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Browsing MIT Open Access Articles by Title

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  • Seto, Jennifer E.; Polat, Baris E.; VanVeller, Brett; Langer, Robert; Blankschtein, Daniel; Lopez, Renata F. V. (Elsevier, 2011-10)
    Chemical penetration enhancers are often used to enhance transdermal drug delivery. However, the fundamental mechanisms that govern the interactions between penetration enhancers and skin are not fully understood. Therefore, ...
  • Lamport, Zachary A.; Broadnax, Angela D.; Harrison, David; Barth, Katrina J.; Mendenhall, Lee; Hamilton, Clayton T.; Guthold, Martin; Welker, Mark E.; Jurchescu, Oana D.; Thonhauser, Timo (Nature Publishing Group, 2016-11)
    We report on the synthesis and electrical properties of nine new alkylated silane self-assembled monolayers (SAMs) – (EtO)3Si(CH2)nN = CHPhX where n = 3 or 11 and X = 4-CF[subscript 3], 3,5-CF[subscript 3], 3-F-4-CF[subscript ...
  • Sather, Aaron C.; Lee, Hong Geun; De La Rosa, Valentina Y.; Yang, Yang; Mueller, Peter; Buchwald, Stephen Leffler (American Chemical Society (ACS), 2015-09)
    A new biaryl monophosphine ligand (AlPhos, L1) allows for the room-temperature Pd-catalyzed fluorination of a variety of activated (hetero)aryl triflates. Furthermore, aryl triflates and bromides that are prone to give ...
  • Sletten, Ellen M.; Swager, Timothy M (American Chemical Society (ACS), 2014-09)
    “Fluoro” refers to both fluorescent and fluorinated compounds. Despite the shared prefix, there are very few fluorescent molecules that are soluble in perfluorinated solvents. This paucity is surprising, given that optical ...
  • Beharry, Andrew A.; Kool, Eric T.; Samson, Leona D; Nagel, Zachary D. (Public Library of Science, 2016-04)
    Common alkylating antitumor drugs, such as temozolomide, trigger their cytotoxicity by methylating the O6-position of guanosine in DNA. However, the therapeutic effect of these drugs is dampened by elevated levels of the ...
  • Li, Zeyang; Theile, Christopher S.; Chen, Guan-Yu; Bilate, Angelina M.; Duarte, Joao N.; Avalos, Ana M.; Fang, Tao; Barberena, Roberto; Sato, Shuji; Ploegh, Hidde (Wiley Blackwell, 2015-09)
    The site-specific modification of proteins with fluorophores can render a protein fluorescent without compromising its function. To avoid self-quenching from multiple fluorophores installed in close proximity, we used ...
  • Uttamapinant, Chayasith; White, Katherine A.; Baruah, Hemanta; Thompson, Samuel; Fernandez-Suarez, Marta; Puthenveetil, Sujiet; Ting, Alice Y. (National Academy of Sciences (U.S.), 2010-06)
    Biological microscopy would benefit from smaller alternatives to green fluorescent protein for imaging specific proteins in living cells. Here we introduce PRIME (PRobe Incorporation Mediated by Enzymes), a method for ...
  • Lim, Jeewoo; Swager, Timothy Manning (Wiley-VCH Verlag GmbH & Co. KGaA, 2010-09)
    It's just a phase: A highly fluorinated compound with a rigid three-dimensional architecture was synthesized as a monomer for poly(p-phenyleneethynylene)s (PPEs). Fluorous biphase reactions were applied for the synthesis ...
  • Iniguez, Sergio D.; Alcantara, Lyonna F.; Warren, Brandon L.; Riggs, Lace M.; Parise, Eric M.; Vialou, Vincent; Wright, Katherine N.; Dayrit, Genesis; Nieto, Steven J.; Wilkinson, Matthew B.; Lobo, Mary Kay; Neve, Rachael L.; Nestler, Eric J.; Bolaños-Guzmán, Carlos A. (Society for Neuroscience, 2014-01)
    The mechanisms underlying the enduring neurobiological consequences of antidepressant exposure during adolescence are poorly understood. Here, we assessed the long-term effects of exposure to fluoxetine (FLX), a selective ...
  • Kerman, Andrew J. (2013-10)
    It has long been thought that macroscopic phase coherence breaks down in effectively lower-dimensional superconducting systems even at zero temperature due to enhanced topological quantum phase fluctuations. In ...
  • Görler, T.; Told, D.; Jenko, F.; Holland, C.; Rhodes, T. L.; White, Anne E. (American Institute of Physics (AIP), 2014-12)
    Previous nonlinear gyrokinetic simulations of specific DIII-D L-mode cases have been found to significantly underpredict the ion heat transport and associated density and temperature fluctuation levels by up to almost one ...
  • Yoshihara, Fumiki; Nakamura, Yasunobu; Yan, Fei; Gustavsson, Simon; Bylander, Jonas; Oliver, William D.; Tsai, Jaw-Shen (American Physical Society, 2014-01)
    We infer the high-frequency flux noise spectrum in a superconducting flux qubit by studying the decay of Rabi oscillations under strong driving conditions. The large anharmonicity of the qubit and its strong inductive ...
  • Birenbaum, Jeffrey; Sears, Adam P; Hover, David; Gudmundsen, Ted J.; Rosenberg, Danna; Samach, Gabriel; Weber, S; Yoder, Jonilyn L.; Clarke, John; Kerman, Andrew J.; Yan, Fei; Gustavsson, Simon; Kamal, Archana; Orlando, Terry Philip; Oliver, William D (Nature Publishing Group, 2016-11)
    The scalable application of quantum information science will stand on reproducible and controllable high-coherence quantum bits (qubits). Here, we revisit the design and fabrication of the superconducting flux qubit, ...
  • Mulgaonkar, Yash; Araki, Brandon; Koh, Je-sung; Guerrero-Bonilla, Luis; Aukes, Daniel M.; Makineni, Anurag; Tolley, Michael T.; Rus, Daniela L.; Wood, Robert J.; Kumar, Vijay (Institute of Electrical and Electronics Engineers (IEEE), 2016-05)
    The agility and ease of control make a quadrotor aircraft an attractive platform for studying swarm behavior, modeling, and control. The energetics of sustained flight for small aircraft, however, limit typical applications ...
  • Saxe, Rebecca R.; Young, Liane (MIT Press, 2009-04)
    Human moral judgment depends critically on “theory of mind,” the capacity to represent the mental states of agents. Recent studies suggest that the right TPJ (RTPJ) and, to lesser extent, the left TPJ (LTPJ), the precuneus ...
  • Cloutier, J.; Ambady, N.; Gabrieli, John D. E.; O'Young, Daniel (Elsevier, 2011-05)
    The current study examines the effect of violations of social expectancies on the neural substrates of person perception. In an event-related fMRI experiment, participants were presented with the photographs of either ...
  • Ghosh, Satrajit S.; Guenther, Frank H.; Perkell, Joseph S.; Cai, Shanqing (Society for Neuroscience, 2011-11)
    Within the human motor repertoire, speech production has a uniquely high level of spatiotemporal complexity. The production of running speech comprises the traversing of spatial positions with precisely coordinated articulator ...
  • Li, Junlun; Kuleli, Huseyin Sadi; Zhang, Haijiang; Toksoz, M. Nafi (Society of Exploration Geophysicists, 2011-12)
    A new, relatively high frequency, full waveform matching method was used to study the focal mechanisms of small, local earthquakes induced in an oil field, which are monitored by a sparse near-surface network and a deep ...
  • Tian, Yuan; Ning, Jieyuan; Yu, Chunquan; Cai, Chen; Tao, Kai (Seismological Society of China, 2014-01)
    The 2008 Wenchuan earthquake, a major intraplate earthquake with Mw 7.9, occurred on the slowly deforming Longmenshan fault. To better understand the causes of this devastating earthquake, we need knowledge of the regional ...
  • Barrett, John Patrick; Formaggio, Joseph A; Furse, Daniel Lawrence; Kaboth, Asher Cunningham; Kelsey, James E; Solomon-Oblath, Noah (Elsevier, 2015-01)
    The focal-plane detector system for the KArlsruhe TRItium Neutrino (KATRIN) experiment consists of a multi-pixel silicon p-i-n-diode array, custom readout electronics, two superconducting solenoid magnets, an ultra high-vacuum ...
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