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Browsing MIT Open Access Articles by Title

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  • Gyorgy, Andras; Del Vecchio, Domitilla (Public Library of Science, 2014-03)
    Predicting the dynamic behavior of a large network from that of the composing modules is a central problem in systems and synthetic biology. Yet, this predictive ability is still largely missing because modules display ...
  • Temme, Karsten; Hill, Rena; Segall-Shapiro, Thomas Hale; Moser, Felix; Voigt, Christopher A. (Oxford University Press (OUP), 2012-05)
    Synthetic genetic sensors and circuits enable programmable control over the timing and conditions of gene expression. They are being increasingly incorporated into the control of complex, multigene pathways and cellular ...
  • Miller, Miles Aaron; Hafner, Marc; Sontag, Eduardo; Davidsohn, Noah Justin; Subramanian, Sairam; Purnick, Priscilla E. M.; Lauffenburger, Douglas A.; Weiss, Ron (Public Library of Science, 2012-07)
    Synthetic biology efforts have largely focused on small engineered gene networks, yet understanding how to integrate multiple synthetic modules and interface them with endogenous pathways remains a challenge. Here we present ...
  • Miller, Miles Aaron; Hafner, Marc; Sontag, Eduardo; Davidsohn, Noah Justin; Subramanian, Sairam; Purnick, Priscilla E. M.; Lauffenburger, Douglas A.; Weiss, Ron (Public Library of Science, 2012-07)
    Synthetic biology efforts have largely focused on small engineered gene networks, yet understanding how to integrate multiple synthetic modules and interface them with endogenous pathways remains a challenge. Here we present ...
  • Broustis, Ioannis; Syrivelis, Dimitris; Georgiadis, Leonidas; Tassiulas, Leandros; Paschos, Georgios (Springer, 2013-07)
    Intersession network coding (NC) can provide significant performance benefits via mixing packets at wireless routers; these benefits are especially pronounced when NC is applied in conjunction with intelligent scheduling. ...
  • Hobbie, Sven N; Viswanathan, Karthik; Bachelet, Ido; Aich, Udayanath; Subramanian, Vidya; Raman, Rahul; Sasisekharan, Ram; Shriver, Zachary H.; Shriver, Zachary (BioMed Central Ltd, 2013-04)
    Background: The ongoing global efforts to control influenza epidemics and pandemics require high-throughput technologies to detect, quantify, and functionally characterize viral isolates. The 2009 influenza pandemic as ...
  • Ercolessi, Elisa; Evangelisti, Stefano; Franchini, Fabio; Ravanini, Francesco (American Physical Society, 2013-09)
    We show that the elliptic parametrization of the coupling constants of the quantum XYZ spin chain can be analytically extended outside of their natural domain, to cover the whole phase diagram of the model, which is composed ...
  • Jevtov, Irena; Glatter, Timo; Schittenhelm, Ralf B.; Rinner, Oliver; Roguska, Katarzyna; Wepf, Alexander; Junger, Martin A.; Kohler, Katja; Choi, Hyungwon; Schmidt, Alexander; Nesvizhskii, Alexey I.; Stocker, Hugo; Hafen, Ernst; Aebersold, Ruedi; Gstaiger, Matthias (Nature Publishing Group, 2011-11)
    Genetic analysis in Drosophila melanogaster has been widely used to identify a system of genes that control cell growth in response to insulin and nutrients. Many of these genes encode components of the insulin receptor/target ...
  • Vecchio, Domitilla Del (IOP Publishing, 2012-08)
    Modularity is a property by which the behavior of a system does not change upon interconnection. It is crucial for understanding the behavior of a complex system from the behavior of the composing subsystems. Whether ...
  • Jonas, Kristina; Chen, Y. Erin; Laub, Michael T.; Chen, Y. Erin; Laub, Michael T. (Elsevier, 2011-06)
    Background: Complex regulatory circuits in biology are often built of simpler subcircuits or modules. In most cases, the functional consequences and evolutionary origins of modularity remain poorly defined. Results: Here, ...
  • Rus, Daniela L.; Gilpin, Kyle W. (Institute of Electrical and Electronics Engineers (IEEE), 2010-09)
    We have presented a detailed retrospective on modular robots and discussed connections between modular robots and programmable matter. This field has seen a great deal of creativity and innovation at the level of designing ...
  • Conforti, Matteo; De Angelis, Costantino; Akylas, Triantaphyllos R.; Aceves, Alejandro B. (American Physical Society, 2012-06)
    We consider a model consisting of two subsystems with crossing linear dispersion curves that describes, for example, light propagation in binary waveguide arrays. This model admits bright-dark gap solitons in both the ...
  • Ekstrom, Leeland B.; Roelfsema, Pieter R.; Arsenault, John T.; Kolster, Hauke; Vanduffel, Wim (Society for Neuroscience, 2009-08)
    Spatial attention influences representations in visual cortical areas as well as perception. Some models predict a contrast gain, whereas others a response or activity gain when attention is directed to a contrast-varying ...
  • Gibson, Phillip; Schreuder-Gibson, Heidi; Yip, Pearl; Denker, Brendan; Benaddi, Hamid; Wang, Sa; Bromberg, Lev E.; Hatton, T. Alan (Hindawi Publishing Corporation, 2013-01)
    The role of water in protective fabrics is critical to comfort and material performance. Excessive perspiration in clothing causes discomfort, and bound water can adversely affect the ability of carbon to adsorb chemicals. ...
  • Kumar, Yadunanda; Liang, Cui; Limmon, Gino V.; Liang, Li; Engelward, Bevin P.; Ooi, Eng Eong; Chen, Jianzhu; Tannenbaum, Steven Robert (Public Library of Science, 2014-02)
    Background: Management of influenza, a major contributor to the worldwide disease burden, is complicated by lack of reliable methods for early identification of susceptible individuals. Identification of molecular markers ...
  • Buehler, Markus J.; Uzel, Sebastien Guy Marcel (American Society of Mechanical Engineers, 2010-02)
    Collagen is a crucial structural protein material, formed through a hierarchical assembly of tropocollagen molecules, arranged in collagen fibrils that constitute the basis for larger-scale fibrils and fibers. Osteogenesis ...
  • Hayashi, Takuma; Horiuchi, Akiko; Sano, Kenji; Hiraoka, Nobuyoshi; Kanai, Yae; Shiozawa, Tanri; Tonegawa, Susumu; Konishi, Ikuo (Hindawi Pub. Corp., 2011-01)
    Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, ...
  • Brohawn, Stephen G.; Schwartz, Thomas (Nature Publishing Group, 2009-10)
    Nuclear pore complexes (NPCs) facilitate all nucleocytoplasmic transport. These massive protein assemblies are modular, with a stable structural scaffold supporting more dynamically attached components. The scaffold is ...
  • Bilokapic, Silvija; Schwartz, Thomas (National Academy of Sciences (U.S.), 2012-09)
    Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs), enormous assemblies composed of multiple copies of ∼30 different proteins called nucleoporins. To unravel the basic scaffold underlying the NPC, we ...
  • Liu, Judy S.; Schubert, Christian R.; Fu, Xiaoqin; Fourniol, Franck J.; Jaiswal, Jyoti K.; Houdusse, Anne; Stultz, Collin M.; Moores, Carolyn A.; Walsh, Christopher A.; Schubert, Christian R.; Stultz, Collin M. (Elsevier, 2012-07)
    Doublecortin (Dcx) defines a growing family of microtubule (MT)-associated proteins (MAPs) involved in neuronal migration and process outgrowth. We show that Dcx is essential for the function of Kif1a, a kinesin-3 motor ...
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