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Browsing MIT Open Access Articles by Title

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  • Baker, Tania; Sauer, Robert T.; Abdelhakim, Aliaa H. (National Academy of Sciences (U.S.), 2009-09)
    A hyperstable complex of the tetrameric MuA transposase with recombined DNA must be remodeled to allow subsequent DNA replication. ClpX, a AAA+ enzyme, fulfills this function by unfolding one transpososome subunit. Which ...
  • Calvo, Jennifer; Moroski-Erkul, Catherine A.; Lake, Annabelle; Eichinger, Lindsey Wood; Shah, Dharini; Jhun, Iny; Limsirichai, Prajit; Bronson, Roderick T.; Christiani, David C.; Meira, Lisiane B.; Samson, Leona D. (Public Library of Science, 2013-04)
    Alkylating agents comprise a major class of front-line cancer chemotherapeutic compounds, and while these agents effectively kill tumor cells, they also damage healthy tissues. Although base excision repair (BER) is essential ...
  • Marino-Enriquez, Adrian; Zhang, Yi-Xiang; Sioletic, Stefano; Kozakewich, Elena; Grebliunaite, Ruta; Ou, Wen-bin; Sicinska, Ewa; Raut, Chandrajit P.; Demetri, George D.; Perez-Atayde, Antonio R.; Wagner, Andrew J.; Fletcher, Jonathan A.; Fletcher, Christopher D. M.; Look, A. Thomas; Snyder, Eric; Gutierrez, Alejandro (Proceedings of the National Academy of Sciences (PNAS), 2011-09)
    Well-differentiated liposarcoma (WDLPS), one of the most common human sarcomas, is poorly responsive to radiation and chemotherapy, and the lack of animal models suitable for experimental analysis has seriously impeded ...
  • Sasaki, Tomoyuki; Lian, Shanshan; Qi, Jie; Bayliss, Peter E.; Carr, Christopher E.; Johnson, Jennifer L.; Guha, Sujay; Kobler, Patrick; Catz, Sergio D.; Gill, Matthew; Jia, Kailiang; Klionsky, Daniel J.; Kishi, Shuji (Public Library of Science, 2014-06)
    Spinster (Spin) in Drosophila or Spinster homolog 1 (Spns1) in vertebrates is a putative lysosomal H[superscript +]-carbohydrate transporter, which functions at a late stage of autophagy. The Spin/Spns1 defect induces ...
  • Picard, Nathalie; Leslie, Jennifer H.; Trowbridge, Sara Kishi; Subramanian, Jaichandar; Nedivi, Elly; Fagiolini, Michela (Society for Neuroscience, 2014-03)
    During development, experience plays a crucial role in sculpting neuronal connections. Patterned neural activity guides formation of functional neural circuits through the selective stabilization of some synapses and the ...
  • Sathasivam, Kirupa; Neueder, Andreas; Gipson, Theresa Anne; Landles, Christian; Benjamin, Agnesska C.; Bondulich, Marie K.; Amith, Donna L.; Faull, Richard L. M.; Roos, Raymund A. C.; Howland, David; Detloff, Peter J.; Housman, David E.; Bates, Gillian P. (National Academy of Sciences (U.S.), 2013-01)
    Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It is caused by a CAG repeat expansion in exon ...
  • Gipson, Theresa Anne; Housman, David E.; Sathasivam, Kirupa; Neueder, Andreas; Landles, Christian; Benjamin, Agnesska C.; Bondulich, Marie K.; Smith, Donna L.; Faull, Richard L. M.; Roos, Raymund A. C.; Howland, David; Detloff, Peter J.; bates, Gillian P. (National Academy of Sciences (U.S.), 2013-01)
    Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It is caused by a CAG repeat expansion in exon ...
  • Greenblatt, Wesley H.; Rubenstein, Eric M.; Kreft, Stefan G.; Swanson, Robert; Hochstrasser, Mark (Rockefeller University Press, The, 2012-06)
    Little is known about quality control of proteins that aberrantly or persistently engage the endoplasmic reticulum (ER)-localized translocon en route to membrane localization or the secretory pathway. Hrd1 and Doa10, the ...
  • Ceresoli, Davide; Marzari, Nicola; Lopez, M. G.; Thonhauser, T. (American Physical Society, 2010-05)
    We extend the recently developed converse NMR approach [Thonhauser et al., J. Chem. Phys. 131, 101101 (2009)] such that it can be used in conjunction with norm-conserving, nonlocal pseudopotentials. This extension permits ...
  • Kulik, Heather J.; Steeves, Adam H.; Field, Robert W. (Elsevier ScienceDirect, 2009-08)
    Based on high-level ab initio calculations, we predict the existence of a strong 4Σ+–4Σ+ [superscript 4 sigma superscript + - superscript 4 sigma superscript +] optical transition (dav=1.6 D) [(d subscript av = 1.6 D)] ...
  • Guttman, Mitchell; Garber, Manuel; Levin, Joshua Z.; Donaghey, Julie; Robinson, James; Adiconis, Xian; Fan, Lin; Koziol, Magdalena J.; Gnirke, Andreas; Nusbaum, Chad; Rinn, John L.; Lander, Eric S.; Regev, Aviv (Nature Publishing Group, 2010-07)
    RNA-Seq provides an unbiased way to study a transcriptome, including both coding and noncoding genes. To date, most RNA-Seq studies have critically depended on existing annotations, and thus focused on expression levels ...
  • Datta, Soumendu; Saha-Dasgupta, Tanusri; Kabir, Mohammad Mukul (American Physical Society, 2011-07)
    Using first-principles density-functional-theory–based calculations, we analyze the structural stability of small clusters of 3d late transition metals. We consider the relative stability of the two structures: layer-like ...
  • Mueller, Timothy K.; Ceder, Gerbrand (American Physical Society, 2010-11)
    We present a low-temperature structural model for lithium imide (Li[subscript 2]NH) that is consistent with experimental studies. Using the cluster expansion formalism and density-functional theory, we have identified a ...
  • Hurwitz, Michael Eliezer; Vanderzalm, Pamela J.; Bloom, Laird; Goldman, Julia; Garriga, Gian; Horvitz, H. Robert (Public Library of Science, 2009-04)
    The engulfment of apoptotic cells is required for normal metazoan development and tissue remodeling. In Caenorhabditis elegans, two parallel and partially redundant conserved pathways act in cell-corpse engulfment. One ...
  • Christodoulou, Joanna; Walker, Linsey M.; Del Tufo, Stephanie N.; Katzir, Tami; Gabrieli, John D. E.; Gabrieli, Susan; Chang, Bernard S. (John Wiley & Sons, Inc, 2012-06)
    Purpose:  Periventricular nodular heterotopia (PNH) is a malformation of cortical development associated with epilepsy and dyslexia. Evidence suggests that heterotopic gray matter can be functional in brain malformations ...
  • Stevens, Robin Jean; Akbergenova, Yulia; Jorquera, Ramon A.; Littleton, J. Troy (Society for Neuroscience, 2012-12)
    Sustained neuronal communication relies on the coordinated activity of multiple proteins that regulate synaptic vesicle biogenesis and cycling within the presynaptic terminal. Synaptogyrin and synaptophysin are conserved ...
  • Gruber, Jonathan; Ananat, Elizabeth Oltmans; Staiger, Douglas; Levine, Phillip B. (MIT Press, 2009-01)
    Abortion legalization in the early 1970s led to dramatic changes in fertility. Some research has suggested that it altered cohort outcomes, but this literature has been limited and controversial. In this paper, we provide ...
  • Stangenberg, Lars; Ellson, Chris; Cortez-Retamozo, Virna; Ortiz-Lopez, Adriana; Yuan, Hushan; Blois, Joseph; Smith, Ralph A.; Yaffe, Michael B.; Weissleder, Ralph; Benoist, Christophe; Mathis, Diane; Josephson, Lee; Mahmood, Umar (Wiley Blackwell, 2009-07)
    Objective: To test a novel self-activating viridin (SAV) prodrug that slowly releases wortmannin, a potent phosphoinositide 3-kinase inhibitor, in a model of antibody-mediated inflammatory arthritis. Methods: The SAV ...
  • Kurs, Andre B.; Joannopoulos, John D.; Soljacic, Marin; Johnson, Steven G. (Optical Society of America, 2011-06)
    We present numerical experiments showing how coupled-mode theory can be systematically applied to join very dissimilar photonic crystal waveguides with 100% transmission. Our approach relies on appropriately tuning the ...
  • Nahmod, Andrea R.; Rey-Bellet, Luc; Sheffield, Scott Roger; Staffilani, Gigliola (International Press, 2011-01)
    We prove absolute continuity of Gaussian measures associated to complex Brownian bridges under certain gauge transformations. As an application we prove that the invariant measure for the periodic derivative nonlinear ...
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