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Browsing MIT Open Access Articles by Title

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  • Stains, Cliff I.; Lukovic, Elvedin; Imperiali, Barbara (American Chemical Society, 2010-09)
    Recent efforts have identified the p38alpha Ser/Thr kinase as a potential target for the treatment of inflammatory diseases as well as non-small cell lung carcinoma. Despite the significance of p38alpha, no direct activity ...
  • Bock, Florian J.; Tanzer, Maria C.; Haschka, Manuel D.; Krumschnabel, Gerhard; Goetsch, Katrin; Kofler, Reinhard; Villunger, Andreas; Sohm, Benedicte (Nature Publishing Group, 2015-06)
    The tumour suppressor p53 is an important mediator of cell cycle arrest and apoptosis in response to DNA damage, acting mainly by transcriptional regulation of specific target genes. The exact details how p53 modulates ...
  • McFadden, David Glenn; Vernon, Amanda; Santiago, Philip M.; Martinez-McFaline, Raul; Bhutkar, Arjun (AJ); Crowley, Denise M.; McMahon, Martin; Sadow, Peter M.; Jacks, Tyler E. (National Academy of Sciences (U.S.), 2014-04)
    Anaplastic thyroid carcinoma (ATC) has among the worst prognoses of any solid malignancy. The low incidence of the disease has in part precluded systematic clinical trials and tissue collection, and there has been little ...
  • Kirsch, David G.; Santiago, Philip M.; di Tomaso, Emmanuelle; Sullivan, Julie M.; Hou, Wu-Shiun; Dayton, Talya Lucia; Jeffords, Laura B.; Sodha, Pooja; Mercer, Kim L.; Cohen, Rhianna; Takeuchi, Osamu; Korsmeyer, Stanley J.; Bronson, Roderick T.; Kim, Carla F.; Haigis, Kevin M.; Jain, Rakesh K.; Jacks, Tyler E. (American Association for the Advancement of Science (AAAS), 2009-12)
    Acute exposure to ionizing radiation can cause lethal damage to the gastrointestinal (GI) tract, a condition called the GI syndrome. Whether the target cells affected by radiation to cause the GI syndrome are derived from ...
  • Wiktor-Brown, Dominika M.; Sukup-Jackson, Michelle R.; Fakhraldeen, Saja A.; Hendricks, Carrie A.; Engelward, Bevin P. (Elsevier B.V., 2011-12)
    The tumor suppressor p53 is a transcription factor whose function is critical for maintaining genomic stability in mammalian cells. In response to DNA damage, p53 initiates a signaling cascade that results in cell cycle ...
  • Lin, Yu-Li; Sengupta, Shomit; Gurdziel, Katherine; Bell, George W.; Jacks, Tyler E.; Flores, Elsa R. (Public Library of Science, 2009-10)
    The p53 family activates many of the same genes in response to DNA damage. Because p63 and p73 have structural differences from p53 and play distinct biological functions in development and metastasis, it is likely that ...
  • Mahlstein, Irina; Daniel, J. S.; Solomon, Susan (Nature Publishing Group, 2013-04)
    Human-induced climate change causes significant changes in local climates, which in turn lead to changes in regional climate zones. Large shifts in the world distribution of Köppen–Geiger climate classifications by the end ...
  • Wang, Daiwei; Cane, Mark A. (American Meteorological Society, 2011-12)
    By analyzing a set of the Coupled Model Intercomparison Project phase 3 (CMIP3) climate model projections of the twenty-first century, it is found that the shallow meridional overturning of the Pacific subtropical cells ...
  • O'Donnell, Frederick J.; Jensen, Katharine E.; Missaggia, Leo J.; Loh, William; Plant, Jason J.; Juodawlkis, Paul W. (Institute of Electrical and Electronics Engineers, 2009-08)
    We report the demonstration of a lensed-fiber-pigtailed InGaAsP-InP quantum-well semiconductor optical amplifier based on the slab-coupled optical waveguide (SCOW) concept. At a 5-A bias current and a wavelength of 1540 ...
  • Verghese, Simon; Ruff, Albert C.; Brattain, Michael A.; McIntosh, K. Alexander; Smith, Gary M.; Funk, Joseph E. (The International Society for Optical Engineering, 2009-04)
    Avalanche Photodiode (APD) photon counting arrays are finding an increasing role in defense applications in laser radar and optical communications. As these system concepts mature, the need for reliable screening, test, ...
  • Nguyen, Hoang; Block, Frederick J., IV (Institute of Electrical and Electronics Engineers, 2010-03)
    Packet acquisition for a time-frequency hopped asynchronous random multiple access (RMA) system is investigated. A novel analytical approach to performance evaluation is provided, which enables the waveform designer to ...
  • Zeger, Linda (Institute of Electrical and Electronics Engineers (IEEE), 2010-01)
    Many commercial and military systems use some form of random access. ALOHA type protocols are particularly useful for multicast traffic and have low complexity; however, they suffer from low capacity and large loss ...
  • Cranford, Steven Wayne; Buehler, Markus J. (American Physical Society, 2011-11)
    Graphene holds promise as an ultracapacitor due to its high specific surface area and intrinsic capacitance. To exploit both, a maximum surface area must be accessible while the two-dimensional (2D) graphene is deformed ...
  • Stein, Itai Y.; Wardle, Brian L. (Royal Society of Chemistry, 2015-11)
    Existing theories for quantifying the morphology of nanofibers (NFs) in aligned arrays either neglect or assume a simple functional form for the curvature of the NFs, commonly known as the NF waviness. However, since such ...
  • Poonen, Bjorn (Oxford University Press, 2014-03)
    Extending work of Bell and of Bell, Ghioca, and Tucker, we prove that for a p-adic analytic self-map f on a closed unit polydisk, if every coefficient of f(x)−x has valuation greater than that of p [1over (p−1)], then the ...
  • Pottebaum, Indira; Cann, Susan G.; Cabral, Alberto; Astolfi, David K.; Fedynyshyn, Theodore H.; Roberts, Jeanette M. (The International Society for Optical Engineering, 2009-04)
    We have developed an improved AFM-based technique to measure intrinsic material roughness (IMR) after base development. We have investigated the contribution of different polymeric PAGs to IMR. These polymeric PAGs include ...
  • Jackson, Jean E. (Wiley-Blackwell Pubishers, 2011-05)
    INTRODUCTION The topic of pain offers a treasure trove of anthropological research projects that pose intriguing intellectual challenges. To begin with an obvious point, pain, especially chronic pain, is a hugely important ...
  • Kastrup, Christian; Nahrendorf, Matthias; Figueiredo, Jose Luiz; Lee, Haeshin; Kambhampati, Swetha; Lee, Timothy; Cho, Seung Woo; Gorbatov, Rostic; Iwamoto, Yoshiko; Dang, Tram T.; Dutta, Partha; Yeon, Ju Hun; Cheng, Hao; Pritchard, Christopher D.; Vegas, Arturo; Siegel, Cory D.; MacDougall, Samantha; Okonkwo, Michael E.; Thai, Anh; Stone, James R.; Coury, Arthur J.; Weissleder, Ralph; Langer, Robert; Anderson, Daniel Griffith (National Academy of Sciences (U.S.), 2012-12)
    The treatment of diseased vasculature remains challenging, in part because of the difficulty in implanting drug-eluting devices without subjecting vessels to damaging mechanical forces. Implanting materials using adhesive ...
  • Bieri, Samuel; Serbyn, Maksym; Todadri, Senthil; Lee, Patrick A. (American Physical Society, 2012-12)
    Motivated by recent experiments on Ba[subscript 3]NiSb[subscript 2]O[subscript 9], we investigate possible quantum spin liquid ground states for spin S=1 Heisenberg models on the triangular lattice. We use variational Monte ...
  • Stachler, Matthew D; Taylor-Weiner, Amaro; Peng, Shouyong; McKenna, Aaron; Agoston, Agoston T; Odze, Robert D; Davison, Jon M; Nason, Katie S; Loda, Massimo; Leshchiner, Ignaty; Stewart, Chip; Stojanov, Petar; Seepo, Sara; Lawrence, Michael S; Ferrer-Torres, Daysha; Lin, Jules; Chang, Andrew C; Gabriel, Stacey B; Beer, David G; Getz, Gad; Carter, Scott L; Bass, Adam J; Lander, Eric Steven (Nature Publishing Group, 2015-07)
    Barrett’s esophagus, is thought to progress to esophageal adenocarcinoma (EAC) through a stepwise progression with loss of CDKN2A followed by p53 inactivation and aneuploidy. Here, we present whole exome sequencing from ...
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