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Browsing MIT Open Access Articles by Author "Langer, Robert"

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Browsing MIT Open Access Articles by Author "Langer, Robert"

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  • Ilyinskii, Petr O.; Roy, Christopher J.; O’Neil, Conlin P.; Browning, Erica A.; Pittet, Lynnelle A.; Altreuter, David H.; Alexis, Frank; Tonti, Elena; Shi, Jinjun; Basto, Pamela Antonia; Iannacone, Matteo; Radovic-Moreno, Aleksandar F.; Farokhzad, Omid C.; von Andrian, Ulrich H.; Johnston, Lloyd P. M.; Kishimoto, Takashi Kei; Langer, Robert (Elsevier, 2014-03)
    Augmentation of immunogenicity can be achieved by particulate delivery of an antigen and by its co-administration with an adjuvant. However, many adjuvants initiate strong systemic inflammatory reactions in vivo, leading ...
  • Hook, Andrew L.; Scurr, David J.; Burley, Jonathan C.; Langer, Robert; Anderson, Daniel Griffith; Davies, Martyn C.; Alexander, Morgan R. (Royal Society of Chemistry, 2013)
    Polymer microarrays are a key enabling technology for the discovery of novel materials. This technology can be further enhanced by expanding the combinatorial space represented on an array. However, not all materials are ...
  • Polat, Baris E.; Seto, Jennifer E.; Blankschtein, Daniel; Langer, Robert (Wiley Blackwell, 2011-02)
    This study investigated the effect of sodium lauryl sulfate (SLS) on skin structural perturbation when utilized simultaneously with low-frequency sonophoresis (LFS). Pig full-thickness skin (FTS) and pig split-thickness ...
  • Li, Lele; Tong, Rong; Chu, Hunghao; Wang, Weiping; Langer, Robert; Kohane, Daniel S. (National Academy of Sciences (U.S.), 2014-12)
    The in vivo application of aptamers as therapeutics could be improved by enhancing target-specific accumulation while minimizing off-target uptake. We designed a light-triggered system that permits spatiotemporal regulation ...
  • Siegwart, Daniel J.; Leiendecker, Matthias; Langer, Robert; Anderson, Daniel Griffith (American Chemical Society, 2012-02)
    Conventional synthesis of polymers by ATRP is relatively low throughput, involving iterative optimization of conditions in an inert atmosphere. Automated, high-throughput controlled radical polymerization was developed to ...
  • Sanni, Olutoba; Chang, Chien-Yi; Langer, Robert; Davies, Martyn C.; Williams, Philip M.; Williams, Paul; Alexander, Morgan R.; Hook, Andrew L.; Anderson, Daniel Griffith (Wiley Blackwell, 2014-12)
    A new class of material resistant to bacterial attachment has been discovered that is formed from polyacrylates with hydrocarbon pendant groups. In this study, the relationship between the nature of the hydrocarbon moiety ...
  • Love, Kevin T.; Langer, Robert; Anderson, Daniel Griffith; Haq, Rizwan; Yokoyama, Satoru; Hawryluk, Elena B.; Jonsson, Goran B.; Frederick, Dennie Tompers; McHenry, Kevin; Porter, Dale; Tran, Thanh-Nga; Garraway, Levi A.; Duncan, Lyn McDivitt; Morton, Donald L.; Hoon, Dave S. B.; Wargo, Jennifer A.; Song, Jun S.; Fisher, David E. (National Academy of Sciences (U.S.), 2013-02)
    Although targeting oncogenic mutations in the BRAF serine/threonine kinase with small molecule inhibitors can lead to significant clinical responses in melanoma, it fails to eradicate tumors in nearly all patients. Successful ...
  • Wang, Jane; Bettinger, Christopher J.; Langer, Robert; Borenstein, Jeffrey T. (Landes Bioscience, 2010-10)
    Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery ...
  • Ma, Mingming; Guo, Liang; Anderson, Daniel Griffith; Langer, Robert (American Association for the Advancement of Science (AAAS), 2013-01)
    Here we describe the development of a water-responsive polymer film. Combining both a rigid matrix (polypyrrole) and a dynamic network (polyol-borate), strong and flexible polymer films were developed that can exchange ...
  • Sharei, Armon Reza; Cho, Nahyun; Mao, Shirley; Jackson, Emily L.; Poceviciute, Roberta; Adamo, Andrea; Zoldan, Janet; Langer, Robert; Jensen, Klavs F. (MyJoVE Corporation, 2013-11)
    Rapid mechanical deformation of cells has emerged as a promising, vector-free method for intracellular delivery of macromolecules and nanomaterials. This technology has shown potential in addressing previously challenging ...
  • Celiz, A. D.; Smith, J. G. W.; Patel, A. K.; Langer, Robert; Anderson, Daniel Griffith; Barrett, D. A.; Young, L. E.; Davies, Martyn C.; Denning, C.; Alexander, Morgan R. (Royal Society of Chemistry, 2014-05)
    Materials discovery provides the opportunity to identify novel materials that are tailored to complex biological environments by using combinatorial mixing of monomers to form large libraries of polymers as micro arrays. ...
  • Abrahamsson, Christoffer K.; Yang, Fan; Park, Hyoungshin; Brunger, Jonathan M.; Valonen, Piia K.; Langer, Robert; Welter, Jean F.; Caplan, Arnold I.; Guilak, Farshid; Freed, Lisa E. (Mary Ann Liebert, Inc., 2010-07)
    Human mesenchymal stem cells (hMSCs) and three-dimensional (3D) woven poly(ɛ-caprolactone) (PCL) scaffolds are promising tools for skeletal tissue engineering. We hypothesized that in vitro culture duration and medium ...
  • Mei, Ying; Saha, Krishanu; Bogatyrev, Said R.; Yang, Jing; Hook, Andrew L.; Kalcioglu, Zeynep Ilke; Cho, Seung Woo; Mitalipova, Maisam; Pyzocha, Neena; Rojas, Fredrick P.; Van Vliet, Krystyn J.; Davies, Martyn C.; Alexander, Morgan R.; Langer, Robert; Jaenisch, Rudolf; Anderson, Daniel G. (Nature Publishing Group, 2010-08)
    Both human embryonic stem cells and induced pluripotent stem cells can self-renew indefinitely in culture; however, present methods to clonally grow them are inefficient and poorly defined for genetic manipulation and ...
  • Hook, Andrew L.; Chang, Chien-Yi; Yang, Jing; Luckett, Jeni; Cockayne, Alan; Atkinson, Steve; Mei, Ying; Bayston, Roger; Irvine, Derek J.; Langer, Robert; Williams, Paul; Davies, Martyn C.; Alexander, Morgan R.; Anderson, Daniel Griffith (Nature Publishing Group, 2012-08)
    Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric ...
  • Sun, Shuo; Wang, Ming; Knupp, Sarah A.; Soto-Feliciano, Yadira; Hu, Xiao; Kaplan, David L.; Langer, Robert; Anderson, Daniel G.; Xu, Qiaobing (American Chemical Society, 2012-01)
    A combinatorial library of lipidoids was constructed and studied for in vitro gene delivery. The library of lipidoids was synthesized by reacting commercially available amines with lipophilic acrylates, acrylamides, or ...
  • Siegwart, Daniel; Whitehead, Kathryn Ann; Nuhn, Lutz; Sahay, Gaurav; Cheng, Hao; Jiang, Shan; Ma, Minglin; Lytton-Jean, Abigail K. R.; Vegas, Arturo; Fenton, Patrick; Levins, Christopher G.; Love, Kevin T.; Lee, Haeshin; Cortez, Christina; Collins, Sean P.; Li, Ying Fei; Jang, Janice; Querbes, William; Zurenko, Christopher; Novobrantseva, Tatiana; Langer, Robert; Anderson, Daniel G. (National Academy of Sciences (U.S.), 2011-08)
    Analogous to an assembly line, we employed a modular design for the high-throughput study of 1,536 structurally distinct nanoparticles with cationic cores and variable shells. This enabled elucidation of complexation, ...
  • Gu, Minghao; Kilduff, James E.; Belfort, Georges; Vegas, Arturo; Anderson, Daniel Griffith; Langer, Robert (Elsevier, 2013-05)
    Using combinatorial methods, we synthesized a series of new vinyl amide monomers and graft-polymerized them to light-sensitive poly(ether sulfone) (PES) porous films for protein resistance. To increase the discovery rate ...
  • Chen, Sidi; Zhou, Yang; Yim, Michael J.; Swiech, Lukasz; Kempton, Hannah R.; Dahlman, James E.; Parnas, Oren; Eisenhaure, Thomas M.; Jovanovic, Marko; Graham, Daniel B.; Jhunjhunwala, Siddharth; Heidenreich, Matthias; Xavier, Ramnik J.; Langer, Robert; Hacohen, Nir; Regev, Aviv; Feng, Guoping; Sharp, Phillip A.; Zhang, Feng; Platt, Randall; Anderson, Daniel Griffith; Yim, Michael J.; Kempton, Hannah R.; Dahlman, James E.; Sharp, Phillip A. (Elsevier, 2014-09)
    CRISPR-Cas9 is a versatile genome editing technology for studying the functions of genetic elements. To broadly enable the application of Cas9 in vivo, we established a Cre-dependent Cas9 knockin mouse. We demonstrated in ...
  • Bonner, Daniel K.; Zhao, Xiaoyong; Buss, Hilda; Langer, Robert; Hammond, Paula T. (Elsevier, 2012-09)
    Crosslinked polyethylenimines (PEIs) have been frequently examined over the past decade since they can maintain the transfection efficiency of commercially available, 25 k branched PEI, but exhibit less cytotoxicity. The ...
  • Celiz, Adam D.; Rajamohan, Divya; Langer, Robert; Davies, Martyn C.; Alexander, Morgan R.; Denning, Chris; Patel, Asha; Anderson, Daniel Griffith (Elsevier, 2015-05)
    Cardiomyocytes from human stem cells have applications in regenerative medicine and can provide models for heart disease and toxicity screening. Soluble components of the culture system such as growth factors within serum ...
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