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Browsing MIT Open Access Articles by Title

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  • Hover, Franz S.; Patrikalakis, Nicholas M.; Mullane, John; Keller, Samuel; Rao, Akshay; Adams, Martin; Yeo, Anthony (Institute of Electrical and Electronics Engineers (IEEE), 2010)
    This paper presents a simultaneous localisation and mapping (SLAM) algorithm implemented on an autonomous sea kayak with a commercial off-the-shelf X-band marine radar mounted. The Autonomous Surface Craft (ASC) was driven ...
  • Hu, Chih-Chi Andrew; Dougan, Stephanie K.; McGehee, Annette M.; Love, J. Christopher; Ploegh, Hidde (Nature Publishing Group, 2009-04)
    XBP-1, a transcription factor that drives the unfolded protein response (UPR), is activated in B cells when they differentiate to plasma cells. Here, we show that in the B cells, whose capacity to secrete IgM has been ...
  • Engreitz, Jesse Michael; Lander, Eric S.; Pandya-Jones, Amy; McDonel, Patrick; Shishkin, Alexander; Sirokman, Klara; Surka, Christine; Kadri, Sabah; Xing, Jeffrey; Goren, Alon; Plath, Kathrin; Guttman, Mitchell (American Association for the Advancement of Science (AAAS), 2013-07)
    Many large noncoding RNAs (lncRNAs) regulate chromatin, but the mechanisms by which they localize to genomic targets remain unexplored. We investigated the localization mechanisms of the Xist lncRNA during X-chromosome ...
  • Welstead, G. Grant; Creyghton, Menno P.; Bilodeau, Steve; Cheng, Albert W.; Markoulaki, Styliani; Young, Richard A.; Jaenisch, Rudolf (National Academy of Sciences (U.S.), 2012-07)
    Embryogenesis requires the timely and coordinated activation of developmental regulators. It has been suggested that the recently discovered class of histone demethylases (UTX and JMJD3) that specifically target the ...
  • Sutton, Patrick J.; Jones, Gareth; Chatterji, Shourov K.; Kalmus, Peter; Leonor, Isabel; Poprocki, Stephen; Rollins, Jameson; Searle, Antony; Stein, Leo Chaim; Tinto, Massimo; Was, Michal (Institute of Physics Publishing, 2010-05)
    Autonomous gravitational-wave searches—fully automated analyses of data that run without human intervention or assistance—are desirable for a number of reasons. They are necessary for the rapid identification of ...
  • Goldman, Peter J.; Grove, Tyler L.; Booker, Squire J.; Drennan, Catherine L. (National Academy of Sciences (U.S.), 2013-10)
    The 2-deoxy-scyllo-inosamine (DOIA) dehydrogenases are key enzymes in the biosynthesis of 2-deoxystreptamine–containing aminoglycoside antibiotics. In contrast to most DOIA dehydrogenases, which are NAD-dependent, the DOIA ...
  • Chou, F. C.; Liu, L.-K.; Chen, C. H.; Sheu, H. S.; Shu, G. J.; Chu, M.-W.; Huang, F.-T.; Lee, Patrick A. (American Physical Society, 2009-01)
    We have recently demonstrated that x=0.71 and 0.84 are the two most stable single-phase compounds above x=0.5 in gamma-Na[subscript x]CoO[subscript 2] [G. J. Shu et al., Phys. Rev. B 76, 184115 (2007); F. C. Chou et al., ...
  • Pooley, David; Rappaport, Saul A.; Blackburne, Jeffrey A.; Schechter, Paul L.; Wambsganss, Joachim (Institute of Physics Publishing, 2012-01)
    We present a microlensing analysis of 61 Chandra observations of 14 quadruply lensed quasars. X-ray flux measurements of the individual quasar images give a clean determination of the microlensing effects in the lensing ...
  • Huenemoerder, David P.; Schulz, Norbert S.; Testa, Paola; Kesich, Anthony; Canizares, Claude R. (American Astronomical Society, 2009-11)
    θ(1) Ori E is a young, moderate mass binary system, a rarely observed case of spectral-type G-giants of about 3 solar masses, which are still collapsing toward the main sequence, where they presumably become X-ray faint. ...
  • Bitter, M.; Delgado-Aparicio, L.; Hill, K.; Pablant, N.; Reinke, Matthew Logan; Podpaly, Yuri; Hutchinson, Ian H.; Rice, John E.; Gao, Chi; Greenwald, Martin J.; Howard, Nathaniel Thomas; Hubbard, Amanda E.; Hughes, Jerry W.; White, Anne E.; Wolfe, Stephen M. (American Institute of Physics (AIP), 2012-11)
    This research describes advancements in the spectral analysis and error propagation techniques associated with x-ray imaging crystal spectroscopy (XICS) that have enabled this diagnostic to be used to accurately constrain ...
  • Yao, Y.; Tripp, T. M.; Wang, Q. D.; Danforth, C. W.; Canizares, Claude R.; Shull, J. M.; Marshall, Herman Lee; Song, L. (American Astronomical Society, 2009-05)
    The observed intergalactic O vi absorbers at z > 0 have been regarded as a significant reservoir of the “missing baryons.” However, to fully understand how these absorbers contribute to the baryon inventory, it is crucial ...
  • Figueroa-Feliciano, Enectali (Institute of Electrical and Electronics Engineers, 2010-06)
    One of the instruments on the International X-ray Observatory (IXO), under study with NASA, ESA and JAXA, is the X-ray Microcalorimeter Spectrometer (XMS). This instrument, which will provide high spectral resolution images, ...
  • Schulz, Norbert S.; Canizares, Claude R.; Huenemoerder, David P.; Tibbetts, Kevin (IOP Publishing, 2003-09)
    The Orion Trapezium is one of the youngest and closest star-forming regions within our Galaxy. With a dynamic age of ~3 × 10[superscript 5] yr, it harbors a number of very young hot stars, which likely are on the zero-age ...
  • Canizares, Claude R.; Jeltema, Tesla E. (IOP Publishing, 2003-03)
    With a Chandra ACIS-S3 observation, we detect 42 X-ray point sources in the elliptical galaxy NGC 720, including a possible central source. Most of these sources will be low-mass X-ray binaries, and 12 are located within ...
  • Huenemoerder, David P.; Canizares, Claude R.; Schulz, Norbert S. (IOP Publishing, 2001-10)
    We have obtained high-resolution X-ray spectra of the coronally active binary II Pegasi (HD 224085), covering the wavelength range of 1.5-25 Å. For the first half of our 44 ks observation, the source was in a quiescent ...
  • Zhu, Guangyu; Lippard, Stephen J.; Wang, Dong; Huang, Xuhui (National Academy of Sciences (U.S.), 2010-05)
    DNA is a major target of anticancer drugs. The resulting adducts interfere with key cellular processes, such as transcription, to trigger downstream events responsible for drug activity. cis-Diammine(pyridine)chloroplatinum(II), ...
  • Goldman, Peter John; McLaughlin, Martin I.; Drennan, Catherine L.; Grove, Tyler L.; Sites, Lauren A.; Booker, Squire J. (National Academy of Sciences (U.S.), 2013-05)
    Arylsulfatases require a maturating enzyme to perform a co- or posttranslational modification to form a catalytically essential formylglycine (FGly) residue. In organisms that live aerobically, molecular oxygen is used ...
  • Schulz, Norbert S.; Testa, Paola; Huenemoerder, David P.; Ishibashi, Kazunori; Canizares, Claude R. (IOP Publishing, 2006-08)
    Massive stars rarely show intrinsic X-ray variability. One exception is θ[superscript 2] Ori A, which has shown strong variability over the last 5 years. We observed a large outburst of the X-ray source with the High Energy ...
  • Grossman, Alan D.; Merrikh, Houra; Goranov, Alexi I.; Breier, Adam M. (Blackwell Publishing, 2009-09)
    yabA encodes a negative regulator of replication initiation in Bacillus subtilis and homologues are found in many other Gram-positive species. YabA interacts with the β-processivity clamp (DnaN) of DNA polymerase and with ...
  • Puthenveetil, Sujiet; Liu, Daniel S.; White, Katharine Alice; Thompson, Samuel M.; Ting, Alice Y. (American Chemical Society, 2009-10)
    Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covalent ligation of lipoic acid onto specific lysine side chains of three acceptor proteins involved in oxidative metabolism. Our lab has shown that LplA ...
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