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Browsing MIT Open Access Articles by Author "Griffith, Linda G."

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Browsing MIT Open Access Articles by Author "Griffith, Linda G."

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  • Miller, Miles Aaron; Meyer, Aaron Samuel; Beste, Michael T.; Lasisi, Zainab A.; Reddy, Sonika N.; Jeng, Karen; Griffith, Linda G.; Lauffenburger, Douglas A.; Chen, Chia-Hung; Han, Jongyoon; Isaacson, Keith B. (National Academy of Sciences (U.S.), 2013-05)
    A Disintegrin and Metalloproteinases (ADAMs) are the principal enzymes for shedding receptor tyrosine kinase (RTK) ectodomains and ligands from the cell surface. Multiple layers of activity regulation, feedback, and catalytic ...
  • Moss, Marcia L.; Powell, Gary; Miller, Miles Aaron; Edwards, Lori; Qi, Bin; Qing-Xiang Amy, Sang; De Strooper, Bart; Tesseur, Ina; Lichtenthaler, Stefan F.; Taverna, Mara; Zhong, Julia Li; Dingwall, Colin; Ferdous, Taheera; Schlomann, Uwe; Zhou, Pei; Griffith, Linda G.; Lauffenburger, Douglas A.; Petrovich, Robert; Bartsch, Jorg W. (American Society for Biochemistry and Molecular Biology, 2011-09)
    Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24–204), ...
  • Young, Carissa L.; Lauffenburger, Douglas A.; Griffith, Linda G.; Borenstein, Jeffrey T.; Ebrahimkhani, Mohammad Reza (Elsevier, 2014-05)
    Reliable in vitro human disease models that capture the complexity of in vivo tissue behaviors are crucial to gain mechanistic insights into human disease and enable the development of treatments that are effective across ...
  • Williams, Courtney M.; Mehta, Geeta; Peyton, Shelly R.; Zeiger, Adam Scott; Van Vliet, Krystyn J.; Griffith, Linda G. (Mary Ann Liebert, Inc., 2011-03)
    The liver carries out a variety of essential functions regulated in part by autocrine signaling, including hepatocyte-produced growth factors and extracellular matrix (ECM). The local concentrations of autocrine factors ...
  • Neiman, Jaclyn A. Shepard; Hughes, David J.; Griffith, Linda G.; Ebrahimkhani, Mohammad Reza; Raredon, Micha Sam Brickman (Elsevier, 2014-03)
    Liver is a central nexus integrating metabolic and immunologic homeostasis in the human body, and the direct or indirect target of most molecular therapeutics. A wide spectrum of therapeutic and technological needs drives ...
  • Tsukamoto, Kosuke; Kocher, Olivier; Krieger, Monty; Buck, Lorenna Dianne; Griffith, Linda G.; Inman, Samuel Walker (Public Library of Science, 2013-07)
    Background: PDZK1 is a four PDZ-domain containing cytoplasmic protein that binds to a variety of membrane proteins via their C-termini and can influence the abundance, localization and/or function of its target proteins. ...
  • Wu, Shan; Wells, Alan; Griffith, Linda G.; Lauffenburger, Douglas A. (Elsevier B.V., 2011-10)
    Biomimetic scaffolds have been proposed as a means to facilitate tissue regeneration by multi-potent stromal cells (MSCs). Effective scaffold colonization requires a control of multiple MSC responses including survival, ...
  • Buck, Lorenna D.; Inman, S. Walker; Rusyn, Ivan; Griffith, Linda G. (Wiley Blackwell, 2014-01)
    Although oxygen and extracellular matrix cues both influence differentiation state and metabolic function of primary rat and human hepatocytes, relatively little is known about how these factors together regulate behaviors ...
  • Cambria, Elena; Renggli, Kasper; Kroll, Carsten; Krueger, Andrew T.; Imperiali, Barbara; Griffith, Linda G.; Chopko Ahrens, Caroline; Cook, Christi Dionne (American Chemical Society (ACS), 2015-06)
    Synthetic extracellular matrices are widely used in regenerative medicine and as tools in building in vitro physiological culture models. Synthetic hydrogels display advantageous physical properties, but are challenging ...
  • Hendriks, Bart S.; Cosgrove, Benjamin D.; Alexopoulos, Leonidas G.; Hang, Ta-Chun; Sorger, Peter K.; Griffith, Linda G.; Lauffenburger, Douglas A. (Royal Society of Chemistry, 2010-04)
    Idiosyncratic drug hepatotoxicity is a major problem in pharmaceutical development due to poor prediction capability of standard preclinical toxicity assessments and limited knowledge of its underlying mechanisms. Findings ...
  • Wells, Alan; Griffith, Linda G.; Wells, Jakob Z.; Taylor, Donald P. (American Association for Cancer Research, 2013-06)
    Metastatic dissemination with subsequent clinical outgrowth leads to the greatest part of morbidity and mortality from most solid tumors. Even more daunting is that many of these metastatic deposits silently lie undetected, ...
  • Chopko Ahrens, Caroline; Lowden, Erika L.; Engler, Amanda C.; Griffith, Linda G.; Hammond, Paula T. (American Chemical Society (ACS), 2012-06)
    The temperature- and pH-dependent solubility of poly(γ-propargyl l-glutamate) (PPLG) functionalized through a copper-catalyzed 1,3-cycloaddition reaction between an alkyne and an azide can be tuned with precision over a ...
  • Jay, Steven M.; Kurtagic, Elma; Alvarez, Luis M.; De Picciotto, Seymour; Sanchez Palacios, Edgar I.; Hawkins, Jessica F.; Prince, Robin N.; Guerrero, Yadir; Treasure, Carolyn L.; Lee, Richard T.; Griffith, Linda G. (American Society for Biochemistry and Molecular Biology (ASBMB), 2011-05)
    The ErbB receptor family is dysregulated in many cancers, and its therapeutic manipulation by targeted antibodies and kinase inhibitors has resulted in effective chemotherapies. However, many malignancies remain refractory ...
  • Jay, Steven M.; Murthy, Ashwin C.; Hawkins, Jessica F.; Wortzel, Joshua R.; Steinhauser, Matthew L.; Alvarez, Luis M.; Gannon, Joseph; Macrae, Calum A.; Griffith, Linda G.; Lee, Richard T. (American Heart Association, 2013-06)
    Background—Doxorubicin (DOXO) is an effective anthracycline chemotherapeutic, but its use is limited by cumulative dose-dependent cardiotoxicity. Neuregulin-1β is an ErbB receptor family ligand that is effective against ...
  • Griffith, Linda G.; Wells, Alan; Stolz, Donna B. (Wiley Blackwell, 2014-05)
    Interest in “engineering liver” arises from multiple communities: therapeutic replacement; mechanistic models of human processes; and drug safety and efficacy studies. An explosion of micro- and nanofabrication, biomaterials, ...
  • Ng, Chee Ping; Mohamed Sharif, Abdul Rahim; Heath, Daniel E.; Chow, John W.; Zhang, Claire BY.; Chan-Park, Mary B.; Hammond, Paula T.; Chan, Jerry K. Y.; Griffith, Linda G. (Elsevier, 2014-02)
    Large-scale expansion of highly functional adult human mesenchymal stem cells (aMSCs) remains technologically challenging as aMSCs lose self renewal capacity and multipotency during traditional long-term culture and their ...
  • Chen, Chia-Hung; Sarkar, Aniruddh; Song, Yong-Ak; Miller, Miles Aaron; Kim, Sung Jae; Griffith, Linda G.; Lauffenburger, Douglas A.; Han, Jongyoon (American Chemical Society (ACS), 2011-06)
    We introduce an integrated microfluidic device consisting of a biomolecule concentrator and a microdroplet generator, which enhances the limited sensitivity of low-abundance enzyme assays by concentrating biomolecules ...
  • Luangphakdy, Viviane; Walker, Esteban; Shinohara, Kentaro; Pan, Hui; Hefferan, Theresa; Bauer, Thomas W.; Stockdale, Linda; Saini, Sunil; Dadsetan, Mahrokh; Runge, M. Brett; Vasanji, Amit; Yaszemski, Michael; Muschler, George F.; Griffith, Linda G. (Mary Ann Liebert, Inc., 2013-01)
    Treatment of large segmental bone defects remains an unsolved clinical challenge, despite a wide array of existing bone graft materials. This project was designed to rapidly assess and compare promising biodegradable ...
  • Guye, Patrick; Kipniss, Nathan; Velazquez, Jeremy J.; Schoenfeld, Eldi; Kiani, Samira; Griffith, Linda G.; Weiss, Ron; Ebrahimkhani, Mohammad Reza (Nature Publishing Group, 2016-01)
    Human induced pluripotent stem cells (hiPSCs) have potential for personalized and regenerative medicine. While most of the methods using these cells have focused on deriving homogenous populations of specialized cells, ...
  • Rodrigues, Melanie; Griffith, Linda G.; Wells, Alan (Biomed Central Ltd., 2010-10)
    Multipotential stromal cells (MSCs) have been touted to provide an alternative to conservative procedures of therapy, be it heart transplants, bone reconstruction, kidney grafts, or skin, neuronal and cartilage repair. A ...
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