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Browsing MIT Open Access Articles by Title

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  • Baker, Tania; Grant, Robert A.; Sauer, Robert T.; Roman-Hernandez, Giselle (United States National Academy of Sciences, 2009-04)
    The N-end rule is a conserved degradation pathway that relates the stability of a protein to its N-terminal amino acid. Here, we present crystal structures of ClpS, the bacterial N-end rule adaptor, alone and engaged with ...
  • Laloe, Jean-Baptiste; Kim, Tae Hee; Moodera, Jagadeesh (Hindawi Pub. Corp., 2011-04)
    Since the discovery of its superconducting properties in 2001, magnesium diboride has generated terrific scientific and engineering research interest around the world. With a 𝑇 Since the ...
  • Chang, Shu-Wei; Buehler, Markus J. (Elsevier, 2014-03)
    Collagenous tissues, made of collagen molecules, such as tendon and bone, are intriguing materials that have the ability to respond to mechanical forces by altering their structures from the molecular level up, and convert ...
  • Bao, Gang; Thomas, Wendy; Hwang, Wonmuk; Fletcher, Daniel A.; Zhu, Cheng; Mofrad, Mohammad R. K.; Kamm, Roger Dale; Grodzinsky, Alan J. (Springer New York, 2010-03)
    Recent advances have led to the emergence of molecular biomechanics as an essential element of modern biology. These efforts focus on theoretical and experimental studies of the mechanics of proteins and nucleic acids, and ...
  • Bezman, Natalie A.; Kim, Charles C.; Sun, Joseph C.; Min-Oo, Gundula; Hendricks, Deborah W.; Kamimura, Yosuke; Best, J. Adam; Goldrath, Ananda W.; Lanier, Lewis L.; Regev, Aviv; Immunological Genome Project Consortium (2012-08)
    Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared ...
  • Hu, Wei; Su, Yongchao; Zhou, Lei; Pang, Aimin; Cai, Rulin; Ma, Xingang; Li, Shenhui (MDPI AG, 2014-01)
    Neutral polymer bonding agent (NPBA) is one of the most promising polymeric materials, widely used in nitrate ester plasticized polyether (NEPE) propellant as bonding agent. The structure and dynamics of NPBA under different ...
  • Buehler, Markus J.; Qin, Zhao (American Physical Society, 2010-05)
    The alpha-helix to beta-sheet transition (α-β transition) is a universal deformation mechanism in alpha-helix rich protein materials such as wool, hair, hoof, and cellular proteins. Through a combination of molecular and ...
  • Luo, Tengfei; Esfarjani, Keivan; Shiomi, Junichiro; Henry, Asegun; Chen, Gang (American Institute of Physics (AIP), 2011-04)
    Heat transfer across thermal interface materials is a critical issue for microelectronics thermal management. Polydimethylsiloxane (PDMS), one of the most important components of thermal interface materials presents a large ...
  • Fournier, Gregory P.; Andam, Cheryl P.; Alm, Eric J.; Gogarten, Peter (Springer Science + Business Media B.V., 2011-12)
    Aminoacyl-tRNA synthetases (aaRS) consist of several families of functionally conserved proteins essential for translation and protein synthesis. Like nearly all components of the translation machinery, most aaRS families ...
  • Yost, Shane Robert; Wang, Lee-Ping; Van Voorhis, Troy (American Chemical Society, 2011-06)
    We present an investigation of the band levels and charge transfer (CT) states at the interface between two organic semiconductors, metal-free phthalocyanine (H2Pc) and 3,4,9,10-perylenetetracarboxylic bisbenzimidazole ...
  • Nair, Arun K.; Gautieri, Alfonso; Chang, Shu-Wei; Buehler, Markus J. (Nature Publishing Group, 2013-04)
    Bone is a natural composite of collagen protein and the mineral hydroxyapatite. The structure of bone is known to be important to its load-bearing characteristics, but relatively little is known about this structure or the ...
  • Beste, Michael T.; Pfaffle-Doyle, Nicole; Prentice, Emily A.; Lauffenburger, Douglas A.; Morris, Stephanie N.; Isaacson, Keith B.; Griffith, Linda G. (American Association for the Advancement of Science (AAAS), 2014-02)
    Clinical management of endometriosis is limited by the complex relationship between symptom severity, heterogeneous surgical presentation, and variability in clinical outcomes. As a complement to visual classification ...
  • Miraldi, Emily R.; Sharfi, Hadar; Friedline, Randall H.; Johnson, Hannah; Zhang, Tejia; Lau, Ken S.; Ko, Hwi Jin; Curran, Timothy G.; Haigis, Kevin M.; Yaffe, Michael B.; Bonneau, Richard; Lauffenburger, Douglas A.; Kahn, Barbara B.; Kim, Jason K.; Neel, Benjamin G.; Saghatelian, Alan; White, Forest M. (Royal Society of Chemistry, 2013-05)
    Metabolic syndrome describes a set of obesity-related disorders that increase diabetes, cardiovascular, and mortality risk. Studies of liver-specific protein-tyrosine phosphatase 1b (PTP1b) deletion mice (L-PTP1b[superscript ...
  • Fleischer, Shar-Li Karl; Zhou, Yan; Field, Robert W.; Nelson, Keith Adam (American Physical Society (APS), 2011-10)
    Intense single-cycle THz pulses resonantly interacting with molecular rotations are shown to induce field-free orientation and alignment under ambient conditions. We calculate and measure the degree of both orientation and ...
  • O'hUigin, Colm; Kulkarni, Smita; Xu, Yunping; Deng, Zhihui; Kidd, Judith; Kidd, Kenneth; Gao, Xiaojiang; Carrington, Mary (Elsevier B.V., 2011-09)
    Differential expression of human leukocyte antigen C (HLA-C) allotypes is mediated by the binding of a microRNA, miR-148a, to the 3′ untranslated region of some, but not all, HLA-C alleles. The binding results in lower ...
  • Chakraborty, Arup K.; Das, Jayajit; Zikherman, Julie; Yang, Ming; Govern, Christopher C.; Ho, Mary; Weiss, Arthur; Roose, Jeroen (American Association for the Advancement of Science, 2009-04)
    Activation of Ras proteins underlies functional decisions in diverse cell types. Two molecules, Ras-GRP and SOS (Ras–guanine nucleotide–releasing protein and Son of Sevenless, respectively), catalyze Ras activation in ...
  • Ferrer, Jorge M.; Lang, Matthew J.; Kamm, Roger Dale; Lee, Hyungsuk (American Physical Society, 2010-07)
    Two types of measurement are presented that relate molecular events to macroscopic behavior of F-actin networks. First, shear modulus is measured by oscillating an embedded microbead. Second, a microbead is translated at ...
  • Sboner, Andrea; Demichelis, Francesca; Calza, Stefano; Pawitan, Yudi; Setlur, Sunita R.; Hoshida, Yujin; Perner, Sven; Adami, Hans-Olov; Fall, Katja; Mucci, Lorelei A.; Kantoff, Philip W.; Stampfer, Meir; Andersson, Swen-Olof; Varenhorst, Eberhard; Johansson, Jan-Erik; Gerbstein, Mark B.; Golub, Todd R.; Rubin, Mark A.; Andren, Ove (BioMed Central Ltd., 2010-03)
    Background: Current prostate cancer prognostic models are based on pre-treatment prostate specific antigen (PSA) levels, biopsy Gleason score, and clinical staging but in practice are inadequate to accurately predict disease ...
  • Yi, Peng; Rutledge, Gregory C. (American Institute of Physics, 2009-10)
    Homogeneous nucleation of the crystal phase in n-octane melts was studied by molecular simulation with a realistic, united-atom model for n-octane. The structure of the crystal phase and the melting point of n-octane were ...
  • Uzel, Sebastien Guy Marcel; Buehler, Markus J. (Elsevier B.V., 2011-02)
    Collagen is a key constituent in structural materials found in biology, including bone, tendon, skin and blood vessels. Here we report a first molecular level model of an entire overlap region of a C-terminal cross-linked ...
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