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Browsing MIT Open Access Articles by Title

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  • Karp, Peter D.; Berger, Bonnie; Kovats, Diane; Lengauer, Thomas; Linial, Michal; Sabeti, Pardis; Hide, Winston; Rost, Burkhard (Public Library of Science, 2015-01)
    Speed is of the essence in combating Ebola; thus, computational approaches should form a significant component of Ebola research. As for the development of any modern drug, computational biology is uniquely positioned to ...
  • Seneff, Stephanie; Davidson, Robert M.; Liu, Jingjing (MDPI AG, 2012-11)
    In a recent paper, we proposed that a contributing factor in autism is a deficiency in cholesterol sulfate supply. In this paper, we investigate a link between preeclampsia and subsequent autism in the child, and we ...
  • Tree, Douglas R.; Muralidhar, Abhiram; Doyle, Patrick S.; Dorfman, Kevin D. (American Chemical Society (ACS), 2013-10)
    The details surrounding the crossover from wormlike-specific to universal polymeric behavior has been the subject of debate and confusion even for the simple case of a dilute, unconfined wormlike chain. We have directly ...
  • Gregory, Jeremy; Fredholm, Susan A.; Kirchain, Randolph E., Jr. (Institute of Electrical and Electronics Engineers, 2009-07)
    This paper uses economic value metrics to evaluate the retention of value of secondary materials and provides a framework for characterizing value throughout a material and product life-cycle. These economic value metrics ...
  • Seneff, Stephanie; Lauritzen, Ann; Davidson, Robert M.; Lentz-Marino, Laurie (MDPI AG, 2013-01)
    This paper makes two claims: (1) autism can be characterized as a chronic low-grade encephalopathy, associated with excess exposure to nitric oxide, ammonia and glutamate in the central nervous system, which leads to ...
  • Seneff, Stephanie; Lauritzen, Ann; Davidson, Robert M.; Lentz-Marino, Laurie (MDPI AG, 2012-12)
    Theoretical inferences, based on biophysical, biochemical, and biosemiotic considerations, are related here to the pathogenesis of cardiovascular disease, diabetes, and other degenerative conditions. We suggest that the ...
  • Kitamura, Takashi; Pignatelli di Spinazzola, Mich; Suh, Junghyup; Kohara, Keigo; Tonegawa, Susumu; Yoshiki, Atsushi; Abe, Kuniya (American Association for the Advancement of Science (AAAS), 2014-01)
    Episodic memory requires associations of temporally discontiguous events. In the entorhinal-hippocampal network, temporal associations are driven by a direct pathway from layer III of the medial entorhinal cortex (MECIII) ...
  • Papas, Klearchos K.; Suszynski, Thomas M.; Colton, Clark K. (Lippincott Williams & Wilkins, 2009-12)
    Purpose of review: There is a critical need for meaningful viability and potency assays that characterize islet preparations for release prior to clinical islet cell transplantation (ICT). Development, testing, and ...
  • Papas, Klearchos K.; Bellin, Melena D.; Sutherland, David E. R.; Suszynski, Thomas M.; Kitzmann, Jennifer P.; Avgoustiniatos, Efstathios S.; Gruessner, Angelika C.; Mueller, Kathryn R.; Beilman, Gregory J.; Balamurugan, Appakalai N.; Loganathan, Gopalakrishnan; Colton, Clark K.; Koulmanda, Maria; Weir, Gordon C.; Wilhelm, Josh J.; Qian, Dajun; Niland, Joyce C.; Hering, Bernhard J. (Public Library of Science, 2015-08)
    Background Reliable in vitro islet quality assessment assays that can be performed routinely, prospectively, and are able to predict clinical transplant outcomes are needed. In this paper we present data on the utility ...
  • Lohith, Talakad G; Osterweil, Emily K; Fujita, Masahiro; Jenko, Kimberly J; Bear, Mark; Innis, Robert B (BioMed Central Ltd, 2013-05)
    Abstract Background: Fragile X syndrome (FXS) is a common inherited form of intellectual disability caused by loss of function of the fragile X mental retardation protein. Recent animal ...
  • Johnson, Simon; Larson, William; Papageorgiou, Chris; Subramanian, Arvind (Elsevier B.V., 2013-03)
    This paper sheds light on two problems in the Penn World Table (PWT) GDP estimates. First, we show that these estimates vary substantially across different versions of the PWT despite being derived from very similar ...
  • Park, Daniel Kyu; Singh, Rohit; Baym, Michael Hartmann; Liao, Chung-Shou; Berger, Bonnie (Oxford University Press, 2011-01)
    We describe IsoBase, a database identifying functionally related proteins, across five major eukaryotic model organisms: Saccharomyces cerevisiae, Drosophila melanogaster, Caenorhabditis elegans, Mus musculus and Homo ...
  • Lange, Julian; Skaletsky, Helen; van Daalen, Saskia K.M.; Embry, Stephanie L.; Korver, Cindy M.; Brown, Laura G.; Oates, Robert D.; Silber, Sherman; Repping, Sjoerd; Page, David C. (Elsevier, 2009-09)
    Massive palindromes in the human Y chromosome harbor mirror-image gene pairs essential for spermatogenesis. During evolution, these gene pairs have been maintained by intrapalindrome, arm-to-arm recombination. The mechanism ...
  • Hou, Han Wei; Warkiani, Majid Ebrahimi; Khoo, Bee Luan; Li, Zi Rui; Soo, Ross A.; Tan, Daniel Shao-Weng; Lim, Wan-Teck; Han, Jongyoon; Bhagat, Ali Asgar S.; Lim, Chwee Teck (Nature Publishing Group, 2013-02)
    Presence and frequency of rare circulating tumor cells (CTCs) in bloodstreams of cancer patients are pivotal to early cancer detection and treatment monitoring. Here, we use a spiral microchannel with inherent centrifugal ...
  • Stevens, Justin; van Nieuwenhuizen, Gerrit Jan (Elsevier, 2015-04)
    A data-driven method was applied to Au+Au collisions a t√s[subscript NN] = 200 GeV made with the STAR detector at RHIC to isolate pseudorapidity distance Δη-dependent and Δη-independent correlations by using two- and ...
  • Marinescu, Smaranda C.; Levine, Daniel S.; Zhao, Yu; Schrock, Richard Royce; Hoveyda, Amir H. (American Chemical Society, 2011-08)
    Monoaryloxide–pyrrolide (MAP) complexes of molybdenum were employed for the selective ethenolysis of 1,2-disubstituted Z olefins in the presence of the corresponding E olefins. Reactions were performed in the presence of ...
  • Wang, Y.; Phon, T. H.; Pfeifer, B.; Ajikumar, Parayil Kumaran; Xiao, Wen-Hai; Tyo, Keith E. J.; Simeon, Fritz; Tyo, Keith E. J.; Leonard, Effendi; Mucha, Oliver; Stephanopoulos, Gregory (American Association for the Advancement of Science (AAAS), 2010-09)
    Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its analogs remains limited. Here, we report a multivariate-modular ...
  • Anghel, Catalina V; Quon, Gerald; Haider, Syed; Nguyen, Francis; Deshwar, Amit G; Morris, Quaid D; Boutros, Paul C (BioMed Central, 2015-05)
    Background Tumour samples containing distinct sub-populations of cancer and normal cells present challenges in the development of reproducible biomarkers, as these biomarkers are based on bulk signals from mixed tumour ...
  • Liao, Chung-Shou; Lu, Kanghao; Baym, Michael Hartmann; Singh, Rohit (Oxford University Press, 2009-06)
    Motivation: With the increasing availability of large protein–protein interaction networks, the question of protein network alignment is becoming central to systems biology. Network alignment is further delineated into two ...
  • Serbyn, Maksym; Lee, Patrick A. (American Physical Society, 2011-01)
    We investigate the isotope effect on the London penetration depth of a superconductor which measures nS/m* [n subscript s / m superscript asterisk], the ratio of superfluid density to effective mass. We use a simplified ...
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