Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Chen, Jingyang; Ghorai, Manas K.; Kenney, Grace; Stubbe, JoAnne (Oxford University Press (OUP), 2008-05)
    The bleomycins (BLMs) are a family of natural glycopeptides used clinically as antitumor agents. In the presence of required cofactors (Fe[superscript 2+] and O[subscript 2]), BLM causes both single-stranded (ss) and ...
  • Strieter, Eric R.; Bhayana, Brijesh; Buchwald, Stephen Leffler (American Chemical Society (ACS), 2008-12)
    The copper-catalyzed N-arylation of amides, i.e., the Goldberg reaction, is an efficient method for the construction of products relevant to both industry and academic settings. Herein, we present mechanistic details ...
  • Polacheck, William J.; German, Alexandra E.; Mammoto, Akiko; Ingber, Donald E.; Kamm, Roger Dale (National Academy of Sciences (U.S.), 2014-02)
    Solid tumors are characterized by high interstitial fluid pressure, which drives fluid efflux from the tumor core. Tumor-associated interstitial flow (IF) at a rate of ∼3 µm/s has been shown to induce cell migration in the ...
  • Tingley, Dustin; Yamamoto, Teppei; Hirose, Kentaro; Keele, Luke; Imai, Kosuke (UCLA Statistics/American Statistical Association, 2014-08)
    In this paper, we describe the R package mediation for conducting causal mediation analysis in applied empirical research. In many scientific disciplines, the goal of researchers is not only estimating causal effects of a ...
  • Kagey, Michael H.; Newman, Jamie J.; Bilodeau, Steve; Zhan, Ye; Orlando, David A.; van Berkum, Nynke L.; Ebmeier, Christopher C.; Goossens, Jesse; Rahl, Peter B.; Levine, Stuart S.; Taatjes, Dylan J.; Dekker, Job; Young, Richard A. (Nature Publishing Group, 2010-08)
    Transcription factors control cell-specific gene expression programs through interactions with diverse coactivators and the transcription apparatus. Gene activation may involve DNA loop formation between enhancer-bound ...
  • Finkelstein, Amy; Taubman, Sarah L.; Allen, Heidi L.; Wright, Bill J.; Baicker, Katherine (American Association for the Advancement of Science (AAAS), 2014-01)
    In 2008, Oregon initiated a limited expansion of a Medicaid program for uninsured, low-income adults, drawing names from a waiting list by lottery. This lottery created a rare opportunity to study the effects of Medicaid ...
  • Clifford, Gari D.; Blaya, Joaquin Andres; Hall-Clifford, Rachel; Fraser, Hamish S. (BioMed Central Ltd., 2008-06)
  • Romero, R.; Emanuel, Kerry Andrew (American Geophysical Union, 2013-06)
    Medicanes or “Mediterranean hurricanes” are extreme cyclonic windstorms morphologically and physically similar to tropical cyclones. Owing to their potential destructiveness on the islands and continental coastal zones, ...
  • Engelhardt, Gary V.; Gruber, Jonathan (American Economic Association, 2011-11)
    We examine the impact of the expansion of public prescription-drug insurance coverage from Medicare Part D and find evidence of substantial crowd-out. Using the 2002-2007 waves of the Medical Expenditure Panel Survey, we ...
  • D'Eramo, Francesco; Liu, Hong; Rajagopal, Krishna (IOP Publishing, 2011-11)
    The propagation of hard partons through the strongly interacting matter created in high-energy heavy-ion collisions involves widely separated scales. The methods of effective field theories can provide a factorized description ...
  • Oskooi, Ardavan; Roundy, David; Ibanescu, Mihai; Bermel, Peter A.; Joannopoulos, John D.; Johnson, Steven G. (Elsevier, 2009-11)
    This paper describes Meep, a popular free implementation of the finite-difference time-domain (FDTD) method for simulating electromagnetism. In particular, we focus on aspects of implementing a full-featured FDTD package ...
  • Miller, Matthew P.; Unal, Elcin; Brar, Gloria A.; Amon, Angelika B. (eLife Sciences Publications, Ltd., 2012-12)
    During meiosis, a single round of DNA replication is followed by two consecutive rounds of nuclear divisions called meiosis I and meiosis II. In meiosis I, homologous chromosomes segregate, while sister chromatids remain ...
  • Chisholm, Jennifer; Hawley, R. Scott; Orr-Weaver, Terry L.; Whitfield, Zachary James (Public Library of Science, 2013-09)
    Oocytes are stockpiled with proteins and mRNA that are required to drive the initial mitotic divisions of embryogenesis. But are there proteins specific to meiosis whose levels must be decreased to begin embryogenesis ...
  • Lander, Eric S.; Berger, Michael F.; Hodis, Eran; Heffernan, Timothy P.; Deribe, Yonathan Lissanu; Lawrence, Michael S.; Protopopov, Alexei; Ivanova, Elena; Watson, Ian R.; Nickerson, Elizabeth; Ghosh, Papia; Zhang, Hailei; Zeid, Rhamy; Ren, Xiaojia; Cibulskis, Kristian; Sivachenko, Andrey Y.; Wagle, Nikhil; Sucker, Antje; Sougnez, Carrie; Onofrio, Robert (Nature Publishing Group, 2012-05)
    Melanoma is notable for its metastatic propensity, lethality in the advanced setting and association with ultraviolet exposure early in life. To obtain a comprehensive genomic view of melanoma in humans, we sequenced the ...
  • Gregg, Patricia M.; Behn, M. D.; Lin, J.; Grove, Timothy L. (American Geophysical Union (AGU), 2009-11)
    We examine mantle melting, fractional crystallization, and melt extraction beneath fast slipping, segmented oceanic transform fault systems. Three-dimensional mantle flow and thermal structures are calculated using a ...
  • Till, Christy B.; Grove, Timothy L.; Krawczynski, Michael J. (American Geophysical Union (AGU), 2012-06)
    Here we develop a lherzolite melting model and explore the effects of variations in mantle composition, pressure, temperature, and H[subscript 2]O content on melt composition. New experiments and a compilation of experimental ...
  • Choi, Philip S.; Zakhary, Lisa; Choi, Wen-Yee; Caron, Sophie; Alvarez-Saavedra, Ezequiel; Miska, Eric A.; McManus, Mike; Harfe, Brian; Giraldez, Antonio J.; Horvitz, H. Robert; Schier, Alexander F.; Dulac, Catherine (Elsevier B.V., 2008-01)
    MicroRNAs (miRNAs) are highly expressed in vertebrate neural tissues, but the contribution of specific miRNAs to the development and function of different neuronal populations is still largely unknown. We report that miRNAs ...
  • Leksa, Nina Carolina; Schwartz, Thomas (Landes Bioscience, 2010-07)
    The nuclear pore complex (NPC) regulates all traffic between the cytoplasm and the nucleus. It is a large protein assembly composed of multiple copies of ~30 nucleoporins (nups). Structural studies of the NPC have been ...
  • Abel, Steven M.; Roose, Jeroen P.; Groves, Jay T.; Weiss, Arthur; Chakraborty, Arup K. (American Chemical Society (ACS), 2012-02)
    Many key biochemical reactions that mediate signal transduction in cells occur at the cell membrane, yet how the two-dimensional membrane environment influences the collective behavior of signaling networks is poorly ...
  • Braff, William A.; Bazant, Martin Z.; Buie, Cullen R. (Nature Publishing Group, 2013-08)
    In order for the widely discussed benefits of flow batteries for electrochemical energy storage to be applied at large scale, the cost of the electrochemical stack must come down substantially. One promising avenue for ...
Open Access