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Browsing MIT Open Access Articles by Title

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  • Sacred Cars? Cost-Effective Regulation of Stationary and Nonstationary Pollution Sources 
    Fowlie, Meredith; Knittel, Christopher Roland; Wolfram, Catherine (American Economic Association, 2012-02)
    For political and practical reasons, environmental regulations sometimes treat point-source polluters, such as power plants, differently from mobile-source polluters, such as vehicles. This paper measures the extent of ...
  • Sacrificial-Post Templating Method for Block Copolymer Self-Assembly 
    Alexander-Katz, Alfredo; Ross, Caroline A.; Berggren, Karl K.; Tavakkoli Kermani Ghariehali, Amir; Nicaise, Sam; Hannon, Adam F.; Gotrik, Kevin W. (Wiley Blackwell, 2013-07)
    A sacrificial-post templating method is presented for directing block copolymer self-assembly to form nanostructures consisting of monolayers and bilayers of microdomains. In this approach, the topographical post template ...
  • Saddle Point in the Minimax Converse for Channel Coding 
    Polyanskiy, Yury (Institute of Electrical and Electronics Engineers, 2013-05)
    A minimax metaconverse has recently been proposed as a simultaneous generalization of a number of classical results and a tool for the nonasymptotic analysis. In this paper, it is shown that the order of optimizing the ...
  • Safe and Efficient Tetrazole Synthesis in a Continuous Flow Microreactor 
    Palde, Prakash B.; Jamison, Timothy F. (Wiley Blackwell, 2011-03)
    Safer flow: The synthesis of 5-substituted tetrazoles in flow (see scheme) is safe, efficient, scalable, requires no metal promoter, and uses a near-equimolar amount of NaN[subscript 3], yet nonetheless displays a broad ...
  • Safe Asset Scarcity and Aggregate Demand 
    Farhi, Emmanuel; Gourinchas, Pierre-Olivier; Caballero, Ricardo J (American Economic Association, 2016-05)
    We explore the consequences of safe asset scarcity on aggregate demand in a stylized IS-LM/Mundell Fleming style environment. Acute safe asset scarcity forces the economy into a "safety trap" recession. In the open economy, ...
  • Safe Fall: Humanoid robot fall direction change through intelligent stepping and inertia shaping 
    Yun, Seung-kook; Goswami, Ambarish; Sakagami, Yoshiaki (Institute of Electrical and Electronics Engineers (IEEE), 2009-08)
    Although fall is a rare event in the life of a humanoid robot, we must be prepared for it because its consequences are serious. In this paper we present a fall strategy which rapidly modifies the robot's fall direction in ...
  • Safely active mobility for urban baby boomers: The role of neighborhood design 
    Lee, Jae Seung; Zegras, Pericles C; Ben-Joseph, Eran (Elsevier, 2013-12)
    Many urban designers and researchers argue that walkable urban environments can encourage older residents’ walking activities that benefit their physical health. However, walking also exposes older adults to safety risks, ...
  • Safety and tolerability of an intratumorally injected DNAzyme, Dz13, in patients with nodular basal-cell carcinoma: a phase 1 first-in-human trial (DISCOVER) 
    Cho, Eun-Ae; Cai, Hong; Au-Yeung, Annie; China, Carlos; Yosufi, Benafsha; Arkenau, Hendrik-Tobias; Moloney, Fergal J.; Scolyer, Richard A.; Raftery, Mark J.; Deng, Jason Z.; Morton, Stephen Winford; Hammond, Paula T.; Damian, Diona L.; Francis, Douglas J.; Chesterman, Colin N.; Barnetson, Ross St. C.; Halliday, Gary M.; Khachigian, Levon M. (Elsevier, 2013-05)
    Background The nuclear transcription factor c-Jun is preferentially expressed in basal-cell carcinoma. Dz13 is a deoxyribozyme that targets JUN messenger RNA and has inhibited the growth of a range of tumours in mice. We ...
  • Safety control of hidden mode hybrid systems 
    Verma, Rajeev; Del Vecchio, Domitilla (Institute of Electrical and Electronics Engineers, 2011-12)
    In this paper, we consider the safety control problem for hidden mode hybrid systems (HMHSs), which are a special class of hybrid automata in which the mode is not available for control. For these systems, safety control ...
  • Safety control of piece-wise continuous order preserving systems 
    Ghaemi, Reza; Del Vecchio, Domitilla (Institute of Electrical and Electronics Engineers, 2011-12)
    This paper is concerned with safety control of systems with imperfect state information and disturbance input. Specifically, we consider the class of systems whose dynamics preserve a partial ordering. We provide necessary ...
  • Safety-Driven Design for Software-Intensive Aerospace and Automotive Systems 
    Stringfellow, Margaret V.; Leveson, Nancy G.; Owens, Brandon D. (Institute of Electrical and Electronics Engineers, 2010-03)
    Too often, systems are designed and then an attempt is made to add safety features or to prove that the design is safe after the fact. Safety has to be designed into a system from the start-it cannot be effectively added ...
  • Safety in Semi-autonomous Multi-vehicle Systems: A Hybrid Control Approach 
    Verma, Rajeev; Del Vecchio, Domitilla (Institute of Electrical and Electronics Engineers (IEEE), 2011-09)
    In this article, we have illustrated the application of a formal hybrid control approach to design semiautonomous multivehicle systems that are guaranteed to be safe. Our experimental results illustrate that, in a structured ...
  • Safety, pharmacokinetics, and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome 
    Khwaja, Omar S.; Ho, Eugenia; Barnes, Katherine V.; O'Leary, Heather M.; Pereira, Luis M.; Finkelstein, Yaron; Nelson III, Charles A.; Vogel-Farley, Vanessa; DeGregorio, Geneva; Holm, Ingrid A.; Khatwa, Umakanth; Kapur, Kush; Alexander, Mark E.; Finnegan, Deidre M.; Cantwell, Nicole G.; Walco, Alexandra C.; Rappaport, Leonard; Gregas, Matt; Fichorova, Raina N.; Shannon, Michael W.; Sur, Mriganka; Kaufmann, Walter E. (National Academy of Sciences (U.S.), 2014-03)
    Rett syndrome (RTT) is a severe X-linked neurodevelopmental disorder mainly affecting females and is associated with mutations in MECP2, the gene encoding methyl CpG-binding protein 2. Mouse models suggest that recombinant ...
  • Saints, heroes, sages, and villains 
    Markovits, Julia (Springer Science + Business Media B.V., 2012-03)
    This essay explores the question of how to be good. My starting point is a thesis about moral worth that I’ve defended in the past: roughly, that an action is morally worthy if and only it is performed for the reasons ...
  • Salivary mucins in host defense and disease prevention 
    Frenkel, Erica Shapiro; Ribbeck, Katharina (Co-Action Publishing, 2015-12)
    Mucus forms a protective coating on wet epithelial surfaces throughout the body that houses the microbiota and plays a key role in host defense. Mucins, the primary structural components of mucus that creates its viscoelastic ...
  • Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals 
    Mazzoni, Esteban O.; Mahony, Shaun; Peljto, Mirza; Patel, Tulsi; McCuine, Scott; Wichterle, Hynek; Reeder, Christopher Campbell; Gifford, David K.; Thornton, Seraphim R.; Boyer, Laurie; Young, Richard A. (Nature Publishing Group, 2013-08)
    Hox genes controlling motor neuron subtype identity are expressed in rostrocaudal patterns that are spatially and temporally collinear with their chromosomal organization. Here we demonstrate that Hox chromatin is subdivided ...
  • SAMNet: a network-based approach to integrate multi-dimensional high throughput datasets 
    Spencer, Sarah J.; Ursu, Oana; Fraenkel, Ernest; Gosline, Sara Jane Calafell (Royal Society of Chemistry, 2012-09)
    The rapid development of high throughput biotechnologies has led to an onslaught of data describing genetic perturbations and changes in mRNA and protein levels in the cell. Because each assay provides a one-dimensional ...
  • SAMNetWeb: identifying condition-specific networks linking signaling and transcription 
    Oh, Coyin; Fraenkel, Ernest; Gosline, Sara Calafell (Oxford University Press, 2014-11)
    Motivation: High-throughput datasets such as genetic screens, mRNA expression assays and global phospho-proteomic experiments are often difficult to interpret due to inherent noise in each experimental system. Computational ...
  • Sample-Averaged Biexciton Quantum Yield Measured by Solution-Phase Photon Correlation 
    Beyler, Andrew P.; Bischof, Thomas Stanley; Cui, Jian; Coropceanu, Igor; Harris, Daniel Kelly; Bawendi, Moungi G (American Chemical Society (ACS), 2014-11)
    The brightness of nanoscale optical materials such as semiconductor nanocrystals is currently limited in high excitation flux applications by inefficient multiexciton fluorescence. We have devised a solution-phase photon ...
  • Sample covariance based estimation of Capon algorithm error probabilities 
    Richmond, Christ D.; Movassagh, Ramis; Movassagh, Ramis; Edelman, Alan (Institute of Electrical and Electronics Engineers (IEEE), 2011-04)
    The method of interval estimation (MIE) provides a strategy for mean squared error (MSE) prediction of algorithm performance at low signal-to-noise ratios (SNR) below estimation threshold where asymptotic predictions fail. ...
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