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Browsing MIT Open Access Articles by Title

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  • Burrage, Lindsay C.; Baskin-Hill, Annie E.; Sinasac, David S.; Singer, Jonathan B.; Croniger, Colleen M.; Kirby, Andrew; Kulbokas, E. J.; Daly, Mark J.; Lander, Eric S.; Broman, Karl W.; Nadeau, Joseph H. (Springer-Verlag, 2010-02)
    Discovery of genes that confer resistance to diseases such as diet-induced obesity could have tremendous therapeutic impact. We previously demonstrated that the C57BL/6J-Chr[superscript A/J]/NaJ panel of chromosome ...
  • Wang, Tim; Wei, Jenny J.; Sabatini, David M.; Lander, Eric S. (American Association for the Advancement of Science (AAAS), 2013-12)
    The bacterial clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 system for genome editing has greatly expanded the toolbox for mammalian genetics, enabling the rapid generation of isogenic cell lines ...
  • Moser, Felix; Horwitz, Andrew; Chen, Jacinto; Lim, Wendell A.; Voigt, Christopher A. (American Chemical Society (ACS), 2013-09)
    Methylating chemicals are common in industry and agriculture and are often toxic, partly due to their propensity to methylate DNA. The Escherichia coli Ada protein detects methylating compounds by sensing aberrant methyl ...
  • Lesch, Bluma J.; Page, David C. (Nature Publishing Group, 2012-10)
    The germ line represents a continuous cellular link between generations and between species, but the germ cells themselves develop in a specialized, organism-specific context. The model organisms Caenorhabditis elegans, ...
  • Chen, Chi-Hua; Fiecas, Mark; Gutierrez, E. D.; Panizzon, Matthew S.; Eyler, Lisa T.; Vuoksimaa, Eero; Thompson, Wesley K.; Fennema-Notestine, Christine; Hagler, Donald J., Jr.; Jernigan, Terry L.; Neale, Michael C.; Franz, Carol E.; Lyons, Michael J.; Fischl, Bruce; Tsuang, Ming T.; Dale, Anders M.; Kremen, William S. (National Academy of Sciences (U.S.), 2013-10)
    Animal data show that cortical development is initially patterned by genetic gradients largely along three orthogonal axes. We previously reported differences in genetic influences on cortical surface area along an ...
  • Cesarini, David Alexander; Dawes, Christopher T.; Johannesson, Magnus; Lichtenstein, Paul; Wallace, Bjorn (MIT Press, 2009-05)
    In this paper, we use the classical twin design to provide estimates of genetic and environmental influences on experimentally elicited preferences for risk and giving. Using standardmethods from behavior genetics, we ...
  • Abdullah, Syahril; Wendy-Yeo, Wai Yeng; Hosseinkhani, Hossein; Hosseinkhani, Mohsen; Masrawa, Ehab; Ramasamy, Rajesh; Rosli, Rozita; Rahman, Sabariah A.; Domb, Abraham J. (Hindawi Publishing Corporation, 2010)
    A novel cationic polymer, dextran-spermine (D-SPM), has been found to mediate gene expression in a wide variety of cell lines and in vivo through systemic delivery. Here, we extended the observations by determining the ...
  • Jiang, Xiaofang; Peery, Ashley; Hall, A. B.; Sharma, Atashi; Chen, Xiao-Guang; Komissarov, Aleksey; Riehle, Michelle M.; Shouche, Yogesh; Sharakhova, Maria V.; Lawson, Daniel; Pakpour, Nazzy; Arensburger, Peter; Davidson, Victoria L. M.; Eiglmeier, Karin; Emrich, Scott J.; George, Phillip; Kennedy, Ryan C.; Mane, Shrinivasrao P.; Maslen, Gareth; Oringanje, Chioma; Qi, Yumin; Settlage, Robert; Tojo, Marta; Tubio, Jose M. C.; Unger, Maria F.; Wang, Bo; Vernick, Kenneth D.; Ribeiro, Jose M. C.; James, Anthony A.; Michel, Kristin; Riehle, Michael A.; Luckhart, Shirley; Sharakhov, Igor V.; Tu, Zhijian; Waterhouse, Robert (BioMed Central Ltd, 2014-09)
    Background: Anopheles stephensi is the key vector of malaria throughout the Indian subcontinent and Middle East and an emerging model for molecular and genetic studies of mosquito-parasite interactions. The type form of ...
  • McKenna, Aaron; Hanna, Matthew; Banks, Eric; Sivachenko, Andrey; Cibulskis, Kristian; Kernytsky, Andrew; Garimella, Kiran; Altshuler, David; Gabriel, Stacey B.; Daly, Mark J.; DePristo, Mark A. (Cold Spring Harbor Laboratory Press, 2010-07)
    Next-generation DNA sequencing (NGS) projects, such as the 1000 Genomes Project, are already revolutionizing our understanding of genetic variation among individuals. However, the massive data sets generated by NGS—the ...
  • Carvalho, Carla M.; Kropinski, Andrew M.; Lingohr, Erika J.; Santos, Silvio B.; King, Jonathan Alan; Azeredo, Joana (BioMed Central Ltd, 2012-01)
    Background Campylobacter is the leading cause of foodborne diseases worldwide. Bacteriophages (phages) are naturally occurring predators of bacteria, ubiquitous in the environment, with high host specificity and thus ...
  • Sullivan, Matthew B.; Krastins, Bryan; Hughes, Jennifer L.; Hughes, Jennifer L.; Kelly, Libusha; Chase, Michael; Sarracino, David; Chisholm, Sallie (Penny) (2009-10)
    Prochlorococcus, an abundant phototroph in the oceans, are infected by members of three families of viruses: myo-, podo- and siphoviruses. Genomes of myo- and podoviruses isolated on Prochlorococcus contain DNA replication ...
  • Yin, Hao; Xue, Wen; Chen, Sidi; Benedetti, Eric; Grompe, Markus; Kotelianski, Victor E.; Bogorad, Roman; Sharp, Phillip A.; Jacks, Tyler E.; Anderson, Daniel Griffith (Nature Publishing Group, 2014-03)
    We demonstrate CRISPR-Cas9–mediated correction of a Fah mutation in hepatocytes in a mouse model of the human disease hereditary tyrosinemia. Delivery of components of the CRISPR-Cas9 system by hydrodynamic injection ...
  • Ran, F. Ann; Hsu, Patrick; Wright, Jason; Agarwala, Vineeta; Scott, David Arthur; Zhang, Feng (Nature Publishing Group, 2013-11)
    Targeted nucleases are powerful tools for mediating genome alteration with high precision. The RNA-guided Cas9 nuclease from the microbial clustered regularly interspaced short palindromic repeats (CRISPR) adaptive immune ...
  • Lander, Eric S. (Nature Publishing Group, 2011-08)
    The evolution of the amniotic egg was one of the great evolutionary innovations in the history of life, freeing vertebrates from an obligatory connection to water and thus permitting the conquest of terrestrial environments. ...
  • Dmytrenko, Oleg; Russell, Shelbi L.; Loo, Wesley T.; Liao, Li; Roeselers, Guus; Sharma, Raghav; Stewart, Frank J.; Newton, Irene L. G.; Woyke, Tanja; Wu, Dongying; Lang, Jenna Morgan; Eisen, Jonathan A.; Cavanaugh, Colleen M.; Fontanez, Kristina M. (BioMed Central Ltd, 2014-10)
    Background Symbioses between chemoautotrophic bacteria and marine invertebrates are rare examples of living systems that are virtually independent of photosynthetic primary production. These associations have evolved ...
  • Gu, Hongcang; Bock, Christoph; Mikkelsen, Tarjei Sigurd; Jäger, Natalie; Smith, Zachary D.; Tomazou, Eleni; Gnirke, Andreas; Lander, Eric S.; Meissner, Alexander (Nature Publishing Group, 2010-01)
    Bisulfite sequencing measures absolute levels of DNA methylation at single-nucleotide resolution, providing a robust platform for molecular diagnostics. Here, we optimize bisulfite sequencing for genome-scale analysis ...
  • Meacham, Corbin Elizabeth; Lawton, Lee N.; Pritchard, Justin R.; Joughin, Brian A.; Ehrenberger, Tobias; Fenouille, Nina; Zuber, Johannes; Williams, Richard T.; Young, Richard A.; Soto Feliciano, Yadira Marie; Hemann, Michael (Cold Spring Harbor Laboratory Press, 2015-03)
    We performed a genome-scale shRNA screen for modulators of B-cell leukemia progression in vivo. Results from this work revealed dramatic distinctions between the relative effects of shRNAs on the growth of tumor cells in ...
  • Lindquist, Robert A.; Ottina, Kathleen; Wheeler, Douglas B.; Hsu, Peggy P.; Thoreen, Carson C.; Guertin, David A.; Ali, Siraj M.; Sengupta, Shomit; Shaul, Yoav D.; Lamprecht, Michael R.; Madden, Katherine L.; Papallo, Adam R.; Jones, Thouis R.; Sabatini, David M.; Carpenter, Anne E. (Cold Spring Harbor Laboratory Press, 2011-01)
    The evolutionarily conserved target of rapamycin complex 1 (TORC1) controls cell growth in response to nutrient availability and growth factors. TORC1 signaling is hyperactive in cancer, and regulators of TORC1 signaling ...
  • Konermann, Silvana; Brigham, Mark D.; Trevino, Alexandro E.; Joung, Julia; Barcena, Clea; Hsu, Patrick D.; Habib, Naomi; Gootenberg, Jonathan S.; Nishimasu, Hiroshi; Nureki, Osamu; Zhang, Feng; Abudayyeh, Omar Osama (2016-05-22)
    Systematic interrogation of gene function requires the ability to perturb gene expression in a robust and generalizable manner. Here we describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient ...
  • Chen, Xiao-Guang; Jiang, Xuanting; Gu, Jinbao; Xu, Meng; Wu, Yang; Deng, Yuhua; Zhang, Chi; Bonizzoni, Mariangela; Dermauw, Wannes; Vontas, John; Armbruster, Peter; Huang, Xin; Yang, Yulan; Zhang, Hao; He, Weiming; Peng, Hongjuan; Liu, Yongfeng; Wu, Kun; Chen, Jiahua; Lirakis, Manolis; Topalis, Pantelis; Van Leeuwen, Thomas; Hall, Andrew Brantley; Jiang, Xiaofang; Thorpe, Chevon; Mueller, Rachel Lockridge; Sun, Cheng; Yan, Guiyun; Tu, Zhijian Jake; Fang, Xiaodong; James, Anthony A.; Waterhouse, Robert (National Academy of Sciences (U.S.), 2015-11)
    The Asian tiger mosquito, Aedes albopictus, is a highly successful invasive species that transmits a number of human viral diseases, including dengue and Chikungunya fevers. This species has a large genome with significant ...
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