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Browsing MIT Open Access Articles by Title

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  • Leung, Anthony K.L.; Sharp, Phillip A.; Leung, Anthony K. L. (Elsevier B.V., 2010-10)
    MicroRNAs (miRNAs) are a class of ~22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding ...
  • Bousquet, Marina; Harris, Marian H.; Zhou, Beiyan; Lodish, Harvey F. (National Academy of Sciences (U.S.), 2010-12)
    MicroRNA miR-125b has been implicated in several kinds of leukemia. The chromosomal translocation t(2;11)(p21;q23) found in patients with myelodysplasia and acute myeloid leukemia leads to an overexpression of miR-125b of ...
  • Mukherji, Shankar; Ebert, Margaret S.; Zheng, Grace X. Y.; Sharp, Phillip A.; van Oudenaarden, Alexander; Tsang, John S. (Nature Publishing Group, 2011-08)
    MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner. We performed single-cell measurements using quantitative fluorescence microscopy and flow ...
  • Kumar, Smriti R.; Kumar, Arooshi R.; Shah, Parag P.; Rai, Shesh N.; Panguluri, Siva K.; Kakar, Sham S. (BioMed Central Ltd., 2011-09)
    Background: Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide. According to the National Cancer Institute, ovarian cancer has the highest mortality rate among all the reproductive ...
  • Alexander, Ryan; Lodish, Harvey F.; Sun, Lei (Informa Healthcare, 2011-02)
    Introduction: Obesity and obesity-related disease have reached pandemic proportions and are prevalent even in developing countries. Adipose tissue is increasingly being recognized as a key regulator of whole-body energy ...
  • Zhang, L.; Sankaran, V. G.; Lodish, Harvey F. (Nature Publishing Group, 2012-05)
    MicroRNAs (miRNAs) are a class of small regulatory noncoding RNAs that modulate the expression of their target genes through either mRNA degradation or inhibition of protein translation. In recent years, miRNAs have been ...
  • Tan, Kai S; Choi, Hyungwon; Jiang, Xiaoou; Yin, Lu; Seet, Ju E; Patzel, Volker; Chow, Vincent T; Tan, Kai; Seet, Ju; Engelward, Bevin P. (BioMed Central Ltd, 2014-07)
    Background: Tissue regeneration in the lungs is gaining increasing interest as a potential influenza management strategy. In this study, we explored the role of microRNAs, short non-coding RNAs involved in post-transcriptional ...
  • Bousquet, Marina; Lodish, Harvey F. (Expert Reviews, Ltd., 2011-04)
    Leukemia is a complex disease with many different types and subtypes caused by a huge diversity of genetic and epigenetic aberrations. Until recently, alterations of protein-coding genes were thought to be the sole cause ...
  • Hsieh, Po-Jang; Tse, Peter U. (Public Library of Science, 2009-04)
    Motion-induced blindness (MIB) occurs when a dot embedded in a motion field subjectively vanishes. Here we report the first psychophysical data concerning effects of microsaccade/eyeblink rate upon perceptual switches ...
  • Fries, Pascal; Womelsdorf, Thilo; Bosman, Conrado A.; Desimone, Robert (Society for Neuroscience, 2009-06)
    Rhythms occur both in neuronal activity and in behavior. Behavioral rhythms abound at frequencies at or below 10 Hz. Neuronal rhythms cover a very wide frequency range, and the phase of neuronal low-frequency rhythms ...
  • Ng, Shengyong; Velmurugan, Soundarapandian; Galstian, Ani; Shan, Jing; Logan, David J.; Carpenter, Anne E.; Thomas, David; Sim, B. Kim Lee; Mota, Maria M.; Hoffman, Stephen L.; Bhatia, Sangeeta N.; March-Riera, Sandra; Bhatia, Sangeeta N. (Elsevier, 2013-07)
    The Plasmodium liver stage is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage. However, ...
  • Spring, Bryan Q.; Palanisami, Akilan; Hasan, Tayyaba (SPIE, 2014-06)
    Molecular-targeted probes are emerging with applications for optical biopsy of cancer. An underexplored potential clinical use of these probes is to monitor residual cancer micrometastases that escape cytoreductive surgery ...
  • Sabatini, David M.; Wood, Kris C.; Konieczkowski, David J.; Johannessen, Cory M.; Boehm, Jesse S.; Tamayo, Pablo; Botvinnik, Olga B.; Mesirov, Jill P.; Hahn, William C.; Root, David E.; Garraway, Levi A. (American Association for the Advancement of Science (AAAS), 2012-05)
    Cell microarrays are a promising tool for performing large-scale functional genomic screening in mammalian cells at reasonable cost, but owing to technical limitations they have been restricted for use with a narrow range ...
  • Selimović, Šeila; Oh, Jonghyun; Bae, Hojae; Dokmeci, Mehmet; Khademhosseini, Ali (MDPI AG, 2012-09)
    Hydrogels in which cells are encapsulated are of great potential interest for tissue engineering applications. These gels provide a structure inside which cells can spread and proliferate. Such structures benefit from ...
  • Paparcone, Raffaella; Buehler, Markus J. (American Institute of Physics (AIP), 2009-06)
    Amyloid fibril formation and characterization are crucial due to their association with severe degenerative disorders such as Alzheimer’s, type II diabetes, and Parkinson’s disease. Here we present an atomistic-based ...
  • Khademhosseini, Ali; Chung, Bong Geun (Institute of Electrical and Electronics Engineers, 2009-05)
    Microscale technologies are emerging as enabling tools for tissue engineering and biology. Here, we present our experience in developing microscale technologies to regulate cell-microenvironment interactions and generate ...
  • Shiga, Takuma; Shiomi, Junichiro; Ma, Jie; Delaire, Olivier; Radzynski, Tomasz; Lusakowski, Andrzej; Esfarjani, Keivan; Chen, Gang (American Physical Society, 2012-04)
    The microscopic physics behind low-lattice thermal conductivity of single-crystal rock salt lead telluride (PbTe) is investigated. Mode-dependent phonon (normal and umklapp) scattering rates and their impact on thermal ...
  • Regnault, N.; Todadri, Senthil (American Physical Society, 2013-10)
    In two dimensions strongly interacting bosons in a magnetic field can form an integer quantum Hall state. This state has a bulk gap, no fractional charges or topological order in the bulk, but nevertheless quantized Hall ...
  • Safavi-Naini, Arghavan; Rabl, P.; Weck, P. F.; Sadeghpour, H. R. (American Physical Society, 2011-08)
    Motional heating of ions in microfabricated traps is one of the open challenges hindering experimental realizations of large-scale quantum processing devices. Recently, a series of measurements of the heating rates in ...
  • Gerber, U.; Hofmann, C. P.; Kampfer, Florian; Wiese, U. J. (American Physical Society, 2010-02)
    We consider a microscopic model for a doped quantum ferromagnet as a test case for the systematic low-energy effective field theory for magnons and holes, which is constructed in complete analogy to the case of quantum ...
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