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Browsing MIT Open Access Articles by Title

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  • Hess, Gaelen T.; Cragnolini, Juan J.; Popp, Maximilian W.; Allen, Mark A.; Dougan, Stephanie K.; Spooner, Eric; Ploegh, Hidde L.; Belcher, Angela M.; Guimaraes, Carla P. (American Chemical Society (ACS), 2012-07)
    We exploit bacterial sortases to attach a variety of moieties to the capsid proteins of M13 bacteriophage. We show that pIII, pIX, and pVIII can be functionalized with entities ranging from small molecules (e.g., fluorophores, ...
  • Yi, Hyunjung; Ghosh, Debadyuti; Ham, Moon-Ho; Qi, Jifa; Barone, Paul W.; Strano, Michael S.; Belcher, Angela M. (American Chemical Society (ACS), 2012-01)
    Second near-infrared (NIR) window light (950–1400 nm) is attractive for in vivo fluorescence imaging due to its deep penetration depth in tissues and low tissue autofluorescence. Here we show genetically engineered ...
  • Ghosh, Debadyuti; Lee, Youjin; Thomas, Stephanie; Kohli, Aditya G.; Yun, Dong Soo; Belcher, Angela M.; Kelly, Kimberly A. (Nature Publishing Group, 2012-09)
    Molecular imaging allows clinicians to visualize the progression of tumours and obtain relevant information for patient diagnosis and treatment1. Owing to their intrinsic optical, electrical and magnetic properties, ...
  • Ghosh, Debadyuti; Belcher, Angela M.; Bardhan, Neelkanth Manoj (Wiley Blackwell, 2013-04)
    We report a first method for using M13 bacteriophage as a multifunctional scaffold for optically imaging bacterial infections in vivo. We demonstrate that M13 virus conjugated with hundreds of dye molecules (M13-Dye) can ...
  • Klasse, Per Johan; Dufour, Jason; Veazey, Ronald S.; Barouch, Dan H.; Moore, John P. (National Academy of Sciences, 2012-05)
    Vaccination and the application of a vaginal microbicide have traditionally been considered independent methods to prevent the sexual transmission of HIV-1 to women. Both techniques can be effective in macaque models, and ...
  • Cloud, Jason M.; Zeger, Linda; Medard, Muriel (Institute of Electrical and Electronics Engineers (IEEE), 2012-02)
    We design a cross-layer approach to aid in developing a cooperative solution using multi-packet reception (MPR), network coding (NC), and medium access (MAC). We construct a model for the behavior of the IEEE 802.11 MAC ...
  • Khabbazian, Majid; Kuhn, Fabian; Lynch, Nancy Ann; Medard, Muriel; Parandehgheibi, Ali (Association for Computing Machinery (ACM), 2011-06)
    Most medium access control (MAC) mechanisms discard collided packets and consider interference harmful. Recent work on Analog Network Coding (ANC) suggests a different approach, in which multiple interfering transmissions ...
  • Celik, Guner Dincer; Zussman, Gil; Khan, Wajahat F.; Modiano, Eytan H. (Institute of Electrical and Electronics Engineers, 2010-02)
    The physical layer of future wireless networks will be based on novel radio technologies such as UWB and MIMO. One of the important capabilities of such technologies is the ability to capture a few packets simultaneously. ...
  • Uzuner, Ozlem; Zhang, Xiaoran; Sibanda, Tawanda (BMJ Publishing Group, 2009)
    Objectives The authors study two approaches to assertion classification. One of these approaches, Extended NegEx (ENegEx), extends the rule-based NegEx algorithm to cover alter-association assertions; the other, Statistical ...
  • Tulabandhula, Theja; Rudin, Cynthia; Jaillet, Patrick (Springer Berlin / Heidelberg, 2011-10)
    The goal of the Machine Learning and Traveling Repairman Problem (ML&TRP) is to determine a route for a “repair crew,” which repairs nodes on a graph. The repair crew aims to minimize the cost of failures at the nodes, but ...
  • Rudin, Cynthia; Waltz, David; Anderson, Roger N.; Boulanger, Albert; Salleb-Aouissi, Ansaf; Chow, Maggie; Dutta, Haimonti; Gross, Philip N.; Huang, Bert; Ierome, Steve; Isaac, Delfina F.; Kressner, Arthur; Passonneau, Rebecca J.; Radeva, Axinia; Wu, Leon (Institute of Electrical and Electronics Engineers, 2012-02)
    Power companies can benefit from the use of knowledge discovery methods and statistical machine learning for preventive maintenance. We introduce a general process for transforming historical electrical grid data into ...
  • Rudin, Cynthia; Tulabandhula, Theja (Association for Computing Machinery (ACM), 2013-07)
    This work proposes a way to align statistical modeling with decision making. We provide a method that propagates the uncertainty in predictive modeling to the uncertainty in operational cost, where operational cost is the ...
  • Courgeon, Matthieu; Martin, Jean-Claude; Mutlu, Bilge; Picard, Rosalind W.; Hoque, Mohammed Ehasanul (Association for Computing Machinery (ACM), 2013-09)
    MACH--My Automated Conversation coacH--is a novel system that provides ubiquitous access to social skills training. The system includes a virtual agent that reads facial expressions, speech, and prosody and responds with ...
  • Trenkle, James D.; Jamison, Timothy F. (Wiley Blackwell, 2009-06)
    Ringing the changes: The total synthesis of the title compound centers around a novel strategy that employs a nickel(0)–phosphine complex and triethyl borane in an efficient closure of a 14-membered ring through C--C bond ...
  • Chen, Hui (American Finance Association, 2010-11)
    I build a dynamic capital structure model that demonstrates how business-cycle variations in expected growth rates, economic uncertainty, and risk premia influence firms’ financing and default policies. Countercyclical ...
  • Caballero, Ricardo J. (American Economic Association, 2010)
    The recent financial crisis has damaged the reputation of macroeconomics, largely for its inability to predict the impending financial and economic crisis. To be honest, this inability to predict does not concern me much. ...
  • Zeiger, Adam Scott; Loe, Felicia C.; Li, Ran; Raghunath, Michael; Van Vliet, Krystyn J. Van (Public Library of Science, 2012-05)
    Microenvironments of biological cells are dominated in vivo by macromolecular crowding and resultant excluded volume effects. This feature is absent in dilute in vitro cell culture. Here, we induced macromolecular crowding ...
  • Sohn, Jane J.; Schetter, Aaron J.; Yfantis, Harris G.; Ridnour, Lisa A.; Horikawa, Izumi; Kahn, Mohammed A.; Robles, Ana I.; Hussain, S. Perwez; Goto, Akiteru; Bowman, Elise D.; Hofseth, Lorne J.; Bartkova, Jirina; Bartek, Jiri; Wogan, Gerald N.; Wink, David A.; Harris, Curtis C. (Public Library of Science, 2012-09)
    Background: Cellular senescence can be a functional barrier to carcinogenesis. We hypothesized that inflammation modulates carcinogenesis through senescence and DNA damage response (DDR). We examined the association between ...
  • Commisso, Cosimo; Davidson, Shawn Michael; Soydaner-Azeloglu, Rengin G.; Parker, Seth J.; Kamphorst, Jurre J.; Hackett, Sean; Grabocka, Elda; Nofal, Michel; Drebin, Jeffrey A.; Thompson, Craig B.; Rabinowitz, Joshua D.; Metallo, Christian M.; Vander Heiden, Matthew G.; Bar-Sagi, Dafna (Nature Publishing Group, 2013-05)
    Macropinocytosis is a highly conserved endocytic process by which extracellular fluid and its contents are internalized into cells through large, heterogeneous vesicles known as macropinosomes. Oncogenic Ras proteins have ...
  • Tian, Bozhi; Liu, Jia; Dvir, Tal; Jin, Lihua; Tsui, Jonathan H.; Qing, Quan; Suo, Zhigang; Langer, Robert; Kohane, Daniel S.; Lieber, Charles M. (Nature Publishing Group, 2012-11)
    The development of three-dimensional (3D) synthetic biomaterials as structural and bioactive scaffolds is central to fields ranging from cellular biophysics to regenerative medicine. As of yet, these scaffolds cannot ...
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