Browsing MIT Open Access Articles by Title
Now showing items 8783-8802 of 55765
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Convergence-order analysis for differential-inequalities-based bounds and relaxations of the solutions of ODEs
(Springer US, 2018-08-01)Abstract For the performance of global optimization algorithms, the rate of convergence of convex relaxations to the objective and constraint functions is critical. We extend results from Bompadre and Mitsos ... -
Convergence-order analysis of branch-and-bound algorithms for constrained problems
(Springer-Verlag, 2017-06)The performance of branch-and-bound algorithms for deterministic global optimization is strongly dependent on the ability to construct tight and rapidly convergent schemes of lower bounds. One metric of the efficiency of ... -
Convergent and Biomimetic Enantioselective Total Synthesis of (−)-Communesin F
(American Chemical Society (ACS), 2016-05)The first biomimetic enantioselective total synthesis of (-)-communesin F based on a late-stage heterodimerization and aminal exchange is described. Our synthesis features the expedient diazene-directed assembly of two ... -
Convergent diversity-oriented side-chain macrocyclization scan for unprotected polypeptides
(Royal Society of Chemistry, The, 2013-12)Here we describe a general synthetic platform for side-chain macrocyclization of an unprotected peptide library based on the S[subscript N]Ar reaction between cysteine thiolates and a new generation of highly reactive ... -
Convergent dysbiosis of gastric mucosa and fluid microbiome during stomach carcinogenesis
(Springer Nature Singapore, 2022-06-04)Abstract Background A complex microbiota in the gastric mucosa (GM) has been unveiled recently and its dysbiosis is identified to be associated with gastric cancer (GC). ... -
Convergent Evolution of Calcineurin Pathway Roles in Thermotolerance and Virulence in Candida glabrata
(Genetics Society of America, The, 2012-06)Candida glabrata is an emerging human fungal pathogen that is frequently drug tolerant, resulting in difficulties in treatment and a higher mortality in immunocompromised patients. The calcium-activated protein phosphatase ... -
Convergent evolution of chicken Z and human X chromosomes by expansion and gene acquisition
(Nature Publishing Group, 2010-07)In birds, as in mammals, one pair of chromosomes differs between the sexes. In birds, males are ZZ and females ZW. In mammals, males are XY and females XX. Like the mammalian XY pair, the avian ZW pair is believed to have ... -
Convergent synthesis of a steroidal antiestrogen-mitomycin C hybrid using “click” chemistry
(Royal Society of Chemistry, 2012-09)A convergent synthesis of a novel estrogen receptor-targeted drug hybrid was developed based on structures of the potent anti-proliferative mitomycin C and the steroidal anti-estrogen RU 39411. The steroidal antiestrogen ... -
A Convergent Synthetic Platform for Single-Nanoparticle Combination Cancer Therapy: Ratiometric Loading and Controlled Release of Cisplatin, Doxorubicin, and Camptothecin
(American Chemical Society (ACS), 2014-04)The synthesis of polymer therapeutics capable of controlled loading and synchronized release of multiple therapeutic agents remains a formidable challenge in drug delivery and synthetic polymer chemistry. Herein, we report ... -
Converging-diverging shock-driven instabilities along soft hydrogel surfaces
(American Physical Society (APS), 2023)Intense surface eruptions are observed along the curved surface of a confined cylindrical film of hydrogel subject to laser-induced converging-diverging shock loading. Detailed numerical simulations are used to identify ... -
Conversations With Dr. Oleh Hornykiewicz, Founding Father of the Dopamine Era in Parkinson's: How Do You Wish to Be Remembered?
(Wiley, 2020-10)On May 26, 2020, Dr. Oleh Hornykiewicz died at the age of 93 years. His twin discoveries in the early 1960s of dopamine deficiency in the brains of subjects with Parkinson's disease and the amelioration of patients' symptoms ... -
Converse and duality results for combinatorial source-channel coding in binary Hamming spaces
(Institute of Electrical and Electronics Engineers (IEEE), 2015-06)This article continues the recent investigation of combinatorial joint source-channel coding. For the special case of a binary source and channel subject to distortion measured by Hamming distance, the lower (converse) ... -
Converse results on existence of sum of squares Lyapunov functions
(Institute of Electrical and Electronics Engineers (IEEE), 2012-03)Despite the pervasiveness of sum of squares (sos) techniques in Lyapunov analysis of dynamical systems, the converse question of whether sos Lyapunov functions exist whenever polynomial Lyapunov functions exist has remained ... -
A Converse to Banach's Fixed Point Theorem and its CLS Completeness
(Association for Computing Machinery (ACM), 2018-06)Banach's fixed point theorem for contraction maps has been widely used to analyze the convergence of iterative methods in non-convex problems. It is a common experience, however, that iterative maps fail to be globally ... -
A Converse to Banach's Fixed Point Theorem and its CLS Completeness
(Association for Computing Machinery (ACM), 2018-06-20)Banach's fixed point theorem for contraction maps has been widely used to analyze the convergence of iterative methods in non-convex problems. It is a common experience, however, that iterative maps fail to be globally ... -
A Converse to Lieb–Robinson Bounds in One Dimension Using Index Theory
(Springer International Publishing, 2022-07-26)Abstract Unitary dynamics with a strict causal cone (or “light cone”) have been studied extensively, under the name of quantum cellular automata (QCAs). In particular, QCAs in one dimension have been completely ... -
Conversion between Doubly and Triply Carboxylate Bridged Bis(ethylzinc) Complexes and Formation of the (μ-Oxo)tetrazinc Carboxylate [Zn[subscript 4]O(Ar[superscript Tol]CO[subscript 2)[subscript 6]]
(American Chemical Society (ACS), 2014-03)Ethylzinc 2,6-bis(p-tolyl)benzoate converts between two forms in solution. Through NMR spectroscopic techniques and X-ray crystallography, the species in equilibrium were identified as [Zn[subscript 2](Ar[superscript ... -
Conversion efficiency, scaling and global optimization of high harmonic generation
(Institute of Electrical and Electronics Engineers, 2009-08)Closed form expressions for the high harmonic generation (HHG) conversion efficiency in the plateau and cut-off region are derived showing agreement with previous observations. Application of these results to optimal ... -
Conversion of a yeast prion protein to an infectious form in bacteria
(National Academy of Sciences (U.S.), 2010-05)Prions are infectious, self-propagating protein aggregates that have been identified in evolutionarily divergent members of the eukaryotic domain of life. Nevertheless, it is not yet known whether prokaryotes can support ...