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Browsing MIT Open Access Articles by Author "Boyden, Edward Stuart"

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Browsing MIT Open Access Articles by Author "Boyden, Edward Stuart"

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  • Zorzos, Anthony Nicholas; Scholvin, Jorg; Boyden, Edward Stuart; Fonstad, Clifton G., Jr. (Optical Society of America, 2012-11)
    To deliver light to the brain for neuroscientific and neuroengineering applications like optogenetics, in which light is used to activate or silence neurons expressing specific photosensitive proteins, optical fibers are ...
  • Lee, Seung-Hee; Kwan, Alex C.; Zhang, Siyu; Phoumthipphavong, Victoria; Flannery, John G.; Masmanidis, Sotiris C.; Taniguchi, Hiroki; Huang, Z. Josh; Zhang, Feng; Boyden, Edward Stuart; Deisseroth, Karl; Dan, Yang (Nature Publishing Group, 2012-08)
    Inhibitory interneurons are essential components of the neural circuits underlying various brain functions. In the neocortex, a large diversity of GABA (γ-aminobutyric acid) interneurons has been identified on the basis ...
  • Tsunematsu, Tomomi; Kilduff, Thomas S.; Boyden, Edward Stuart; Takahashi, Satoru; Tominaga, Makoto; Yamanaka, Akihiro (Society for Neuroscience, 2011-05)
    Orexin/hypocretin neurons have a crucial role in the regulation of sleep and wakefulness. To help determine how these neurons promote wakefulness, we generated transgenic mice in which orexin neurons expressed halorhodopsin ...
  • Kodandaramaiah, Suhasa Bangalo; Talei Franzesi, Giovanni; Chow, Brian Y.; Boyden, Edward Stuart; Forest, Craig R. (Nature Publishing Group, 2012-05)
    Whole-cell patch-clamp electrophysiology of neurons is a gold-standard technique for high-fidelity analysis of the biophysical mechanisms of neural computation and pathology, but it requires great skill to perform. We have ...
  • Kahn, Itamar; Desai, Mitul; Knoblich, Ulf; Bernstein, Jacob; Henninger, Michael Alan; Graybiel, Ann M.; Boyden, Edward Stuart; Buckner, Randy L.; Moore, Christopher I. (Society for Neuroscience, 2011-10)
    The blood oxygenation level-dependent (BOLD) signal serves as the basis for human functional MRI (fMRI). Knowledge of the properties of the BOLD signal, such as how linear its response is to sensory stimuli, is essential ...
  • Joo, Jaebum; Chow, Brian Y.; Prakash, Manu; Boyden, Edward Stuart; Jacobson, Joseph (Nature Publishing Group, 2011-07)
    Rational control over the morphology and the functional properties of inorganic nanostructures has been a long-standing goal in the development of bottom-up device fabrication processes. We report that the geometry of ...
  • Han, Xue; Chow, Brian Yichiun; Zhou, Huihui; Klapoetke, Nathan Cao; Chuong, Amy S.; Rajimehr, Reza; Yang, Aimei; Baratta, Michael V.; Winkle, Jonathan Andrew; Desimone, Robert; Boyden, Edward Stuart (Frontiers Research Foundation, 2011-04)
    Technologies for silencing the electrical activity of genetically targeted neurons in the brain are important for assessing the contribution of specific cell types and pathways toward behaviors and pathologies. Recently ...
  • Chow, Brian Yichiun; Han, Xue; Dobry, Allison S.; Qian, Xiaofeng; Chuong, Amy S.; Li, Mingjie; Henninger, Michael Alan; Belfort, Gabriel M.; Lin, Yingxi; Monahan, Patrick E.; Boyden, Edward Stuart (Nature Publishing Group, 2010-01)
    The ability to silence the activity of genetically specified neurons in a temporally precise fashion would provide the opportunity to investigate the causal role of specific cell classes in neural computations, behaviours ...
  • Boyden, Edward Stuart (BioMed Central Ltd., 2011-05)
    Understanding how different kinds of neuron in the brain work together to implement sensations, feelings, thoughts, and movements, and how deficits in specific kinds of neuron result in brain diseases, has long been a ...
  • Han, Xue; Qian, Xiaofeng; Stern, Patrick; Chuong, Amy S.; Boyden, Edward Stuart (Frontiers Research Foundation, 2009-07)
    Synchronous neural activity occurs throughout the brain in association with normal and pathological brain functions. Despite theoretical work exploring how such neural coordination might facilitate neural computation and ...
  • Zamft, Bradley Michael; Marblestone, Adam H.; Kording, Konrad; Schmidt, Daniel; Tyo, Keith; Church, George; Martin Alarcon, Daniel Albert; Boyden, Edward Stuart (Public Library of Science, 2012-08)
    High-throughput recording of signals embedded within inaccessible micro-environments is a technological challenge. The ideal recording device would be a nanoscale machine capable of quantitatively transducing a wide range ...
  • Han, Xue; Qian, Xiaofeng; Bernstein, Jacob G.; Zhou, Huihui; Talei Franzesi, Giovanni; Stern, Patrick; Bronson, Roderick T.; Graybiel, Ann M.; Desimone, Robert; Boyden, Edward Stuart (Elsevier B.V., 2009-04)
    To understand how brain states and behaviors are generated by neural circuits, it would be useful to be able to perturb precisely the activity of specific cell types and pathways in the nonhuman primate nervous system. We ...
  • Börgers, Christoph; LeBeau, Fiona E. N.; Boyden, Edward Stuart; Kopell, Nancy J.; Franzesi, Giovanni Talei (Public Library of Science, 2012-02)
    In networks of excitatory and inhibitory neurons with mutual synaptic coupling, specific drive to sub-ensembles of cells often leads to gamma-frequency (25–100 Hz) oscillations. When the number of driven cells is too small, ...
  • Zorzos, Anthony Nicholas; Boyden, Edward Stuart; Fonstad, Clifton G., Jr. (Optical Society of America, 2010-12)
    Optical fibers are commonly inserted into living tissues such as the brain in order to deliver light to deep targets for neuroscientific and neuroengineering applications such as optogenetics, in which light is used to ...
  • Alivisatos, A. Paul; Andrews, Anne M.; Boyden, Edward Stuart; Chun, Miyoung; Church, George M.; Deisseroth, Karl; Donoghue, John P.; Fraser, Scott E.; Lippincott-Schwartz, Jennifer; Looger, Loren L.; Masmanidis, Sotiris; McEuen, Paul L.; Nurmikko, Arto V.; Park, Hongkun; Peterka, Darcy S.; Reid, Clay; Roukes, Michael L.; Scherer, Axel; Schnitzer, Mark; Sejnowski, Terrence J.; Shepard, Kenneth L.; Tsao, Doris; Turrigiano, Gina; Weiss, Paul S.; Xu, Chris; Yuste, Rafael; Zhuang, Xiaowei (American Chemical Society, 2013-03)
    Neuroscience is at a crossroads. Great effort is being invested into deciphering specific neural interactions and circuits. At the same time, there exist few general theories or principles that explain brain function. We ...
  • Kim, Kyung Man; Baratta, Michael V.; Yang, Aimei; Lee, Doheon; Boyden, Edward Stuart; Fiorillo, Christopher D. (Public Library of Science, 2012-04)
    Activation of dopamine receptors in forebrain regions, for minutes or longer, is known to be sufficient for positive reinforcement of stimuli and actions. However, the firing rate of dopamine neurons is increased for only ...
  • Marblestone, Adam H.; Zamft, Bradley M.; Maguire, Yael G.; Shapiro, Mikhail G.; Cybulski, Thaddeus R.; Glaser, Joshua I.; Amodei, Dario; Stranges, P. Benjamin; Kalhor, Reza; Seo, Dongjin; Alon, Elad; Maharbiz, Michel M.; Carmena, Jose M.; Rabaey, Jan M.; Church, George M.; Kording, Konrad P.; Dalrymple, David Allen; Boyden, Edward Stuart (Frontiers Research Foundation, 2013-10)
    Simultaneously measuring the activities of all neurons in a mammalian brain at millisecond resolution is a challenge beyond the limits of existing techniques in neuroscience. Entirely new approaches may be required, ...
  • Glaser, Joshua I.; Zamft, Bradley M.; Marblestone, Adam H.; Moffitt, Jeffrey R.; Tyo, Keith; Church, George; Kording, Konrad P.; Boyden, Edward Stuart (Public Library of Science, 2013-07)
    A molecular device that records time-varying signals would enable new approaches in neuroscience. We have recently proposed such a device, termed a “molecular ticker tape”, in which an engineered DNA polymerase (DNAP) ...
  • Boyden, Edward Stuart; McCarthy, M. M.; Moore-Kochlacs, C.; Gu, X.; Han, X.; Kopell, N. (Proceedings of the National Academy of Sciences (PNAS), 2011-06)
    Enhanced oscillations at beta frequencies (8–30 Hz) are a signature neural dynamic pathology in the basal ganglia and cortex of Parkinson's disease patients. The mechanisms underlying these pathological beta oscillations ...
  • Boyden, Edward Stuart; Chow, Brian Y. (American Association for the Advancement of Science (AAAS), 2011-06)
    Optogenetic tools are DNA-encoded molecules that, when genetically targeted to cells, enable the control of specific physiological processes within those cells through exposure to light. These tools can pinpoint how these ...
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