M.; Kriegsman, Barry A.; Irvine, Darrell J.; Wittrup, Karl Dane (Biomed Central Ltd., 2012-09)
    Background: One of the great challenges for an HIV vaccine is to elicit broadly neutralizing antibodies specific for conserved epitopes from which the virus cannot easily escape. The CD4 binding site is one such epitope ...
  • Sarkar, Debanjan; Vemula, Praveen K.; Zhao, Weian; Gupta, Ashish; Karnik, Rohit; Karp, Jeffrey Michael (Elsevier, 2010-04)
    Cell therapy has the potential to impact the quality of life of suffering patients. Systemic infusion is a convenient method of cell delivery; however, the efficiency of engraftment presents a major challenge. It has been ...
  • Swami, Archana; Reagan, Michaela R.; Basto, Pamela Antonia; Mishima, Yuji; Kamaly, Nazila; Glavey, Siobhan; Zhang, Sufeng; Moschetta, Michele; Seevaratnam, Dushanth; Zhang, Yong; Liu, Jinhe; Memarzadeh, Masoumeh; Wu, Jun; Manier, Salomon; Shi, Jinjun; Bertrand, Nicolas; Lu, Zhi Ning; Nagano, Kenichi; Baron, Roland; Sacco, Antonio; Roccaro, Aldo M.; Farokhzad, Omid C.; Ghobrial, Irene M. (National Academy of Sciences (U.S.), 2014-06)
    Bone is a favorable microenvironment for tumor growth and a frequent destination for metastatic cancer cells. Targeting cancers within the bone marrow remains a crucial oncologic challenge due to issues of drug availability ...
  • Varanasi, Kripa K.; Chamarthy, Pramod; Chauhan, Shakti; de Bock, Peter; Deng, Tao; Kulkarni, Ambarish; Mandrusiak, Gary; Rush, Brian; Russ, Boris; Denault, Lauraine; Weaver, Stanton; Gerner, Frank M.; Leland, Quinn; Yerkes, Kirk (Nano Science and Technology Institute, 2009-05)
    In the DARPA Thermal Ground Plane (TGP) program[1],we are developing a new thermal technology that will enable a monumental thermal technological leap to an entirely new class of electronics, particularly electronics ...
  • Krom, Russell-John; Saluja, Prerna; Lobritz, Michael Andrew; Collins, James J. (American Chemical Society (ACS), 2015-07)
    The increasing incidence of antibiotic-resistant bacterial infections is creating a global public health threat. Because conventional antibiotic drug discovery has failed to keep pace with the rise of resistance, a growing ...
  • Parker, Jillian A.; Kiefer, Jonathan D.; Knihtila, Ryan; McGee, John; Verdine, Greg; Mattos, Carla; Kauke, Monique Jacqueline; Traxlmayr, Michael; Wittrup, Karl Dane (Nature Publishing Group, 2017-07)
    Ras is at the hub of signal transduction pathways controlling cell proliferation and survival. Its mutants, present in about 30% of human cancers, are major drivers of oncogenesis and render tumors unresponsive to standard ...
  • Shi, Jiahai; Kundrat, Lenka; Pishesha, Novalia; Bilate, Angelina M.; Theile, Christopher S.; Maruyama, Takeshi; Dougan, Stephanie K.; Ploegh, Hidde; Lodish, Harvey F. (National Academy of Sciences (U.S.), 2014-06)
    We developed modified RBCs to serve as carriers for systemic delivery of a wide array of payloads. These RBCs contain modified proteins on their plasma membrane, which can be labeled in a sortase-catalyzed reaction under ...
  • Lu, Timothy K; Cleto, Sara (American Society for Microbiology, 2017-10)
    Peptides that are synthesized independently of the ribosome in plants, fungi, and bacteria can have clinically relevant anticancer, antihemochromatosis, and antiviral activities, among many other. Despite their natural ...
  • Barbero, Roberto Juan; Carnelli, Lino; Simon, Anna; Kao, Albert; Monforte, Alessandra d'Arminio; Riccò, Moreno; Bianchi, Daniele; Belcher, Angela M. (Royal Society of Chemistry, 2013)
    In this work, a biologically catalysed CO2 mineralization process for the capture of CO2 from point sources was designed, constructed at a laboratory scale, and, using standard chemical process scale-up protocols, was ...
  • van der Valk, Dewy C.; Blaser, Mark C.; Grolman, Joshua M.; Wu, Pin-Jou; Lee, Lang H.; Wen, Jennifer R.; Ha, Anna H.; Buffolo, Fabrizio; van Mil, Alain; Bouten, Carlijn V. C.; Body, Simon C.; Mooney, David J.; Sluijter, Joost P. G.; Aikawa, Masanori; Hjortnaes, Jesper; Aikawa, Elena; van der Valk, Dewy; van der Ven, Casper; Blaser, Mark; Grolman, Joshua; Fenton, Owen; Lee, Lang; Tibbitt, Mark; Andresen, Jason; Wen, Jennifer; Ha, Anna; Bouten, Carlijn; Body, Simon; Mooney, David; Sluijter, Joost; van der Ven, Casper F.t.; Fenton, Owen S.; Tibbitt, Mark W; Langer, Robert S (MDPI AG, 2018-05)
    In calcific aortic valve disease (CAVD), microcalcifications originating from nanoscale calcifying vesicles disrupt the aortic valve (AV) leaflets, which consist of three (biomechanically) distinct layers: the fibrosa, ...
  • Tay, Andy; Warkiani, Majid Ebrahimi; Yeap, Wei Hseun; Wong, Siew Cheng; Pavesi, Andrea; Adriani, Giulia; Kamm, Roger Dale (Nature Publishing Group, 2016-05)
    The limitations of current cancer therapies highlight the urgent need for a more effective therapeutic strategy. One promising approach uses an alternating electric field; however, the mechanisms involved in the disruption ...
  • Nielsen, David R.; Yoon, Sang-Hwal; Yuan, Clara J.; Prather, Kristala L. Jones (John Wiley & Sons, Inc., 2010-01)
    The functional reconstruction of acetoin and meso-2,3-butanediol (meso-2,3-BD) biosynthetic pathways in Escherichia coli have been explored systematically. Pathway construction involved the in vivo screening of prospective ...
  • Ryu, Min-Hyung; Kang, In-Hye; Nelson, Mathew D.; Jensen, Tricia M.; Lyuksyutova, Anna I.; Siltberg-Liberles, Jessica; Raizen, David M.; Gomelsky, Mark (National Academy of Sciences (U.S.), 2014-06)
    Bacteriophytochromes sense light in the near-infrared window, the spectral region where absorption by mammalian tissues is minimal, and their chromophore, biliverdin IXα, is naturally present in animal cells. These properties ...
  • Belmont, Brian Joshua; Niles, Jacquin (American Chemical Society, 2010-06)
    The importance and pervasiveness of naturally occurring regulation of RNA function in biology is increasingly being recognized. A common mechanism uses inducible protein−RNA interactions to shape diverse aspects of cellular ...
  • Lam, Felix H.; Ghaderi, Adel; Fink, Gerald R.; Stephanopoulos, Gregory (American Association for the Advancement of Science (AAAS), 2014-10)
    Ethanol toxicity in the yeast Saccharomyces cerevisiae limits titer and productivity in the industrial production of transportation bioethanol. We show that strengthening the opposing potassium and proton electrochemical ...
  • Nielsen, David R.; Leonard, Effendi; Yoon, Sang-Hwal; Tseng, Hsien-chung; Yuan, Clara J.; Prather, Kristala L. Jones (Elsevier B.V., 2009-05)
    Alternative microbial hosts have been engineered as biocatalysts for butanol biosynthesis. The butanol synthetic pathway of Clostridium acetobutylicum was first re-constructed in Escherichia coli to establish a baseline ...
Open Access