Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Sun, Tingwan; Jain, Tushar; Caffry, Isabelle; Yu, Yao; Cao, Yuan; Lynaugh, Heather; Brown, Michael; Xu, Yingda; Kelly, Ryan Lewis; Vasquez, Maximiliano; Wittrup, Karl Dane (Landes Bioscience, 2015-06)
    Although improvements in technology for the isolation of potential therapeutic antibodies have made the process increasingly predictable, the development of biologically active monoclonal antibodies (mAbs) into drugs can ...
  • Shalem, Ophir; Zhang, Feng; Sanjana, Neville (Nature Publishing Group, 2015-04)
    Forward genetic screens are powerful tools for the discovery and functional annotation of genetic elements. Recently, the RNA-guided CRISPR (clustered regularly interspaced short palindromic repeat)-associated Cas9 nuclease ...
  • Angelosanto, Jill; Brosnahan, Kathleen; Ross, Kenneth; Hahn, Cynthia; Russell, Kate; Drury, Linda; Norton, Stephanie; Nadler, Lee; Stegmaier, Kimberly; Haining, W. Nicholas (BioMed Central Ltd, 2008-08)
    Background: The differentiation of naive T and B cells into memory lymphocytes is essential for immunity to pathogens. Therapeutic manipulation of this cellular differentiation program could improve vaccine efficacy and ...
  • Pardo-Martin, Carlos; Allalou, Amin Mohamed; Medina, Jaime; Eimon, Peter; Wählby, Carolina; Yanik, Mehmet Fatih (Nature Publishing Group, 2013-02)
    Most gene mutations and biologically active molecules cause complex responses in animals that cannot be predicted by cell culture models. Yet animal studies remain too slow and their analyses are often limited to only a ...
  • Pardo-Martin, Carlos; Chang, Tsung-Yao; Koo, Bryan Kyo; Gilleland, Cody Lee; Wasserman, Steven Charles; Yanik, Mehmet Fatih (Nature Publishing Group, 2010-07)
    We demonstrate a high-throughput platform for cellular-resolution in vivo chemical and genetic screens on zebrafish larvae. The system automatically loads zebrafish from reservoirs or multiwell plates, and positions and ...
  • Xu, Feng; Beyazoglu, Turker; Emre, Ahmet E.; Hefner, Evan; Manzur, Tariq; Demirci, Utkan; Moon, SangJun (Society of Photo-optical Instrumentation Engineers, 2010-04)
    Cell-based biosensors (CBBs) have important applications in biosecurity and rapid diagnostics. Current CBB technologies have challenges including cell immobilization on the sensors, high throughput fabrication and portability, ...
  • Kothapalli, Chandrasekhar R.; Van Veen, Ed; de Valence, Sarra; Chung, Seok; Zervantonakis, Ioannis; Gertler, Frank; Kamm, Roger Dale (Royal Society of Chemistry, 2010-11)
    Studying neurite guidance by diffusible or substrate bound gradients is challenging with current techniques. In this study, we present the design, fabrication and utility of a microfluidic device to study neurite guidance ...
  • Rohde, Christopher Benjamin; Gilleland, Cody Lee; Samara, Chrysanthi; Yanik, Mehmet Fatih (SPIE, 2010-02)
    Therapeutic treatment of spinal cord injuries, brain trauma, stroke, and neurodegenerative diseases will greatly benefit from the discovery of compounds that enhance neuronal regeneration following injury. We previously ...
  • Chen, Chia-Hung; Miller, Miles Aaron; Sarkar, Aniruddh; Beste, Michael T.; Lauffenburger, Douglas A.; Griffith, Linda G.; Han, Jongyoon (2012-10)
    In this study, we integrated several components, including a droplet generator, a pico-injector, and an analytical inference technique, Proteolytic Activity Matrix Analysis (PrAMA), to create a platform for assessing ...
  • Yew, Elijah Y.S.; So, Peter T. C.; Rowlands, Christopher James; Yew, Elijah Y.S. (Elsevier, 2013-12)
    High-resolution microscopy methods based on different nonlinear optical (NLO) contrast mechanisms are finding numerous applications in biology and medicine. While the basic implementations of these microscopy methods are ...
  • Samara, Chrysanthi; Gilleland, Cody Lee; Zeng, Fei; Rohde, Christopher Benjamin; Yanik, Mehmet Fatih (Society of Photo-optical Instrumentation Engineers, 2009-02)
    In recent years, the advantages of using small invertebrate animals as model systems for human disease have become increasingly apparent and have resulted in three Nobel Prizes in medicine or chemistry during the last six ...
  • Wen, X.; Datta, A.; Traverso, L. M.; Pan, L.; Xu, X.; Moon, Euclid Eberle (Nature Publishing Group, 2015-11)
    Optical lithography, the enabling process for defining features, has been widely used in semiconductor industry and many other nanotechnology applications. Advances of nanotechnology require developments of high-throughput ...
  • Zhao, Wen-Ning; Cheng, Chialin; Theriault, Kraig M.; Sheridan, Steven D.; Tsai, Li-Huei; Haggarty, Stephen J. (Sage Publications, 2012-08)
    Wnt/β-catenin signaling has emerged as a central player in pathways implicated in the pathophysiology and treatment of neuropsychiatric disorders. To identify potential novel therapeutics for these disorders, high-throughput ...
  • Cox, David D.; Pinto, Nicolas; Doukhan, David; DiCarlo, James (Public Library of Science, 2009-11)
    While many models of biological object recognition share a common set of ‘‘broad-stroke’’ properties, the performance of any one model depends strongly on the choice of parameters in a particular instantiation of that ...
  • Pinto, Nicolas; Doukhan, David; DiCarlo, James; Cox, David D. (Public Library of Science, 2009-11)
    While many models of biological object recognition share a common set of “broad-stroke” properties, the performance of any one model depends strongly on the choice of parameters in a particular instantiation of that ...
  • Armiento, Rickard R.; Kozinsky, Boris; Hautier, Geoffroy; Fornari, Marco; Ceder, Gerbrand (American Physical Society, 2014-04)
    We screen a large chemical space of perovskite alloys for systems with optimal properties to accommodate a morphotropic phase boundary (MPB) in their composition-temperature phase diagram, a crucial feature for high ...
  • Watson, Christa; Ge, Jing; Cohen, Joel; Pyrgiotakis, Georgios; Engelward, Bevin P.; Demokritou, Philip (American Chemical Society (ACS), 2014-03)
    The likelihood of intentional and unintentional engineered nanoparticle (ENP) exposure has dramatically increased due to the use of nanoenabled products. Indeed, ENPs have been incorporated in many useful products and have ...
  • Steinmeyer, Joseph Daly; Yanik, Mehmet Fatih (Public Library of Science, 2012-04)
    The complexity of neurons and neuronal circuits in brain tissue requires the genetic manipulation, labeling, and tracking of single cells. However, current methods for manipulating cells in brain tissue are limited to ...
  • Lee, Seung-Kon; Baek, Jinyoung; Jensen, Klavs F. (American Chemical Society (ACS), 2014-02)
    Uniform polymer microbeads with highly loaded quantum dots (QDs) are produced using high-throughput coherent jet breakup of a biocompatible poly(ethylene glycol) diacrylate (PEGDA) prepolymer resin, followed by in-line ...
  • Kim, Daekeun; So, Peter T. C. (Society of Photo-optical Instrumentation Engineers, 2010-02)
    Two-photon excitation microfabrication has been shown to be useful in the field of photonics and biomedicine. It generates 3D microstructures and provides sub-diffraction fabrication resolution. Nevertheless, laser direct ...
Open Access