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Browsing MIT Open Access Articles by Title

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  • Jevtov, Irena; Glatter, Timo; Schittenhelm, Ralf B.; Rinner, Oliver; Roguska, Katarzyna; Wepf, Alexander; Junger, Martin A.; Kohler, Katja; Choi, Hyungwon; Schmidt, Alexander; Nesvizhskii, Alexey I.; Stocker, Hugo; Hafen, Ernst; Aebersold, Ruedi; Gstaiger, Matthias (Nature Publishing Group, 2011-11)
    Genetic analysis in Drosophila melanogaster has been widely used to identify a system of genes that control cell growth in response to insulin and nutrients. Many of these genes encode components of the insulin receptor/target ...
  • Vecchio, Domitilla Del (IOP Publishing, 2012-08)
    Modularity is a property by which the behavior of a system does not change upon interconnection. It is crucial for understanding the behavior of a complex system from the behavior of the composing subsystems. Whether ...
  • Jonas, Kristina; Chen, Y. Erin; Laub, Michael T.; Chen, Y. Erin; Laub, Michael T. (Elsevier, 2011-06)
    Background: Complex regulatory circuits in biology are often built of simpler subcircuits or modules. In most cases, the functional consequences and evolutionary origins of modularity remain poorly defined. Results: Here, ...
  • Rus, Daniela L.; Gilpin, Kyle W. (Institute of Electrical and Electronics Engineers (IEEE), 2010-09)
    We have presented a detailed retrospective on modular robots and discussed connections between modular robots and programmable matter. This field has seen a great deal of creativity and innovation at the level of designing ...
  • Singh, Rohit; Singh, Rishabh; Xu, Zhilei; Krosnick, Rebecca P.; Solar Lezama, Armando (Springer-Verlag, 2014)
    One problem with the constraint-based approaches to synthesis that have become popular over the last few years is that they only scale to relatively small routines, on the order of a few dozen lines of code. This paper ...
  • Conforti, Matteo; De Angelis, Costantino; Akylas, Triantaphyllos R.; Aceves, Alejandro B. (American Physical Society, 2012-06)
    We consider a model consisting of two subsystems with crossing linear dispersion curves that describes, for example, light propagation in binary waveguide arrays. This model admits bright-dark gap solitons in both the ...
  • Ekstrom, Leeland B.; Roelfsema, Pieter R.; Arsenault, John T.; Kolster, Hauke; Vanduffel, Wim (Society for Neuroscience, 2009-08)
    Spatial attention influences representations in visual cortical areas as well as perception. Some models predict a contrast gain, whereas others a response or activity gain when attention is directed to a contrast-varying ...
  • Gibson, Phillip; Schreuder-Gibson, Heidi; Yip, Pearl; Denker, Brendan; Benaddi, Hamid; Wang, Sa; Bromberg, Lev E.; Hatton, T. Alan (Hindawi Publishing Corporation, 2013-01)
    The role of water in protective fabrics is critical to comfort and material performance. Excessive perspiration in clothing causes discomfort, and bound water can adversely affect the ability of carbon to adsorb chemicals. ...
  • Kumar, Yadunanda; Liang, Cui; Limmon, Gino V.; Liang, Li; Engelward, Bevin P.; Ooi, Eng Eong; Chen, Jianzhu; Tannenbaum, Steven Robert (Public Library of Science, 2014-02)
    Background: Management of influenza, a major contributor to the worldwide disease burden, is complicated by lack of reliable methods for early identification of susceptible individuals. Identification of molecular markers ...
  • Buehler, Markus J.; Uzel, Sebastien Guy Marcel (American Society of Mechanical Engineers, 2010-02)
    Collagen is a crucial structural protein material, formed through a hierarchical assembly of tropocollagen molecules, arranged in collagen fibrils that constitute the basis for larger-scale fibrils and fibers. Osteogenesis ...
  • Hayashi, Takuma; Horiuchi, Akiko; Sano, Kenji; Hiraoka, Nobuyoshi; Kanai, Yae; Shiozawa, Tanri; Tonegawa, Susumu; Konishi, Ikuo (Hindawi Pub. Corp., 2011-01)
    Uterine leiomyosarcoma (LMS) develops more often in the muscle tissue layer of the uterine body than in the uterine cervix. The development of gynecologic tumors is often correlated with female hormone secretion; however, ...
  • Brohawn, Stephen G.; Schwartz, Thomas (Nature Publishing Group, 2009-10)
    Nuclear pore complexes (NPCs) facilitate all nucleocytoplasmic transport. These massive protein assemblies are modular, with a stable structural scaffold supporting more dynamically attached components. The scaffold is ...
  • Bilokapic, Silvija; Schwartz, Thomas (National Academy of Sciences (U.S.), 2012-09)
    Nucleocytoplasmic transport is mediated by nuclear pore complexes (NPCs), enormous assemblies composed of multiple copies of ∼30 different proteins called nucleoporins. To unravel the basic scaffold underlying the NPC, we ...
  • Liu, Judy S.; Schubert, Christian R.; Fu, Xiaoqin; Fourniol, Franck J.; Jaiswal, Jyoti K.; Houdusse, Anne; Stultz, Collin M.; Moores, Carolyn A.; Walsh, Christopher A.; Schubert, Christian R.; Stultz, Collin M. (Elsevier, 2012-07)
    Doublecortin (Dcx) defines a growing family of microtubule (MT)-associated proteins (MAPs) involved in neuronal migration and process outgrowth. We show that Dcx is essential for the function of Kif1a, a kinesin-3 motor ...
  • Baker, Tania; Grant, Robert A.; Sauer, Robert T.; Roman-Hernandez, Giselle (United States National Academy of Sciences, 2009-04)
    The N-end rule is a conserved degradation pathway that relates the stability of a protein to its N-terminal amino acid. Here, we present crystal structures of ClpS, the bacterial N-end rule adaptor, alone and engaged with ...
  • Laloe, Jean-Baptiste; Kim, Tae Hee; Moodera, Jagadeesh (Hindawi Pub. Corp., 2011-04)
    Since the discovery of its superconducting properties in 2001, magnesium diboride has generated terrific scientific and engineering research interest around the world. With a 𝑇 Since the ...
  • Chang, Shu-Wei; Buehler, Markus J. (Elsevier, 2014-03)
    Collagenous tissues, made of collagen molecules, such as tendon and bone, are intriguing materials that have the ability to respond to mechanical forces by altering their structures from the molecular level up, and convert ...
  • Bao, Gang; Thomas, Wendy; Hwang, Wonmuk; Fletcher, Daniel A.; Zhu, Cheng; Mofrad, Mohammad R. K.; Kamm, Roger Dale; Grodzinsky, Alan J. (Springer New York, 2010-03)
    Recent advances have led to the emergence of molecular biomechanics as an essential element of modern biology. These efforts focus on theoretical and experimental studies of the mechanics of proteins and nucleic acids, and ...
  • Bezman, Natalie A.; Kim, Charles C.; Sun, Joseph C.; Min-Oo, Gundula; Hendricks, Deborah W.; Kamimura, Yosuke; Best, J. Adam; Goldrath, Ananda W.; Lanier, Lewis L.; Regev, Aviv; Immunological Genome Project Consortium (2012-08)
    Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared ...
  • Hu, Wei; Su, Yongchao; Zhou, Lei; Pang, Aimin; Cai, Rulin; Ma, Xingang; Li, Shenhui (MDPI AG, 2014-01)
    Neutral polymer bonding agent (NPBA) is one of the most promising polymeric materials, widely used in nitrate ester plasticized polyether (NEPE) propellant as bonding agent. The structure and dynamics of NPBA under different ...
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