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Browsing MIT Open Access Articles by Title

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  • Leitermann, Olivia; Kirtley, James L., Jr. (Institute of Electrical and Electronics Engineers (IEEE), 2010-11)
    Certain energy storage technologies are well-suited to the high-frequency, high-cycling operation which is required in provision of load frequency control (LFC). To limit the total stored energy capacity required while ...
  • Snee, Preston T.; Somers, Rebecca C.; Bawendi, Moungi G; Nocera, Daniel G (2012-08)
    Energy transfer between a CdSe/ZnS nanocrystal (NC) donor and a rhodamine isothiocyanate (RITC) acceptor has been achieved via a functionalized poly(acrylic acid) (PAA) encapsulating layer over the surface of the NC. The ...
  • Ferrara, Daniela; Mohler, Kathrin Juliane; Waheed, Nadia; Adhi, Mehreen; Liu, Jonathan Jaoshin; Grulkowski, Ireneusz; Kraus, Martin F.; Baumal, Caroline; Hornegger, Joachim; Fujimoto, James G.; Duker, Jay S. (Elsevier, 2014-03)
    Objective To characterize en face features of the retinal pigment epithelium (RPE) and choroid in eyes with chronic central serous chorioretinopathy (CSCR) using a high-speed, enhanced-depth swept-source optical coherence ...
  • Alasil, Tarek; Ferrara, Daniela; Adhi, Mehreen; Brewer, Erika; Baumal, Caroline R.; Hornegger, Joachim; Witkin, Andre J.; Reichel, Elias; Duker, Jay S.; Waheed, Nadia K.; Kraus, Martin; Fujimoto, James G (Elsevier, 2014-12)
    Objective To define morphologic features of polypoidal choroidal vasculopathy (PCV) using en face images from swept-source optical coherence tomography (SS OCT). Design Prospective cross-sectional study. Methods The ...
  • Shen, Zuolian; Kang, Jinsuk; Shakya, Arvind; Tabaka, Marcin; Jarboe, Elke A; Tantin, Dean; Regev, Aviv (eLife Sciences Publications, Ltd, 2017-05)
    Embryonic stem cells co-express Oct4 and Oct1, a related protein with similar DNA-binding specificity. To study the role of Oct1 in ESC pluripotency and transcriptional control, we constructed germline and inducible-conditional ...
  • Pardal, Miguel L.; Harrison, Mark; Marques, Jose Alves; Sarma, Sanjay Emani (Institute of Electrical and Electronics Engineers (IEEE), 2012-11)
    Radio Frequency Identification (RFID) technology allows automatic data capture from tagged objects moving in a supply chain. This data can be very useful if it is used to answer traceability queries, however it is distributed ...
  • Beisel, Uli; Reeves, R. Guy; Boete, Christophe; Castro, Luisa Reis; Cesard, Nicolas (BioMed Central, 2015-08)
    Background Pioneering technologies (e.g., nanotechnology, synthetic biology or climate engineering) are often associated with potential new risks and uncertainties that can become sources of controversy. The communication ...
  • Osaki, Tatsuya; Sivathanu, Vivek; Kamm, Roger Dale (Nature Publishing Group, 2018-03)
    Neurovascular coupling plays a key role in the pathogenesis of neurodegenerative disorders including motor neuron disease (MND). In vitro models provide an opportunity to understand the pathogenesis of MND, and offer the ...
  • Martorell, Jordi; Edelman, Elazer R.; Santoma, Pablo; Molins, Jose J.; Garcia-Granada, Andres A.; Bea, Jose A.; Balcells-Camps, Mercedes (Wiley Blackwell, 2012-04)
    This paper reviews how biomedical engineers, in collaboration with physicians, biologists, chemists, physicists, and mathematicians, have developed models to explain how the impact of vascular interventions on blood flow ...
  • Deerinck, Thomas J.; Sancak, Yasemin; Poulos, Thomas L.; Mootha, Vamsi K.; Sosinsky, Gina E.; Ellisman, Mark H.; Martell, Jeffrey Daniel; Ting, Alice Y. (Nature Publishing Group, 2012-10)
    Electron microscopy (EM) is the standard method for imaging cellular structures with nanometer resolution, but existing genetic tags are inactive in most cellular compartments[superscript 1] or require light and can be ...
  • Jay, Steven M.; Kurtagic, Elma; Alvarez, Luis M.; De Picciotto, Seymour; Sanchez Palacios, Edgar I.; Hawkins, Jessica F.; Prince, Robin N.; Guerrero, Yadir; Treasure, Carolyn L.; Lee, Richard T.; Griffith, Linda G. (American Society for Biochemistry and Molecular Biology (ASBMB), 2011-05)
    The ErbB receptor family is dysregulated in many cancers, and its therapeutic manipulation by targeted antibodies and kinase inhibitors has resulted in effective chemotherapies. However, many malignancies remain refractory ...
  • Jay, Steven M.; Murthy, Ashwin C.; Hawkins, Jessica F.; Wortzel, Joshua R.; Steinhauser, Matthew L.; Alvarez, Luis M.; Gannon, Joseph; Macrae, Calum A.; Griffith, Linda G.; Lee, Richard T. (American Heart Association, 2013-06)
    Background—Doxorubicin (DOXO) is an effective anthracycline chemotherapeutic, but its use is limited by cumulative dose-dependent cardiotoxicity. Neuregulin-1β is an ErbB receptor family ligand that is effective against ...
  • Bryson, Bryan D; Del Rosario, Amanda M; Yaffe, Michael B; Gootenberg, Jonathan S; White, Forest M (Wiley Blackwell, 2015-04)
    Mass spectrometry-based analysis of the acetylproteome has highlighted a role for acetylation in a wide array of biological processes including gene regulation, metabolism, and cellular signaling. To date, anti-acetyllysine ...
  • Hosseini, Vahid; Ahadian, Samad; Ostrovidov, Serge; Camci-Unal, Gulden; Chen, Song; Kaji, Hirokazu; Ramalingam, Murugan; Khademhosseini, Ali (Mary Ann Liebert, Inc., 2012-09)
    To engineer tissue-like structures, cells must organize themselves into three-dimensional (3D) networks that mimic the native tissue microarchitecture. Microfabricated hydrogel substrates provide a potentially useful ...
  • Brigham, Christopher J.; Sinskey, Anthony J.; Song, Yuyang; Matsumoto, Ken’ichiro; Yamada, Miwa; Gohda, Aoi; Taguchi, Seiichi (Springer-Verlag, 2011-11)
    The first biosynthetic system for lactate (LA)-based polyesters was previously created in recombinant Escherichia coli (Taguchi et al. 2008). Here, we have begun efforts to upgrade the prototype polymer production system ...
  • Schneider, Martin W; Yamano, Takashi; Nishimasu, Hiroshi; Nureki, Osamu; Crosetto, Nicola; Gao, Linyi; Cox, David Benjamin Turitz; Yan, Winston Xia; Manteiga, John Colonnese; Zhang, Feng (Nature Publishing Group, 2017-06)
    The RNA-guided endonuclease Cpf1 is a promising tool for genome editing in eukaryotic cells. However, the utility of the commonly used Acidaminococcus sp. BV3L6 Cpf1 (AsCpf1) and Lachnospiraceae bacterium ND2006 Cpf1 ...
  • Bilate, Angelina M.; Huang, Nai-Jia; Li, Zeyang; Li, Hojun; Patterson, Heide C.; Dougan, Stephanie K.; Maruyama, Takeshi; Pishesha, Novalia; Wibowo, Marsha C; Dhesycka, Rhogerry; Bousbaine, Djenet; Lodish, Harvey F; Ploegh, Hidde (National Academy of Sciences (U.S.), 2017-03)
    Current therapies for autoimmune diseases rely on traditional immunosuppressive medications that expose patients to an increased risk of opportunistic infections and other complications. Immunoregulatory interventions that ...
  • Mata-Fink, Jordi; Hanson, M.; Kriegsman, Barry A.; Irvine, Darrell J.; Wittrup, Karl Dane (Biomed Central Ltd., 2012-09)
    Background: One of the great challenges for an HIV vaccine is to elicit broadly neutralizing antibodies specific for conserved epitopes from which the virus cannot easily escape. The CD4 binding site is one such epitope ...
  • Sarkar, Debanjan; Vemula, Praveen K.; Zhao, Weian; Gupta, Ashish; Karnik, Rohit; Karp, Jeffrey Michael (Elsevier, 2010-04)
    Cell therapy has the potential to impact the quality of life of suffering patients. Systemic infusion is a convenient method of cell delivery; however, the efficiency of engraftment presents a major challenge. It has been ...
  • Swami, Archana; Reagan, Michaela R.; Basto, Pamela Antonia; Mishima, Yuji; Kamaly, Nazila; Glavey, Siobhan; Zhang, Sufeng; Moschetta, Michele; Seevaratnam, Dushanth; Zhang, Yong; Liu, Jinhe; Memarzadeh, Masoumeh; Wu, Jun; Manier, Salomon; Shi, Jinjun; Bertrand, Nicolas; Lu, Zhi Ning; Nagano, Kenichi; Baron, Roland; Sacco, Antonio; Roccaro, Aldo M.; Farokhzad, Omid C.; Ghobrial, Irene M. (National Academy of Sciences (U.S.), 2014-06)
    Bone is a favorable microenvironment for tumor growth and a frequent destination for metastatic cancer cells. Targeting cancers within the bone marrow remains a crucial oncologic challenge due to issues of drug availability ...
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