Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Buehler, Markus J.; Uzel, Sebastien Guy Marcel (American Society of Mechanical Engineers, 2010-02)
    Collagen is a crucial structural protein material, formed through a hierarchical assembly of tropocollagen molecules, arranged in collagen fibrils that constitute the basis for larger-scale fibrils and fibers. Osteogenesis ...
  • Hayashi, Takuma; Horiuchi, Akiko; Sano, Kenji; Hiraoka, Nobuyoshi; Kanai, Yae; Shiozawa, Tanri; Tonegawa, Susumu; Konishi, Ikuo (Hindawi Pub. Corp., 2011-01)
    Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, ...
  • Brohawn, Stephen G.; Schwartz, Thomas (Nature Publishing Group, 2009-10)
    Nuclear pore complexes (NPCs) facilitate all nucleocytoplasmic transport. These massive protein assemblies are modular, with a stable structural scaffold supporting more dynamically attached components. The scaffold is ...
  • Bilokapic, Silvija; Schwartz, Thomas (National Academy of Sciences (U.S.), 2012-09)
    Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs), enormous assemblies composed of multiple copies of ∼30 different proteins called nucleoporins. To unravel the basic scaffold underlying the NPC, we ...
  • Liu, Judy S.; Schubert, Christian R.; Fu, Xiaoqin; Fourniol, Franck J.; Jaiswal, Jyoti K.; Houdusse, Anne; Stultz, Collin M.; Moores, Carolyn A.; Walsh, Christopher A.; Schubert, Christian R.; Stultz, Collin M. (Elsevier, 2012-07)
    Doublecortin (Dcx) defines a growing family of microtubule (MT)-associated proteins (MAPs) involved in neuronal migration and process outgrowth. We show that Dcx is essential for the function of Kif1a, a kinesin-3 motor ...
  • Baker, Tania; Grant, Robert A.; Sauer, Robert T.; Roman-Hernandez, Giselle (United States National Academy of Sciences, 2009-04)
    The N-end rule is a conserved degradation pathway that relates the stability of a protein to its N-terminal amino acid. Here, we present crystal structures of ClpS, the bacterial N-end rule adaptor, alone and engaged with ...
  • Laloe, Jean-Baptiste; Kim, Tae Hee; Moodera, Jagadeesh (Hindawi Pub. Corp., 2011-04)
    Since the discovery of its superconducting properties in 2001, magnesium diboride has generated terrific scientific and engineering research interest around the world. With a 𝑇 Since the ...
  • Chang, Shu-Wei; Buehler, Markus J. (Elsevier, 2014-03)
    Collagenous tissues, made of collagen molecules, such as tendon and bone, are intriguing materials that have the ability to respond to mechanical forces by altering their structures from the molecular level up, and convert ...
  • Bao, Gang; Thomas, Wendy; Hwang, Wonmuk; Fletcher, Daniel A.; Zhu, Cheng; Mofrad, Mohammad R. K.; Kamm, Roger Dale; Grodzinsky, Alan J. (Springer New York, 2010-03)
    Recent advances have led to the emergence of molecular biomechanics as an essential element of modern biology. These efforts focus on theoretical and experimental studies of the mechanics of proteins and nucleic acids, and ...
  • Bezman, Natalie A.; Kim, Charles C.; Sun, Joseph C.; Min-Oo, Gundula; Hendricks, Deborah W.; Kamimura, Yosuke; Best, J. Adam; Goldrath, Ananda W.; Lanier, Lewis L.; Regev, Aviv; Immunological Genome Project Consortium (2012-08)
    Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared ...
  • Hu, Wei; Su, Yongchao; Zhou, Lei; Pang, Aimin; Cai, Rulin; Ma, Xingang; Li, Shenhui (MDPI AG, 2014-01)
    Neutral polymer bonding agent (NPBA) is one of the most promising polymeric materials, widely used in nitrate ester plasticized polyether (NEPE) propellant as bonding agent. The structure and dynamics of NPBA under different ...
  • Buehler, Markus J.; Qin, Zhao (American Physical Society, 2010-05)
    The alpha-helix to beta-sheet transition (α-β transition) is a universal deformation mechanism in alpha-helix rich protein materials such as wool, hair, hoof, and cellular proteins. Through a combination of molecular and ...
  • Luo, Tengfei; Esfarjani, Keivan; Shiomi, Junichiro; Henry, Asegun; Chen, Gang (American Institute of Physics (AIP), 2011-04)
    Heat transfer across thermal interface materials is a critical issue for microelectronics thermal management. Polydimethylsiloxane (PDMS), one of the most important components of thermal interface materials presents a large ...
  • Fournier, Gregory P.; Andam, Cheryl P.; Alm, Eric J.; Gogarten, Peter (Springer Science + Business Media B.V., 2011-12)
    Aminoacyl-tRNA synthetases (aaRS) consist of several families of functionally conserved proteins essential for translation and protein synthesis. Like nearly all components of the translation machinery, most aaRS families ...
  • Yost, Shane Robert; Wang, Lee-Ping; Van Voorhis, Troy (American Chemical Society, 2011-06)
    We present an investigation of the band levels and charge transfer (CT) states at the interface between two organic semiconductors, metal-free phthalocyanine (H2Pc) and 3,4,9,10-perylenetetracarboxylic bisbenzimidazole ...
  • Nair, Arun K.; Gautieri, Alfonso; Chang, Shu-Wei; Buehler, Markus J. (Nature Publishing Group, 2013-04)
    Bone is a natural composite of collagen protein and the mineral hydroxyapatite. The structure of bone is known to be important to its load-bearing characteristics, but relatively little is known about this structure or the ...
  • Beste, Michael T.; Pfaffle-Doyle, Nicole; Prentice, Emily A.; Lauffenburger, Douglas A.; Morris, Stephanie N.; Isaacson, Keith B.; Griffith, Linda G. (American Association for the Advancement of Science (AAAS), 2014-02)
    Clinical management of endometriosis is limited by the complex relationship between symptom severity, heterogeneous surgical presentation, and variability in clinical outcomes. As a complement to visual classification ...
  • Miraldi, Emily R.; Sharfi, Hadar; Friedline, Randall H.; Johnson, Hannah; Zhang, Tejia; Lau, Ken S.; Ko, Hwi Jin; Curran, Timothy G.; Haigis, Kevin M.; Yaffe, Michael B.; Bonneau, Richard; Lauffenburger, Douglas A.; Kahn, Barbara B.; Kim, Jason K.; Neel, Benjamin G.; Saghatelian, Alan; White, Forest M. (Royal Society of Chemistry, 2013-05)
    Metabolic syndrome describes a set of obesity-related disorders that increase diabetes, cardiovascular, and mortality risk. Studies of liver-specific protein-tyrosine phosphatase 1b (PTP1b) deletion mice (L-PTP1b[superscript ...
  • Fleischer, Shar-Li Karl; Zhou, Yan; Field, Robert W.; Nelson, Keith Adam (American Physical Society (APS), 2011-10)
    Intense single-cycle THz pulses resonantly interacting with molecular rotations are shown to induce field-free orientation and alignment under ambient conditions. We calculate and measure the degree of both orientation and ...
  • O'hUigin, Colm; Kulkarni, Smita; Xu, Yunping; Deng, Zhihui; Kidd, Judith; Kidd, Kenneth; Gao, Xiaojiang; Carrington, Mary (Elsevier B.V., 2011-09)
    Differential expression of human leukocyte antigen C (HLA-C) allotypes is mediated by the binding of a microRNA, miR-148a, to the 3′ untranslated region of some, but not all, HLA-C alleles. The binding results in lower ...
Open Access