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Browsing MIT Open Access Articles by Title

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  • Vu, Quang Hieu; Ooi, Beng Chin; Rinard, Martin C.; Tan, Kian-Lee (Institute of Electrical and Electronics Engineers, 2009-04)
    Over the past few years, peer-to-peer (P2P) systems have rapidly grown in popularity and have become a dominant means for sharing resources. In these systems, load balancing is a key challenge because nodes are often ...
  • Yildirim, Ferah; Ji, Shengbo; Kronenberg, Golo; Barco, Angel; Olivares, Roman; Benito, Eva; Dirnagl, Ulrich; Gertz, Karen; Endres, Matthias; Harms, Christoph; Meisel, Andreas (Public Library of Science, 2014-04)
    Epigenetic transcriptional regulation by histone acetylation depends on the balance between histone acetyltransferase (HAT) and deacetylase activities (HDAC). Inhibition of HDAC activity provides neuroprotection, indicating ...
  • Ji, Peng; Yeh, Victor; Ramirez, Tzutzuy; Murata-Hori, Maki; Lodish, Harvey F. (Ferrata Storti Foundation, 2010-09)
    Background: During the final stages of differentiation of mammalian erythroid cells, the chromatin is condensed and enucleated. We previously reported that Rac GTPases and their downstream target, mammalian homolog of ...
  • Taniguchi, Makoto; Carreira, Maria B.; Smith, Laura N.; Zirlin, Benjamin C.; Neve, Rachael L.; Cowan, Christopher W. (Elsevier, 2012-01)
    Chromatin remodeling by histone deacetylases (HDACs) is a key mechanism regulating behavioral adaptations to cocaine use. We report here that cocaine and cyclic adenosine monophosphate (cAMP) signaling induce the transient ...
  • Jones, Richard Bradley; O'Connor, Rachel; Mueller, Stefanie; Foley, Maria Hottelet; Szeto, Gregory Lee; Karel, Dan; Lichterfeld, Mathias; Kovacs, Colin; Ostrowski, Mario A.; Trocha, Alicja; Irvine, Darrell J.; Walker, Bruce D. (Public Library of Science, 2014-08)
    Resting memory CD4[superscript +] T-cells harboring latent HIV proviruses represent a critical barrier to viral eradication. Histone deacetylase inhibitors (HDACis), such as suberanilohydroxamic acid (SAHA), romidepsin, ...
  • Zwaans, Bernadette M.M.; Silberman, Dafne M.; Goren, Alon; Zhong, Lei; Ram, Oren; Truelove, Jessica; Guimaraes, Alexander R.; Toiber, Debra; Cosentino, Claudia; Greenson, Joel K.; MacDonald, Alasdair I.; McGlynn, Liane; Maxwell, Fraser; Edwards, Joanne; Giacosa, Sofia; Guccione, Ernesto; Weissleder, Ralph; Bernstein, Bradley E.; Regev, Aviv; Shiels, Paul G.; Lombard, David B.; Mostoslavsky, Raul; Sebastian, Carlos; Gymrek, Melissa A.; Bernstein, Bradley E. (Elsevier, 2012-12)
    Reprogramming of cellular metabolism is a key event during tumorigenesis. Despite being known for decades (Warburg effect), the molecular mechanisms regulating this switch remained unexplored. Here, we identify SIRT6 as a ...
  • Creyghton, Menno P.; Cheng, Albert W.; Welstead, G. Grant; Kooistra, Tristan G.; Carey, Bryce W.; Steine, Eveline J.; Hanna, Jacob; Lodato, Michael Anthony; Frampton, Garrett M.; Sharp, Phillip A.; Boyer, Laurie; Young, Richard A.; Jaenisch, Rudolf (National Academy of Sciences (U.S.), 2010-11)
    Developmental programs are controlled by transcription factors and chromatin regulators, which maintain specific gene expression programs through epigenetic modification of the genome. These regulatory events at enhancers ...
  • Yuan, Chih-Chi; Jin, Yi; Chen, Chang Feng; Chapman, Brad A.; Ohsumi, Toshiro K.; Glass, Karen C.; Kutateladze, Tatiana G.; Borowsky, Mark L.; Struhl, Kevin; Oettinger, Marjorie A.; Matthews, Adam G. W. (Elsevier, 2012-01)
    The preferential in vitro interaction of the PHD finger of RAG2, a subunit of the V(D)J recombinase, with histone H3 tails simultaneously trimethylated at lysine 4 and symmetrically dimethylated at arginine 2 (H3R2me2sK4me3) ...
  • Heintzman, Nathaniel D.; Hon, Gary C.; Hawkins, R. David; Kheradpour, Pouya; Stark, Alexander; Harp, Lindsey F.; Ye, Zhen; Lee, Leonard K.; Stuart, Rhona K.; Ching, Christina W.; Ching, Keith A.; Antosiewicz-Bourget, Jessica E.; Liu, Hui; Zhang, Xinmin; Green, Roland D.; Lobanenkov, Victor V.; Stewart, Ron; Thomson, James A.; Crawford, Gregory E.; Kellis, Manolis; Ren, Bing (Nature Publishing Group, 2009-03)
    The human body is composed of diverse cell types with distinct functions. Although it is known that lineage specification depends on cell-specific gene expression, which in turn is driven by promoters, enhancers, insulators ...
  • Monier, Erwan; Schlosser, Adam; Sokolov, Andrei P. (Copernicus GmbH, 2013-05)
    Both historical and idealized climate model experiments are performed with a variety of Earth system models of intermediate complexity (EMICs) as part of a community contribution to the Intergovernmental Panel on Climate ...
  • Mahlstein, Irina; Gent, Peter R.; Solomon, Susan (American Geophysical Union (AGU), 2013-06)
    In contrast to Arctic sea ice, average Antarctic sea ice area is not retreating but has slowly increased since satellite measurements began in 1979. While most climate models from the Coupled Model Intercomparison Project ...
  • McCants, Anne E. C. (M.I.T. Press, 2009)
  • Cavicchi, Elizabeth (Springer-Verlag, 2008-08)
    Two students, meeting together with a teacher, redid historical experiments. Unlike conventional instruction where science topics and practices often fragment, they experienced interrelatedness among phenomena, participants’ ...
  • Win, Moe Z.; Dardari, Davide; Molisch, A. F.; Wiesbeck, W.; Zhang, Jinyun (Institute of Electrical and Electronics Engineers, 2009-03)
    This mathematical modeling method for wireless networks is designed to take into account propagation effects and interference from unwanted transmissions.
  • Rigby, Matthew; Muhle, Jens; Miller, Benjamin R.; Prinn, Ronald G.; Krummel, P. B.; Steele, L. P.; Fraser, P. J.; Salameh, P. K.; Harth, C. M.; Weiss, R. F.; Greally, B. R.; O'Doherty, Simon; Simmonds, P. G.; Vollmer, M. K.; Reimann, S.; Kim, J.; Kim, K.-R.; Wang, H. J.; Olivier, Jos G. J.; Dlugokencky, E.; Dutton, G. S.; Hall, B. D.; Elkins, J. W. (European Geosciences Union / Copernicus, 2010-11)
    We present atmospheric sulfur hexafluoride (SF6)[SF subscript 6] mole fractions and emissions estimates from the 1970s to 2008. Measurements were made of archived air samples starting from 1973 in the Northern Hemisphere ...
  • Boyden, Edward Stuart (BioMed Central Ltd., 2011-05)
    Understanding how different kinds of neuron in the brain work together to implement sensations, feelings, thoughts, and movements, and how deficits in specific kinds of neuron result in brain diseases, has long been a ...
  • de Foy, B.; Krotkov, N. A.; Bei, Naifang; Herndon, S. C.; Huey, L. G.; Martinez, A.-P.; Ruiz-Suarez, L. G.; Wood, E. C.; Zavala, Miguel; Molina, Luisa Tan (Copernicus Publications on behalf of the European Geophysical Society, 2009-12)
    Large sulfur dioxide plumes were measured in the Mexico City Metropolitan Area (MCMA) during the MILAGRO field campaign. This paper seeks to identify the sources of these plumes and the meteorological processes that affect ...
  • Jones, Benjamin F.; Olken, Benjamin A. (American Economic Association, 2009-07)
    Assassinations are a persistent feature of the political landscape. Using a new dataset of assassination attempts on all world leaders from 1875 to 2004, we exploit inherent randomness in the success or failure of assassination ...
  • Mallal, Simon; Heckerman, David; Harrigan, P. Richard; Haubrich, Richard; Riddler, Sharon A.; Haas, David W.; Kadie, Carl M.; Szeto, Sharon; Tao, Iris; Swenson, Luke C.; Chan, Dennison; Carlson, Jonathan M.; John, Mina; Walker, Bruce D.; Frahm, Nicole; Sela, Jennifer; Rosato, Pamela; Brockman, Mark A.; Brumme, Chanson J.; Brumme, Zabrina L.; Brander, Christian (Public Library of Science, 2009-08)
    Background: Despite the extensive genetic diversity of HIV-1, viral evolution in response to immune selective pressures follows broadly predictable mutational patterns. Sites and pathways of Human Leukocyte-Antigen ...
  • Kuehne, H.; Serre, T.; Jhuang, H.; Garrote, Estibaliz; Poggio, Tomaso A. (Institute of Electrical and Electronics Engineers (IEEE), 2012-01)
    With nearly one billion online videos viewed everyday, an emerging new frontier in computer vision research is recognition and search in video. While much effort has been devoted to the collection and annotation of large ...
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