Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Title

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Title

Sort by: Order: Results:

  • Yang, Shun-Chieh; Chang, Su-Sen; Chen, Yu-Chian (Public Library of Science, 2011-12)
    The relationship between abnormal HER2 expression and cancer is important in cancer therapeutics. Formation and spread of cancer cells may be restricted by inhibiting HER2. We conducted ligand-based and structure-based ...
  • Donley, J. L.; Koekemoer, A. M.; Brusa, M.; Capak, P.; Civano, F.; Ilbert, O.; Impey, C. D.; Kartaltepe, J. S.; Miyaji, T.; Salvato, M.; Sanders, D. B.; Trump, J. R.; Zamorani, G.; Cardamone, Carolin (IOP Publishing, 2012-03)
    Spitzer/IRAC selection is a powerful tool for identifying luminous active galactic nuclei (AGNs). For deep IRAC data, however, the AGN selection wedges currently in use are heavily contaminated by star-forming galaxies, ...
  • Keele, Luke; Tingley, Dustin; Yamamoto, Teppei (Wiley Blackwell, 2015-05)
    Causal analysis in program evaluation has primarily focused on the question about whether or not a program, or package of policies, has an impact on the targeted outcome of interest. However, it is often of scientific and ...
  • Guttman, Mitchell; Garber, Manuel; Clamp, Michele; Zody, Michael C.; Friedman, Nir; Xie, Xiaohui (Oxford University Press (OUP), 2009-06)
    Motivation: Comparing the genomes from closely related species provides a powerful tool to identify functional elements in a reference genome. Many methods have been developed to identify conserved sequences across species; ...
  • Andersen, Kristian G.; Shlyakhter, Ilya; Tabrizi, Shervin; Winnicki, Sarah; Yen, Angela; Park, Daniel J.; Griesemer, Dustin; Karlsson, Elinor K.; Wong, Sunny H.; Cabili, Moran N.; Adegbola, Richard A.; Bamezai, Rameshwar N.K.; Hill, Adrian V. S.; Vannberg, Fredrik O.; Rinn, John L.; Lander, Eric S.; Schaffner, Stephen F.; Sabeti, Pardis C.; Grossman, Sharon Rachel (Elsevier, 2013-02)
    Although several hundred regions of the human genome harbor signals of positive natural selection, few of the relevant adaptive traits and variants have been elucidated. Using full-genome sequence variation from the 1000 ...
  • Daly, Mark J.; Altshuler, David; Xavier, Ramnik J.; Sklar, Pamela; Purcell, Shaun M.; International Schizophrenia Consortium; Nguyen, Aylwin C. Y.; Scolnick, Edward Mark; Rossin, Elizabeth; Plenge, Robert M.; Raychaudhuri, Soumya (Public Library of Science, 2009-06)
    Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ...
  • Raychaudhuri, Soumya; Plenge, Robert M.; Rossin, Elizabeth; Ng, Aylwin C. Y.; Purcell, Shaun M.; Sklar, Pamela; Scolnick, Edward Mark; Xavier, Ramnik J.; Altshuler, David; Daly, Mark J. (Public Library of Science, 2009-06)
    Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within them, but also the biological relationships among those key genes. Here ...
  • Simchi-Levi, David; Schmidt, William; Wei, Yehua; Combs, Keith; Ge, Yao; Gusikhin, Oleg; Sanders, Michael; Zhang, Don; Zhang, Yun (Institute for Operations Research and the Management Sciences (INFORMS), 2015-10)
    Firms are exposed to a variety of low-probability, high-impact risks that can disrupt their operations and supply chains. These risks are difficult to predict and quantify; therefore, they are difficult to manage. As a ...
  • Ong, Shao-En; Schenone, Monica; Margolin, Adam A.; Li, Xiaoyu; Do, Kathy; Doud, Mary Kathryn; Mani, D. R.; Kuai, Letian; Wang, Xiang; Wood, John L.; Tolliday, Nicola J.; Koehler, Angela Nicole; Marcaurelle, Lisa A.; Golub, Todd R.; Gould, Robert J.; Schreiber, Stuart L.; Carr, Steven A. (National Academy of Sciences, 2009-03)
    Most small-molecule probes and drugs alter cell circuitry by interacting with 1 or more proteins. A complete understanding of the interacting proteins and their associated protein complexes, whether the compounds are ...
  • Barker, Nick; van Oudenaarden, Alexander; Clevers, Hans; van Oudenaarden, Alexander (Elsevier, 2012-10)
    Decades ago, two nonoverlapping crypt stem cell populations were proposed: Leblond’s Crypt Base Columnar (CBC) cell and Potten’s +4 cell. The identification of CBC markers including Lgr5 has confirmed Leblond’s predictions ...
  • von Hippel, Eric A.; von Krogh, Georg (2013-11-27)
    Problem-solving research, and formal problem-solving practice as well, begins with the assumption that a problem has been identified or formulated for solving. The problem-solving process then involves a search for a ...
  • Daniel, J. S.; Portmann, R. W.; Solomon, Susan; Murphy, Daniel M. (American Geophysical Union (AGU), 2012-07)
    [1] Weekly cycles in several meteorological parameters have been previously reported. Yet the extent to which these cycles are caused by anthropogenic activity remains unclear. Some of the complications associated with ...
  • Petersen, Roger D. (Oxford University Press, 2012-10)
    I wish to address both a substantive and a methodological issue in this chapter. Substantively, I will discuss the process of state disintegration and reconstruction. Here, I will draw on the experience of Eastern Europe ...
  • Van Maanen, John (Cambridge University Press, 2010-11)
    This chapter is about three highly intertwined concepts. The first concerns occupational communities and the work cultures they nourish. The second concerns the work identities that are valued (and devalued) in such ...
  • Haslanger, Sally (Springer Science + Business Media B.V., 2011)
    Introduction: Are sagging pants cool? Are cows food? Are women more submissive than men? Are blacks more criminal than whites? Taking the social world at face value, many people would be tempted to answer these questions ...
  • Feldman, Dan; Sugaya, Andrew; Sung, Cynthia Rueyi; Rus, Daniela L. (Association for Computing Machinery (ACM), 2013-11)
    This paper describes a system that takes as input GPS data streams generated by users' phones and creates a searchable database of locations and activities. The system is called iDiary and turns large GPS signals collected ...
  • Schultz, David; Liskov, Barbara H. (Association for Computing Machinery (ACM), 2013-04)
    Numerous sensitive databases are breached every year due to bugs in applications. These applications typically handle data for many users, and consequently, they have access to large amounts of confidential information. This ...
  • Li, Matthew; Milner, Danny A.; Cima, Michael J. (Public Library of Science, 2015-05)
    Atherosclerosis and malignancy are pervasive pathological conditions that account for the bulk of morbidity and mortality in developed countries. Our current understanding of the patholobiology of these fundamental disorders ...
  • Pini, Giorgio; Scusa, Maria Flora; Congiu, Laura; Benincasa, Alberto; Morescalchi, Paolina; Bottiglioni, Ilaria; Di Marco, Pietro; Borelli, Paolo; Bonuccelli, Ubaldo; Della-Chiesa, Andrea; Prina-Mello, Adriele; Tropea, Daniela (Hindawi Publishing Corporation, 2012)
    Rett syndrome (RTT) is a devastating neurodevelopmental disorder that affects one in ten thousand girls and has no cure. The majority of RTT patients display mutations in the gene that codes for the methyl-CpG-binding ...
  • Grodzinsky, Alan J.; Wheeler, Cameron A.; Jafarzadeh, Seyed R.; Rocke, David M. (Elsevier Ltd., 2009-02)
    Objective To determine changes in chondrocyte transcription of a range of anabolic, catabolic and signaling genes following simultaneous treatment of cartilage with Insulin-like growth factor-1 (IGF-1) and ramp-and-hold ...
Open Access