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Browsing MIT Open Access Articles by Author "Griffith, Linda G."

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Browsing MIT Open Access Articles by Author "Griffith, Linda G."

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  • Miller, Miles Aaron; Meyer, Aaron Samuel; Beste, Michael Thomas; Lasisi, Zainab A.; Reddy, Sonika N.; Jeng, Karen; Griffith, Linda G.; Lauffenburger, Douglas A.; Chen, Chia-Hung; Han, Jongyoon; Isaacson, Keith (National Academy of Sciences (U.S.), 2013-05)
    A Disintegrin and Metalloproteinases (ADAMs) are the principal enzymes for shedding receptor tyrosine kinase (RTK) ectodomains and ligands from the cell surface. Multiple layers of activity regulation, feedback, and catalytic ...
  • Moss, Marcia L.; Powell, Gary; Miller, Miles Aaron; Edwards, Lori; Qi, Bin; Qing-Xiang Amy, Sang; De Strooper, Bart; Tesseur, Ina; Lichtenthaler, Stefan F.; Taverna, Mara; Zhong, Julia Li; Dingwall, Colin; Ferdous, Taheera; Schlomann, Uwe; Zhou, Pei; Griffith, Linda G.; Lauffenburger, Douglas A.; Petrovich, Robert; Bartsch, Jorg W. (American Society for Biochemistry and Molecular Biology, 2011-09)
    Prodomains of A disintegrin and metalloproteinase (ADAM) metallopeptidases can act as highly specific intra- and intermolecular inhibitors of ADAM catalytic activity. The mouse ADAM9 prodomain (proA9; amino acids 24–204), ...
  • Williams, Courtney M.; Mehta, Geeta; Peyton, Shelly R.; Zeiger, Adam Scott; Van Vliet, Krystyn J.; Griffith, Linda G. (Mary Ann Liebert, Inc., 2011-03)
    The liver carries out a variety of essential functions regulated in part by autocrine signaling, including hepatocyte-produced growth factors and extracellular matrix (ECM). The local concentrations of autocrine factors ...
  • Tsukamoto, Kosuke; Kocher, Olivier; Krieger, Monty; Buck, Lorenna Dianne; Griffith, Linda G.; Inman, Samuel Walker (Public Library of Science, 2013-07)
    Background: PDZK1 is a four PDZ-domain containing cytoplasmic protein that binds to a variety of membrane proteins via their C-termini and can influence the abundance, localization and/or function of its target proteins. ...
  • Hendriks, Bart S.; Cosgrove, Benjamin D.; Alexopoulos, Leonidas G.; Hang, Ta-Chun; Sorger, Peter K.; Griffith, Linda G.; Lauffenburger, Douglas A. (Royal Society of Chemistry, 2010-04)
    Idiosyncratic drug hepatotoxicity is a major problem in pharmaceutical development due to poor prediction capability of standard preclinical toxicity assessments and limited knowledge of its underlying mechanisms. Findings ...
  • Chopko, Caroline M.; Lowden, Erika L.; Engler, Amanda C.; Griffith, Linda G.; Hammond, Paula T. (American Chemical Society (ACS), 2012-06)
    The temperature- and pH-dependent solubility of poly(γ-propargyl l-glutamate) (PPLG) functionalized through a copper-catalyzed 1,3-cycloaddition reaction between an alkyne and an azide can be tuned with precision over a ...
  • Jay, Steven M.; Kurtagic, Elma; Alvarez, Luis M.; De Picciotto, Seymour; Sanchez Palacios, Edgar I.; Hawkins, Jessica F.; Prince, Robin N.; Guerrero, Yadir; Treasure, Carolyn L.; Lee, Richard T.; Griffith, Linda G. (American Society for Biochemistry and Molecular Biology (ASBMB), 2011-05)
    The ErbB receptor family is dysregulated in many cancers, and its therapeutic manipulation by targeted antibodies and kinase inhibitors has resulted in effective chemotherapies. However, many malignancies remain refractory ...
  • Jay, Steven M.; Murthy, Ashwin C.; Hawkins, Jessica F.; Wortzel, Joshua R.; Steinhauser, Matthew L.; Alvarez, Luis M.; Gannon, Joseph; Macrae, Calum A.; Griffith, Linda G.; Lee, Richard T. (American Heart Association, 2013-06)
    Background—Doxorubicin (DOXO) is an effective anthracycline chemotherapeutic, but its use is limited by cumulative dose-dependent cardiotoxicity. Neuregulin-1β is an ErbB receptor family ligand that is effective against ...
  • Ng, Chee Ping; Mohamed Sharif, Abdul Rahim; Heath, Daniel E.; Chow, John W.; Zhang, Claire BY.; Chan-Park, Mary B.; Hammond, Paula T.; Chan, Jerry KY.; Griffith, Linda G. (Elsevier, 2014-02)
    Large-scale expansion of highly functional adult human mesenchymal stem cells (aMSCs) remains technologically challenging as aMSCs lose self renewal capacity and multipotency during traditional long-term culture and their ...
  • Chen, Chia-Hung; Sarkar, Aniruddh; Song, Yong-Ak; Miller, Miles Aaron; Kim, Sung Jae; Griffith, Linda G.; Lauffenburger, Douglas A.; Han, Jongyoon (American Chemical Society (ACS), 2011-06)
    We introduce an integrated microfluidic device consisting of a biomolecule concentrator and a microdroplet generator, which enhances the limited sensitivity of low-abundance enzyme assays by concentrating biomolecules ...
  • Rodrigues, Melanie; Griffith, Linda G.; Wells, Alan (Biomed Central Ltd., 2010-10)
    Multipotential stromal cells (MSCs) have been touted to provide an alternative to conservative procedures of therapy, be it heart transplants, bone reconstruction, kidney grafts, or skin, neuronal and cartilage repair. A ...
  • Oelker, Abigail M.; Morey, Shannon M.; Griffith, Linda G.; Hammond, Paula T. (Royal Society of Chemistry, 2012-09)
    As a platform for investigating the individual effects of substrate stiffness, permeability, and ligand density on cellular behavior, we developed a set of hydrogels with stiffness tuned by polymer backbone rigidity, ...
  • Chen, Chia-Hung; Miller, Miles Aaron; Sarkar, Aniruddh; Beste, Michael T.; Lauffenburger, Douglas A.; Griffith, Linda G.; Han, Jongyoon (2012-10)
    In this study, we integrated several components, including a droplet generator, a pico-injector, and an analytical inference technique, Proteolytic Activity Matrix Analysis (PrAMA), to create a platform for assessing ...
  • Stains, Cliff I.; Tedford, Nathan C.; Walkup, Traci C.; Goguen, Brenda N.; Griffith, Linda G.; Lauffenburger, Douglas A.; Imperiali, Barbara; Lukovic, Elvedin; Stains, Cliff I.; Tedford, Nathan C.; Walkup, Traci C.; Goguen, Brenda N.; Griffith, Linda G.; Lauffenburger, Douglas A. (Elsevier, 2012-02)
    Protein kinases catalyze protein phosphorylation and thereby control the flow of information through signaling cascades. Currently available methods for concomitant assessment of the enzymatic activities of multiple kinases ...
  • Soldatow, Valerie Y.; LeCluyse, Edward L.; Griffith, Linda G.; Rusyn, Ivan (Royal Society of Chemistry, 2013)
    Over the years, various liver-derived in vitro model systems have been developed to enable investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices, isolated microsomes, perfused liver, ...
  • Hang, Ta-Chun; Lauffenburger, Douglas A.; Griffith, Linda G.; Stolz, Donna B. (American Physiological Society, 2011-11)
    Primary rat liver sinusoidal endothelial cells (LSEC) are difficult to maintain in a differentiated state in culture for scientific studies or technological applications. Relatively little is known about molecular regulatory ...
  • Peyton, Shelly R.; Kalcioglu, Zeynep Ilke; Cohen, Joshua C.; Runkle, Anne P.; Van Vliet, Krystyn J.; Lauffenburger, Douglas A.; Griffith, Linda G. (Wiley Blackwell, 2010-12)
    Design of 3D scaffolds that can facilitate proper survival, proliferation, and differentiation of progenitor cells is a challenge for clinical applications involving large connective tissue defects. Cell migration within ...
  • Griffith, Linda G.; Rodrigues, Melanie; Nuschke, Austin; Wells, Alan; Yates, Cecelia C. (Mary Ann Liebert, 2013-09)
    Multipotential stromal cells/mesenchymal stem cells (MSCs) are attractive candidates for regenerative therapy due to the ability of these cells to differentiate and positively influence neighboring cells. However, on ...
  • Beste, Michael T.; Pfaffle-Doyle, Nicole; Prentice, Emily A.; Lauffenburger, Douglas A.; Morris, Stephanie N.; Isaacson, Keith B.; Griffith, Linda G. (American Association for the Advancement of Science (AAAS), 2014-02)
    Clinical management of endometriosis is limited by the complex relationship between symptom severity, heterogeneous surgical presentation, and variability in clinical outcomes. As a complement to visual classification ...
  • Platt, Manu O.; Wilder, Catera L.; Wells, Alan; Griffith, Linda G.; Lauffenburger, Douglas A. (John Wiley & Sons, Inc., 2009-11)
    Bone marrow-derived multipotent stromal cells (MSCs) offer great promise for regenerating tissue. Although certain transcription factors have been identified in association with tendency toward particular MSC differentiation ...
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