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Browsing MIT Open Access Articles by Title

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  • Grossman, Alan D.; Merrikh, Houra; Goranov, Alexi I.; Breier, Adam M. (Blackwell Publishing, 2009-09)
    yabA encodes a negative regulator of replication initiation in Bacillus subtilis and homologues are found in many other Gram-positive species. YabA interacts with the β-processivity clamp (DnaN) of DNA polymerase and with ...
  • Puthenveetil, Sujiet; Liu, Daniel S.; White, Katharine Alice; Thompson, Samuel M.; Ting, Alice Y. (American Chemical Society, 2009-10)
    Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covalent ligation of lipoic acid onto specific lysine side chains of three acceptor proteins involved in oxidative metabolism. Our lab has shown that LplA ...
  • Ju, Shulin; Tardiff, David W.; Han, Haesun; Divya, Kanneganti; Zhong, Quan; Maquat, Lynne E.; Bosco, Daryl A.; Hayward, Lawrence J.; Brown, Robert H.; Lindquist, Susan; Ringe, Dagmar; Petsko, Gregory A. (Public Library of Science, 2011-04)
    FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant ...
  • Jarosz, Daniel F.; Beuning, Penny J.; Cohen, Susan E.; Walker, Graham C. (Elsevier, 2007-01)
    The observation that mutations in the Escherichia coli genes umuC+ and umuD+ abolish mutagenesis induced by UV light strongly supported the counterintuitive notion that such mutagenesis is an active rather than passive ...
  • Li, Yan; Stojanovic, Vladimir Marko (Institute of Electrical and Electronics Engineers, 2009-08)
    This paper proposes an equation-based multi-scenario iterative robust optimization methodology for analog/mixed-signal circuits. We show that due to local circuit performance monotonicity in random variations constraint ...
  • Rodney, David; Schuh, Christopher A. (American Physical Society, 2009-11)
    A Monte Carlo approach allowing for stress control is employed to study the yield stress of a two-dimensional metallic glass in the limit of low temperatures and long (infinite) time scales. The elementary thermally activated ...
  • White, Roger (Wiley-Blackwell Pubishers, 2010-12)
    1. Introduction I believe that Tom is the proud father of a baby boy. Why do I think his child is a boy? A natural answer might be that I remember that his name is ‘Owen’ which is usually a boy’s name. Here I’ve given ...
  • Borodin, Alexei; Olshanski, Grigori (Independent University of Moscow, 2013-04)
    The classification results for the extreme characters of two basic “big” groups, the infinite symmetric group S(∞) and the infinite-dimensional unitary group U(∞), are remarkably similar. It does not seem to be possible ...
  • Nakashiba, Toshiaki; Cushman, Jesse D.; Pelkey, Kenneth A.; Renaudineau, Sophie; Buhl, Derek L.; McHugh, Thomas J.; Barrera, Vanessa Rodriguez; Chittajallu, Ramesh; Iwamoto, Keisuke S.; McBain, Chris J.; Fanselow, Michael S.; Tonegawa, Susumu; Buhl, Derek L.; McHugh, Thomas J. (Elsevier B.V., 2012-03)
    Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus, are highly active during the first few weeks after functional integration into the neuronal network, distinguishing them from ...
  • Li, Juying; Song, Jun S.; Bell, Robert J. A.; Tran, Thanh-Nga T.; Haq, Rizwan; Liu, Huifei; Love, Kevin T.; Langer, Robert; Anderson, Daniel G.; Larue, Lionel; Fisher, David E. (Public Library of Science, 2012-05)
    Studies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. Here, we generated Yy1 conditional knockout mice in the melanocyte-lineage and observed ...
  • Lu, Yuan-Ming; Ran, Ying; Lee, Patrick A. (American Physical Society, 2011-06)
    Due to strong geometric frustration and quantum fluctuation, the S = 1/2 quantum Heisenberg antiferromagnet on the kagome lattice has long been considered as an ideal platform to realize a spin liquid (SL), a phase exhibiting ...
  • Weight, Alisha K.; Belser, Jessica A.; Tumpey, Terrence M.; Chen, Jianzhu; Klibanov, Alexander M. (Springer-Verlag, 2013-09)
    Purpose: Previously, polymer-attached zanamivir had been found to inhibit influenza A viruses in vitro far better than did small-molecule zanamivir (1) itself. The aim of this study was to identify in vitro—using the ...
  • Lander, Eric S.; Andersson, Leif; Hjalm, Goran; Andersson, Goran; Lindblad-Toh, Kerstin; Wadelius, Claes; Kullander, Klas; Zierath, Juleen R.; Ponten, Fredrik; De, Sachinandan; Stromberg, Sara; Yan, Jie; Barres, Romain; Lindroth, Anders M.; Gnirke, Andreas; Saenz-Vash, Veronica; Wang, Li; Zhang, Xiaolan; Larhammar, Martin; Wallerman, Ola; Mikkelsen, Tarjei S.; Jaffe, Jacob D.; Jiang, Lin; Markljung, Ellen; Carr, Steven A. (Public Library of Science, 2009-12)
    A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold upregulation of IGF2 in skeletal muscle. The mutation has major effects on muscle growth, size ...
  • Amsterdam, Adam; Lai, Kevin; Komisarczuk, Anna Z.; Becker, Thomas S.; Bronson, Roderick T.; Hopkins, Nancy H.; Lees, Jacqueline (American Association for Cancer Research, 2009-06)
    We screened an existing collection of zebrafish insertional mutants for cancer susceptibility by histologic examination of heterozygotes at 2 years of age. As most mutants had no altered cancer predisposition, this provided ...
  • Blaker-Lee, Alicia; Gupta, Sunny; McCammon, Jasmine M.; De Rienzo, Gianluca; Sive, Hazel L. (Company of Biologists, The, 2012-05)
    Deletion or duplication of one copy of the human 16p11.2 interval is tightly associated with impaired brain function, including autism spectrum disorders (ASDs), intellectual disability disorder (IDD) and other phenotypes, ...
  • Wardle, Fiona C; Odom, Duncan T; Bell, George W.; Wiellette, Elizabeth L; Herbolsheimer, Elizabeth; Smith, James C; Yuan, Bingbing B.; Sive, Hazel L.; Danford, Timothy William; Young, Richard A. (BioMed Central Ltd, 2006-08)
    We have designed a zebrafish genomic microarray to identify DNA-protein interactions in the proximal promoter regions of over 11,000 zebrafish genes. Using these microarrays, together with chromatin immunoprecipitation ...
  • Nissen, Robert M.; Amsterdam, Adam; Hopkins, Nancy H. (BioMed Central Ltd, 2006-06)
    Background: Craniofacial birth defects result from defects in cranial neural crest (NC) patterning and morphogenesis. The vertebrate craniofacial skeleton is derived from cranial NC cells and the patterning of these cells ...
  • Connolly, Colin B.; Au, Yat Shan; Chae, Eunmi; Tscherbul, Timur V.; Buchachenko, Alexei A.; Ketterle, Wolfgang; Doyle, John M. (American Physical Society, 2013-07)
    We investigate Zeeman relaxation in cold Sb([superscript 4]S[subscript 3/2]∘)–He collisions in a magnetic field. Ensembles of >10[superscript 13] laser-ablated Sb atoms are cooled in cryogenic [superscript 4]He buffer gas ...
  • Johnson, Cort; Newman, Bonna Kay; Brahms, Nathan; Doyle, John M.; Greytak, Thomas J.; Kleppner, Daniel (American Physical Society, 2010-06)
    We have measured the ratio γ of the diffusion cross section to the angular momentum reorientation cross section in the colliding Fe-3He and Ni-3He systems. Nickel (Ni) and iron (Fe) atoms are introduced via laser ablation ...
  • Dong, Hui Yuan; Wang, Jin; Fung, Kin Hung; Fang, Nicholas Xuanlai (American Physical Society (APS), 2011-12)
    We show that, under the presence of a static magnetic field, the photon eigenfrequencies of a circular gyromagnetic cylinder experience a splitting that is proportional to the angular momentum density of light at the ...
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