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Browsing MIT Open Access Articles by Title

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  • Status and Prospects of the DMTPC Directional Dark Matter Experiment 
    Monroe, Jocelyn (American Institute of Physics (AIP), 2011-07)
    The DMTPC directional dark matter detection experiment is a low-pressure CF4 gas time projection chamber, instrumented with charge and scintillation photon readout. This detector design strategy emphasizes reconstruction ...
  • Steering trajectories of rolling cells by 2D asymmetric receptor patterning 
    Lee, Chia-Hua; Bose, Suman; Karp, Jeffrey Michael; Karnik, Rohit N. (Institute of Electrical and Electronics Engineers (IEEE), 2010-03)
    We demonstrate a simple method to make high-resolution P-selectin patterns based on microcontact printing for controlling cell rolling. SEM characterization revealed well-defined patterns that could direct the trajectories ...
  • SteinerNet: a web server for integrating ‘omic’ data to discover hidden components of response pathways 
    Tuncbag, Nurcan; McCallum, Scott; Huang, Shao-shan Carol; Fraenkel, Ernest (Oxford University Press (OUP), 2012-05)
    High-throughput technologies including transcriptional profiling, proteomics and reverse genetics screens provide detailed molecular descriptions of cellular responses to perturbations. However, it is difficult to integrate ...
  • Stent Thrombogenicity Early in High Risk Interventional Settings is Driven by Stent Design and Deployment, and Protected by Polymer-Drug Coatings 
    Kolandaivelu, Kumaran; Swaminathan, Rajesh; Gibson, William J.; Kolachalama, Vijaya Bhasker; Nguyen-Ehrenreich, Kim-Lien; Giddings, Virginia L.; Coleman, Leslie; Wong, Gee K.; Edelman, Elazer R. (American Heart Association, 2011-02)
    Background—Stent thrombosis is a lethal complication of endovascular intervention. Concern has been raised about the inherent risk associated with specific stent designs and drug-eluting coatings, yet clinical and animal ...
  • Stepwise Connectivity of the Modal Cortex Reveals the Multimodal Organization of the Human Brain 
    Sepulcre, Jorge; Sabuncu, Mert R.; Yeo, Thomas B.; Lui, Hesheng; Johnson, Keith A. (Society for Neuroscience, 2012-05)
    How human beings integrate information from external sources and internal cognition to produce a coherent experience is still not well understood. During the past decades, anatomical, neurophysiological and neuroimaging ...
  • Stereo vision and laser odometry for autonomous helicopters in GPS-denied indoor environments 
    Prentice, Samuel James; He, Ruijie; Bachrach, Abraham Galton; Achtelik, Markus Wilhelm; Roy, Nicholas (SPIE, 2009-04)
    This paper presents our solution for enabling a quadrotor helicopter to autonomously navigate unstructured and unknown indoor environments. We compare two sensor suites, specifically a laser rangefinder and a stereo camera. ...
  • Sterile neutrinos, coherent scattering, and oscillometry measurements with low-temperature bolometers 
    Formaggio, Joseph A.; Figueroa-Feliciano, Enectali; Anderson, Adam Jonathan (American Physical Society, 2012-01)
    Coherent neutrino-nucleon scattering offers a unique approach in the search for physics beyond the standard model. When used in conjunction with monoenergetic neutrino sources, the technique can be sensitive to the existence ...
  • Sterile neutrino search with kaon decay at rest 
    Spitz, Joshua B. (American Physical Society, 2012-05)
    Monoenergetic muon neutrinos (235.5 MeV) from positive kaon decay at rest are considered as a source for an electron neutrino appearance search. In combination with a liquid argon time projection chamber based detector, ...
  • Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth 
    Griffiths, Beatrice; Lewis, Caroline A; Bensaad, Karim; Ros, Susana; Zhang, Qifeng; Ferber, Emma C; Konisti, Sofia; Peck, Barrie; Miess, Heike; East, Philip; Wakelam, Michael; Harris, Adrian L; Schulze, Almut (BioMed Central Ltd., 2013-01)
    Background: Regulation of lipid metabolism via activation of sterol regulatory element binding proteins (SREBPs) has emerged as an important function of the Akt/mTORC1 signaling axis. Although the contribution of dysregulated ...
  • A Stevedore's Protein Knot 
    Mirny, Leonid A.; Kardar, Mehran; Bölinger, Daniel; Sułkowska, Joanna I.; Hsu, Hsiao-Ping; Onuchic, José N.; Virnau, Peter (Public Library of Science, 2010-04)
    Protein knots, mostly regarded as intriguing oddities, are gradually being recognized as significant structural motifs. Seven distinctly knotted folds have already been identified. It is by and large unclear how these ...
  • Stiffness and strength of suture joints in nature 
    Li, Yaning; Ortiz, Christine; Boyce, Mary Cunningham (American Physical Society (APS), 2011-12)
    Suture joints are remarkable mechanical structures found throughout nature composed of compliant interlocking seams connecting stiffer components. This study investigates the underlying mechanisms and the role of geometry ...
  • Stimulating Energy Technology Innovation 
    Moniz, Ernest J. (MIT Press, 2012-04)
    The innovation system has interrelated components of invention, translation, adoption, and diffusion. Energy technology innovation has lagged that in other domains, and there is a compelling public interest in picking up ...
  • Stimulation of dendritic cells enhances immune response after photodynamic therapy 
    Mroz, Pawel; Castano, Ana P.; Hamblin, Michael R. (Society of Photo-optical Instrumentation Engineers, 2009-01)
    Photodynamic therapy (PDT) involves the administration of photosensitizers followed by illumination of the primary tumor with red light producing reactive oxygen species that cause vascular shutdown and tumor cell necrosis ...
  • Stirring Strongly Coupled Plasma 
    Fadafan, Kazem Bitaghsir; Liu, Hong; Rajagopal, Krishna; Wiedemann, Urs Achim (Springer Berlin Heidelberg, 2009-02)
    We determine the energy it takes to move a test quark along a circle of radius L with angular frequency ω through the strongly coupled plasma of $\mathcal{N}=4$ supersymmetric Yang–Mills (SYM) theory. We find that for most ...
  • STITCHER: Dynamic assembly of likely amyloid and prion beta-structures from secondary structure predictions 
    Bryan, Allen W.; O'Donnell, Charles William; Menke, Matthew; Cowen, Lenore J.; Lindqu, Susan; Berger, Bonnie (John Wiley & Sons, Inc., 2011-09)
    The supersecondary structure of amyloids and prions, proteins of intense clinical and biological interest, are difficult to determine by standard experimental or computational means. In addition, significant conformational ...
  • STK33 kinase inhibitor BRD-8899 has no effect on KRAS-dependent cancer cell viability 
    Luo, Tuoping; Masson, Kristina; Jaffe, Jacob D.; Silkworth, Whitney; Lee, Nathan Ross; Scherer, Christina A.; Scholl, Claudia; Fröhling, Stefan; Carr, Steven A.; Stern, Andrew M.; Schreiber, Stuart L.; Golub, Todd R. (National Academy of Sciences, 2012-02)
    Approximately 30% of human cancers harbor oncogenic gain-of-function mutations in KRAS. Despite interest in KRAS as a therapeutic target, direct blockade of KRAS function with small molecules has yet to be demonstrated. ...
  • Stochastic Analysis of Retroactivity in Transcriptional Networks through Singular Perturbation 
    Ghaemi, Reza; Del Vecchio, Domitilla (Institute of Electrical and Electronics Engineers, 2012-06)
    The input/output dynamic behavior of a biomolecular system is affected by interconnection to other downstream systems through impedance-like effects called retroactivity. In this paper, we study the effects of retroactivity ...
  • Stochastic and Dynamic Routing Problems for Multiple Uninhabited Aerial Vehicles 
    Frazzoli, Emilio; Enright, John J.; Bullo, Francesco; Savla, Ketan (American Institute of Aeronautics and Astronautics, 2009-01)
    Consider a routing problem for a team of vehicles in the plane: target points appear randomly over time in a bounded environment and must be visited by one of the vehicles. It is desired to minimize the expected system time ...
  • A stochastic and dynamic vehicle routing problem with time windows and customer impatience 
    Pavone, Marco; Frazzoli, Emilio; Bisnik, N.; Isler, V. (Springer, 2008-10)
    In this paper, we study the problem of designing motion strategies for a team of mobile agents, required to fulfill request for on-site service in a given planar region. In our model, each service request is generated by ...
  • A stochastic broadcast feedback approach to regulating cell population for microfluidic angiogenesis platforms 
    Asada, Harry; Das, Anusuya; Wood, Levi Benjamin; Kamm, Roger Dale (Institute of Electrical and Electronics Engineers, 2009-07)
    This paper presents a framework for controlling the development of a vascular system in an in vitro angiogenesis process. Based on online measurement of cell growth and a stochastic cell population model, a closed-loop ...
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