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Browsing MIT Open Access Articles by Title

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  • Fender, Rob; Lee, Julia C.; Ponti, Gabriele; Tzioumis, Anastasios K.; Edwards, Philip G.; Broderick, Jess W.; Neilsen, Joey; Coriat, Mickael (IOP Publishing, 2014-03)
    Recently, Diaz Trigo et al. reported an XMM-Newton detection of relativistically Doppler-shifted emission lines associated with steep-spectrum radio emission in the stellar-mass black hole candidate 4U 1630-47 during its ...
  • Sojoudi, Hossein; McKinley, Gareth H.; Gleason, Karen K. (Royal Society of Chemistry, 2014-10)
    Thin films of bilayer poly(divinyl benzene) p(DVB)/poly(perfluorodecylacrylate) (p-PFDA) are synthesized via iCVD on steel and silicon substrates. Nanomechanical measurements reveal that the elastic modulus and hardness ...
  • Gifford, Scott Michael; Sharma, Shalabh; Moran, Mary Ann (Frontiers Research Foundation, 2014-04)
    For bacterial communities containing hundreds to thousands of distinct populations, connecting functional processes and environmental dynamics at high taxonomic resolution has remained challenging. Here we use the expression ...
  • Kim, Dohoon; Tsai, Li-Huei (New York Academy of Sciences, 2009-08)
    Aberrant cell cycle activity and DNA damage have been observed in neurons in association with various neurodegenerative conditions. While there is strong evidence for a causative role for these events in neurotoxicity, it ...
  • Jin, Bilian; Ernst, Jason; Tiedemann, Rochelle L.; Xu, Hongyan; Sureshchandra, Suhas; Kellis, Manolis; Dalton, Stephen; Liu, Chen; Choi, Jeong-Hyeon; Robertson, Keith D. (Elsevier, 2012-11)
    DNA methylation, mediated by the combined action of three DNA methyltransferases (DNMT1, DNMT3A, and DNMT3B), is essential for mammalian development and is a major contributor to cellular transformation. To elucidate how ...
  • Bomblies, Arne; Laminou, Ibrahim M; Duchemin, Jean-Bernard; Yamana, Teresa K.; Eltahir, Elfatih A. B. (BioMed Central Ltd, 2013-08)
    Background: Individuals continuously exposed to malaria gradually acquire immunity that protects from severe disease and high levels of parasitization. Acquired immunity has been incorporated into numerous models of malaria ...
  • Moxley, Joel F.; Jewett, Michael C.; Antoniewicz, Maciek R.; Villas-Boas, Silas G.; Alper, Hal; Wheeler, Robert T.; Tong, Lily V.; Hinnebusch, Alan G.; Ideker, Trey; Nielsen, Jens; Stephanopoulos, Gregory (National Academy of Sciences, 2009-04)
    Genome sequencing dramatically increased our ability to understand cellular response to perturbation. Integrating system-wide measurements such as gene expression with networks of protein–protein interactions and transcription ...
  • Huang, Shao-shan Carol; Clarke, David C.; Gosline, Sara Jane Calafell; Labadorf, Adam; Chouinard, Candace R.; Gordon, William; Lauffenburger, Douglas A.; Fraenkel, Ernest (Public Library of Science, 2013-02)
    Cellular signal transduction generally involves cascades of post-translational protein modifications that rapidly catalyze changes in protein-DNA interactions and gene expression. High-throughput measurements are improving ...
  • Cohen, Judah; Furtado, Jason C.; Jones, Justin; Barlow, Mathew; Whittleston, David; Entekhabi, Dara (American Meteorological Society, 2014-07)
    Previous research has linked wintertime Arctic Oscillation (AO) variability to indices of Siberian snow cover and upward wave activity flux in the preceding fall season. Here, daily data are used to examine the surface and ...
  • Lambrecht, Bart M.; Myers, Stewart C. (John Wiley & Sons, Inc, 2012-10)
    We develop a dynamic agency model in which payout, investment, and financing decisions are made by managers who attempt to maximize the rents they take from the firm, subject to a capital market constraint. Managers smooth ...
  • Chen, Haogang; Mao, Yandong; Wang, Xi; Zhou, Dong; Zeldovich, Nickolai; Kaashoek, M. Frans (Association for Computing Machinery (ACM), 2011-07)
    Avoiding kernel vulnerabilities is critical to achieving security of many systems, because the kernel is often part of the trusted computing base. This paper evaluates the current state-of-the-art with respect to kernel ...
  • Duplantier, Bertrand; Sheffield, Scott Roger (Springer-Verlag, 2010-12)
    Consider a bounded planar domain D, an instance h of the Gaussian free field on D, with Dirichlet energy ... and a constant 0[less than or equal to]γ<2. The Liouville quantum gravity measure on D is the weak limit as ...
  • Peng, Zhangli; Dao, Ming; Suresh, Subra; Li, Xuejin; Pivkin, Igor V.; Karniadakis, George E. (National Academy of Sciences (U.S.), 2013-08)
    We study the biomechanical interactions between the lipid bilayer and the cytoskeleton in a red blood cell (RBC) by developing a general framework for mesoscopic simulations. We treated the lipid bilayer and the cytoskeleton ...
  • Eddy, Matthew T.; Su, Yongchao; Silvers, Robert; Andreas, Loren; Clark, Lindsay; Wagner, Gerhard; Pintacuda, Guido; Emsley, Lyndon; Griffin, Robert Guy (Springer-Verlag, 2015-01)
    The human voltage dependent anion channel 1 (VDAC) is a 32 kDa β-barrel integral membrane protein that controls the transport of ions across the outer mitochondrial membrane. Despite the determination of VDAC solution and ...
  • Hartley, Meredith D.; Schneggenburger, Philipp E.; Imperiali, Barbara (National Academy of Sciences (U.S.), 2013-12)
    Membrane-bound polyprenol-dependent pathways are important for the assembly of essential glycoconjugates in all domains of life. However, despite their prevalence, the functional significance of the extended linear polyprenyl ...
  • Chaparro, Jose P.; Bershteyn, A.; Riley, E. B.; Yao, R. S.; Zachariah, Roshini Sarah; Irvine, Darrell J. (Institute of Electrical and Electronics Engineers, 2009-05)
    The physicochemical context in which molecules are presented at the surfaces of microbes has tremendous implications for the immune response to vaccination. The spacing and mobility of molecules may control interactions ...
  • Nguyen, David N.; Mahon, Kerry P.; Chikh, Ghania; Kim, Phillip; Chung, Hattie; Vicari, Alain P.; Love, Kevin T.; Goldberg, Michael; Chen, Steve; Krieg, Arthur M.; Chen, Jianzhu; Langer, Robert; Anderson, Daniel Griffith (National Academy of Sciences (U.S.), 2012-03)
    The specific activation of Toll-like receptors (TLRs) has potential utility for a variety of therapeutic indications including antiviral immunotherapy and as vaccine adjuvants. TLR7 and TLR 8 may be activated by their ...
  • Ong, Ta-Chung; Clark, Lindsay; Teijido, Oscar; van der Wel, Patrick C. A.; Garces, Robert; Wagner, Gerhard; Rostovtseva, Tatiana K.; Eddy, Matthew Thomas; Griffin, Robert Guy (American Chemical Society (ACS), 2012-03)
    We employ a combination of [superscript 13]C/[superscript 15]N magic angle spinning (MAS) NMR and [superscript 2]H NMR to study the structural and functional consequences of different membrane environments on VDAC1 and, ...
  • Love, Kevin T.; Mahon, Kerry P.; Levins, Christopher G.; Whitehead, Kathryn Ann; Querbes, William; Dorkin, J. Robert; Qin, June; Cantley, William; Qin, Liu Liang; Racie, Timothy; Frank-Kamenetsky, Maria; Yip, Ka; Alvarez, Rene; Sah, Dinah W. Y.; de Fougerolles, Antonin; Fitzgerald, Kevin; Koteliansky, Victor; Akinc, Akin; Langer, Robert; Anderson, Daniel G. (National Academy of Sciences, 2010-02)
    Significant effort has been applied to discover and develop vehicles which can guide small interfering RNAs (siRNA) through the many barriers guarding the interior of target cells. While studies have demonstrated the ...
  • Zhang, Yunlong; Pelet, Jeisa M.; Heller, Daniel A.; Dong, Yizhou; Chen, Delai; Gu, Zhen; Joseph, Brian J.; Wallas, Jasmine; Anderson, Daniel Griffith (Wiley-VCH Verlag GmbH & Co., 2013-09)
    Rationally designed siRNA delivery materials that are enabled by lipid-modified aminoglycosides are demonstrated. Leading materials identified are able to self-assemble with siRNA into well-defined nanoparticles and induce ...
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