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Browsing MIT Open Access Articles by Title

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  • Tonegawa, Susumu; McHugh, Thomas J. (Wiley Blackwell, 2009-07)
    The acquisition of Pavlovian fear learning engages the hippocampus when the conditioned stimuli are multimodal or temporally isolated from the unconditioned stimuli. By subjecting CA3-NR1 KO mice to conditioning protocols ...
  • Zukerberg, Lawrence R; Patrick, Gentry N; Nikolic, Margareta; Humbert, Sandrine; Wu, Chin-Lee; Vidal, Marc; Van Etten, Richard A; Tsai, Li-Huei; Lanier, Lorene M.; Gertler, Frank (Elsevier, 2000-06)
    Cyclin-dependent kinase 5 (Cdk5) is a small serine/threonine kinase that plays a pivotal role during development of the CNS. Cables, a novel protein, interacts with Cdk5 in brain lysates. Cables also binds to and is a ...
  • Mao, Yandong; Kohler, Eddie; Morris, Robert (Association for Computing Machinery (ACM), 2012-04)
    We present Masstree, a fast key-value database designed for SMP machines. Masstree keeps all data in memory. Its main data structure is a trie-like concatenation of B+-trees, each of which handles a fixed-length slice of ...
  • Brodal, Gerth Stolting; Demaine, Erik D.; Fineman, Jeremy T.; Iacono, John; Langerman, Stefan; Munro, J. Ian (Society for Industrial and Applied Mathematics, 2010-01)
    Several existing cache-oblivious dynamic dictionaries achieve O(logB N) (or slightly better O(logB N over M )) memory transfers per operation, where N is the number of items stored, M is the memory size, and B is ...
  • Niesen, Urs; Shah, Devavrat; Wornell, Gregory W. (Institute of Electrical and Electronics Engineers, 2009-08)
    We consider the problem of delivering content cached in a wireless network of n nodes randomly located on a square of area n. In the most general form, this can be analyzed by considering the 2[superscript n] timesn-dimensional ...
  • Szatanek, Tomasz; Anderson-White, Brooke R.; Faugno-Fusci, David M.; White, Michael; Gubbels, Marc-Jan; Saeij, Jeroen (Wiley Blackwell, 2012-04)
    Toxoplasma gondii is an obligate intracellular protozoan parasite whose rapid lytic replication cycles define its pathogenicity. We identified a temperature-sensitive growth mutant, FV-P6, which irreversibly arrests before ...
  • Topalidou, Irini; van Oudenaarden, Alexander; Chalfie, Martin (National Academy of Sciences (U.S.), 2011-03)
    Variable expressivity of mutant phenotypes in genetically identical individuals is a phenomenon widely reported but poorly understood. For example, mutations in the gene encoding the transcription factor ALR-1 in Caenorhabditis ...
  • Horvitz, H Robert; Ma, Long; Gao, Xiaoyang; Luo, Jintao; Huang, Liange; Teng, Yanling (Public Library of Science, 2012-07)
    RNA splicing is a major regulatory mechanism for controlling eukaryotic gene expression. By generating various splice isoforms from a single pre–mRNA, alternative splicing plays a key role in promoting the evolving complexity ...
  • de la Cruz, Ignacio Perez; Ma, Long; Horvitz, H. Robert (Public Library of Science, 2014-02)
    Loss-of-function mutations in the Caenorhabditis elegans gene sup-18 suppress the defects in muscle contraction conferred by a gain-of-function mutation in SUP-10, a presumptive regulatory subunit of the SUP-9 two-pore ...
  • Reddy, Kirthi C.; Hunter, Ryan C.; Bhatla, Nikhil; Newman, Dianne K.; Kim, Dennis H. (National Academy of Sciences (U.S.), 2011-08)
    Caenorhabditis elegans exhibits a diverse range of behaviors in response to bacteria. The presence of bacterial food influences C. elegans aerotaxis, aggregation, locomotion, and pathogen avoidance behaviors through the ...
  • Saffer, Adam M.; Kim, Dong hyun; van Oudenaarden, Alexander; Horvitz, H. Robert (Public Library of Science, 2011-12)
    The Caenorhabditis elegans class A and B synthetic multivulva (synMuv) genes redundantly antagonize an EGF/Ras pathway to prevent ectopic vulval induction. We identify a class A synMuv mutation in the promoter of the lin-3 ...
  • Kim, Seokhee; Sauer, Robert T. (National Academy of Sciences, 2012-05)
    DegP, a member of the highly conserved HtrA family, performs quality-control degradation of misfolded proteins in the periplasm of Gram-negative bacteria and is required for high-temperature survival of Escherichia coli. ...
  • Sainlos, Matthieu; Iskenderian-Epps, Wendy S.; Olivier, Nelson B.; Choquet, Daniel; Imperiali, Barbara (American Chemical Society, 2013-03)
    We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate ...
  • Cohen, A. L.; McCorkle, D. C.; Putron, S. J.; Starczak, V. R.; Zicht, A. E.; Drenkard, Elizabeth Joan (Springer-Verlag, 2013-03)
    Ocean acidification (OA) threatens the existence of coral reefs by slowing the rate of calcium carbonate (CaCO[subscript 3]) production of framework-building corals thus reducing the amount of CaCO3 the reef can produce ...
  • Brophy, Megan Brunjes; Hayden, Joshua A.; Nolan, Elizabeth M. (American Chemical Society, 2012-10)
    Calprotectin (CP) is an antimicrobial protein produced and released by neutrophils that inhibits the growth of pathogenic microorganisms by sequestering essential metal nutrients in the extracellular space. In this work, ...
  • Frey, Daniel (Institute of Electrical and Electronics Engineers (IEEE), 2011)
    This paper concerns the problem of calculating expectation shift due to variability which tends to occur whenever the function of a random variable is nonlinear and especially tends to occur in the neighborhood of a local ...
  • Qian, Xiaofeng; Li, Ju; Yip, Sidney (American Physical Society, 2010-11)
    We present an efficient and accurate computational approach to study phase-coherent quantum transport in molecular and nanoscale electronics. We formulate a Green’s-function method in the recently developed ab initio ...
  • Chang, Hsi-Ming; Procura, Massimiliano; Thaler, Jesse; Waalewijn, Wouter J. (American Physical Society, 2013-09)
    By using observables that only depend on charged particles (tracks), one can efficiently suppress pileup contamination at the LHC. Such measurements are not infrared safe in perturbation theory, so any calculation of ...
  • Chang, Hsi-Ming; Procura, Massimiliano; Thaler, Jesse; Waalewijn, Wouter J. (American Physical Society, 2013-08)
    In e[superscript +]e[superscript -] event shapes studies at LEP, two different measurements were sometimes performed: a “calorimetric” measurement using both charged and neutral particles and a “track-based” measurement ...
  • Temkin, Richard J.; Bigelow, Timothy S.; Rasmussen, David A.; Woskov, Paul P.; Sirigiri, Jagadishwar R.; Shapiro, Michael; Tax, David Samuel; Kowalski, Elizabeth Joan (Institute of Electrical and Electronics Engineers, 2009-11)
    The ITER transmission lines (TLs) must be designed to deliver 20 MW from a 24 MW, 170 GHz gyrotron system. Miter bends are the main source of loss for these highly overmoded, corrugated, cylindrical waveguide TLs. Previous ...
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