Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Green, Nathaniel M.; Laws, Amy; Kiefer, Kerstin; Busconi, Liliana; Kim, You-Me; Brinkmann, Melanie M.; Trail, Erin Hodges; Yasuda, Kei; Christensen, Sean R.; Shlomchik, Mark J.; Vogel, Stefanie; Connor, John H.; Ploegh, Hidde; Eilat, Dan; Rifkin, Ian R.; van Seventer, Jean Maguire; Marshak-Rothstein, Ann (American Association of Immunologists, Inc., 2009-07)
    Type I IFNs play an important, yet poorly characterized, role in systemic lupus erythematosus. To better understand the interplay between type I IFNs and the activation of autoreactive B cells, we evaluated the effect of ...
  • Kharas, Michael G.; Lengner, Christopher J.; Al-Shahrour, Fatima; Bullinger, Lars; Ball, Brian; Zaidi, Samir; Morgan, Kelly; Tam, Winnie; Paktinat, Mahnaz; Okabe, Rachel; Gozo, Maricel; Einhorn, William; Lane, Steven W.; Scholl, Claudia; Frohling, Stefan; Fleming, Mark; Ebert, Benjamin L.; Gilliland, D. Gary; Jaenisch, Rudolf; Daley, George Q. (Nature Publishing Group, 2010-07)
    RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant ...
  • Witchley, Jessica N.; Mayer, Mirjam; Wagner, Daniel E.; Owen, Jared Huntsman; Reddien, Peter; Witchley, Jessica N.; Wagner, Daniel E. (Elsevier B.V., 2013-08)
    Regeneration requires both potential and instructions for tissue replacement. In planarians, pluripotent stem cells have the potential to produce all new tissue. The identities of the cells that provide regeneration ...
  • Geyer, Hartmut; Herr, Hugh M. (Institute of Electrical and Electronics Engineers, 2010-06)
    While neuroscientists identify increasingly complex neural circuits that control animal and human gait, biomechanists find that locomotion requires little control if principles of legged mechanics are heeded that shape and ...
  • Chalkiadaki, Angeliki; Igarashi, Masaki; Nasamu, Armiyaw Sebastian; Knezevic, Jovana; Guarente, Leonard Pershing (Public Library of Science, 2014-07)
    SIRT1 is a metabolic sensor and regulator in various mammalian tissues and functions to counteract metabolic and age-related diseases. Here we generated and analyzed mice that express SIRT1 at high levels specifically in ...
  • Overduin, Simon A.; d'Avella, Andrea; Carmena, Jose M.; Bizzi, Emilio (Frontiers Research Foundation, 2014-03)
    Electrical microstimulation studies provide some of the most direct evidence for the neural representation of muscle synergies. These synergies, i.e., coordinated activations of groups of muscles, have been proposed as ...
  • Cheung, Vincent Chi-Kwan; Turolla, Andrea; Agostini, Michela; Silvoni, Stefano; Bennis, Caoimhe; Kasi, Patrick; Paganoni, Sabrina; Bonato, Paolo; Bizzi, Emilio (National Academy of Sciences (U.S.), 2012-08)
    The experimental findings herein reported are aimed at gaining a perspective on the complex neural events that follow lesions of the motor cortical areas. Cortical damage, whether by trauma or stroke, interferes with the ...
  • Cuthbert, Michael Scott; Ariza, Christopher T. (International Society for Music Information Retrieval, 2010-08)
    Music21 is an object-oriented toolkit for analyzing, searching, and transforming music in symbolic (score- based) forms. The modular approach of the project allows musicians and researchers to write simple scripts rapidly ...
  • Gong, Nan-wei; Laibowitz, Mat; Paradiso, Joseph A. (New Interfaces for Musical Expression, 2009)
    In this project, we have developed a real-time writing instrument for music control. The controller, MusicGrip, can capture the subtle dynamics of the user’s grip while writing or drawing and map this to musical control ...
  • von Fintel, Kai; Gillies, Anthony S. (Springer Netherlands, 2010-05)
    It is a recurring matra that epistemic must creates a statement that is weaker than the corresponding flat-footed assertion: It must be raining vs. It’s raining. Contrary to classic discussions of the phenomenon such as ...
  • Sheh, Alexander; Lee, Chung-Wei; Masumura, Kenichi; Rickman, Barry H.; Nohmi, Takehiko; Wogan, Gerald N.; Fox, James G.; Schauer, David B. (National Academy of Sciences (U.S.), 2010-08)
    Helicobacter pylori is a human carcinogen, but the mechanisms evoked in carcinogenesis during this chronic inflammatory disease remain incompletely characterized. We determined whether chronic H. pylori infection induced ...
  • Yang, Yue; Huang, Jinghe; Toth, Ildiko; Lichterfeld, Mathias; Yu, Xu G. (Public Library of Science, 2010-12)
    Escape mutations in HIV-1 cytotoxic T cell (CTL) epitopes can abrogate recognition by the TCR of HIV-1-specific CD8+ T cells, but may also change interactions with alternative MHC class I receptors. Here, we show that ...
  • Lander, Eric S. (American Association for the Advancement of Science, 2011-07)
    Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing data from 74 tumor-normal pairs. The majority ...
  • Hobbie, Sven N.; Kalapala, Sarath K.; Bottger, Erik C.; Shcherbakov, Dmitry (Public Library of Science, 2010-04)
    Recent studies have suggested that ribosomal protein S12 modulates 16S rRNA function and susceptibility to 2-deoxystreptamine aminoglycosides. To study whether the non-restrictive K42R mutation in RpsL affects 2-deoxystreptamine ...
  • Leshchiner, Ignaty; Alexa, Kristen; Kelsey, Peter; Adzhubei, Ivan; Austin-Tse, Christina A.; Cooney, Jeffrey D.; Anderson, Heidi; King, Matthew J.; Stottmann, Rolf W.; Garnaas, Maija K.; Ha, Seungshin; Drummond, Iain A.; Paw, Barry H.; North, Trista E.; Beier, David R.; Goessling, Wolfram; Sunyaev, Shamil R. (Cold Spring Harbor Laboratory Press, 2012-05)
    Genetic mapping of mutations in model systems has facilitated the identification of genes contributing to fundamental biological processes including human diseases. However, this approach has historically required the prior ...
  • Melom, Jan Elizabeth; Littleton, J. Troy (Society for Neuroscience, 2013-01)
    Glia exhibit spontaneous and activity-dependent fluctuations in intracellular Ca[superscript 2+], yet it is unclear whether glial Ca[superscript 2+] oscillations are required during neuronal signaling. Somatic glial ...
  • Mullins, James I.; Heath, Laura; Hughes, James P.; Kicha, Jessica; Styrchak, Sheila; Wong, Kim G.; Rao, Ushnal; Hansen, Alexis; Harris, Kevin S.; Laurent, Jean-Pierre; Li, Deyu; Simpson, Jeffrey H.; Essigmann, John M.; Loeb, Lawrence A.; Parkins, Jeffrey (Public Library of Science, 2011-01)
    The deoxycytidine analog KP1212, and its prodrug KP1461, are prototypes of a new class of antiretroviral drugs designed to increase viral mutation rates, with the goal of eventually causing the collapse of the viral ...
  • Lees, Jacqueline; Caron, Alicia M.; Danielian, Paul S.; West, Julie C.; Stone, James R.; Berman, Seth D. (United States National Academy of Sciences, 2009-08)
    The retinoblastoma tumor-suppressor protein, pRb, is a member of the pocket protein family that includes p107 and p130. These proteins have well-defined roles in regulating entry into and exit from the cell cycle and also ...
  • Kirby, Andrew; Gnirke, Andreas; Jaffe, David B.; Baresova, Veronika; Pochet, Nathalie; Blumenstiel, Brendan; Ye, Chun; Aird, Daniel; Stevens, Christine; Robinson, James T.; Cabili, Moran N.; Gat-Viks, Irit; Kelliher, Edward; Daza, Riza; DeFelice, Matthew; Hulkova, Helena; Sovova, Jana; Vylet'al, Petr; Antignac, Corinne; Guttman, Mitchell; Handsaker, Robert E.; Perrin, Danielle; Steelman, Scott; Sigurdsson, Snaevar; Scheinman, Steven J.; Sougnez, Carrie; Cibulskis, Kristian; Parkin, Melissa; Green, Todd; Rossin, Elizabeth; Zody, Michael C.; Xavier, Ramnik J.; Pollak, Martin R.; Alper, Seth L.; Lindblad-Toh, Kerstin; Gabriel, Stacey; Hart, P. Suzanne; Regev, Aviv; Nusbaum, Chad; Kmoch, Stanislav; Bleyer, Anthony J.; Lander, Eric S.; Daly, Mark J. (Nature Publishing Group, 2013-02)
    Although genetic lesions responsible for some mendelian disorders can be rapidly discovered through massively parallel sequencing of whole genomes or exomes, not all diseases readily yield to such efforts. We describe the ...
  • Auerbach, Benjamin; Osterweil, Emily; Bear, Mark (Nature Publishing Group, 2011-11)
    Tuberous sclerosis complex and fragile X syndrome are genetic diseases characterized by intellectual disability and autism. Because both syndromes are caused by mutations in genes that regulate protein synthesis in neurons, ...
Open Access