Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Melas, Ioannis N.; Lauffenburger, Douglas A.; Alexopoulos, Leonidas G. (Institute of Electrical and Electronics Engineers (IEEE), 2013-11)
    Hepatocellular Carcinoma (HCC) is one of the leading causes of death worldwide, with only a handful of treatments effective in unresectable HCC. Most of the clinical trials for HCC using new generation interventions ...
  • Shan, Jing; Ross, Nathan T.; Logan, David J.; Thomas, David; Duncan, Stephen A.; North, Trista E.; Goessling, Wolfram; Carpenter, Anne E.; Schwartz, Robert; Bhatia, Sangeeta N. (2013-06)
    Cell-based therapies hold the potential to alleviate the growing burden of liver diseases. Such therapies require human hepatocytes, which, within the stromal context of the liver, are capable of many rounds of replication. ...
  • Barthelme, Dominik; Sauer, Robert T. (American Association for the Advancement of Science, 2012-07)
    Proteasomes are the major energy-dependent proteolytic machines in the eukaryotic and archaeal domains of life. To execute protein degradation, the 20S core peptidase combines with the AAA+ ring of the 19S regulatory ...
  • Regev, Aviv (Nature Publishing Group, 2013-04)
    The differentiation of hematopoietic stem cells into cells of the immune system has been studied extensively in mammals, but the transcriptional circuitry that controls it is still only partially understood. Here, the ...
  • Eyford, Brett A.; Ahmad, Rushdy; Enyaru, John C.; Carr, Steven A.; Pearson, Terry W. (Public Library of Science, 2013-08)
    Control of human African sleeping sickness, caused by subspecies of the protozoan parasite Trypanosoma brucei, is based on preventing transmission by elimination of the tsetse vector and by active diagnostic screening and ...
  • Simcoe, Robert A.; Chen, Shi-Fan S.; Miller, Daniel Robert; Sullivan, P. W. (IOP Publishing, 2015-02)
    Luminous distant quasars are unique probes of the high-redshift intergalactic medium (IGM) and of the growth of massive galaxies and black holes in the early universe. Absorption due to neutral hydrogen in the IGM makes ...
  • Apyan, Aram; Barbieri, R.; Bauer, Gerry P.; Busza, Wit; Cali, Ivan Amos; Chan, M.; Di Matteo, Leonardo; Dutta, V.; Gomez-Ceballos, Guillelmo; Goncharov, Maxim; Gulhan, Doga Can; Klute, Markus; Lai, Yue Shi; Lee, Y.-J.; Levin, A.; Luckey, P. David, Jr.; Ma, Teng; Paus, Christoph M. E.; Ralph, Duncan Kelley; Roland, Christof E.; Roland, Gunther M.; Stephans, George S. F.; Stockli, Fabian; Sumorok, Konstanty C.; Velicanu, Dragos Alexandru; Veverka, Jan; Wyslouch, Boleslaw; Yang, M.; Zanetti, Marco; Zhukova, Victoria (Springer-Verlag, 2014-12)
    In searches for new physics in the energy regime of the LHC, it is becoming increasingly important to distinguish single-jet objects that originate from the merging of the decay products of W bosons produced with high ...
  • Balewski, Jan T.; Betancourt, Michael Joseph; Corliss, Ross; Hays-Wehle, James Prewitt; Leight, William Axel; Milner, Richard G.; Redwine, Robert P; Seele, J.; Steadman, Stephen G.; Surrow, Bernd; van Nieuwenhuizen, G.; Walker, M. (American Physical Society, 2012-02)
    We report transverse momentum (pT≤15  GeV/c) spectra of π[superscript ±], K[superscript ±], p, p̅ , K[subscript S][superscript 0], and ρ[superscript 0] at midrapidity in p+p and Au+Au collisions at √sNN=200  GeV. Perturbative ...
  • Surrow, Bernd; Balewski, Jan T.; Betancourt, Michael Joseph; Hays-Wehle, James Prewitt; Hoffman, A. M.; Jones, Christopher LaDon; Kocoloski, Adam Philip; Leight, William Axel; Milner, Richard G.; Redwine, Robert P.; Sakuma, Tai; Seele, Joseph Patrick; Stephans, George S. F.; van Nieuwenhuizen, Gerrit Jan; Walker, M.; Corliss, Ross Cameron (American Physical Society, 2010-02)
    We present the first measurements of identified hadron production, azimuthal anisotropy, and pion interferometry from Au+Au collisions below the nominal injection energy at the BNL Relativistic Heavy-Ion Collider (RHIC) ...
  • Greenstone, Michael; Hornbeck, Richard; Moretti, Enrico (University of Chicago Press, 2010-06)
    We quantify agglomeration spillovers by comparing changes in total factor productivity (TFP) among incumbent plants in “winning” counties that attracted a large manufacturing plant and “losing” counties that were the new ...
  • Miller, Miles Aaron; Feng, Xiao-Jiang; Li, Genyuan; Rabitz, Herschel A. (Public Library of Science, 2012-06)
    This work presents an adapted Random Sampling - High Dimensional Model Representation (RS-HDMR) algorithm for synergistically addressing three key problems in network biology: (1) identifying the structure of biological ...
  • Thaler, Jesse; Van Tilburg, Ken (Springer-Verlag, 2011-03)
    We introduce a new jet shape—N-subjettiness—designed to identify boosted hadronically-decaying objects like electroweak bosons and top quarks. Combined with a jet invariant mass cut, N-subjettiness is an effective ...
  • Oloritun, Rahman O.; Madan, Anmol; Khayal, Inas; Pentland, Alex Paul (Elsevier, 2013-06)
    Studies have suggested that propinquity; social, cultural, physical and psychological similarities are major factors in close friendship ties. These studies were subject to human recall of interactions with no details of ...
  • Pintilie, Grigore Dimitrie; Zhang, Junjie; Chiu, Wah; Gossard, David C. (Institute of Electrical and Electronics Engineers, 2009-04)
    Segmentation of density maps obtained using cryo-electron microscopy (cryo-EM) is a challenging task, and is typically accomplished by time-intensive interactive methods. The goal of segmentation is to identify the regions ...
  • Mitsos, Alexander; Melas, Ioannis N.; Siminelakis, Paraskeuas; Chairakaki, Aikaterini D.; Saez-Rodriguez, Julio; Alexopoulos, Leonidas G. (Public Library of Science, 2009-10)
    Understanding the mechanisms of cell function and drug action is a major endeavor in the pharmaceutical industry. Drug effects are governed by the intrinsic properties of the drug (i.e., selectivity and potency) and the ...
  • Yang, Ming; Chakraborty, Arup K.; Govern, Christopher C. (American Physical Society, 2012-01)
    In biochemical networks, identifying key proteins and protein-protein reactions that regulate fluctuation-driven transitions leading to pathological cellular function is an important challenge. Using large deviation theory, ...
  • Yang, Shun-Chieh; Chang, Su-Sen; Chen, Yu-Chian (Public Library of Science, 2011-12)
    The relationship between abnormal HER2 expression and cancer is important in cancer therapeutics. Formation and spread of cancer cells may be restricted by inhibiting HER2. We conducted ligand-based and structure-based ...
  • Donley, J. L.; Koekemoer, A. M.; Brusa, M.; Capak, P.; Civano, F.; Ilbert, O.; Impey, C. D.; Kartaltepe, J. S.; Miyaji, T.; Salvato, M.; Sanders, D. B.; Trump, J. R.; Zamorani, G.; Cardamone, Carolin (IOP Publishing, 2012-03)
    Spitzer/IRAC selection is a powerful tool for identifying luminous active galactic nuclei (AGNs). For deep IRAC data, however, the AGN selection wedges currently in use are heavily contaminated by star-forming galaxies, ...
  • Keele, Luke; Tingley, Dustin; Yamamoto, Teppei (Wiley Blackwell, 2015-05)
    Causal analysis in program evaluation has primarily focused on the question about whether or not a program, or package of policies, has an impact on the targeted outcome of interest. However, it is often of scientific and ...
  • Guttman, Mitchell; Garber, Manuel; Clamp, Michele; Zody, Michael C.; Friedman, Nir; Xie, Xiaohui (Oxford University Press (OUP), 2009-06)
    Motivation: Comparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved sequences across species; ...
Open Access