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Browsing MIT Open Access Articles by Title

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  • Tonegawa, Susumu; McHugh, Thomas J. (Wiley Blackwell, 2009-07)
    The acquisition of Pavlovian fear learning engages the hippocampus when the conditioned stimuli are multimodal or temporally isolated from the unconditioned stimuli. By subjecting CA3-NR1 KO mice to conditioning protocols ...
  • Zukerberg, Lawrence R; Patrick, Gentry N; Nikolic, Margareta; Humbert, Sandrine; Wu, Chin-Lee; Vidal, Marc; Van Etten, Richard A; Tsai, Li-Huei; Lanier, Lorene M.; Gertler, Frank (Elsevier, 2000-06)
    Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a ...
  • Agrawal, Kunal; Fineman, Jeremy T.; Krage, Jordan; Leiserson, Charles E.; Toledo, Sivan (Association for Computing Machinery (ACM), 2012-06)
    This paper considers the problem of scheduling streaming applications on uniprocessors in order to minimize the number of cache-misses. Streaming applications are represented as a directed graph (or multigraph), where nodes ...
  • Mao, Yandong; Kohler, Eddie; Morris, Robert Tappan (Association for Computing Machinery (ACM), 2012-04)
    We present Masstree, a fast key-value database designed for SMP machines. Masstree keeps all data in memory. Its main data structure is a trie-like concatenation of B+-trees, each of which handles a fixed-length slice of ...
  • Brodal, Gerth Stolting; Demaine, Erik D.; Fineman, Jeremy T.; Iacono, John; Langerman, Stefan; Munro, J. Ian (Society for Industrial and Applied Mathematics, 2010-01)
    Several existing cache-oblivious dynamic dictionaries achieve O(logB N) (or slightly better O(logB N over M )) memory transfers per operation, where N is the number of items stored, M is the memory size, and B is ...
  • Niesen, Urs; Shah, Devavrat; Wornell, Gregory W. (Institute of Electrical and Electronics Engineers, 2009-08)
    We consider the problem of delivering content cached in a wireless network of n nodes randomly located on a square of area n. In the most general form, this can be analyzed by considering the 2[superscript n] timesn-dimensional ...
  • Szatanek, Tomasz; Anderson-White, Brooke R.; Faugno-Fusci, David M.; White, Michael; Gubbels, Marc-Jan; Saeij, Jeroen (Wiley Blackwell, 2012-04)
    Toxoplasma gondii is an obligate intracellular protozoan parasite whose rapid lytic replication cycles define its pathogenicity. We identified a temperature-sensitive growth mutant, FV-P6, which irreversibly arrests before ...
  • Topalidou, Irini; van Oudenaarden, Alexander; Chalfie, Martin (National Academy of Sciences (U.S.), 2011-03)
    Variable expressivity of mutant phenotypes in genetically identical individuals is a phenomenon widely reported but poorly understood. For example, mutations in the gene encoding the transcription factor ALR-1 in Caenorhabditis ...
  • Horvitz, H. Robert; Ma, Long; Gao, Xiaoyang; Luo, Jintao; Huang, Liange; Teng, Yanling (Public Library of Science, 2012-07)
    RNA splicing is a major regulatory mechanism for controlling eukaryotic gene expression. By generating various splice isoforms from a single pre–mRNA, alternative splicing plays a key role in promoting the evolving complexity ...
  • de la Cruz, Ignacio Perez; Ma, Long; Horvitz, H. Robert (Public Library of Science, 2014-02)
    Loss-of-function mutations in the Caenorhabditis elegans gene sup-18 suppress the defects in muscle contraction conferred by a gain-of-function mutation in SUP-10, a presumptive regulatory subunit of the SUP-9 two-pore ...
  • Reddy, Kirthi C.; Hunter, Ryan C.; Bhatla, Nikhil; Newman, Dianne K.; Kim, Dennis H. (National Academy of Sciences (U.S.), 2011-08)
    Caenorhabditis elegans exhibits a diverse range of behaviors in response to bacteria. The presence of bacterial food influences C. elegans aerotaxis, aggregation, locomotion, and pathogen avoidance behaviors through the ...
  • Saffer, Adam M.; Kim, Dong hyun; van Oudenaarden, Alexander; Horvitz, H. Robert (Public Library of Science, 2011-12)
    The Caenorhabditis elegans class A and B synthetic multivulva (synMuv) genes redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. We identify a class A synMuv mutation in the promoter of the lin-3 ...
  • Kim, Seokhee; Sauer, Robert T. (National Academy of Sciences, 2012-05)
    DegP, a member of the highly conserved HtrA family, performs quality-control degradation of misfolded proteins in the periplasm of Gram-negative bacteria and is required for high-temperature survival of Escherichia coli. ...
  • Sainlos, Matthieu; Iskenderian, Wendy S.; Olivier, Nelson B.; Choquet, Daniel; Imperiali, Barbara (American Chemical Society, 2013-03)
    We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate ...
  • Zeng, Yi; Bazant, Martin Z. (Cambridge University Press/Materials Research Society, 2013-06)
    Using the recently developed Cahn-Hilliard reaction (CHR) theory, we present a simple mathematical model of the transition from solid-solution radial diffusion to two-phase shrinking-core dynamics during ion intercalation ...
  • Johnson, Samuel Buck; Taylor, Washington (Springer-Verlag/International School for Advanced Studies (SISSA), 2014-10)
    We carry out a systematic analysis of Calabi-Yau threefolds that are elliptically fibered with section (“EFS”) and have a large Hodge number h[superscript 2,1]. EFS Calabi-Yau threefolds live in a single connected space, ...
  • Cohen, A. L.; McCorkle, D. C.; Putron, S. J.; Starczak, V. R.; Zicht, A. E.; Drenkard, Elizabeth Joan (Springer-Verlag, 2013-03)
    Ocean acidification (OA) threatens the existence of coral reefs by slowing the rate of calcium carbonate (CaCO[subscript 3]) production of framework-building corals thus reducing the amount of CaCO3 the reef can produce ...
  • Caraveo, Gabriela; Baru, Valeriya; Lindquist, Susan; Auluck, Pavan K.; Whitesell, Luke; Chung, Chee Yeun; Mosharov, Eugene V.; Yan, Xiohui; Ben-Johny, Manu; Soste, Martin; Picotti, Paola; Kim, Hanna; Caldwell, Kim A.; Caldwell, Guy A.; Sulzer, David; Yue, David T. (National Academy of Sciences (U.S.), 2014-08)
    Calcineurin (CN) is a highly conserved Ca[superscript 2+]–calmodulin (CaM)-dependent phosphatase that senses Ca[superscript 2+] concentrations and transduces that information into cellular responses. Ca[superscript 2+] ...
  • Ouchi, Takanari; Sadoway, Donald Robert; Kim, Hojong; Ning, Xiaohui (Electrochemical Society, 2014-09)
    The performance of a calcium-antimony (Ca-Sb) alloy serving as the positive electrode in a Ca∥Sb liquid metal battery was investigated in an electrochemical cell, Ca(in Bi) | LiCl-NaCl-CaCl[subscript 2] | Ca(in Sb). The ...
  • Ouchi, Takanari; Kim, Hojong; Spatocco, Brian Leonard; Sadoway, Donald Robert (Nature Publishing Group, 2016-03)
    Calcium is an attractive material for the negative electrode in a rechargeable battery due to its low electronegativity (high cell voltage), double valence, earth abundance and low cost; however, the use of calcium has ...
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