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Browsing MIT Open Access Articles by Title

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  • Lambrecht, Bart M.; Myers, Stewart C. (John Wiley & Sons, Inc, 2012-10)
    We develop a dynamic agency model in which payout, investment, and financing decisions are made by managers who attempt to maximize the rents they take from the firm, subject to a capital market constraint. Managers smooth ...
  • Chen, Haogang; Mao, Yandong; Wang, Xi; Zhou, Dong; Zeldovich, Nickolai; Kaashoek, M. Frans (Association for Computing Machinery (ACM), 2011-07)
    Avoiding kernel vulnerabilities is critical to achieving security of many systems, because the kernel is often part of the trusted computing base. This paper evaluates the current state-of-the-art with respect to kernel ...
  • Duplantier, Bertrand; Sheffield, Scott Roger (Springer-Verlag, 2010-12)
    Consider a bounded planar domain D, an instance h of the Gaussian free field on D, with Dirichlet energy ... and a constant 0[less than or equal to]γ<2. The Liouville quantum gravity measure on D is the weak limit as ...
  • Peng, Zhangli; Dao, Ming; Suresh, Subra; Li, Xuejin; Pivkin, Igor V.; Karniadakis, George E. (National Academy of Sciences (U.S.), 2013-08)
    We study the biomechanical interactions between the lipid bilayer and the cytoskeleton in a red blood cell (RBC) by developing a general framework for mesoscopic simulations. We treated the lipid bilayer and the cytoskeleton ...
  • Eddy, Matthew T.; Su, Yongchao; Silvers, Robert; Andreas, Loren; Clark, Lindsay; Wagner, Gerhard; Pintacuda, Guido; Emsley, Lyndon; Griffin, Robert Guy (Springer-Verlag, 2015-01)
    The human voltage dependent anion channel 1 (VDAC) is a 32 kDa β-barrel integral membrane protein that controls the transport of ions across the outer mitochondrial membrane. Despite the determination of VDAC solution and ...
  • Hartley, Meredith D.; Schneggenburger, Philipp E.; Imperiali, Barbara (National Academy of Sciences (U.S.), 2013-12)
    Membrane-bound polyprenol-dependent pathways are important for the assembly of essential glycoconjugates in all domains of life. However, despite their prevalence, the functional significance of the extended linear polyprenyl ...
  • Chaparro, Jose P.; Bershteyn, A.; Riley, E. B.; Yao, R. S.; Zachariah, Roshini Sarah; Irvine, Darrell J. (Institute of Electrical and Electronics Engineers, 2009-05)
    The physicochemical context in which molecules are presented at the surfaces of microbes has tremendous implications for the immune response to vaccination. The spacing and mobility of molecules may control interactions ...
  • Nguyen, David N.; Mahon, Kerry P.; Chikh, Ghania; Kim, Phillip; Chung, Hattie; Vicari, Alain P.; Love, Kevin T.; Goldberg, Michael; Chen, Steve; Krieg, Arthur M.; Chen, Jianzhu; Langer, Robert; Anderson, Daniel Griffith (National Academy of Sciences (U.S.), 2012-03)
    The specific activation of Toll-like receptors (TLRs) has potential utility for a variety of therapeutic indications including antiviral immunotherapy and as vaccine adjuvants. TLR7 and TLR 8 may be activated by their ...
  • Ong, Ta-Chung; Clark, Lindsay; Teijido, Oscar; van der Wel, Patrick C. A.; Garces, Robert; Wagner, Gerhard; Rostovtseva, Tatiana K.; Eddy, Matthew Thomas; Griffin, Robert Guy (American Chemical Society (ACS), 2012-03)
    We employ a combination of [superscript 13]C/[superscript 15]N magic angle spinning (MAS) NMR and [superscript 2]H NMR to study the structural and functional consequences of different membrane environments on VDAC1 and, ...
  • Love, Kevin T.; Mahon, Kerry P.; Levins, Christopher G.; Whitehead, Kathryn Ann; Querbes, William; Dorkin, J. Robert; Qin, June; Cantley, William; Qin, Liu Liang; Racie, Timothy; Frank-Kamenetsky, Maria; Yip, Ka; Alvarez, Rene; Sah, Dinah W. Y.; de Fougerolles, Antonin; Fitzgerald, Kevin; Koteliansky, Victor; Akinc, Akin; Langer, Robert; Anderson, Daniel G. (National Academy of Sciences, 2010-02)
    Significant effort has been applied to discover and develop vehicles which can guide small interfering RNAs (siRNA) through the many barriers guarding the interior of target cells. While studies have demonstrated the ...
  • Zhang, Yunlong; Pelet, Jeisa M.; Heller, Daniel A.; Dong, Yizhou; Chen, Delai; Gu, Zhen; Joseph, Brian J.; Wallas, Jasmine; Anderson, Daniel Griffith (Wiley-VCH Verlag GmbH & Co., 2013-09)
    Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce ...
  • Jiang, Shan; Eltoukhy, Ahmed A.; Love, Kevin T.; Langer, Robert; Anderson, Daniel Griffith (American Chemical Society (ACS), 2013-03)
    The safe, targeted and effective delivery of gene therapeutics remains a significant barrier to their broad clinical application. Here we develop a magnetic nucleic acid delivery system composed of iron oxide nanoparticles ...
  • Dhar, Prajnaparamita; Eck, Elizabeth; Israelachvili, Jacob N.; Lee, Dong Woog; Min, Younjin; Ramachandran, Arun; Waring, Alan J.; Zasadzinski, Joseph A. (Elsevier, 2012-01)
    The size distribution of domains in phase-separated lung surfactant monolayers influences monolayer viscoelasticity and compressibility which, in turn, influence monolayer collapse and set the compression at which the ...
  • Hang, Ta-Chun; Lauffenburger, Douglas A.; Griffith, Linda G.; Stolz, Donna B. (American Physiological Society, 2011-11)
    Primary rat liver sinusoidal endothelial cells (LSEC) are difficult to maintain in a differentiated state in culture for scientific studies or technological applications. Relatively little is known about molecular regulatory ...
  • Dong, Yizhou; Love, Kevin T.; Dorkin, Joseph Robert; Sirirungruang, Sasilada; Zhang, Yunlong; Chen, Delai; Bogorad, Roman; Yin, Hao; Chen, Yi; Vegas, Arturo; Alabi, Christopher A.; Sahay, Gaurav; Olejnik, Karsten; Wang, Weiheng; Schroeder, Avi; Lytton-Jean, Abigail; Siegwart, Daniel J.; Akinc, Akin; Barnes, Carmen; Barros, Scott A.; Carioto, Mary; Fitzgerald, Kevin; Hettinger, Julia; Kumar, Varun; Novobrantseva, Tatiana I.; Qin, June; Querbes, William; Koteliansky, Victor; Langer, Robert; Anderson, Daniel Griffith (National Academy of Sciences (U.S.), 2014-02)
    siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA carriers with a wide therapeutic index. ...
  • Miljkovic, Nenad; Enright, Ryan; Maroo, Shalabh C.; Cho, H. Jeremy; Wang, Evelyn N. (ASME International, 2011-04)
    Environmental scanning electron microscope (ESEM) images of water evaporation from superhydrophilic and superhydrophobic nanostructured surfaces are presented. The nanostructured surfaces consiste of an array of equidistant ...
  • Miljkovic, Nenad; Enright, Ryan; Wang, Evelyn N. (ASME International, 2012-06)
    False color environmental scanning electron microscope (ESEM) images of water freezing on smooth (θe ≈ 120°) and nanostructured (l ~ 50 nm, θe ≈ 170 - 180°) hydrophobic surfaces are presented. To obtain the freezing dynamics ...
  • Wang, Jiang; Vayanos, Dimitri (Oxford University Press, 2011-11)
    We analyze how asymmetric information and imperfect competition affect liquidity and asset prices. Our model has three periods: Agents are identical in the first, become heterogeneous and trade in the second, and consume ...
  • Guerrieri, Veronica; Lorenzoni, Guido (Econometric Society, 2009-12)
    In this paper, we build a model where the presence of liquidity constraints tends to magnify the economy's response to aggregate shocks. We consider a decentralized model of trade, where agents may use money or credit to ...
  • Amat, Miguel A.; Rutledge, Gregory C. (American Institute of Physics, 2010-03)
    A molecular dynamics study is presented to assess the performance of a united-atom model in the prediction of liquid-vapor interfacial properties for short-chain perfluoroalkanes and their alkane counterparts. In particular, ...
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