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Browsing MIT Open Access Articles by Title

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  • Anggono, Victor; Tsai, Li-Huei; Gotz, Jurgen (Hindawi Publishing Corporation, 2016-04)
    Alzheimer’s disease (AD) manifests as a progressive loss in memory, cognition, and language that is commonly associated with elevated levels of amyloid-beta (Aβ) peptide and hyperphosphorylated tau in the brain. There is ...
  • Selcher, Joel C.; Xu, Weifeng; Hanson, Jesse E.; Malenka, Robert C.; Madison, Daniel V. (Elsevier, 2011-11)
    Receptor subunit composition is believed to play a major role in the synaptic trafficking of AMPA receptors (AMPARs), and thus in activity-dependent synaptic plasticity. To isolate a physiological role of GluA1-containing ...
  • Papp, Edit; Borhegyi, Zsolt; Tomioka, Ryohei; Mody, István; Freund, Tamás F.; Rockland, Kathleen (Springer-Verlag, 2011-06)
    The nucleus accumbens (NAc) is positioned to integrate signals originating from limbic and cortical areas and to modulate reward-related motor output of various goal-directed behaviours. The major target of the NAc GABAergic ...
  • Tharakaraman, Kannan; Jayaraman, Akila; Raman, Rahul; Viswanathan, Karthik; Stebbins, Nathan W.; Johnson, David Alan; Shriver, Zachary H.; Sasisekharan, V.; Sasisekharan, Ram; Stebbins, Nathan W. (Elsevier B.V., 2013-06)
    The advent of H7N9 in early 2013 is of concern for a number of reasons, including its capability to infect humans, the lack of clarity in the etiology of infection, and because the human population does not have pre-existing ...
  • Raman, Rahul; Tharakaraman, Kannan; Jayaraman, Akila; Sasisekharan, Ram; Shriver, Zachary H.; Sasisekharan, Viswanathan (Elsevier, 2014-08)
    Influenza A viruses are rapidly evolving pathogens with the potential for novel strains to emerge and result in pandemic outbreaks in humans. Some avian-adapted subtypes have acquired the ability to bind to human glycan ...
  • Viswanathan, Karthik; Chandrasekaran, Aarthi; Srinivasan, Aravind; Raman, Rahul; Sasisekharan, V.; Sasisekharan, Ram (2010-08)
    Influenza A viruses, members of the Orthomyxoviridae family, are responsible for annual seasonal influenza epidemics and occasional global pandemics. The binding of viral coat glycoprotein hemagglutinin (HA) to sialylated ...
  • Nikel, Pablo I.; Romero-Campero, Francisco J.; Zeidman, Joshua A.; Goni-Moreno, Angel; de Lorenzo, Victor (American Society for Microbiology, 2015-03)
    The growth of the soil bacterium Pseudomonas putida KT2440 on glycerol as the sole carbon source is characterized by a prolonged lag phase, not observed with other carbon substrates. We examined the bacterial growth in ...
  • Eavarone, David A.; Kiziltepe, Tanyel; Sasisekharan, Ram; Sengupta, Shiladitya; Harfouche, Rania; Hentschel, Dirk M.; Piecewicz, Stephanie; Basu, Sudipta; Print, Cristin (American Heart Association, 2009-10)
    Background— Therapeutic vasculogenesis is an emerging concept that can potentially be harnessed for the management of ischemic pathologies. The present study elucidates the potential coregulation of vasculogenesis by the ...
  • Aich, Udayanath; Beckley, Nia; Shriver, Zachary H.; Raman, Rahul; Viswanathan, Karthik; Hobbie, Sven N.; Sasisekharan, Ram (John Wiley & Sons, Inc, 2011-05)
    Agglutination of red blood cells (RBCs), including chicken RBCs (cRBCs), has been used extensively to estimate viral titer, to screen glycan-receptor binding preference, and to assess the protective response of vaccines. ...
  • Jayaraman, Akila; Koh, Xiaoying; Li, Jing; Raman, Rahul; Viswanathan, Karthik; Shriver, Zachary H.; Sasisekharan, Ram (Portland Press, 2012-05)
    The glycoprotein HA (haemagglutinin) on the surface of influenza A virus plays a central role in recognition and binding to specific host cell-surface glycan receptors and in fusion of viral membrane to the host nuclear ...
  • Samsel, Anthony; Seneff, Stephanie (MDPI AG, 2013-04)
    Glyphosate, the active ingredient in Roundup[superscript ®], is the most popular herbicide used worldwide. The industry asserts it is minimally toxic to humans, but here we argue otherwise. Residues are found in the main ...
  • Newey, Whitney K.; Windmeijer, Frank (Econometric Society, 2009-05)
    Using many moment conditions can improve efficiency but makes the usual generalized method of moments (GMM) inferences inaccurate. Two-step GMM is biased. Generalized empirical likelihood (GEL) has smaller bias, but the ...
  • Bliss, Daniel W., Jr.; Forsythe, Keith W.; Davis, Shakti K.; Fawcett, Glenn S.; Rabideau, Daniel J.; Horowitz, Larry L.; Kraut, Shawn (Institute of Electrical and Electronics Engineers, 2009-03)
    Multiple-input multiple-output (MIMO) extensions to radar systems enable a number of advantages compared to traditional approaches. These advantages include improved angle estimation and target detection. In this paper, ...
  • Kumar, Anil; Ajoy, Ashok (Springer India, 2016-09)
    G N Ramachandran made several remarkable contributions to biophysics and structural biology over the course of his celebrated career. In a pair of seminal papers in 1971, he also laid the foundation for the technique of ...
  • Chen, Anthony J. -W.; Britton, Michael; Turner, Gary R.; Vytlacil, Jason; Thompson, Todd Wesley; D'Esposito, Mark (Frontiers Research Foundation, 2012-06)
    Humans survive in environments that contain a vast quantity and variety of visual information. All items of perceived visual information must be represented within a limited number of brain networks. The human brain requires ...
  • Lieberman, Chad E.; Willcox, Karen E. (Society for Industrial and Applied Mathematics, 2012-07)
    Inference of model parameters is one step in an engineering process often ending in predictions that support decision in the form of design or control. Incorporation of end goals into the inference process leads to more ...
  • McKinley, Gareth H.; Clasen, C.; Bico, J.; Entov, V. M. (Cambridge University Press, 2009-09)
    This paper discusses the breakup of capillary jets of dilute polymer solutions and the dynamics associated with the transition from dripping to jetting. High-speed digital video imaging reveals a new scenario of transition ...
  • O'Leary, Michael Boyer; Mortensen, Mark (INFORMS, 2009-06)
    Research regarding geographically dispersed teams (GDTs) is increasingly common and has yielded many insights regarding the effects of spatio-temporal and socio-demographic factors on GDT functioning and performance. Largely ...
  • Ritvo, Harriet (Oxford University Press, 2012-04)
    The nineteenth century saw numerous transfers and attempted transfers of animal populations, mostly as the result of the spread of European agriculture. The exchange of animal populations facilitated by the acclimatization ...
  • Conde, Joao (Frontiers Research Foundation, 2015-09)
    Since Richard Feynman and his famous talk “There’s plenty of room at the bottom” in an American Physical Society meeting at Caltech in 1959, Nanotechnology has led to the development of novel materials and devices with a ...
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