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Browsing MIT Open Access Articles by Author "Brown, Emery N."

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Browsing MIT Open Access Articles by Author "Brown, Emery N."

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  • Taylor, Norman E.; Chemali, Jessica J.; Brown, Emery N.; Solt, Ken (Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins, 2013-01)
    Background: A recent study showed that methylphenidate induces emergence from isoflurane anesthesia. Methylphenidate inhibits dopamine and norepinephrine reuptake transporters. The objective of this study was to test the ...
  • Chemali, Jessica J.; Van Dort, Christa J.; Brown, Emery N.; Solt, Ken (Ovid Technologies (Wolters Kluwer) - Lippincott Williams & Wilkins, 2012-05)
    Background: A recent study showed that methylphenidate induces emergence from isoflurane general anesthesia. Isoflurane and propofol are general anesthetics that may have distinct molecular mechanisms of action. The objective ...
  • Zhang, Quan; Brown, Emery N.; Strangman, Gary E. (SPIE, 2007-07)
    The sensitivity of near-infrared spectroscopy (NIRS) to evoked brain activity is reduced by physiological interference in at least two locations: 1. the superficial scalp and skull layers, and 2. in brain tissue itself. ...
  • Zhang, Quan; Brown, Emery N.; Strangman, Gary E. (SPIE, 2007-11)
    Following previous Monte Carlo simulations, we describe in detail an example of detecting evoked visual hemodynamic responses in a human subject as a preliminary demonstration of the novel global interference cancellation ...
  • Chen, Zhe; Vijayan, Sujith; Ching, ShiNung; Hale, Gregory John; Flores Plaza, Francisco Javier; Wilson, Matthew A.; Brown, Emery N. (Institute of Electrical and Electronics Engineers, 2011-08)
    Understanding the way in which groups of cortical neurons change their individual and mutual firing activity during the induction of general anesthesia may improve the safe usage of many anesthetic agents. Assessing neuronal ...
  • Chen, Zhe; Brown, Emery N.; Barbieri, Riccardo (Institute of Electrical and Electronics Engineers, 2009-06)
    Tracking the autonomic control and respiratory sinus arrhythmia (RSA) from electrocardiogram and respiratory measurements is an important problem in cardiovascular control. We propose a point process adaptive filter algorithm ...
  • Pierce, Eric T.; Harrell, Grace; Chen, Zhe; Purdon, Patrick Lee; Brown, Emery N.; Barbieri, Riccardo (Institute of Electrical and Electronics Engineers, 2009-05)
    Evaluation of baroreflex control of heart rate (HR) has important implications in clinical practice of anesthesia and postoperative care. In this paper, we present a point process method to assess the dynamic baroreflex ...
  • Cajigas, Iahn; Goldsmith, Mary T.; Duschau-Wicke, Alexander; Riener, Robert; Smith, Maurice A.; Brown, Emery N.; Bonato, Paolo (Institute of Electrical and Electronics Engineers, 2010-08)
    Lower extremity rehabilitation has seen recent increased interest. New tools are available to improve gait retraining in both adults and children. However, it remains difficult to determine optimal ways to plan interventions ...
  • Purdon, Patrick Lee; Brown, Emery N.; Wong, Kin Foon Kevin; Smith, Anne C.; Pierce, Eric T.; Harrell, P. Grace; Walsh, John L.; Salazar, Andres Felipe; Tavares, Casie L.; Cimenser, Aylin; Prerau, Michael J.; Mukamel, Eran A.; Sampson, Aaron (Institute of Electrical and Electronics Engineers (IEEE), 2011-08)
    Accurate quantification of loss of response to external stimuli is essential for understanding the mechanisms of loss of consciousness under general anesthesia. We present a new approach for quantifying three possible ...
  • Smith, Anne C.; Shah, Sudhin A.; Hudson, Andrew E.; Purpura, Keith P.; Victor, Jonathan D.; Brown, Emery N.; Schiff, Nicholas D. (Elsevier, 2009-10)
    Deep brain stimulation (DBS) is an established therapy for Parkinson's Disease and is being investigated as a treatment for chronic depression, obsessive compulsive disorder and for facilitating functional recovery of ...
  • Sampson, A.L.; Mukamel, E.A.; Babadi, Behtash; Prerau, Michael J.; Brown, Emery N.; Purdon, Patrick Lee (Institute of Electrical and Electronics Engineers (IEEE), 2012-08)
    Phase-amplitude modulation is a form of cross frequency coupling where the phase of one frequency influences the amplitude of another higher frequency. It has been observed in neurophysiological recordings during sensory, ...
  • Shanechi, Maryam M.; Chemali, Jessica J.; Liberman, Max; Solt, Ken; Brown, Emery N. (Public Library of Science, 2013-10)
    Medically-induced coma is a drug-induced state of profound brain inactivation and unconsciousness used to treat refractory intracranial hypertension and to manage treatment-resistant epilepsy. The state of coma is achieved ...
  • Chemali, Jessica; Ching, ShiNung; Solt, Ken; Purdon, Patrick Lee; Brown, Emery N. (IOP Publishing, 2013-09)
    Objective. Burst suppression is an electroencephalogram pattern in which bursts of electrical activity alternate with an isoelectric state. This pattern is commonly seen in states of severely reduced brain activity such ...
  • Chen, Zhe; Brown, Emery N.; Barbieri, Riccardo (Institute of Electrical and Electronics Engineers, 2010-06)
    Human heartbeat intervals are known to have nonlinear and nonstationary dynamics. In this paper, we propose a model of R-R interval dynamics based on a nonlinear Volterra-Wiener expansion within a point process framework. ...
  • Nguyen, David P.; Kloosterman, Fabian; Barbieri, Riccardo; Brown, Emery N.; Wilson, Matthew A. (Frontiers Media S.A., 2009-06)
    Fast oscillations or “ripples” are found in the local field potential (LFP) of the rodent hippocampus during awake and sleep states. Ripples have been found to correlate with memory related neural processing, however, the ...
  • Eran, A; Li, J B; Vatalaro, K; McCarthy, J; Rahimov, F; Collins, C; Markianos, K; Margulies, D M; Calvo, S E; Kohane, I S; Kunkel, L M; Brown, Emery N. (Nature Publishing Group, 2012-08)
    Adenosine-to-inosine (A-to-I) RNA editing is a neurodevelopmentally regulated epigenetic modification shown to modulate complex behavior in animals. Little is known about human A-to-I editing, but it is thought to constitute ...
  • Wilson, Matthew A.; Brown, Emery N.; Sarma, Sridevi V.; Nguyen, David P.; Czanner, Gabriela; Wirth, Sylvia; Suzuki, Wendy (MIT Press, 2011-09)
    Characterizing neural spiking activity as a function of intrinsic and extrinsic factors is important in neuroscience. Point process models are valuable for capturing such information; however, the process of fully applying ...
  • Haslinger, Robert Heinz; Pipa, Gordon; Lima, Bruss; Singer, Wolf; Brown, Emery N.; Neuenschwander, Sergio (Public Library of Science, 2012-07)
    Even in V1, where neurons have well characterized classical receptive fields (CRFs), it has been difficult to deduce which features of natural scenes stimuli they actually respond to. Forward models based upon CRF stimuli ...
  • Babadi, Behtash; Brown, Emery N.; Ba, Demba E.; Purdon, Patrick Lee (Institute of Electrical and Electronics Engineers (IEEE), 2013-10)
    In this paper, we study the theoretical properties of iteratively re-weighted least squares (IRLS) algorithms and their utility in sparse signal recovery in the presence of noise. We demonstrate a one-to-one correspondence ...
  • Solt, Ken; Brown, Emery N.; Gong, Jen J.; Wong, Kin Foon Kevin; Cotten, Joseph F. (Institute of Electrical and Electronics Engineers (IEEE), 2011-08)
    Understanding the physiological impact of drug treatments on patients is important in assessing their performance and determining possible side effects. While this effect might be best determined in individual subjects, ...
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