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Browsing MIT Open Access Articles by Title

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  • Grossman, Alan D.; Merrikh, Houra; Goranov, Alexi I.; Breier, Adam M. (Blackwell Publishing, 2009-09)
    yabA encodes a negative regulator of replication initiation in Bacillus subtilis and homologues are found in many other Gram-positive species. YabA interacts with the β-processivity clamp (DnaN) of DNA polymerase and with ...
  • Puthenveetil, Sujiet; Liu, Daniel S.; White, Katharine Alice; Thompson, Samuel M.; Ting, Alice Y. (American Chemical Society, 2009-10)
    Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covalent ligation of lipoic acid onto specific lysine side chains of three acceptor proteins involved in oxidative metabolism. Our lab has shown that LplA ...
  • Ju, Shulin; Tardiff, David W.; Han, Haesun; Divya, Kanneganti; Zhong, Quan; Maquat, Lynne E.; Bosco, Daryl A.; Hayward, Lawrence J.; Brown, Robert H.; Lindquist, Susan; Ringe, Dagmar; Petsko, Gregory A. (Public Library of Science, 2011-04)
    FUS/TLS is a nucleic acid binding protein that, when mutated, can cause a subset of familial amyotrophic lateral sclerosis (fALS). Although FUS/TLS is normally located predominantly in the nucleus, the pathogenic mutant ...
  • Jui, Nathan T.; Buchwald, Stephen Leffler; Lindquist, Susan; Tardiff, Daniel F.; Khurana, Vikram; Tambe, Mitali A.; Thompson, Michelle L.; Chung, Chee Yeun; Kamadurai, Hari B.; Kim, Hyoung Tae; Lancaster, Alex K.; Caldwell, Kim A.; Caldwell, Guy A.; Rochet, Jean-Christophe (American Association for the Advancement of Science (AAAS), 2013-10)
    α-Synuclein (α-syn) is a small lipid-binding protein implicated in several neurodegenerative diseases, including Parkinson’s disease, whose pathobiology is conserved from yeast to man. There are no therapies targeting these ...
  • Jarosz, Daniel F.; Beuning, Penny J.; Cohen, Susan E.; Walker, Graham C. (Elsevier, 2007-01)
    The observation that mutations in the Escherichia coli genes umuC+ and umuD+ abolish mutagenesis induced by UV light strongly supported the counterintuitive notion that such mutagenesis is an active rather than passive ...
  • Li, Yan; Stojanovic, Vladimir Marko (Institute of Electrical and Electronics Engineers, 2009-08)
    This paper proposes an equation-based multi-scenario iterative robust optimization methodology for analog/mixed-signal circuits. We show that due to local circuit performance monotonicity in random variations constraint ...
  • Rodney, David; Schuh, Christopher A. (American Physical Society, 2009-11)
    A Monte Carlo approach allowing for stress control is employed to study the yield stress of a two-dimensional metallic glass in the limit of low temperatures and long (infinite) time scales. The elementary thermally activated ...
  • White, Roger (Wiley-Blackwell Pubishers, 2010-12)
    1. Introduction I believe that Tom is the proud father of a baby boy. Why do I think his child is a boy? A natural answer might be that I remember that his name is ‘Owen’ which is usually a boy’s name. Here I’ve given ...
  • Lamming, Dudley W.; Ye, Lan; Astle, Clinton M.; Baur, Joseph A.; Sabatini, David M.; Harrison, David E. (Wiley Blackwell, 2013-06)
    Rapamycin, an inhibitor of the mechanistic target of rapamycin (mTOR) signaling pathway, extends the life span of yeast, worms, flies, and mice. Interventions that promote longevity are often correlated with increased ...
  • Borodin, Alexei; Olshanski, Grigori (Independent University of Moscow, 2013-04)
    The classification results for the extreme characters of two basic “big” groups, the infinite symmetric group S(∞) and the infinite-dimensional unitary group U(∞), are remarkably similar. It does not seem to be possible ...
  • Nakashiba, Toshiaki; Cushman, Jesse D.; Pelkey, Kenneth A.; Renaudineau, Sophie; Buhl, Derek L.; McHugh, Thomas J.; Barrera, Vanessa Rodriguez; Chittajallu, Ramesh; Iwamoto, Keisuke S.; McBain, Chris J.; Fanselow, Michael S.; Tonegawa, Susumu; Buhl, Derek L.; McHugh, Thomas J. (Elsevier B.V., 2012-03)
    Adult-born granule cells (GCs), a minor population of cells in the hippocampal dentate gyrus, are highly active during the first few weeks after functional integration into the neuronal network, distinguishing them from ...
  • Heinz, S.; Sell, P.; Fender, R. P.; Jonker, P. G.; Brandt, W. N.; Calvelo-Santos, D. E.; Tzioumis, A. K.; Nowak, Michael A.; Schulz, Norbert S.; Wijnands, R.; van der Klis, M. (Institute of Physics/American Astronomical Society, 2013-12)
    Because supernova remnants are short-lived, studies of neutron star X-ray binaries within supernova remnants probe the earliest stages in the life of accreting neutron stars. However, such objects are exceedingly rare: ...
  • Dinakar, Karthik; Jones, Birago; Lieberman, Henry A.; Picard, Rosalind W.; Rose, Carolyn; Thoman, Matthew; Reichart, Roi (Association for the Advancement of Artificial Intelligence, 2012-06)
    Adolescent cyber-bullying on social networks is a phenomenon that has received widespread attention. Recent work by sociologists has examined this phenomenon under the larger context of teenage drama and it's manifestations ...
  • Morales-Calderón, M.; Stauffer, J. R.; Stassun, Keivan; Vrba, F. J.; Prato, L.; Hillenbrand, L. A.; Terebey, S.; Covey, K. R.; Rebull, L. M.; Terndrup, D. M.; Gutermuth, R.; Song, I.; Plavchan, P.; Carpenter, J. M.; Marchis, F.; García, E. V.; Margheim, S.; Luhman, K. L.; Angione, J.; Irwin, J. M. (Institute of Physics/American Astronomical Society, 2012-07)
    Eclipsing binaries (EBs) provide critical laboratories for empirically testing predictions of theoretical models of stellar structure and evolution. Pre-main-sequence (PMS) EBs are particularly valuable, both due to their ...
  • Abbey, Darren A; Funt, Jason; Lurie-Weinberger, Mor N; Thompson, Dawn A; Regev, Aviv; Myers, Chad L; Berman, Judith (BioMed Central Ltd, 2014-11)
    The design of effective antimicrobial therapies for serious eukaryotic pathogens requires a clear understanding of their highly variable genomes. To facilitate analysis of copy number variations, single nucleotide polymorphisms ...
  • Li, Juying; Song, Jun S.; Bell, Robert J. A.; Tran, Thanh-Nga T.; Haq, Rizwan; Liu, Huifei; Love, Kevin T.; Langer, Robert; Anderson, Daniel G.; Larue, Lionel; Fisher, David E. (Public Library of Science, 2012-05)
    Studies of coat color mutants have greatly contributed to the discovery of genes that regulate melanocyte development and function. Here, we generated Yy1 conditional knockout mice in the melanocyte-lineage and observed ...
  • Lu, Yuan-Ming; Ran, Ying; Lee, Patrick A. (American Physical Society, 2011-06)
    Due to strong geometric frustration and quantum fluctuation, the S = 1/2 quantum Heisenberg antiferromagnet on the kagome lattice has long been considered as an ideal platform to realize a spin liquid (SL), a phase exhibiting ...
  • Weight, Alisha K.; Belser, Jessica A.; Tumpey, Terrence M.; Chen, Jianzhu; Klibanov, Alexander M. (Springer-Verlag, 2013-09)
    Purpose: Previously, polymer-attached zanamivir had been found to inhibit influenza A viruses in vitro far better than did small-molecule zanamivir (1) itself. The aim of this study was to identify in vitro—using the ...
  • Lander, Eric S.; Andersson, Leif; Hjalm, Goran; Andersson, Goran; Lindblad-Toh, Kerstin; Wadelius, Claes; Kullander, Klas; Zierath, Juleen R.; Ponten, Fredrik; De, Sachinandan; Stromberg, Sara; Yan, Jie; Barres, Romain; Lindroth, Anders M.; Gnirke, Andreas; Saenz-Vash, Veronica; Wang, Li; Zhang, Xiaolan; Larhammar, Martin; Wallerman, Ola; Mikkelsen, Tarjei S.; Jaffe, Jacob D.; Jiang, Lin; Markljung, Ellen; Carr, Steven A. (Public Library of Science, 2009-12)
    A single nucleotide substitution in intron 3 of IGF2 in pigs abrogates a binding site for a repressor and leads to a 3-fold upregulation of IGF2 in skeletal muscle. The mutation has major effects on muscle growth, size ...
  • Jevtov, Irena; Samuelsson, Tore; Yao, Grace; Amsterdam, Adam; Ribbeck, Katharina (Nature Publishing Group, 2014-10)
    Dysfunctional mucus barriers can result in important pulmonary and gastrointestinal conditions, but model systems to study the underlying causes are largely missing. We identified and characterized five mucin homologues ...
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