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Browsing MIT Open Access Articles by Title

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  • Grossman, Alan D.; Merrikh, Houra; Goranov, Alexi I.; Breier, Adam M. (Blackwell Publishing, 2009-09)
    yabA encodes a negative regulator of replication initiation in Bacillus subtilis and homologues are found in many other Gram-positive species. YabA interacts with the β-processivity clamp (DnaN) of DNA polymerase and with ...
  • Puthenveetil, Sujiet; Liu, Daniel S.; White, Katharine Alice; Thompson, Samuel M.; Ting, Alice Y. (American Chemical Society, 2009-10)
    Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covalent ligation of lipoic acid onto specific lysine side chains of three acceptor proteins involved in oxidative metabolism. Our lab has shown that LplA ...
  • Ju, Shulin; Tardiff, Daniel F.; Han, Haesun; Divya, Kanneganti; Zhong, Quan; Maquat, Lynne E.; Bosco, Daryl A.; Hayward, Lawrence J.; Brown, Robert H.; Lindquist, Susan; Ringe, Dagmar; Petsko, Gregory A. (Public Library of Science, 2011-04)
    FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant ...
  • Jui, Nathan T.; Buchwald, Stephen Leffler; Lindquist, Susan; Tardiff, Daniel F.; Khurana, Vikram; Tambe, Mitali A.; Thompson, Michelle L.; Chung, Chee Yeun; Kamadurai, Hari B.; Kim, Hyoung Tae; Lancaster, Alex K.; Caldwell, Kim A.; Caldwell, Guy A.; Rochet, Jean-Christophe (American Association for the Advancement of Science (AAAS), 2013-10)
    α-Synuclein (α-syn) is a small lipid-binding protein implicated in several neurodegenerative diseases, including Parkinson’s disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these ...
  • Jarosz, Daniel F.; Beuning, Penny J.; Cohen, Susan E.; Walker, Graham C. (Elsevier, 2007-01)
    The observation that mutations in the Escherichia coli genes umuC+ and umuD+ abolish mutagenesis induced by UV light strongly supported the counterintuitive notion that such mutagenesis is an active rather than passive ...
  • Li, Yan; Stojanovic, Vladimir Marko (Institute of Electrical and Electronics Engineers, 2009-08)
    This paper proposes an equation-based multi-scenario iterative robust optimization methodology for analog/mixed-signal circuits. We show that due to local circuit performance monotonicity in random variations constraint ...
  • Helal, Ahmed H.; Qian, Bian; McKinley, Gareth H; Hosoi, Anette E (American Physical Society, 2016-06)
    Electrorheological fluids offer potential for developing rapidly actuated hydraulic devices where shear forces or pressure-driven flow are present. In this study, the Bingham yield stress of electrorheological fluids with ...
  • Rodney, David; Schuh, Christopher A. (American Physical Society, 2009-11)
    A Monte Carlo approach allowing for stress control is employed to study the yield stress of a two-dimensional metallic glass in the limit of low temperatures and long (infinite) time scales. The elementary thermally activated ...
  • Edmonds, Eric V.; Shrestha, Maheshwor (Elsevier, 2014-10)
    Can schooling promotion deter child participation in hazardous forms of child labor? We examine two interventions intended to promote schooling and deter child labor for children associated with carpet factories in Kathmandu. ...
  • White, Roger (Wiley-Blackwell Pubishers, 2010-12)
    1. Introduction I believe that Tom is the proud father of a baby boy. Why do I think his child is a boy? A natural answer might be that I remember that his name is ‘Owen’ which is usually a boy’s name. Here I’ve given ...
  • Zhuo, Jia-Min; Tseng, Hua-an; Desai, Mitul; Bucklin, Mark E; Mohammed, Ali I; Robinson, Nick TM; Rangel, Lara M; Jasanoff, Alan P; Gritton, Howard J; Han, Xue; Boyden, Edward (eLife Sciences Publications, Ltd., 2016-12)
    Adult neurogenesis supports performance in many hippocampal dependent tasks. Considering the small number of adult-born neurons generated at any given time, it is surprising that this sparse population of cells can ...
  • Lamming, Dudley W.; Ye, Lan; Astle, Clinton M.; Baur, Joseph A.; Sabatini, David M.; Harrison, David E. (Wiley Blackwell, 2013-06)
    Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR) signaling pathway, extends the life span of yeast, worms, flies, and mice. Interventions that promote longevity are often correlated with increased ...
  • Borodin, Alexei; Olshanski, Grigori (Independent University of Moscow, 2013-04)
    The classification results for the extreme characters of two basic “big” groups, the infinite symmetric group S(∞) and the infinite-dimensional unitary group U(∞), are remarkably similar. It does not seem to be possible ...
  • Harris, Paul L.; DeSteno, David; Dickens, Leah; Breazeal, Cynthia L.; Kory Westlund, Jacqueline Marie; Jeong, Sooyeon (Wiley Blackwell, 2016-04)
    Children ranging from 3 to 5 years were introduced to two anthropomorphic robots that provided them with information about unfamiliar animals. Children treated the robots as interlocutors. They supplied information to the ...
  • Nakashiba, Toshiaki; Cushman, Jesse D.; Pelkey, Kenneth A.; Renaudineau, Sophie; Buhl, Derek L.; McHugh, Thomas J.; Barrera, Vanessa Rodriguez; Chittajallu, Ramesh; Iwamoto, Keisuke S.; McBain, Chris J.; Fanselow, Michael S.; Tonegawa, Susumu (Elsevier B.V., 2012-03)
    Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus, are highly active during the first few weeks after functional integration into the neuronal network, distinguishing them from ...
  • Ansdell, M.; Gaidos, E.; Jacobs, T. L.; LaCourse, D. M.; Jek, K. J.; Mann, A. W.; Wyatt, M. C.; Kennedy, G.; Williams, J. P.; Boyajian, T. S.; Rappaport, Saul A. (IOP Publishing, 2016-01)
    We present ten young ([< over ~]10 Myr) late-K and M dwarf stars observed in K2 Campaign 2 that host protoplanetary disks and exhibit quasi-periodic or aperiodic dimming events. Their optical light curves show ~10–20 dips ...
  • Heinz, Sebastian; Sell, P.; Fender, R. P.; Jonker, P. G.; Brandt, W. N.; Calvelo-Santos, D. E.; Tzioumis, A. K.; Nowak, Michael A.; Schulz, Norbert S.; Wijnands, R.; van der Klis, M. (Institute of Physics/American Astronomical Society, 2013-12)
    Because supernova remnants are short-lived, studies of neutron star X-ray binaries within supernova remnants probe the earliest stages in the life of accreting neutron stars. However, such objects are exceedingly rare: ...
  • Wang, Jing, 1950- (Sage Publications, 2005-08)
    This article tracks the relationship between music and youth culture in China in the context of transnational cell phone branding. A research project conducted by the author as a participant observer/temporary marketing ...
  • Dinakar, Karthik; Jones, Birago; Lieberman, Henry A.; Picard, Rosalind W.; Rose, Carolyn; Thoman, Matthew; Reichart, Roi (Association for the Advancement of Artificial Intelligence, 2012-06)
    Adolescent cyber-bullying on social networks is a phenomenon that has received widespread attention. Recent work by sociologists has examined this phenomenon under the larger context of teenage drama and it's manifestations ...
  • Wolk, Scott J.; Poppenhaeger, Katja; Cody, A. M.; Rebull, L. M.; Forbrich, J.; Gutermuth, R. A.; Hillenbrand, L. A.; Plavchan, P.; Stauffer, J. R.; Covey, K. R.; Song, Inseok; Guenther, Hans Moritz (IOP Publishing, 2015-10)
    We present an IR-monitoring survey with the Spitzer Space Telescope of the star-forming region GGD 12-15. More than 1000 objects were monitored, including about 350 objects within the central 5', which is found to be ...
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