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Browsing MIT Open Access Articles by Title

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  • Tonegawa, Susumu; McHugh, Thomas J. (Wiley Blackwell, 2009-07)
    The acquisition of Pavlovian fear learning engages the hippocampus when the conditioned stimuli are multimodal or temporally isolated from the unconditioned stimuli. By subjecting CA3-NR1 KO mice to conditioning protocols ...
  • Zukerberg, Lawrence R; Patrick, Gentry N; Nikolic, Margareta; Humbert, Sandrine; Wu, Chin-Lee; Vidal, Marc; Van Etten, Richard A; Tsai, Li-Huei; Lanier, Lorene M.; Gertler, Frank (Elsevier, 2000-06)
    Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a ...
  • Agrawal, Kunal; Fineman, Jeremy T.; Krage, Jordan; Leiserson, Charles E.; Toledo, Sivan (Association for Computing Machinery (ACM), 2012-06)
    This paper considers the problem of scheduling streaming applications on uniprocessors in order to minimize the number of cache-misses. Streaming applications are represented as a directed graph (or multigraph), where nodes ...
  • Mao, Yandong; Kohler, Eddie; Morris, Robert (Association for Computing Machinery (ACM), 2012-04)
    We present Masstree, a fast key-value database designed for SMP machines. Masstree keeps all data in memory. Its main data structure is a trie-like concatenation of B+-trees, each of which handles a fixed-length slice of ...
  • Brodal, Gerth Stolting; Demaine, Erik D.; Fineman, Jeremy T.; Iacono, John; Langerman, Stefan; Munro, J. Ian (Society for Industrial and Applied Mathematics, 2010-01)
    Several existing cache-oblivious dynamic dictionaries achieve O(logB N) (or slightly better O(logB N over M )) memory transfers per operation, where N is the number of items stored, M is the memory size, and B is ...
  • Niesen, Urs; Shah, Devavrat; Wornell, Gregory W. (Institute of Electrical and Electronics Engineers, 2009-08)
    We consider the problem of delivering content cached in a wireless network of n nodes randomly located on a square of area n. In the most general form, this can be analyzed by considering the 2[superscript n] timesn-dimensional ...
  • Szatanek, Tomasz; Anderson-White, Brooke R.; Faugno-Fusci, David M.; White, Michael; Gubbels, Marc-Jan; Saeij, Jeroen (Wiley Blackwell, 2012-04)
    Toxoplasma gondii is an obligate intracellular protozoan parasite whose rapid lytic replication cycles define its pathogenicity. We identified a temperature-sensitive growth mutant, FV-P6, which irreversibly arrests before ...
  • Topalidou, Irini; van Oudenaarden, Alexander; Chalfie, Martin (National Academy of Sciences (U.S.), 2011-03)
    Variable expressivity of mutant phenotypes in genetically identical individuals is a phenomenon widely reported but poorly understood. For example, mutations in the gene encoding the transcription factor ALR-1 in Caenorhabditis ...
  • Horvitz, H. Robert; Ma, Long; Gao, Xiaoyang; Luo, Jintao; Huang, Liange; Teng, Yanling (Public Library of Science, 2012-07)
    RNA splicing is a major regulatory mechanism for controlling eukaryotic gene expression. By generating various splice isoforms from a single pre–mRNA, alternative splicing plays a key role in promoting the evolving complexity ...
  • de la Cruz, Ignacio Perez; Ma, Long; Horvitz, H. Robert (Public Library of Science, 2014-02)
    Loss-of-function mutations in the Caenorhabditis elegans gene sup-18 suppress the defects in muscle contraction conferred by a gain-of-function mutation in SUP-10, a presumptive regulatory subunit of the SUP-9 two-pore ...
  • Reddy, Kirthi C.; Hunter, Ryan C.; Bhatla, Nikhil; Newman, Dianne K.; Kim, Dennis H. (National Academy of Sciences (U.S.), 2011-08)
    Caenorhabditis elegans exhibits a diverse range of behaviors in response to bacteria. The presence of bacterial food influences C. elegans aerotaxis, aggregation, locomotion, and pathogen avoidance behaviors through the ...
  • Saffer, Adam M.; Kim, Dong hyun; van Oudenaarden, Alexander; Horvitz, H. Robert (Public Library of Science, 2011-12)
    The Caenorhabditis elegans class A and B synthetic multivulva (synMuv) genes redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. We identify a class A synMuv mutation in the promoter of the lin-3 ...
  • Kim, Seokhee; Sauer, Robert T. (National Academy of Sciences, 2012-05)
    DegP, a member of the highly conserved HtrA family, performs quality-control degradation of misfolded proteins in the periplasm of Gram-negative bacteria and is required for high-temperature survival of Escherichia coli. ...
  • Sainlos, Matthieu; Iskenderian, Wendy S.; Olivier, Nelson B.; Choquet, Daniel; Imperiali, Barbara (American Chemical Society, 2013-03)
    We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate ...
  • Zeng, Yi; Bazant, Martin Z. (Cambridge University Press/Materials Research Society, 2013-06)
    Using the recently developed Cahn-Hilliard reaction (CHR) theory, we present a simple mathematical model of the transition from solid-solution radial diffusion to two-phase shrinking-core dynamics during ion intercalation ...
  • Johnson, Samuel Buck; Taylor, Washington (Springer-Verlag/International School for Advanced Studies (SISSA), 2014-10)
    We carry out a systematic analysis of Calabi-Yau threefolds that are elliptically fibered with section (“EFS”) and have a large Hodge number h[superscript 2,1]. EFS Calabi-Yau threefolds live in a single connected space, ...
  • Cohen, A. L.; McCorkle, D. C.; Putron, S. J.; Starczak, V. R.; Zicht, A. E.; Drenkard, Elizabeth Joan (Springer-Verlag, 2013-03)
    Ocean acidification (OA) threatens the existence of coral reefs by slowing the rate of calcium carbonate (CaCO[subscript 3]) production of framework-building corals thus reducing the amount of CaCO3 the reef can produce ...
  • Caraveo, Gabriela; Baru, Valeriya; Lindquist, Susan; Auluck, Pavan K.; Whitesell, Luke; Chung, Chee Yeun; Mosharov, Eugene V.; Yan, Xiohui; Ben-Johny, Manu; Soste, Martin; Picotti, Paola; Kim, Hanna; Caldwell, Kim A.; Caldwell, Guy A.; Sulzer, David; Yue, David T. (National Academy of Sciences (U.S.), 2014-08)
    Calcineurin (CN) is a highly conserved Ca[superscript 2+]–calmodulin (CaM)-dependent phosphatase that senses Ca[superscript 2+] concentrations and transduces that information into cellular responses. Ca[superscript 2+] ...
  • Kalinowski, Agnieszka; Qin, Zhao; Coffey, Kelli; Kodali, Ravi; Buehler, Markus J.; Dahl, Kris Noel; Losche, Mathias (Elsevier, 2013-05)
    Lamin proteins contribute to nuclear structure and function, primarily at the inner nuclear membrane. The posttranslational processing pathway of lamin A includes farnesylation of the C-terminus, likely to increase membrane ...
  • Brophy, Megan Brunjes; Hayden, Joshua A.; Nolan, Elizabeth M. (American Chemical Society, 2012-10)
    Calprotectin (CP) is an antimicrobial protein produced and released by neutrophils that inhibits the growth of pathogenic microorganisms by sequestering essential metal nutrients in the extracellular space. In this work, ...
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