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Browsing MIT Open Access Articles by Title

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  • ACID: annotation of cassette and integron data 
    Boucher, Yan; Labbate, Maurizio; Polz, Martin F.; Doolittle, W. Ford; Stokes, Harold W.; Gillings, Michael R.; Polz, Martin F.; Koenig, Jeremy E.; Joss, Michael J. (BioMed Central, 2009-04)
    Background: Although integrons and their associated gene cassettes are present in ~10% of bacteria and can represent up to 3% of the genome in which they are found, very few have been properly identified and annotated in ...
  • Acidic Extracellular pH Promotes Activation of Integrin [alpha]v[beta]3 
    Paradise, Ranjani K.; Lauffenburger, Douglas A.; Van Vliet, Krystyn J. (Public Library of Science, 2011-01)
    Acidic extracellular pH is characteristic of the cell microenvironment in several important physiological and pathological contexts. Although it is well established that acidic extracellular pH can have profound effects ...
  • Acknowledgement design for collision-recovery-enabled wireless erasure networks 
    Parandehgheibi, Ali; Sundararajan, Jay Kumar; Medard, Muriel (Institute of Electrical and Electronics Engineers (IEEE), 2010-10)
    Current medium access control mechanisms are based on collision avoidance and collided packets are discarded. The recent work on ZigZag decoding departs from this approach by recovering the original packets from multiple ...
  • Acoustic Bragg Reflectors for Q-Enhancement of Unreleased MEMS Resonators 
    Wang, Wentao; Weinstein, Dana (Institute of Electrical and Electronics Engineers, 2011-05)
    This work presents the design of acoustic Bragg reflectors (ABRs) for unreleased MEMS resonators through analysis and simulation. Two of the greatest challenges to the successful implementation of MEMS are those of packaging ...
  • Acoustic Correlates of Information Structure. 
    Breen, Mara; Fedorenko, Evelina G.; Wagner, Michael; Gibson, Edward A. (Taylor & Francis, 2010-09)
    This paper reports three studies aimed at addressing three questions about the acoustic correlates of information structure in English: (1) do speakers mark information structure prosodically, and, to the extent they do; ...
  • Acoustic energy dissipation and thermalization in carbon nanotubes: Atomistic modeling and mesoscopic description 
    Nicholson, David A.; Jacobs, William M.; Zemer, Hagit; Volkov, Alexey N.; Zhigilei, Leonid V. (American Physical Society, 2012-10)
    The exchange of energy between low-frequency mechanical oscillations and high-frequency vibrational modes in carbon nanotubes (CNTs) is a process that plays an important role in a range of dynamic phenomena involving the ...
  • Acted vs. natural frustration and delight: many people smile in natural frustration 
    Hoque, Mohammed Ehasanul; Picard, Rosalind W. (Institute of Electrical and Electronics Engineers, 2011-05)
    This work is part of research to build a system to combine facial and prosodic information to recognize commonly occurring user states such as delight and frustration. We create two experimental situations to elicit two ...
  • Acting for the Right Reasons 
    Markovits, Julia (Duke University Press, 2010-04)
    This essay examines the thought that our right actions have moral worth only if we perform them for the right reasons. On the face of it, views about the conditions of moral worth seem independent of what first-order ...
  • Action understanding as inverse planning 
    Baker, Christopher Lawrence; Saxe, Rebecca R.; Tenenbaum, Joshua B. (Elsevier, 2009-07)
    Humans are adept at inferring the mental states underlying other agents’ actions, such as goals, beliefs, desires, emotions and other thoughts. We propose a computational framework based on Bayesian inverse planning for ...
  • Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma 
    Lin, Lin; Meyerson, Matthew; Lockwood, William W.; Wang, Zhuwen; Silvers, Amy L.; Bass, Adam J.; Thomas, Dafydd G.; Chang, Andrew C.; Lin, Jules; Orringer, Mark B.; Li, Weiquan; Glover, Thomas W.; Giordano, Thomas J.; Lam, Wan L.; Beer, David G. (National Academy of Sciences, 2012-03)
    Gene amplification is a tumor-specific event during malignant transformation. Recent studies have proposed a lineage-dependency (addiction) model of human cancer whereby amplification of certain lineage transcription factors ...
  • Activation of mGluR5 Induces Rapid and Long-Lasting Protein Kinase D Phosphorylation in Hippocampal Neurons 
    Krueger, Dilja D.; Osterweil, Emily; Bear, Mark (Springer Science + Business Media, 2010-09)
    Metabotropic glutamate receptors (mGluRs), including mGluR5, play a central role in regulating the strength and plasticity of synaptic connections in the brain. However, the signaling pathways that connect mGluRs to their ...
  • Activation of tolerogenic dendritic cells in the tumor draining lymph CD8+ T cells engineered to express CD40 ligand 
    Higham, Eileen M.; Wittrup, Karl Dane; Chen, Jianzhu (The American Association of Immunologists, 2010-03)
    Tolerogenic dendritic cells in the tumor microenvironment can inhibit the generation and maintenance of robust antitumor T cell responses. In this study, we investigated the effects of local delivery of CD40L by tumor-reactive ...
  • Active black holes: Relevant plasma structures, regimes and processes involving all phase space 
    Coppi, Bruno (American Institute of Physics (AIP), 2011-03)
    The presented theory is motivated by the growing body of experimental information on the characteristics, connected with relevant spectral, time, and space resolutions, of the radiation emission from objects considered as ...
  • An active dimanganese(III)-tyrosyl radical cofactor in Escherichia coli class Ib ribonucleotide reductase 
    Cotruvo, Joseph Alfred; Stubbe, JoAnne (American Chemical Society (ACS), 2010-01)
    Escherichia coli class Ib ribonucleotide reductase (RNR) converts nucleoside 5′-diphosphates to deoxynucleoside 5′-diphosphates and is expressed under iron-limited and oxidative stress conditions. This RNR is composed of ...
  • Active Exploration for Robust Object Detection 
    Velez, Javier J.; Hemann, Garrett A.; Huang, Albert S.; Posner, Ingmar; Roy, Nicholas (2011-07)
    Today, mobile robots are increasingly expected to operate in ever more complex and dynamic environments. In order to carry out many of the higher-level tasks envisioned a semantic understanding of a workspace is pivotal. ...
  • Active negative-index metamaterial powered by an electron beam 
    Shapiro, Michael; Trendafilov, S.; Urzhumov, Y.; Alu, A.; Temkin, Richard J.; Shvets, G. (American Physical Society, 2012-08)
    An active negative index metamaterial that derives its gain from an electron beam is introduced. The metamaterial consists of a stack of equidistant parallel metal plates perforated by a periodic array of holes shaped as ...
  • Active real-time imaging system employed with a CW 460-GHz gyrotron and a pyroelectric array camera 
    Han, Seong-Tae; Torrezan de Sousa, Antonio Carlos; Sirigiri, Jagadishwar R.; Shapiro, Michael; Temkin, Richard J. (Institute of Electrical and Electronics Engineers, 2009-11)
    We report experimental testing of an active real-time imaging system useful for many practical applications, such as fast security check, food safety inspection, etc. The system consists of a 460-GHz gyrotron capable of ...
  • Active scaffolds for on-demand drug and cell delivery 
    Zhao, Xuanhe; Kim, Jaeyun; Cezar, Christine A.; Huebsch, Nathaniel David; Lee, Kangwon; Bouhadir, Kamal; Mooney, David J. (National Academy of Sciences (U.S.), 2011-01)
    Porous biomaterials have been widely used as scaffolds in tissue engineering and cell-based therapies. The release of biological agents from conventional porous scaffolds is typically governed by molecular diffusion, ...
  • Active Site Threonine Facilitates Proton Transfer during Dioxygen Activation at the Diiron Center of Toluene/o-Xylene Monooxygenase Hydroxylase 
    Song, Woon Ju; McCormick, Michael S.; Behan, Rachel K.; Sazinsky, Matthew H.; Jiang, Wei; Lin, Jeffery; Krebs, Carsten; Lippard, Stephen J. (American Chemical Society, 2010-10)
    Toluene/o-xylene monooxygenase hydroxylase (ToMOH), a diiron-containing enzyme, can activate dioxygen to oxidize aromatic substrates. To elucidate the role of a strictly conserved T201 residue during dioxygen activation ...
  • Active vibration cancellation of tonal disturbance using orthogonal eigenstructure control 
    Rastgaar Aagaah, Mohammad; Ahmadian, M.; Southward, C. (Society of Photo-Optical Instrumentation Engineers, 2009-04)
    Orthogonal Eigenstructure Control (OEC) is a novel control method that can be used for active vibration cancellation. OEC is an output feedback control method applicable to multiple-input, multiple-output linear systems. ...
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