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Browsing MIT Open Access Articles by Title

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  • Sheng, Morgan Hwa-Tze; Knapska, Ewelina; Macias, Matylda; Mikosz, Marta; Nowak, Aleksandra; Owczarek, Dorota; Wawrzyniak, Marcin; Pieprzyk, Marcelina; Cymerman, Iwona A.; Werka, Tomasz; Maren, Stephen; Jaworski, Jacek; Kaczmarek, Leszek (National Academy of Sciences (U.S.), 2012-10)
    The memory of fear extinction is context dependent: fear that is suppressed in one context readily renews in another. Understanding of the underlying neuronal circuits is, therefore, of considerable clinical relevance for ...
  • Bajaj, Vikram S.; Mak-Jurkauskas, Melody L.; Belenky, Marina; Herzfeld, Judith; Griffin, Robert Guy (National Academy of Sciences, 2009-06)
    Observation and structural studies of reaction intermediates of proteins are challenging because of the mixtures of states usually present at low concentrations. Here, we use a 250 GHz gyrotron (cyclotron resonance maser) ...
  • Hirshfeld-Becker, Dina; Biederman, Joseph; Uchida, Mai; Doehrmann, Oliver; Salvatore, John; Kenworthy, Tara; Brown, Ariel; Kagan, Elana; de los Angeles, Carlo; Chai, Xiaoqian; Leonard, Julia Anne; Gabrieli, Susan; Gabrieli, John D. E. (Elsevier, 2015-05)
    Despite growing evidence for atypical amygdala function and structure in major depression, it remains uncertain as to whether these brain differences reflect the clinical state of depression or neurobiological traits that ...
  • Glantz, Spencer T.; Carpenter, Eric J.; Melkonian, Michael; Gardner, Kevin H.; Wong, Gane Ka-Shu; Chow, Brian Y.; Boyden, Edward (National Academy of Sciences (U.S.), 2016-02)
    Light–oxygen–voltage sensitive (LOV) flavoproteins are ubiquitous photoreceptors that mediate responses to environmental cues. Photosensory inputs are transduced into signaling outputs via structural rearrangements in ...
  • Verhoef, Bram-Ernst; Bohon, Kaitlin S.; Conway, Bevil (Society for Neuroscience, 2015-04)
    Binocular disparity is a powerful depth cue for object perception. The computations for object vision culminate in inferior temporal cortex (IT), but the functional organization for disparity in IT is unknown. Here we ...
  • Jarosiewicz, Beata; Schummers, James; Malik, Wasim Qamar; Brown, Emery N.; Sur, Mriganka (Elsevier, 2012-02)
    Background: Visual perception involves information flow from lower- to higher-order cortical areas, which are known to process different kinds of information. How does this functional specialization arise? As a step toward ...
  • Walker, Graham C.; Modia, Sheetal R.; Camacho, Diogo M.; Kohanski, Michael A.; Collins, James J. (Proceedings of the National Academy of Sciences (PNAS), 2011-08)
    Small RNAs (sRNAs) are important components of posttranscriptional regulation. These molecules are prevalent in bacterial and eukaryotic organisms, and involved in a variety of responses to environmental stresses. The ...
  • Yoshizawa, Susumu; Kumagai, Yohei; Kim, Hana; Ogura, Yoshitoshi; Hayashi, Tetsuya; Iwasaki, Wataru; DeLong, Edward; Kogure, Kazuhiro (National Academy of Sciences (U.S.), 2014-03)
    Light-activated, ion-pumping rhodopsins are broadly distributed among many different bacteria and archaea inhabiting the photic zone of aquatic environments. Bacterial proton- or sodium-translocating rhodopsins can convert ...
  • Dunfield, Derek; Podgorski, Kaspar; Haas, Kurt (Public Library of Science, 2012-01)
    Sensory experience drives dramatic structural and functional plasticity in developing neurons. However, for single-neuron plasticity to optimally improve whole-network encoding of sensory information, changes must be ...
  • Doshi, Vishal; Shah, Devavrat; Medard, Muriel; Effros, Michelle (Institute of Electrical and Electronics Engineers, 2010-08)
    Motivated by applications to sensor networks and privacy preserving databases, we consider the problem of functional compression. The objective is to separately compress possibly correlated discrete sources such that an ...
  • Ang, Wee Han; Lippard, Stephen J. (Royal Society of Chemistry, 2009-09)
    Replacement of a single dA nucleotide positioned at a programmed site in a DNA plasmid with its 7-deaza-analog is described together with its complete resistance to restriction enzymatic cleavage.
  • Agrawal, Amit; Min, Dal-Hee; Singh, Neetu; Zhu, Haihao; Birjiniuk, Alona; Von Maltzahn, Geoffrey; Harris, Todd J.; Xing, Deyin; Woolfenden, Stephen D.; Sharp, Phillip A.; Charest, Alain; Bhatia, Sangeeta N. (American Chemical Society, 2009-09)
    Small interfering RNAs (siRNAs) mediate cleavage of specific, complementary mRNA sequences and thus regulate gene expression. Not surprisingly, their use for treatment of diseases that are rooted in aberrant gene expression, ...
  • Tantama, Mathew; Licht, Stuart (Elsevier B.V., 2009-05)
    The subunits of the muscle-type nicotinic acetylcholine receptor (AChR) are not uniformly oriented in the resting closed conformation: the two α subunits are rotated relative to its non-α subunits. In contrast, all the ...
  • DeKelver, Russell C.; Choi, Vivian M.; Moehle, Erica A.; Paschon, David E.; Hockemeyer, Dirk; Meijsing, Sebastiaan H.; Sancak, Yasemin; Cui, Xiaoxia; Steine, Eveline J.; Miller, Jeffrey C.; Tam, Phillip; Bartsevich, Victor V.; Meng, Xiangdong; Rupniewski, Igor; Gopalan, Sunita M.; Sun, Helena C.; Pitz, Kathleen J.; Rock, Jeremy M.; Zhang, Lei; Davis, Gregory D.; Rebar, Edward J.; Cheeseman, Iain McPherson; Yamamoto, Keith R.; Sabatini, David M.; Jaenisch, Rudolf; Gregory, Philip D.; Urnov, Fyodor D. (Cold Spring Harbor Laboratory Press, 2010-05)
    Isogenic settings are routine in model organisms, yet remain elusive for genetic experiments on human cells. We describe the use of designed zinc finger nucleases (ZFNs) for efficient transgenesis without drug selection ...
  • Possemato, Richard; Marks, Kevin M.; Shaul, Yoav D.; Pacold, Michael E.; Kim, Dohoon; Birsoy, Kivanc; Sethumadhavan, Shalini; Woo, Hin-Koon; Jang, Hyun G.; Jha, Abhishek K.; Chen, Walter W.; Barrett, Francesca G.; Stransky, Nicolas; Tsun, Zhi-Yang; Cowley, Glenn S.; Barretina, Jordi; Kalaany, Nada Y.; Hsu, Peggy P.; Ottina, Kathleen; Chan, Albert M.; Yuan, Bingbing B.; Garraway, Levi A.; Root, David E.; Mino-Kenudson, Mari; Brachtel, Elena F.; Driggers, Edward M.; Sabatini, David M. (Nature Publishing Group, 2011-08)
    Cancer cells adapt their metabolic processes to drive macromolecular biosynthesis for rapid cell growth and proliferation[superscript 1, 2]. RNA interference (RNAi)-based loss-of-function screening has proven powerful for ...
  • Langs, Georg; Golland, Polina; Tie, Yanmei; Rigolo, Laura; Golby, Alexandra J. (2010-12)
    Matching functional brain regions across individuals is a challenging task, largely due to the variability in their location and extent. It is particularly difficult, but highly relevant, for patients with pathologies such ...
  • Swager, Timothy M.; Sydlik, Stefanie Arlene (Wiley Blackwell, 2012-11)
    Current research in materials has devoted much attention to graphene, with a considerable amount of the chemical manipulation going through the oxidized state of the material, known as graphene oxide (GO). In this report, ...
  • Alexander, Harriet; Haley, Sheean T.; Wilson, Samuel T.; Karl, David M.; Dyhrman, Sonya T.; Rouco, Monica (National Academy of Sciences (U.S.), 2015-11)
    A diverse microbial assemblage in the ocean is responsible for nearly half of global primary production. It has been hypothesized and experimentally demonstrated that nutrient loading can stimulate blooms of large eukaryotic ...
  • Gupta, Piyush; Rudnick, Jenny A.; Arendt, Lisa M.; Klebba, Ina; Hinds, John W.; Iyer, Vandana; Naber, Stephen P.; Kuperwasser, Charlotte (Public Library of Science, 2011-09)
    Fibroblasts are important in orchestrating various functions necessary for maintaining normal tissue homeostasis as well as promoting malignant tumor growth. Significant evidence indicates that fibroblasts are functionally ...
  • Bric, Anka; Miething, Cornelius; Bialucha, Carl Uli; Scuoppo, Claudio; Zender, Lars; Krasnitz, Alexander; Xuan, Zhenyu; Zuber, Johannes; Wigler, Michael; Hicks, James; McCombie, Richard W.; Hemann, Michael; Hannon, Gregory J.; Powers, Scott; Lowe, Scott W. (Elsevier, 2009-10)
    Short hairpin RNAs (shRNAs) capable of stably suppressing gene function by RNA interference (RNAi) can mimic tumor-suppressor-gene loss in mice. By selecting for shRNAs capable of accelerating lymphomagenesis in a ...
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