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Browsing MIT Open Access Articles by Author "Housman, David E."

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Browsing MIT Open Access Articles by Author "Housman, David E."

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  • Gipson, Theresa Anne; Housman, David E.; Sathasivam, Kirupa; Neueder, Andreas; Landles, Christian; Benjamin, Agnesska C.; Bondulich, Marie K.; Smith, Donna L.; Faull, Richard L. M.; Roos, Raymund A. C.; Howland, David; Detloff, Peter J.; bates, Gillian P. (National Academy of Sciences (U.S.), 2013-01)
    Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It is caused by a CAG repeat expansion in exon ...
  • Sathasivam, Kirupa; Neueder, Andreas; Gipson, Theresa Anne; Landles, Christian; Benjamin, Agnesska C.; Bondulich, Marie K.; Amith, Donna L.; Faull, Richard L. M.; Roos, Raymund A. C.; Howland, David; Detloff, Peter J.; Housman, David E.; Bates, Gillian P. (National Academy of Sciences (U.S.), 2013-01)
    Huntington disease (HD) is a devastating, late-onset, inherited neurodegenerative disorder that manifests with personality changes, movement disorders, and cognitive decline. It is caused by a CAG repeat expansion in exon ...
  • Jun, H J; Acquaviva, J; Chi, D; Lessard, J; Zhu, H; Woolfenden, S; Bronson, R T; Pfannl, R; Iyer, L; Boskovitz, A; Raval, A; White, Forest M.; Housman, David E.; Whittaker, Charles A.; Charest, Alain (Nature Publishing Group, 2011-10)
    Glioblastoma multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpression of wild-type epidermal growth factor receptor (EGFR) and loss of the tumor suppressor genes Ink4a/Arf and PTEN are salient ...
  • Housman, David E.; Huggins, Gordon S.; Mendelsohn, Michael E.; Kapur, Navin K.; Payne, Douglas D.; Hedgepeth, Alyson Kelley; Montefusco, Maria Claudia; Iyer, Lakshmanan K.; Wooten, Eric C. (Public Library of Science, 2010-01)
    Bicuspid Aortic Valve (BAV) is a highly heritable congenital heart defect. The low frequency of BAV (1% of general population) limits our ability to perform genome-wide association studies. We present the application of ...
  • Peter, Inga; Kelley-Hedgepeth, Alyson; Huggins, Gordon S.; Housman, David E.; Mendelsohn, Michael E.; Vita, Joseph A.; Vasan, Ramachandran S.; Levy, Daniel; Benjamin, Emelia J.; Mitchell, Gary F. (Nature Publishing Group, 2009-10)
    Increased arterial stiffness and wave reflection have been identified as cardiovascular disease risk factors. In light of significant sex differences and the moderate heritability of vascular function measures, we hypothesized ...
  • Crittenden, Jill R.; Dunn, Denise E.; Merali, Farhan I.; Woodman, Ben; Yim, Michael; Borkowska, Anna E.; Frosch, Matthew P.; Bates, Gillian P.; Housman, David E.; Lo, Donald C.; Graybiel, Ann M. (IRL Press at Oxford University Press, 2010-02)
    Huntingtin protein (Htt) is ubiquitously expressed, yet Huntington’s disease (HD), a fatal neurologic disorder produced by expansion of an Htt polyglutamine tract, is characterized by neurodegeneration that occurs primarily ...
  • van Blitterswijk, Marka; Wang, Eric T.; Friedman, Brad A.; Keagle, Pamela J.; Lowe, Patrick; Leclerc, Ashley Lyn; van den Berg, Leonard H.; Housman, David E.; Veldink, Jan H.; Landers, John E. (Public Library of Science, 2013-04)
    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease resulting in severe muscle weakness and eventual death by respiratory failure. Although little is known about its pathogenesis, mutations in fused in ...
  • Whittaker, Charles A.; Housman, David E.; Charest, Alain; Acquaviva, Jaime; Jun, Hyun Jung; Lessard, Julie; Ruiz, Rolando; Zhu, Haihao; Donovan, Melissa; Woolfenden, Steve; Boskovitz, Abraham; Raval, Ami; Bronson, Roderick T.; Pfannl, Rolf (American Association for Cancer Research, 2011-10)
    Glioblastoma multiforme (GBM) is characterized by overexpression of epidermal growth factor receptor (EGFR) and loss of the tumor suppressors Ink4a/Arf. Efforts at modeling GBM using wild-type EGFR in mice have proven ...
  • Parkesh, Raman; Childs-Disney, Jessica L.; Nakamori, Masayuki; Kumar, Amit; Wang, Eric; Wang, Thomas; Hoskins, Jason; Tran, Tuan; Thornton, Charles A.; Disney, Matthew D.; Housman, David E. (American Chemical Society (ACS), 2012-02)
    Myotonic dystrophy type 1 (DM1) is a triplet repeating disorder caused by expanded CTG repeats in the 3′-untranslated region of the dystrophia myotonica protein kinase (DMPK) gene. The transcribed repeats fold into an RNA ...
  • Crook, Zachary Ryan; Housman, David E. (National Academy of Sciences, 2012-04)
    The ability to quantitatively evaluate the impact of a potential therapeutic intervention for Huntington disease (HD) in animal models for the disease is a critical step in the pathway to development of an effective therapy ...
  • Crook, Zachary Ryan; Housman, David E. (National Academy of Sciences, 2012-04)
    The ability to quantitatively evaluate the impact of a potential therapeutic intervention for Huntington disease (HD) in animal models for the disease is a critical step in the pathway to development of an effective therapy ...
  • Sontag, Emily M.; Joachimiak, Lukasz A.; Tan, Zhiqun; Tomlinson, Anthony; Housman, David E.; Glabe, Charles G.; Potkin, Steven G.; Frydman, Judith; Thompson, Leslie M. (National Academy of Sciences (U.S.), 2013-01)
    Aggregation of misfolded proteins is characteristic of a number of neurodegenerative diseases, including Huntington disease (HD). The CCT/TRiC (chaperonin containing TCP-1/TCP-1 ring) chaperonin complex can inhibit aggregation ...
  • Ng, Christopher W.; Yildirim, Ferah; Yap, Soon Ming Micha; Dalin, Simona Sara; Matthews, Bryan; Velez, Patricio J.; Labadorf, Adam; Housman, David E.; Fraenkel, Ernest (National Academy of Sciences (U.S.), 2013-01)
    The earliest stages of Huntington disease are marked by changes in gene expression that are caused in an indirect and poorly understood manner by polyglutamine expansions in the huntingtin (HTT) protein. To explore the ...
  • Boissonneault, Katie; Henningsen, Brooks M; Bates, Stephen S; Robertson, Deborah L; Milton, Sean; Pelletier, Jerry; Hogan, Deborah A; Housman, David E; Housman, David E. (Biomed Central Ltd., 2013-11)
    Background: Pseudo-nitzschia multiseries Hasle (Hasle) (Ps-n) is distinctive among the ecologically important marine diatoms because it produces the neurotoxin domoic acid. Although the biology of Ps-n has been investigated ...
  • Crook, Zachary Ryan; Housman, David E. (Elsevier, 2011-02)
    Mouse models for Huntington's Disease (HD) and HD patients demonstrate motor and behavioral dysfunctions, such as progressive loss of coordination and memory, and share similar transcriptional profiles and striatal neuron ...
  • Williams, Amy L.; Housman, David E.; Rinard, Martin C.; Gifford, David K. (BioMed Central Ltd., 2010-10)
    Hapi is a new dynamic programming algorithm that ignores uninformative states and state transitions in order to efficiently compute minimum-recombinant and maximum likelihood haplotypes. When applied to a dataset containing ...
  • Janas, Maja M.; Wang, Eric Tzy-shi; Love, Tara; Harris, Abigail S.; Stevenson, Kristen; Semmelmann, Karlheinz; Shaffer, Jonathan M.; Chen, Po-Hao; Doench, John G.; Yerramilli, Subrahmanyam V.B.K.; Neuberg, Donna S.; Iliopoulos, Dimitrios; Housman, David E.; Burge, Christopher B.; Novina, Carl D. (Elsevier B.V., 2012-04)
    MicroRNAs (miRNAs) regulate physiological and pathological processes by inducing posttranscriptional repression of target messenger RNAs (mRNAs) via incompletely understood mechanisms. To discover factors required for human ...
  • Tabchy, Adel; Eltonsy, Nevine; Housman, David E.; Mills, Gordon B. (Public Library of Science, 2013-04)
    There is an urgent need to elicit and validate highly efficacious targets for combinatorial intervention from large scale ongoing molecular characterization efforts of tumors. We established an in silico bioinformatic ...
  • Ng, Christopher W.; Yildirim, Ferah; Gipson, Theresa Anne; Labadorf, Adam; Housman, David E.; Fraenkel, Ernest; Vashishtha, Malini; Kratter, Ian H.; Bodai, Laszlo; Song, Wan; Lau, Alice; Vogel-Ciernia, Annie; Troncosco, Juan; Ross, Christopher A.; Bates, Gillian P.; Krainc, Dimitri; Sadri-Vakili, Ghazaleh; Finkbeiner, Steven; Marsh, J. Lawrence; Thompson, Leslie M. (National Academy of Sciences (U.S.), 2013-08)
    Transcriptional dysregulation is an early feature of Huntington disease (HD). We observed gene-specific changes in histone H3 lysine 4 trimethylation (H3K4me3) at transcriptionally repressed promoters in R6/2 mouse and ...
  • Wang, Eric Tzy-shi; Cody, Neal A. L.; Jog, Sonali; Biancolella, Michela; Wang, Thomas T.; Treacy, Daniel J.; Luo, Shujun; Schroth, Gary P.; Housman, David E.; Reddy, Sita; Lécuyer, Eric; Burge, Christopher B.; Wang, Thomas (Elsevier B.V., 2012-08)
    The muscleblind-like (Mbnl) family of RNA-binding proteins plays important roles in muscle and eye development and in myotonic dystrophy (DM), in which expanded CUG or CCUG repeats functionally deplete Mbnl proteins. We ...
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