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Browsing MIT Open Access Articles by Title

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  • Verma, Naveen; Shoeb, Ali H.; Chandrakasan, Anantha P.; Guttag, John V. (Institute of Electrical and Electronics Engineers, 2009-08)
    Continuous on-scalp EEG monitoring provides a non-invasive means to detect the onset of seizures in epilepsy patients, but cables from the scalp pose a severe strangulation hazard during convulsions. Since the power of ...
  • Sarpeshkar, Rahul; Fay, Leon; Misra, Vinith (Institute of Electrical and Electronics Engineers, 2009-09)
    We introduce an electrocardiogram (EKG) preamplifier with a power consumption of 2.8 muW, 8.1 muV[subscript rms] input-referred noise, and a common-mode rejection ratio of 90 dB. Compared to previously reported work, this ...
  • Denison, Timothy; Panken, Eric; Carlson, Dave; Shoeb, Ali H. (Institute of Electrical and Electronics Engineers, 2009-11)
    Implantable neurostimulators for the treatment of epilepsy that are capable of sensing seizures can enable novel therapeutic applications. However, detecting seizures is challenging due to significant intracranial EEG ...
  • Shoeb, Ali H.; Carlson, Dave; Panken, Eric; Denison, Timothy (Institute of Electrical and Electronics Engineers, 2009-11)
    Implantable neurostimulators for the treatment of epilepsy that are capable of sensing seizures can enable novel therapeutic applications. However, detecting seizures is challenging due to significant intracranial EEG ...
  • Melo, Gabriela; Malcolm, Alison E. (Society of Exploration Geophysicists, 2011-05)
    The conditions under which seismic interferometry (SI) leads to the exact Green's function (GF) are rarely met in practice. As a result, we generally recover only estimates of the true GF. This raises the questions: How ...
  • Bousquet, Marina; Nguyen, Diu; Chen, Cynthia; Shields, Lauren; Lodish, Harvey F. (Ferrata Storti Foundation, 2012-06)
    Background: We previously described a t(2;11)(p21;q23) chromosomal translocation found in patients with myelodysplasia or acute myeloid leukemia that leads to over-expression of the microRNA miR-125b, and we showed that ...
  • Chai, Sunghee; Cambronne, Xiaolu A.; Eichhorn, Stephen William; Goodman, Richard H. (National Academy of Sciences (U.S.), 2013-10)
    MicroRNA-134 (miR-134) serves as a widely accepted model for microRNA function in synaptic plasticity. In this model, synaptic activity stimulates miR-134 expression, which then regulates dendrite growth and spine formation. ...
  • Sankaran, Vijay G.; Menne, Tobias F.; Scepanovic, Danilo; Vergilio, Jo-Anne; Ji, Peng; Kim, Jinkuk; Thiru, Prathapan; Orkin, Stuart H.; Lander, Eric S.; Lodish, Harvey F. (National Academy of Sciences (U.S.), 2011-01)
    Many human aneuploidy syndromes have unique phenotypic consequences, but in most instances it is unclear whether these phenotypes are attributable to alterations in the dosage of specific genes. In human trisomy 13, there ...
  • Rissland, Olivia S.; Hong, Sue-Jean; Bartel, David; Rissland, Olivia S. (Elsevier B.V., 2011-09)
    The miR-16 family, which targets genes important for the G1-S transition, is a known modulator of the cell cycle, and members of this family are often deleted or downregulated in many types of cancers. Here, we report the ...
  • Leung, Anthony K.L.; Sharp, Phillip A.; Leung, Anthony K. L. (Elsevier B.V., 2010-10)
    MicroRNAs (miRNAs) are a class of ~22 nucleotide short noncoding RNAs that play key roles in fundamental cellular processes, including how cells respond to changes in environment or, broadly defined, stresses. Responding ...
  • Bousquet, Marina; Harris, Marian H.; Zhou, Beiyan; Lodish, Harvey F. (National Academy of Sciences (U.S.), 2010-12)
    MicroRNA miR-125b has been implicated in several kinds of leukemia. The chromosomal translocation t(2;11)(p21;q23) found in patients with myelodysplasia and acute myeloid leukemia leads to an overexpression of miR-125b of ...
  • Mukherji, Shankar; Ebert, Margaret S.; Zheng, Grace X. Y.; Sharp, Phillip A.; van Oudenaarden, Alexander; Tsang, John S. (Nature Publishing Group, 2011-08)
    MicroRNAs (miRNAs) are short, highly conserved noncoding RNA molecules that repress gene expression in a sequence-dependent manner. We performed single-cell measurements using quantitative fluorescence microscopy and flow ...
  • Kumar, Smriti R.; Kumar, Arooshi R.; Shah, Parag P.; Rai, Shesh N.; Panguluri, Siva K.; Kakar, Sham S. (BioMed Central Ltd., 2011-09)
    Background: Ovarian cancer is the leading cause of death from gynecologic cancer in women worldwide. According to the National Cancer Institute, ovarian cancer has the highest mortality rate among all the reproductive ...
  • Alexander, Ryan; Lodish, Harvey F.; Sun, Lei (Informa Healthcare, 2011-02)
    Introduction: Obesity and obesity-related disease have reached pandemic proportions and are prevalent even in developing countries. Adipose tissue is increasingly being recognized as a key regulator of whole-body energy ...
  • Zhang, L.; Sankaran, V. G.; Lodish, Harvey F. (Nature Publishing Group, 2012-05)
    MicroRNAs (miRNAs) are a class of small regulatory noncoding RNAs that modulate the expression of their target genes through either mRNA degradation or inhibition of protein translation. In recent years, miRNAs have been ...
  • Tan, Kai S; Choi, Hyungwon; Jiang, Xiaoou; Yin, Lu; Seet, Ju E; Patzel, Volker; Chow, Vincent T; Tan, Kai; Seet, Ju; Engelward, Bevin P. (BioMed Central Ltd, 2014-07)
    Background: Tissue regeneration in the lungs is gaining increasing interest as a potential influenza management strategy. In this study, we explored the role of microRNAs, short non-coding RNAs involved in post-transcriptional ...
  • Bousquet, Marina; Lodish, Harvey F. (Expert Reviews, Ltd., 2011-04)
    Leukemia is a complex disease with many different types and subtypes caused by a huge diversity of genetic and epigenetic aberrations. Until recently, alterations of protein-coding genes were thought to be the sole cause ...
  • Hsieh, Po-Jang; Tse, Peter U. (Public Library of Science, 2009-04)
    Motion-induced blindness (MIB) occurs when a dot embedded in a motion field subjectively vanishes. Here we report the first psychophysical data concerning effects of microsaccade/eyeblink rate upon perceptual switches ...
  • Fries, Pascal; Womelsdorf, Thilo; Bosman, Conrado A.; Desimone, Robert (Society for Neuroscience, 2009-06)
    Rhythms occur both in neuronal activity and in behavior. Behavioral rhythms abound at frequencies at or below 10 Hz. Neuronal rhythms cover a very wide frequency range, and the phase of neuronal low-frequency rhythms ...
  • Ng, Shengyong; Velmurugan, Soundarapandian; Galstian, Ani; Shan, Jing; Logan, David J.; Carpenter, Anne E.; Thomas, David; Sim, B. Kim Lee; Mota, Maria M.; Hoffman, Stephen L.; Bhatia, Sangeeta N.; March-Riera, Sandra; Bhatia, Sangeeta N. (Elsevier, 2013-07)
    The Plasmodium liver stage is an attractive target for the development of antimalarial drugs and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a critical early stage. However, ...
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