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Browsing MIT Open Access Articles by Author "Boyden, Edward Stuart"

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Browsing MIT Open Access Articles by Author "Boyden, Edward Stuart"

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  • Zorzos, Anthony Nicholas; Scholvin, Jorg; Boyden, Edward Stuart; Fonstad, Clifton G., Jr. (Optical Society of America, 2012-11)
    To deliver light to the brain for neuroscientific and neuroengineering applications like optogenetics, in which light is used to activate or silence neurons expressing specific photosensitive proteins, optical fibers are ...
  • Lee, Seung-Hee; Kwan, Alex C.; Zhang, Siyu; Phoumthipphavong, Victoria; Flannery, John G.; Masmanidis, Sotiris C.; Taniguchi, Hiroki; Huang, Z. Josh; Zhang, Feng; Boyden, Edward Stuart; Deisseroth, Karl; Dan, Yang (Nature Publishing Group, 2012-08)
    Inhibitory interneurons are essential components of the neural circuits underlying various brain functions. In the neocortex, a large diversity of GABA (γ-aminobutyric acid) interneurons has been identified on the basis ...
  • Tsunematsu, Tomomi; Kilduff, Thomas S.; Boyden, Edward Stuart; Takahashi, Satoru; Tominaga, Makoto; Yamanaka, Akihiro (Society for Neuroscience, 2011-05)
    Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. To help determine how these neurons promote wakefulness, we generated transgenic mice in which orexin neurons expressed halorhodopsin ...
  • Kodandaramaiah, Suhasa Bangalo; Talei Franzesi, Giovanni; Chow, Brian Y.; Boyden, Edward Stuart; Forest, Craig R. (Nature Publishing Group, 2012-05)
    Whole-cell patch-clamp electrophysiology of neurons is a gold-standard technique for high-fidelity analysis of the biophysical mechanisms of neural computation and pathology, but it requires great skill to perform. We have ...
  • Kahn, Itamar; Desai, Mitul; Knoblich, Ulf; Bernstein, Jacob; Henninger, Michael Alan; Graybiel, Ann M.; Boyden, Edward Stuart; Buckner, Randy L.; Moore, Christopher I. (Society for Neuroscience, 2011-10)
    The blood oxygenation level-dependent (BOLD) signal serves as the basis for human functional MRI (fMRI). Knowledge of the properties of the BOLD signal, such as how linear its response is to sensory stimuli, is essential ...
  • Famm, Kristoffer; Litt, Brian; Tracey, Kevin J.; Boyden, Edward Stuart; Slaoui, Moncef (Nature Publishing Group, 2013-04)
    Imagine a day when electrical impulses are a mainstay of medical treatment. Your clinician will administer electroceuticals that target individual nerve fibres or specific brain circuits to treat an array of conditions. ...
  • Joo, Jaebum; Chow, Brian Y.; Prakash, Manu; Boyden, Edward Stuart; Jacobson, Joseph (Nature Publishing Group, 2011-07)
    Rational control over the morphology and the functional properties of inorganic nanostructures has been a long-standing goal in the development of bottom-up device fabrication processes. We report that the geometry of ...
  • Schmidt, Daniel; Tillberg, Paul W.; Chen, Fei; Boyden, Edward Stuart (Nature Publishing Group, 2014-01)
    Ion channels are among the most important proteins in biology, regulating the activity of excitable cells and changing in diseases. Ideally it would be possible to actuate endogenous ion channels, in a temporally precise ...
  • Han, Xue; Chow, Brian Yichiun; Zhou, Huihui; Klapoetke, Nathan Cao; Chuong, Amy S.; Rajimehr, Reza; Yang, Aimei; Baratta, Michael V.; Winkle, Jonathan Andrew; Desimone, Robert; Boyden, Edward Stuart (Frontiers Research Foundation, 2011-04)
    Technologies for silencing the electrical activity of genetically targeted neurons in the brain are important for assessing the contribution of specific cell types and pathways toward behaviors and pathologies. Recently ...
  • Chow, Brian Yichiun; Han, Xue; Dobry, Allison S.; Qian, Xiaofeng; Chuong, Amy S.; Li, Mingjie; Henninger, Michael Alan; Belfort, Gabriel M.; Lin, Yingxi; Monahan, Patrick E.; Boyden, Edward Stuart (Nature Publishing Group, 2010-01)
    The ability to silence the activity of genetically specified neurons in a temporally precise fashion would provide the opportunity to investigate the causal role of specific cell classes in neural computations, behaviours ...
  • Boyden, Edward Stuart (BioMed Central Ltd., 2011-05)
    Understanding how different kinds of neuron in the brain work together to implement sensations, feelings, thoughts, and movements, and how deficits in specific kinds of neuron result in brain diseases, has long been a ...
  • Klapoetke, Nathan Cao; Murata, Yasunobu; Kim, Sung Soo; Pulver, Stefan R.; Birdsey-Benson, Amanda; Cho, Yong Ku; Morimoto, Tania K.; Chuong, Amy S.; Carpenter, Eric J.; Tian, Zhijian; Wang, Jun; Xie, Yinlong; Yan, Zhixiang; Zhang, Yong; Chow, Brian Y.; Surek, Barbara; Melkonian, Michael; Jayaraman, Vivek; Wong, Gane Ka-Shu; Boyden, Edward Stuart; Constantine-Paton, Martha (Nature Publishing Group, 2014-02)
    Optogenetic tools enable examination of how specific cell types contribute to brain circuit functions. A long-standing question is whether it is possible to independently activate two distinct neural populations in mammalian ...
  • Han, Xue; Qian, Xiaofeng; Stern, Patrick; Chuong, Amy S.; Boyden, Edward Stuart (Frontiers Research Foundation, 2009-07)
    Synchronous neural activity occurs throughout the brain in association with normal and pathological brain functions. Despite theoretical work exploring how such neural coordination might facilitate neural computation and ...
  • Forest, Craig R.; Kodandaramaiah, Suhasa Bangalo; Boyden, Edward Stuart (Wiley Blackwell, 2013-07)
    Robotic and automation technologies have played a huge role in in vitro biological science, having proved critical for scientific endeavors such as genome sequencing and high-throughput screening. Robotic and automation ...
  • Tsunematsu, Tomomi; Tabuchi, Sawako; Tanaka, Kenji F.; Tominaga, Makoto; Yamanaka, Akihiro; Boyden, Edward Stuart (Elsevier, 2013-05)
    Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. Recent optogenetic studies revealed that the activation or inhibition of orexin neuronal activity affects the probability of ...
  • Zamft, Bradley Michael; Marblestone, Adam H.; Kording, Konrad; Schmidt, Daniel; Tyo, Keith; Church, George; Martin Alarcon, Daniel Albert; Boyden, Edward Stuart (Public Library of Science, 2012-08)
    High-throughput recording of signals embedded within inaccessible micro-environments is a technological challenge. The ideal recording device would be a nanoscale machine capable of quantitatively transducing a wide range ...
  • Han, Xue; Qian, Xiaofeng; Bernstein, Jacob G.; Zhou, Huihui; Talei Franzesi, Giovanni; Stern, Patrick; Bronson, Roderick T.; Graybiel, Ann M.; Desimone, Robert; Boyden, Edward Stuart (Elsevier B.V., 2009-04)
    To understand how brain states and behaviors are generated by neural circuits, it would be useful to be able to perturb precisely the activity of specific cell types and pathways in the nonhuman primate nervous system. We ...
  • Börgers, Christoph; LeBeau, Fiona E. N.; Boyden, Edward Stuart; Kopell, Nancy J.; Franzesi, Giovanni Talei (Public Library of Science, 2012-02)
    In networks of excitatory and inhibitory neurons with mutual synaptic coupling, specific drive to sub-ensembles of cells often leads to gamma-frequency (25–100 Hz) oscillations. When the number of driven cells is too small, ...
  • Zorzos, Anthony Nicholas; Boyden, Edward Stuart; Fonstad, Clifton G., Jr. (Optical Society of America, 2010-12)
    Optical fibers are commonly inserted into living tissues such as the brain in order to deliver light to deep targets for neuroscientific and neuroengineering applications such as optogenetics, in which light is used to ...
  • Alivisatos, A. Paul; Andrews, Anne M.; Boyden, Edward Stuart; Chun, Miyoung; Church, George M.; Deisseroth, Karl; Donoghue, John P.; Fraser, Scott E.; Lippincott-Schwartz, Jennifer; Looger, Loren L.; Masmanidis, Sotiris; McEuen, Paul L.; Nurmikko, Arto V.; Park, Hongkun; Peterka, Darcy S.; Reid, Clay; Roukes, Michael L.; Scherer, Axel; Schnitzer, Mark; Sejnowski, Terrence J.; Shepard, Kenneth L.; Tsao, Doris; Turrigiano, Gina; Weiss, Paul S.; Xu, Chris; Yuste, Rafael; Zhuang, Xiaowei (American Chemical Society, 2013-03)
    Neuroscience is at a crossroads. Great effort is being invested into deciphering specific neural interactions and circuits. At the same time, there exist few general theories or principles that explain brain function. We ...
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