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Browsing MIT Open Access Articles by Title

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  • Assogba, Yannick M.; Donath, Judith (Institute of Electrical and Electronics Engineers, 2009-01)
    This paper introduces Mycrocosm, a micro-blogging site in which users communicate via statistical graphics, rather than the usual short text statements. Users of Mycrocosm can record everyday "personal statistics" and share ...
  • Hoshi, Namiko; Schenten, Dominik; Nish, Simone A.; Walther, Zenta; Gagliani, Nicola; Flavell, Richard A.; Reizis, Boris; Shen, Zeli; Fox, James G.; Iwasaki, Akiko; Medzhitov, Ruslan (Nature Publishing Group, 2012-10)
    Commensal bacterial sensing by Toll-like receptors is critical for maintaining intestinal homeostasis, but can lead to colitis in the absence of interleukin-10. Although Toll-like receptors are expressed in multiple cell ...
  • Crotty Alexander, Laura E.; Marsh, Brenda J.; Timmer, Anjuli M.; Lin, Ann E.; Zainabadi, Kayvan; Czopik, Agnieszka; Nizet, Victor; Guarente, Leonard Pershing (Public Library of Science, 2013-12)
    The role of sirtuin-1 (SIRT1) in innate immunity, and in particular the influence of SIRT1 on antimicrobial defense against infection, has yet to be reported but is important to define since SIRT1 inhibitors are being ...
  • Festuccia, William T.; Pouliot, Philippe; Bakan, Inan; Sabatini, David M.; Laplante, Mathieu; Sabatini, David M. (Public Library of Science, 2014-04)
    The phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt) axis plays a central role in attenuating inflammation upon macrophage stimulation with toll-like receptor (TLR) ligands. The mechanistic target of rapamycin complex ...
  • Chung, Jaewoo; Xu, Kuang; Colaco, Andrea B.; Schmandt, Christopher M.; Li, Victor O. K. (Institute of Electrical and Electronics Engineers, 2010-01)
    In this paper, we propose a novel concept for a social TV application targeting the demographic of viewers enjoying live sports events, such as road bicycle racing. We intend to enhance the viewing experiences of spectators ...
  • Cassa, Christopher A.; Schmidt, Brian; Kohane, Isaac; Mandl, Kenneth D. (BioMed Central Ltd., 2008-07)
    Background: Genomic sequencing of SNPs is increasingly prevalent, though the amount of familial information these data contain has not been quantified. Methods: We provide a framework for measuring the risk to siblings ...
  • Cassa, Christopher A.; Schmidt, Brian; Kohane, Isaac; Mandl, Kenneth D. (BioMed Central Ltd., 2008-07)
    Background Genomic sequencing of SNPs is increasingly prevalent, though the amount of familial information these data contain has not been quantified. Methods We provide a framework for measuring the risk to siblings ...
  • Hauser, Marc D.; Yang, Charles; Berwick, Robert C.; Tattersall, Ian; Ryan, Michael J.; Watumull, Jeffrey; Chomsky, Avram Noam; Lewontin, Richard C. (Frontiers Research Foundation, 2014-05)
    Understanding the evolution of language requires evidence regarding origins and processes that led to change. In the last 40 years, there has been an explosion of research on this problem as well as a sense that considerable ...
  • Sunyaev, Shamil R.; Lander, Eric S. (National Academy of Sciences, 2012-01)
    Human genetics has been haunted by the mystery of “missing heritability” of common traits. Although studies have discovered >1,200 variants associated with common diseases and traits, these variants typically appear to ...
  • Adams, Allan; Jockers, Hans; Kumar, Vijay; Lapan, Joshua M. (Springer-Verlag, 2011-12)
    We study sigma models in AdS4 with global N = 1 supersymmetry and find that they differ significantly from their flat-space cousins — the target space is constrained to be a K¨ahler manifold with an exact K¨ahler form, ...
  • Onbasli, Mehmet Cengiz; Okyay, Ali K. (SPIE--the International Society for Optical Engineering, 2010-08)
    State-of-the-art copper interconnects suffer from increasing spatial power dissipation due to chip downscaling and RC delays reducing operation bandwidth. Wide bandwidth, minimized Ohmic loss, deep sub-wavelength confinement ...
  • Bernardi, Marco; Lohrman, Jessica; Kirkeminde, Alec; Ferralis, Nicola; Grossman, Jeffrey C.; Ren, Shenqiang; Kumar, Priyank Vijaya (American Chemical Society (ACS), 2012-09)
    Carbon materials are excellent candidates for photovoltaic solar cells: they are Earth-abundant, possess high optical absorption, and maintain superior thermal and photostability. Here we report on solar cells with active ...
  • Rusina, Anastasia; Durach, Maxim; Nelson, Keith Adam; Stockman, Mark I. (SPIE, 2010-08)
    Here, we establish the principal limits for the nanoconcentration of the THz radiation in metal/dielectric waveguides and determine their optimum shapes required for this nanoconcentration. We predict that the adiabatic ...
  • Duguet, T.; Unal, Baris; Ledieu, J.; Dubois, J. M.; Fournee, V.; Thiel, P. A. (American Physical Society, 2011-02)
    Among the three coexisting types of terraces found on the twofold surface of the d-Al-Cu-Co quasicrystal, nanodomains are essentially observed on the transition-metal rich ones, with a coherent interface boundary. Both ...
  • Antoniadis, Dimitri A. (Institute of Electrical and Electronics Engineers, 2010-01)
    Leading edge CMOS technologies today are unique examples of nanoscale engineering at an industrial scale. As we celebrate this remarkable achievement of our industry that forms the ever-expanding technology basis of modern ...
  • Wang, Evelyn N.; Xiao, Rong; Chu, Kuang-Han (SPIE, 2010-02)
    Microfluidic systems offer compact and efficient thermal management strategies. In this work, we investigate novel nanostructured surfaces to control fluidic behavior and enhance heat dissipation in microfluidic systems. ...
  • Bettinger, Christopher J.; Kulig, Katherine M.; Vacanti, Joseph P.; Langer, Robert; Borenstein, Jeffrey T. (Mary Ann Liebert, Inc., 2009-07)
    Synthetic substrates that mimic the properties of extracellular matrix proteins hold significant promise for use in systems designed for tissue engineering applications. In this report, we designed a synthetic polymeric ...
  • Buongiorno, Jacopo; Hu, Lin-Wen (American Society of Mechanical Engineers, 2009-12)
    Colloidal dispersions of nanoparticles are known as `nanofluids'. Such engineered fluids offer the potential for enhancing heat transfer, particularly boiling heat transfer, while avoiding the drawbacks (i.e., erosion, ...
  • Kim, Sung Jae; Song, Yong-Ak; Han, Jongyoon (Royal Society of Chemistry, 2010-01)
    Recently, a new type of electrokinetic concentration devices has been developed in a microfluidic chip format, which allows efficient trapping and concentration of biomolecules by utilizing ion concentration polarization ...
  • Picallo, Clara; Gravelle, Simon; Joly, Laurent; Charlaix, Elisabeth; Bocquet, Lyderic (American Physical Society, 2013-12)
    Osmosis describes the flow of water across semipermeable membranes powered by the chemical free energy extracted from salinity gradients. While osmosis can be expressed in simple terms via the van ’t Hoff ideal gas formula ...
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