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Browsing MIT Open Access Articles by Title

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  • Bornschein, U.; Kerimoglu, C.; Schreiter, S.; Dannemann, M.; Rea, E.; French, Christopher A.; Puliyadi, R.; Groszer, M.; Fisher, S. E.; Mundry, R.; Winter, C.; Hevers, W.; Paabo, S.; Enard, W.; Schreiweis, Christiane; Burguiere, Eric; Goyal, Shubhi; Graybiel, Ann M. (National Academy of Sciences (U.S.), 2014-09)
    The acquisition of language and speech is uniquely human, but how genetic changes might have adapted the nervous system to this capacity is not well understood. Two human-specific amino acid substitutions in the transcription ...
  • Thomas, David K.; Chen, Alice; Ong, Luvena L.; Schwartz, Robert E.; Golub, Todd R.; Bhatia, Sangeeta N. (Proceedings of the National Academy of Sciences (PNAS), 2011-07)
    “Humanized” mice offer a window into aspects of human physiology that are otherwise inaccessible. The best available methods for liver humanization rely on cell transplantation into immunodeficient mice with liver injury ...
  • Cheeseman, Iain McPherson; Welburn, Julie P. I.; Grishchuk, Ekaterina L.; Backer, Chelsea B.; Wilson-Kubalek, Elizabeth M.; Yates III, John R. (Cell Press, 2009-03)
    Mitotic chromosome segregation requires that kinetochores attach to microtubule polymers and harness microtubule dynamics to drive chromosome movement. In budding yeast, the Dam1 complex couples kinetochores with microtubule ...
  • Dodds, Peter Sheridan; Clark, Eric M.; Desu, Suma; Reagan, Andrew J.; Williams, Jake Ryland; Mitchell, Lewis; Harris, Kameron Decker; Kloumann, Isabel M.; Bagrow, James P.; Megerdoomian, Karine; McMahon, Matthew T.; Tivnan, Brian F.; Danforth, Christopher M.; Frank, Morgan Ryan (National Academy of Sciences (U.S.), 2015-02)
    Using human evaluation of 100,000 words spread across 24 corpora in 10 languages diverse in origin and culture, we present evidence of a deep imprint of human sociality in language, observing that (i) the words of natural ...
  • Krishnaswamy, Pavitra; Brown, Emery N.; Herr, Hugh M. (Public Library of Science, 2011-03)
    A common feature in biological neuromuscular systems is the redundancy in joint actuation. Understanding how these redundancies are resolved in typical joint movements has been a long-standing problem in biomechanics, ...
  • Vosoughi, Soroush; Roy, Deb K. (Institute of Electrical and Electronics Engineers (IEEE), 2015-11)
    The spread of rumors on social media, especially in time-sensitive situations such as real-world emergencies, can have harmful effects on individuals and society. In this work, we developed a human-machine collaborative ...
  • Nuschke, Austin; Rodrigues, Melanie; Stolz, Donna B; Chu, Charleen T; Wells, Alan; Griffith, Linda G. (BioMed Central Ltd, 2014-12)
    Introduction Bone marrow mesenchymal stem cells/multipotent stromal cells (MSCs) are recruited to sites of injury and subsequently support regeneration through differentiation or paracrine activity. During periods of ...
  • Gevers, Dirk (Public Library of Science, 2012-08)
    The Human Microbiome Project (HMP) [1],[2] is a concept that was long in the making. After the Human Genome Project, interest grew in sequencing the “other genome" of microbes carried in and on the human body [3],[4]. ...
  • Roubelakis, Maria G.; Zotos, Pantelis; Papachristoudis, Georgios; Michalopoulos, Ioannis; Pappa, Kalliopi I.; Anagnou, Nicholas P.; Kossida, Sophia (BioMed Central Ltd., 2009-06)
    microRNAs (miRNAs) are single-stranded RNA molecules of about 20–23 nucleotides length found in a wide variety of organisms. miRNAs regulate gene expression, by interacting with target mRNAs at specific sites in order to ...
  • Roubelakis, Maria G.; Zotos, Pantelis; Papachristoudis, Georgios; Michalopoulos, Ioannis; Pappa, Kalliopi I.; Anagnou, Nicholas P.; Kossida, Sophia (BioMed Central Ltd., 2009-06)
    Background: microRNAs (miRNAs) are single-stranded RNA molecules of about 20–23 nucleotides length found in a wide variety of organisms. miRNAs regulate gene expression, by interacting with target mRNAs at specific sites ...
  • Calabrese, Francesco; Di Lorenzo, Giusy; Ratti, Carlo (Institute of Electrical and Electronics Engineers (IEEE), 2010-09)
    Understanding and predicting human mobility is a crucial component of transportation planning and management. In this paper we propose a new model to predict the location of a person over time based on individual and ...
  • Chen, Qingfeng; Amaladoss, Anburaj; Ye, Weijian; Liu, Min; Dummler, Sara; Kong, Fang; Wong, Lan Hiong; Loo, Hooi Linn; Loh, Eva; Tan, Shu Qi; Tan, Thiam Chye; Chang, Kenneth T. E.; Dao, Ming; Suresh, Subra; Preiser, Peter R.; Chen, Jianzhu (National Academy of Sciences (U.S.), 2014-01)
    Immunodeficient mouse–human chimeras provide a powerful approach to study host-specific pathogens, such as Plasmodium falciparum that causes human malaria. Supplementation of immunodeficient mice with human RBCs supports ...
  • Helmreich, Stefan (Paradigm Publishers, 2010-12)
    Nineteenth-century Americans and Europeans envisaged the ocean as a sublime space, at once frightening and inviting. Romantic poets such as Byron and Shelley celebrated the sea as a seductive substance with which we ...
  • Hospodsky, Denina; Qian, Jing; Nazaroff, William W.; Yamamoto, Naomichi; Bibby, Kyle; Rismani-Yazdi, Hamid; Peccia, Jordan (Public Library of Science, 2012-04)
    Exposure to specific airborne bacteria indoors is linked to infectious and noninfectious adverse health outcomes. However, the sources and origins of bacteria suspended in indoor air are not well understood. This study ...
  • Demidova-Rice, Tatiana N.; Wolf, Lindsey; Deckenback, Jeffry; Hamblin, Michael R.; Herman, Ira M. (Public Library of Science, 2012-02)
    Previous work in our laboratory has described several pro-angiogenic short peptides derived from endothelial extracellular matrices degraded by bacterial collagenase. Here we tested whether these peptides could stimulate ...
  • Marcus, Adam; Wu, Eugene; Madden, Samuel R.; Miller, Robert C. (VLDB Endowment, 2011-09)
    Crowdsourcing markets like Amazon's Mechanical Turk (MTurk) make it possible to task people with small jobs, such as labeling images or looking up phone numbers, via a programmatic interface. MTurk tasks for processing ...
  • Nikolaidis, Stefanos; Rossano, Gregory; Martinez, Carlos; Fuhlbrigge, Thomas; Lasota, Przemyslaw Andrzej; Shah, Julie A. (Institute of Electrical and Electronics Engineers (IEEE), 2013-10)
    New industrial robotic systems that operate in the same physical space as people highlight the emerging need for robots that can integrate seamlessly into human group dynamics. In this paper we build on our prior investigation, ...
  • Nikolaidis, Stefanos; Shah, Julie A. (Institute of Electrical and Electronics Engineers, 2013-03)
    We design and evaluate human-robot cross-training, a strategy widely used and validated for effective human team training. Cross-training is an interactive planning method in which a human and a robot iteratively switch ...
  • Ritvo, Harriet (American Academy of Arts and Sciences, 2009-06)
    “When I use a word,” says Humpty Dumpty in Through the Looking Glass, “it means just what I choose it to mean– neither more nor less.” Alice demurs on several grounds, appealing first to contrary popular consensus–“But ...
  • Xu, Weihong; Seok, Junhee; Mindrinos, Michael N.; Schweitzer, Anthony C.; Jiang, Hui; Wilhelmy, Julie; Clark, Tyson A.; Kapur, Karen; Xing, Yi; Faham, Malek; Storey, John D.; Moldawer, Lyle L.; Maier, Ronald V.; Tompkins, Ronald G.; Wong, Wing Hung; Davis, Ronald W.; Xiao, Wenzhong; Inflammation and Host Response to Injury Large-Scale Collaborative Research Program (National Academy of Sciences (U.S.), 2011-03)
    A 6.9 million-feature oligonucleotide array of the human transcriptome [Glue Grant human transcriptome (GG-H array)] has been developed for high-throughput and cost-effective analyses in clinical studies. This array allows ...
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