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Browsing MIT Open Access Articles by Title

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  • Mukherjee, Sayak; Zhu, Jing; Zikherman, Julie; Parameswaran, Ramya; Kadlecek, Theresa A.; Wang, Qi; Au-Yeung, Byron; Ploegh, Hidde; Kuriyan, John; Das, Jayajit; Weiss, Arthur (American Association for the Advancement of Science, 2013-01)
    The Src and Syk families of kinases are two distinct sets of kinases that play critical roles in initiating membrane-proximal B cell receptor (BCR) signaling. However, unlike in other lymphocytes, such as T cells, the ...
  • Avalos, Ana M.; Bilate, Angelina M.; Witte, Martin D.; Tai, Albert K.; He, Jiang; Frushicheva, Maria P.; Thill, Peter Daniel; Meyer-Wentrup, Friederike; Theile, Christopher S.; Chakraborty, Arup K.; Zhuang, Xiaowei; Ploegh, Hidde (Rockefeller University Press, 2014-02)
    Valency requirements for B cell activation upon antigen encounter are poorly understood. OB1 transnuclear B cells express an IgG1 B cell receptor (BCR) specific for ovalbumin (OVA), the epitope of which can be mimicked ...
  • Silver, David; Veness, Joel; Ng, Kee Siong; Hutter, Marcus; Uther, William (AI Access Foundation, 2011-01)
    This paper introduces a principled approach for the design of a scalable general reinforcement learning agent. Our approach is based on a direct approximation of AIXI, a Bayesian optimality notion for general reinforcement ...
  • Jiang, Fu-Jiun; Kampfer, Florian; Nyfeler, M. (American Physical Society, 2009-07)
    Motivated by the possible mechanism for the pinning of the electronic liquid crystal direction in YBa2Cu3O6.45 [YBa subscript 2 Cu supscript 3 O subscript 6.45] as proposed by Pardini et al. [Phys. Rev. B 78, 024439 (2008)], ...
  • Xu, Zao; Yue, Dick K. P. (Society of Photo-Optical Instrumentation Engineers (SPIE), 2014-02)
    We present a numerical study of the near-surface underwater solar light statistics using the state-of-the-art Monte Carlo radiative transfer (RT) simulations in the coupled atmosphere-ocean system. Advanced variance-reduction ...
  • Hernandez Rivera, Javier; Hoque, Mohammed Ehasanul; Picard, Rosalind W. (Association for Computing Machinery, 2012-08)
    Have you ever wondered whether it's possible to quantitatively measure how friendly or welcoming a community is? Or imagined which parts of the community are happier than others? In this work, we introduce a new technology ...
  • Kirilenko, Andrei; Lo, Andrew W. (American Economic Association, 2013-02)
    Financial markets have undergone a remarkable transformation over the past two decades due to advances in technology. These advances include faster and cheaper computers, greater connectivity among market participants, and ...
  • Perry, Ruth (Oxford University Press, 2009-11)
    The late Grace Paley was one of the great writers of the twentieth century, loved for her humanity and humor and admired for her brilliant, witty, deeply provocative prose fiction. Her literary voice is sui generis – ...
  • Sontag, David; Meshi, Ofer; Jaakkola, Tommi S.; Globerson, Amir (Neural Information Processing Systems Foundation, 2010-12)
    The problem of learning to predict structured labels is of key importance in many applications. However, for general graph structure both learning and inference in this setting are intractable. Here we show that it is ...
  • Eckhardt, Micah Rye; Picard, Rosalind W. (Institute of Electrical and Electronics Engineers, 2009-09)
    Labeling videos for affect content such as facial expression is tedious and time consuming. Researchers often spend significant amounts of time annotating experimental data, or simply lack the time required to label their ...
  • Skow, Bradford (Wiley Blackwell (Blackwell Publishing), 2011-12)
    Anti-haecceitism is the thesis that the universe could not be nonqualitatively different without being qualitatively different. Haecceitism is the denial of anti-haecceitism.1 In “Haecceitism, Anti-Haecceitism, and ...
  • Giambalvo, Vince; Miller, Haynes R. (Mathematical Sciences Publishers, 2011-09)
    The relations of Barratt and Miller are shown to include all relations among the elements P[superscript i]χP[superscript n−i} in the mod p Steenrod algebra, and a minimal set of relations is given.
  • McKernan, James (Springer, 2010-04)
    We explore the circle of ideas connecting finite generation of the Cox ring, Mori dream spaces and invariant theory.
  • Sun, Hao Sheng; Maze, Ian; Dietz, David M.; Scobie, Kimberly N.; Kennedy, Pamela K.; Damez-Werno, Diane; Neve, Rachael L.; Zachario, Venetia; Shen, Li; Nestler, Eric J. (Society for Neuroscience, 2012-11)
    Dysregulation of histone modifying enzymes has been associated with numerous psychiatric disorders. Alterations in G9a (Ehmt2), a histone methyltransferase that catalyzes the euchromatic dimethylation of histone H3 at ...
  • Urban, Glen L.; MacDonald, Erin; Bordley, Robert; Hauser, John R.; Liberali, Guilherme (Institute for Operations Research and the Management Sciences (INFORMS), 2013-10)
    Researchers and practitioners devote substantial effort to targeting banner advertisements to consumers, but they focus less effort on how to communicate with consumers once targeted. Morphing enables a website to learn, ...
  • Quintana, Lluís; Nieden, Nicole I. zur; Semino, Carlos Eduardo (Mary Ann Liebert, 2008-12)
    Cartilage is the first skeletal tissue to be formed during embryogenesis leading to the creation of all mature cartilages and bones, with the exception of the flat bones in the skull. Therefore, errors occurring during ...
  • Wang, Zhengyuan; Du, Jianguo; Lam, Siew H.; Mathavan, Sinnakarupan; Matsudaira, Paul T.; Gong, Zhiyuan (BioMed Central Ltd., 2010-06)
    Background The zebrafish intestine is a simple tapered tube that is folded into three sections. However, whether the intestine is functionally similar along its length remains unknown. Thus, a systematic structural and ...
  • Kempes, Christopher P.; Okegbe, Chinweike; Mears-Clarke, Zwoisaint; Dietrich, Lars E. P.; Follows, Michael J. (National Academy of Sciences (U.S.), 2014-01)
    A major theme driving research in biology is the relationship between form and function. In particular, a longstanding goal has been to understand how the evolution of multicellularity conferred fitness advantages. Here ...
  • Petroff, Alexander Peter; Sim, Min Sub; Liang, Biqing; Bosak, Tanja (United States National Academy of Sciences, 2009-05)
    Conical stromatolites are thought to be robust indicators of the presence of photosynthetic and phototactic microbes in aquatic environments as early as 3.5 billion years ago. However, phototaxis alone cannot explain the ...
  • Duong, Hai M.; Yamamoto, Namiko; Bui, Khoa; Papavassiliou, Dimitrios V.; Maruyama, Shigeo; Wardle, Brian L. (American Chemical Society (ACS), 2010-04)
    Carbon nanotube (CNT)−CNT contact and CNT distribution effects on anisotropic thermal transport in aligned CNT−polymer nanocomposites (PNCs) are studied using an off-lattice Monte Carlo numerical simulation. Inter-CNT ...
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