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Browsing MIT Open Access Articles by Title

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  • Wang, Evelyn N.; Xiao, Rong; Chu, Kuang-Han (SPIE, 2010-02)
    Microfluidic systems offer compact and efficient thermal management strategies. In this work, we investigate novel nanostructured surfaces to control fluidic behavior and enhance heat dissipation in microfluidic systems. ...
  • Bettinger, Christopher J.; Kulig, Katherine M.; Vacanti, Joseph P.; Langer, Robert; Borenstein, Jeffrey T. (Mary Ann Liebert, Inc., 2009-07)
    Synthetic substrates that mimic the properties of extracellular matrix proteins hold significant promise for use in systems designed for tissue engineering applications. In this report, we designed a synthetic polymeric ...
  • Buongiorno, Jacopo; Hu, Lin-Wen (American Society of Mechanical Engineers, 2009-12)
    Colloidal dispersions of nanoparticles are known as `nanofluids'. Such engineered fluids offer the potential for enhancing heat transfer, particularly boiling heat transfer, while avoiding the drawbacks (i.e., erosion, ...
  • Kim, Sung Jae; Song, Yong-Ak; Han, Jongyoon (Royal Society of Chemistry, 2010-01)
    Recently, a new type of electrokinetic concentration devices has been developed in a microfluidic chip format, which allows efficient trapping and concentration of biomolecules by utilizing ion concentration polarization ...
  • Picallo, Clara; Gravelle, Simon; Joly, Laurent; Charlaix, Elisabeth; Bocquet, Lyderic (American Physical Society, 2013-12)
    Osmosis describes the flow of water across semipermeable membranes powered by the chemical free energy extracted from salinity gradients. While osmosis can be expressed in simple terms via the van ’t Hoff ideal gas formula ...
  • Vandamme, Matthieu; Ulm, Franz-Josef (National Academy of Sciences, 2009-06)
    Concrete, the solid that forms at room temperature from mixing Portland cement with water, sand, and aggregates, suffers from time-dependent deformation under load. This creep occurs at a rate that deteriorates the durability ...
  • Randall, Nicholas X.; Vandamme, Matthieu; Ulm, Franz-Josef (Materials Research Society, 2009-03)
    Instrumented indentation (referred to as nanoindentation at low loads and low depths) has now become established for the single point characterization of hardness and elastic modulus of both bulk and coated materials. This ...
  • Yildiz, Bilge; Van Vliet, Krystyn J.; Herbert, Francis William (Cambridge University Press, 2011-03)
    The damage accumulation behavior of different grain boundary structures in Inconel 690 (Ni-29wt%Cr-9wt%Fe) was investigated in the presence of large, localized plastic strains induced by nanoindentation. Spatially-resolved ...
  • DeMuth, Peter Charles; Su, Xingfang; Samuel, Raymond E.; Hammond, Paula T.; Irvine, Darrell J. (Wiley-Blackwell Publishers, 2010-11)
    Multilayer-coated microneedles achieve transcutaneous delivery of plasmid DNA to the viable epidermis. Cy3-labeled plasmid DNA encoding luciferase (yellow) is deposited on biodegradable microneedle arrays through multilayer ...
  • Batista, Michael A.; Cox, Karen A.; Ortiz, Christine; Grodzinsky, Alan J.; Han, Lin; Tavakoli Nia, Hadi; Onnerfjord, Patrik; Heinegard, Dick (Elsevier, 2014-06)
    Chondroadherin (CHAD), a class IV small leucine rich proteoglycan/protein (SLRP), was hypothesized to play important roles in regulating chondrocyte signaling and cartilage homeostasis. However, its roles in cartilage ...
  • Srisungsitthisunti, Pornsak; Tansarawiput, Chookiat; Zhang, Huaichen; Qi, Minghao; Xu, Xianfan; Moon, Euclid Eberle (SPIE, 2010-08)
    We describe a method of detecting nanometer-level gap and tip/tilt alignment between a focusing zone plate mask and a silicon substrate using interferometric-spatial-phase-imaging (ISPI). The zone plate mask is used to ...
  • Wu, Jonathan; Mari-Buye, Nuria; Fernandez Muinos, Teresa; Borros, Salvador; Favia, Pietro; Semino, Carlos Eduardo (BioMed Central Ltd, 2010-12)
    Background: Isolated hepatocytes removed from their microenvironment soon lose their hepatospecific functions when cultured. Normally hepatocytes are commonly maintained under limited culture medium supply as well as ...
  • Lo, Justin H.; von Maltzahn, Geoffrey; Douglass, Jacqueline; Park, Ji-Ho; Sailor, Michael J.; Ruoslahti, Erkki; Bhatia, Sangeeta N. (Royal Society of Chemistry, 2013-06)
    The success of nanoparticle-based cancer therapies ultimately depends on their ability to selectively and efficiently accumulate in regions of disease. Outfitting nanoparticles to actively target tumor-specific markers has ...
  • Goldberg, Michael Solomon; Xing, Deyin; Ren, Yin; Orsulic, Sandra; Bhatia, Sangeeta N.; Sharp, Phillip A. (National Academy of Sciences (U.S.), 2011-01)
    Inhibition of the DNA repair enzyme poly(ADP-ribose) polymerase 1 (PARP1) with small molecules has been shown to be an effective treatment for ovarian cancer with BRCA mutations. Here, we report the in vivo administration ...
  • Mashelkar, Raghunath Anant; Chimote, Geetanjali; Soni, Shivani; Harfouche, Rania; Basu, Kaushik; Sengupta, Shiladitya (United States National Academy of Sciences, 2009-03)
    The MAPK signal transduction cascade is dysregulated in a majority of human tumors. Here we report that a nanoparticle-mediated targeting of this pathway can optimize cancer chemotherapy. We engineered nanoparticles from ...
  • Dvir, Tal; Bauer, Michael; Schroeder, Avi; Tsui, Jonathan H.; Anderson, Daniel G.; Liao, Ronglih; Kohane, Daniel S.; Langer, Robert (American Chemical Society (ACS), 2011-09)
    We report a nanoparticulate system capable of targeting the heart after myocardial infarction (MI). Targeting is based on overexpression of angiotensin II type 1 (AT1) receptor in the infarcted heart. Liposomes 142 nm in ...
  • Liu, Wenhao; Chauhan, Vikash P.; Lee, Jungmin; Wong, Cliff; Greytak, Andrew B.; Insin, Numpon; Nocera, Daniel G.; Fukumura, Dai; Jain, Rakesh K.; Bawendi, Moungi G.; Popovic, Zoran (Wiley Blackwell, 2010-09)
    A nanoparticle toolset was created within the size limits of 10–150 nm for probing size-dependent nanoparticle distribution in solid tumors. By using multiphoton intravital microscopy, the particles were tracked both ...
  • von Maltzahn, Geoffrey; Park, Ji-Ho; Lin, Kevin Yu-Ming; Singh, Neetu; Schwöppe, Christian; Mesters, Rolf; Berdel, Wolfgang E.; Ruoslahti, Erkki; Sailor, Michael J.; Bhatia, Sangeeta N. (Nature Publishing Group, 2011-06)
    Nanomedicines have enormous potential to improve the precision of cancer therapy, yet our ability to efficiently home these materials to regions of disease in vivo remains very limited. Inspired by the ability of communication ...
  • Kwong, Gabriel A.; Wood, David K.; Bhatia, Sangeeta N.; Lin, Kevin Yu-Ming; Warren, Andrew David (American Chemical Society (ACS), 2013-09)
    Thrombin is a serine protease and regulator of hemostasis that plays a critical role in the formation of obstructive blood clots, or thrombosis, that is a life-threatening condition associated with numerous diseases such ...
  • Cheng, Hao; Kastrup, Christian J.; Ramanathan, Renuka; Siegwart, Daniel J.; Ma, Minglin; Bogatyrev, Said R.; Bogatyrev, Said R.; Whitehead, Kathryn A.; Langer, Robert; Anderson, Daniel G. (American Chemical Society (ACS), 2010-02)
    The targeted delivery of therapeutics to tumors remains an important challenge in cancer nanomedicine. Attaching nanoparticles to cells that have tumoritropic migratory properties is a promising modality to address this ...
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