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Browsing MIT Open Access Articles by Title

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  • Kosuri, Sriram; Endy, Drew; Kelly, Jason R. (BioMed Central Ltd, 2007-12)
    Background Experimental studies of gene expression have identified some of the individual molecular components and elementary reactions that comprise and control cellular behavior. Given our current understanding of gene ...
  • Mazzini, Francesco; Kettler, Daniel; Dubowsky, Steven; Guerrero, Julio (Institute of Electrical and Electronics Engineers, 2009-12)
    World oil demand and advanced oil recovery techniques have made it economically attractive to rehabilitate previously abandoned oil wells. This requires relatively fast mapping of the shape and location of the down-hole ...
  • Shin, Heedeuk; Qiu, Wenjun; Jarecki, Robert; Cox, Jonathan A.; Olsson, Roy H.; Starbuck, Andrew; Wang, Zheng; Rakich, Peter T. (Nature Publishing Group, 2013-06)
    Nanoscale modal confinement is known to radically enhance the effect of intrinsic Kerr and Raman nonlinearities within nanophotonic silicon waveguides. By contrast, stimulated Brillouin-scattering nonlinearities, which ...
  • Pamplona, Vitor F.; Oliveira, Manuel M.; Aliaga, Daniel G.; Raskar, Ramesh (Association for Computing Machinery, 2012-07)
    We introduce tailored displays that enhance visual acuity by decomposing virtual objects and placing the resulting anisotropic pieces into the subject's focal range. The goal is to free the viewer from needing wearable ...
  • Soljacic, Marin; Karalis, Aristeidis; Joannopoulos, John D. (Society of Photo-Optical Instrumentation Engineers, 2009-02)
    A new physical mechanism enabling simultaneous cancellation of group-velocity and attenuation dispersion to extremely high orders for subwavelength light of any small positive, negative or zero value of the group velocity ...
  • Bermel, Peter A.; Ghebrebrhan, Michael; Harradon, Michael R.; Yeng, YiXiang; Celanovic, Ivan; Joannopoulos, John D.; Soljacic, Marin (Springer, 2011-10)
    Selective solar absorbers generally have limited effectiveness in unconcentrated sunlight, because of reradiation losses over a broad range of wavelengths and angles. However, metamaterials offer the potential to limit ...
  • Ghebrebrhan, Michael; Bermel, Peter A.; Yeng, YiXiang; Celanovic, Ivan; Soljacic, Marin; Joannopoulos, John D. (American Physical Society, 2011-03)
    We develop a model for predicting the thermal emission spectrum of a two-dimensional metallic photonic crystal for arbitrary angles based on coupled-mode theory. Calculating the appropriate coupled-mode parameters over a ...
  • Rinard, Martin C.; Ganesh, Vijay; Leek, Tim (Institute of Electrical and Electronics Engineers, 2009-06)
    We present a new automated white box fuzzing technique and a tool, BuzzFuzz, that implements this technique. Unlike standard fuzzing techniques, which randomly change parts of the input file with little or no information ...
  • Hare, Caspar (Oxford University Press, 2010-01)
    Sometimes I lack all-things-considered preferences between items. Sometimes this attitude is insensitive to mild sweetening. There are items A, A+, B, B+, such that, all things considered, I have no preference between A ...
  • Sanjana, Neville E.; Cong, Le; Zhou, Yang; Cunniff, Margaret Mary; Feng, Guoping; Zhang, Feng (Nature Publishing Group, 2012-01)
    Transcription activator-like effectors (TALEs) are a class of naturally occurring DNA-binding proteins found in the plant pathogen Xanthomonas sp. The DNA-binding domain of each TALE consists of tandem 34–amino acid repeat ...
  • Adams, E. Eric; Peterson, Charles H.; Anderson, Sean S.; Cherr, Gary N.; Ambrose, Richard F.; Anghera, Shelly; Bay, Steven; Blum, Michael; Taylor, Caz M.; Condon, Robert; Graham, Monty; Dean, Thomas A.; Guzy, Michael; Hampton, Stephanie; Joye, Samantha; Lambrinos, John; Mate, Bruce; Meffert, Douglas; Somasundaran, Ponisseril; Spies, Robert B.; Tjeerdema, Ronald; Powers, Sean P. (University of California Press, 2012-05)
    The 2010 Deepwater Horizon oil release posed the challenges of two types of spill: a familiar spill characterized by buoyant oil, fouling and killing organisms at the sea surface and eventually grounding on and damaging ...
  • Kaiser, David I. (University of Chicago Press/History of Science Society, 2012-03)
    Though the notion of a scientific textbook has been around for almost three centuries, the category has hardly been stable. The plasticity of the textbook genre may be illustrated by recent variations as well as long-term ...
  • Zimanyi, Christina Marie; Ando, Nozomi; Brignole, Edward J.; Asturias, Francisco J.; Stubbe, JoAnne; Drennan, Catherine L. (Elsevier B.V., 2012-08)
    Ribonucleotide reductases (RNRs) provide the precursors for DNA biosynthesis and repair and are successful targets for anticancer drugs such as clofarabine and gemcitabine. Recently, we reported that dATP inhibits E. coli ...
  • Dhar, Shanta; Kolishetti, Nagesh; Lippard, Stephen J.; Farokhzad, Omid C. (National Academy of Sciences (U.S.), 2011-01)
    Targeted delivery and controlled release of inactive platinum (Pt) prodrugs may offer a new approach to improve the efficacy and tolerability of the Pt family of drugs, which are used to treat 50% of all cancers today. ...
  • Lorestani, Alexander; Ivey, F. Douglas; Thirugnanam, Sivasakthivel; Busby, Michele A.; Marth, Gabor T.; Gubbels, Marc-Jan; Cheeseman, Iain McPherson (Wiley Blackwell, 2012-10)
    The basal complex in Toxoplasma functions as the contractile ring in the cell division process. Basal complex contraction tapers the daughter cytoskeleton toward the basal end and is required for daughter segregation. We ...
  • Ren, Yin; von Maltzhan, Geoffrey; Agrawal, Amit; Mesirov, Jill P.; Lo, Justin H.; Bhatia, Sangeeta N.; Cheung, Hiu Wing; Cowley, Glenn S.; Weir, Barbara A.; Boehm, Jesse S.; Tamayo, Pablo; Karst, Alison M.; Liu, Joyce F.; Hirsch, Michelle S.; Drapkin, Ronny; Root, David E.; Fogal, Valentina; Ruoslahti, Erkki; Hahn, William C. (American Association for the Advancement of Science (AAAS), 2012-08)
    The comprehensive characterization of a large number of cancer genomes will eventually lead to a compendium of genetic alterations in specific cancers. Unfortunately, the number and complexity of identified alterations ...
  • Raman, Rahul; Sasisekharan, Ram; Bachelet, Ido; Bulmera, Mark S.; Rosengaus, Rebeca B. (United States National Academy of Sciences, 2009-04)
    Insect pests such as termites cause damages to crops and man-made structures estimated at over $30 billion per year, imposing a global challenge for the human economy. Here, we report a strategy for compromising insect ...
  • Vander Heiden, Matthew G. (Nature Publishing Group, 2011-09)
    Genetic events in cancer activate signalling pathways that alter cell metabolism. Clinical evidence has linked cell metabolism with cancer outcomes. Together, these observations have raised interest in targeting metabolic ...
  • Ng, Christopher W.; Yildirim, Ferah; Gipson, Theresa Anne; Labadorf, Adam; Housman, David E.; Fraenkel, Ernest; Vashishtha, Malini; Kratter, Ian H.; Bodai, Laszlo; Song, Wan; Lau, Alice; Vogel-Ciernia, Annie; Troncosco, Juan; Ross, Christopher A.; Bates, Gillian P.; Krainc, Dimitri; Sadri-Vakili, Ghazaleh; Finkbeiner, Steven; Marsh, J. Lawrence; Thompson, Leslie M. (National Academy of Sciences (U.S.), 2013-08)
    Transcriptional dysregulation is an early feature of Huntington disease (HD). We observed gene-specific changes in histone H3 lysine 4 trimethylation (H3K4me3) at transcriptionally repressed promoters in R6/2 mouse and ...
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