Chan, Juliana Maria; Zhang, Liangfang; Tong, Rong; Ghosh, Debadyuti; Gao, Weiwei; Liao, Grace V.; Yuet, Kai P.; Gray, David; Rhee, June-Wha; Cheng, Jianjun; Golomb, Gershon; Libby, Peter; Langer, Robert; Farokhzad, Omid C.
(National Academy of Sciences, 2010-02)
There are a number of challenges associated with designing nanoparticles for medical applications. We define two challenges here: (i) conventional targeting against up-regulated cell surface antigens is limited by heterogeneity ...