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Browsing MIT Open Access Articles by Title

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  • Wanniarachchi, Yoshitha A.; Kaczmarek, Piotr; Wan, Andrea; Nolan, Elizabeth M. (American Chemical Society, 2011-09)
    Human α-defensin 5 (HD5, HD5[subscript ox] to specify the oxidized and disulfide linked form) is a 32-residue cysteine-rich host-defense peptide, expressed and released by small intestinal Paneth cells, that exhibits ...
  • Park, Seon Joo; Song, Hyun Seok; Kwon, Oh Seok; Chung, Ji Hyun; Lee, Seung Hwan; An, Ji Hyun; Ahn, Sae Ryun; Lee, Ji Eun; Yoon, Hyeonseok; Park, Tai Hyun; Jang, Jyongsik (Nature Publishing Group, 2014-03)
    The development of molecular detection that allows rapid responses with high sensitivity and selectivity remains challenging. Herein, we demonstrate the strategy of novel bio-nanotechnology to successfully fabricate ...
  • Metallo, Christian M.; Azarin, Samira M.; Moses, Laurel E.; Ji, Lin; Pablo, Juan J. de; Palecek, Sean P. (Mary Ann Liebert, 2010-01)
    Human embryonic stem (hES) cells are an attractive source of cellular material for scientific, diagnostic, and potential therapeutic applications. Protocols are now available to direct hES cell differentiation to specific ...
  • Sherley, James L. (Hindawi Publishing Corporation, 2004)
    In recent months, the American public has been bombarded with reports of prominent stem cell scientists attempting to run end-around plays against current US government policies that restrict research that requires the ...
  • Jaenisch, Rudolf; Hanna, Jacob; Cheng, Albert W.; Saha, Krishanu; Kim, Jongpil; Lengner, Christopher J.; Soldner, Frank; Cassady, John P.; Muffat, Julien; Carey, Bryce W. (National Academy of Sciences, 2010-05)
    Human and mouse embryonic stem cells (ESCs) are derived from blastocyst-stage embryos but have very different biological properties, and molecular analyses suggest that the pluripotent state of human ESCs isolated so far ...
  • Gostjeva, Elena V.; Thilly, William G.; Fomina, Janna N.; Darroudi, Firouz; Gruhl, Amanda Natalie (Elsevier, 2010-12)
    Metakaryotic cells and syncytia with large, hollow, bell-shaped nuclei demonstrate symmetrical and asymmetrical amitotic nuclear fissions in microanatomical positions and numbers expected of stem cell lineages in tissues ...
  • Rahmandad, Hazhir (Public Library of Science, 2014-12)
    Quantifying human weight and height dynamics due to growth, aging, and energy balance can inform clinical practice and policy analysis. This paper presents the first mechanism-based model spanning full individual life and ...
  • Grunwald, Martin; Muniyandi, Manivannan; Kim, Hyun; Kim, Jung; Krause, Frank; Mueller, Stephanie; Srinivasan, Mandayam A. (Frontiers Research Foundation, 2014-04)
    Introduction: The explorative scanning movements of the hands have been compared to those of the eyes. The visual process is known to be composed of alternating phases of saccadic eye movements and fixation pauses. Descriptive ...
  • So, Peter T. C.; Kim, Ki Hean; Sun, Tzu-Lin; Liu, Yuan; Sung, Ming-Chin; Chen, Hsiao-Ching; Yang, Chuen-Huei; Huang, Guan-Tarn; Lin, Wei-Chou; Chiou, Ling-Ling; Lin, Chih-Ju; Lee, Hsuan-Shu; Dong, Chen-Yuan; Hovhannisyan, Vladimir (SPIE, 2010-02)
    Conventionally, the diagnosis of hepatocellular carcinoma (HCC) is performed by qualitative examination of histopathological specimens, which takes times for sample preparation in fixation, section and stain. Our objective ...
  • Michini, Bernard J.; How, Jonathan P. (American Institute of Aeronautics and Astronautics, 2011-03)
    Aircraft carrier deck operations present a complex and uncertain environment in which time-critical scheduling and planning must be done, and to date all course of action planning is done solely by human operators who rely ...
  • Forster, Ryan; Chiba, Kunitoshi; Schaeffer, Lorian; Regalado, Samuel G.; Lai, Christine S.; Gao, Qing; Kiani, Samira; Farin, Henner F.; Clevers, Hans; Cost, Gregory J.; Chan, Andy; Rebar, Edward J.; Urnov, Fyodor D.; Gregory, Philip D.; Pachter, Lior; Jaenisch, Rudolf; Hockemeyer, Dirk (Elsevier, 2014-06)
    Genetically engineered human pluripotent stem cells (hPSCs) have been proposed as a source for transplantation therapies and are rapidly becoming valuable tools for human disease modeling. However, many applications are ...
  • Ng, Shengyong; Schwartz, Robert E.; Galstian, Ani; Gural, Nil; Shan, Jing; Prabhu, Mythili; Mota, Maria M.; Bhatia, Sangeeta N.; March-Riera, Sandra (Elsevier, 2015-02)
    Malaria eradication is a major goal in public health but is challenged by relapsing malaria species, expanding drug resistance, and the influence of host genetics on antimalarial drug efficacy. To overcome these hurdles, ...
  • Bornschein, U.; Kerimoglu, C.; Schreiter, S.; Dannemann, M.; Rea, E.; French, Christopher A.; Puliyadi, R.; Groszer, M.; Fisher, S. E.; Mundry, R.; Winter, C.; Hevers, W.; Paabo, S.; Enard, W.; Schreiweis, Christiane; Burguiere, Eric; Goyal, Shubhi; Graybiel, Ann M. (National Academy of Sciences (U.S.), 2014-09)
    The acquisition of language and speech is uniquely human, but how genetic changes might have adapted the nervous system to this capacity is not well understood. Two human-specific amino acid substitutions in the transcription ...
  • Thomas, David K.; Chen, Alice; Ong, Luvena L.; Schwartz, Robert E.; Golub, Todd R.; Bhatia, Sangeeta N. (Proceedings of the National Academy of Sciences (PNAS), 2011-07)
    “Humanized” mice offer a window into aspects of human physiology that are otherwise inaccessible. The best available methods for liver humanization rely on cell transplantation into immunodeficient mice with liver injury ...
  • Cheeseman, Iain McPherson; Welburn, Julie P. I.; Grishchuk, Ekaterina L.; Backer, Chelsea B.; Wilson-Kubalek, Elizabeth M.; Yates III, John R. (Cell Press, 2009-03)
    Mitotic chromosome segregation requires that kinetochores attach to microtubule polymers and harness microtubule dynamics to drive chromosome movement. In budding yeast, the Dam1 complex couples kinetochores with microtubule ...
  • Dodds, Peter Sheridan; Clark, Eric M.; Desu, Suma; Reagan, Andrew J.; Williams, Jake Ryland; Mitchell, Lewis; Harris, Kameron Decker; Kloumann, Isabel M.; Bagrow, James P.; Megerdoomian, Karine; McMahon, Matthew T.; Tivnan, Brian F.; Danforth, Christopher M.; Frank, Morgan Ryan (National Academy of Sciences (U.S.), 2015-02)
    Using human evaluation of 100,000 words spread across 24 corpora in 10 languages diverse in origin and culture, we present evidence of a deep imprint of human sociality in language, observing that (i) the words of natural ...
  • Krishnaswamy, Pavitra; Brown, Emery N.; Herr, Hugh M. (Public Library of Science, 2011-03)
    A common feature in biological neuromuscular systems is the redundancy in joint actuation. Understanding how these redundancies are resolved in typical joint movements has been a long-standing problem in biomechanics, ...
  • Vosoughi, Soroush; Roy, Deb K. (Institute of Electrical and Electronics Engineers (IEEE), 2015-11)
    The spread of rumors on social media, especially in time-sensitive situations such as real-world emergencies, can have harmful effects on individuals and society. In this work, we developed a human-machine collaborative ...
  • Nuschke, Austin; Rodrigues, Melanie; Stolz, Donna B; Chu, Charleen T; Wells, Alan; Griffith, Linda G. (BioMed Central Ltd, 2014-12)
    Introduction Bone marrow mesenchymal stem cells/multipotent stromal cells (MSCs) are recruited to sites of injury and subsequently support regeneration through differentiation or paracrine activity. During periods of ...
  • Gevers, Dirk (Public Library of Science, 2012-08)
    The Human Microbiome Project (HMP) [1],[2] is a concept that was long in the making. After the Human Genome Project, interest grew in sequencing the “other genome" of microbes carried in and on the human body [3],[4]. ...
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