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Browsing MIT Open Access Articles by Author "Langer, Robert"

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Browsing MIT Open Access Articles by Author "Langer, Robert"

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  • Polat, Baris E.; Seto, Jennifer E.; Blankschtein, Daniel; Langer, Robert (Wiley Blackwell, 2011-02)
    This study investigated the effect of sodium lauryl sulfate (SLS) on skin structural perturbation when utilized simultaneously with low-frequency sonophoresis (LFS). Pig full-thickness skin (FTS) and pig split-thickness ...
  • Siegwart, Daniel J.; Leiendecker, Matthias; Langer, Robert; Anderson, Daniel Griffith (American Chemical Society, 2012-02)
    Conventional synthesis of polymers by ATRP is relatively low throughput, involving iterative optimization of conditions in an inert atmosphere. Automated, high-throughput controlled radical polymerization was developed to ...
  • Love, Kevin T.; Langer, Robert; Anderson, Daniel Griffith; Haq, Rizwan; Yokoyama, Satoru; Hawryluk, Elena B.; Jonsson, Goran B.; Frederick, Dennie Tompers; McHenry, Kevin; Porter, Dale; Tran, Thanh-Nga; Garraway, Levi A.; Duncan, Lyn McDivitt; Morton, Donald L.; Hoon, Dave S. B.; Wargo, Jennifer A.; Song, Jun S.; Fisher, David E. (National Academy of Sciences (U.S.), 2013-02)
    Although targeting oncogenic mutations in the BRAF serine/threonine kinase with small molecule inhibitors can lead to significant clinical responses in melanoma, it fails to eradicate tumors in nearly all patients. Successful ...
  • Wang, Jane; Bettinger, Christopher J.; Langer, Robert; Borenstein, Jeffrey T. (Landes Bioscience, 2010-10)
    Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery ...
  • Abrahamsson, Christoffer K.; Yang, Fan; Park, Hyoungshin; Brunger, Jonathan M.; Valonen, Piia K.; Langer, Robert; Welter, Jean F.; Caplan, Arnold I.; Guilak, Farshid; Freed, Lisa E. (Mary Ann Liebert, Inc., 2010-07)
    Human mesenchymal stem cells (hMSCs) and three-dimensional (3D) woven poly(ɛ-caprolactone) (PCL) scaffolds are promising tools for skeletal tissue engineering. We hypothesized that in vitro culture duration and medium ...
  • Mei, Ying; Saha, Krishanu; Bogatyrev, Said R.; Yang, Jing; Hook, Andrew L.; Kalcioglu, Zeynep Ilke; Cho, Seung-Woo; Mitalipova, Maisam; Pyzocha, Neena; Rojas, Fredrick P.; Van Vliet, Krystyn J.; Davies, Martyn C.; Alexander, Morgan R.; Langer, Robert; Jaenisch, Rudolf; Anderson, Daniel G. (Nature Publishing Group, 2010-08)
    Both human embryonic stem cells and induced pluripotent stem cells can self-renew indefinitely in culture; however, present methods to clonally grow them are inefficient and poorly defined for genetic manipulation and ...
  • Sun, Shuo; Wang, Ming; Knupp, Sarah A.; Soto-Feliciano, Yadira; Hu, Xiao; Kaplan, David L.; Langer, Robert; Anderson, Daniel G.; Xu, Qiaobing (American Chemical Society, 2012-01)
    A combinatorial library of lipidoids was constructed and studied for in vitro gene delivery. The library of lipidoids was synthesized by reacting commercially available amines with lipophilic acrylates, acrylamides, or ...
  • Siegwart, Daniel; Whitehead, Kathryn Ann; Nuhn, Lutz; Sahay, Gaurav; Cheng, Hao; Jiang, Shan; Ma, Minglin; Lytton-Jean, Abigail K. R.; Vegas, Arturo; Fenton, Patrick; Levins, Christopher G.; Love, Kevin T.; Lee, Haeshin; Cortez, Christina; Collins, Sean P.; Li, Ying Fei; Jang, Janice; Querbes, William; Zurenko, Christopher; Novobrantseva, Tatiana; Langer, Robert; Anderson, Daniel G. (National Academy of Sciences (U.S.), 2011-08)
    Analogous to an assembly line, we employed a modular design for the high-throughput study of 1,536 structurally distinct nanoparticles with cationic cores and variable shells. This enabled elucidation of complexation, ...
  • Langer, Robert; Kamaly, Nazila; Fredman, Gabrielle; Subramanian, Manikandan; Gadde, Suresh; Pesic, Alexsandar; Cheung, Louis; Fayad, Zahi Adel; Tabas, Ira; Cameron Farokhzad, Omid (National Academy of Sciences (U.S.), 2013-03)
    Excessive inflammation and failed resolution of the inflammatory response are underlying components of numerous conditions such as arthritis, cardiovascular disease, and cancer. Hence, therapeutics that dampen inflammation ...
  • Langer, Robert; Farokhzad, Omid C.; Gadde, Suresh; Kamaly, Nazila; Fredman, Gabrielle; Subramanian, Manikandan; Pesic, Aleksandar; Cheung, Louis; Fayad, Zahi Adel; Tabas, Ira (National Academy of Sciences (U.S.), 2013-03)
    Excessive inflammation and failed resolution of the inflammatory response are underlying components of numerous conditions such as arthritis, cardiovascular disease, and cancer. Hence, therapeutics that dampen inflammation ...
  • Shapiro, Mikhail G.; Westmeyer, Gil Gregor; Szablowski, Jerzy O.; Küster, Benedict; Shah, Ameer; Langer, Robert; Jasanoff, Alan Pradip; Romero, Philip A.; Arnold, Frances H.; Otey, Christopher R. (Nature Publishing Company, 2010-02)
    The development of molecular probes that allow in vivo imaging of neural signaling processes with high temporal and spatial resolution remains challenging. Here we applied directed evolution techniques to create magnetic ...
  • Hook, Andrew L.; Chang, Chien-Yi; Yang, Jing; Atkinson, Steve; Langer, Robert; Davies, Martyn C.; Williams, Paul; Alexander, Morgan R.; Anderson, Daniel Griffith (Wiley Blackwell, 2013-02)
    A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available ...
  • Mieszawska, Aneta J.; Gianella, Anita; Cormode, David P.; Zhao, Yiming; Meijerink, Andries; Langer, Robert; Farokhzad, Omid C.; Fayad, Zahi A.; Mulder, Willem J. M. (Royal Society of Chemistry, 2012-05)
    Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles ...
  • Kolishetti, Nagesh; Dhar, Shanta; Valencia, Pedro Miguel; Lin, Lucy Q.; Karnik, Rohit N.; Lippard, Stephen J.; Langer, Robert; Farokhzad, Omid C. (National Academy of Sciences (U.S.), 2010-10)
    The genomic revolution has identified therapeutic targets for a plethora of diseases, creating a need to develop robust technologies for combination drug therapy. In the present work, we describe a self-assembled polymeric ...
  • Xiao, Zeyu; Levy-Nissenbaum, Etgar; Alexis, Frank; Lupták, Andrej; Teply, Benjamin A.; Chan, Juliana M.; Shi, Jinjun; Digga, Elise; Cheng, Judy; Langer, Robert; Farokhzad, Omid C. (American Chemical Society, 2012-01)
    One of the major challenges in the development of targeted nanoparticles (NPs) for cancer therapy is to discover targeting ligands that allow for differential binding and uptake by the target cancer cells. Using prostate ...
  • Polat, Baris E.; Lin, Shangchao; Mendenhall, Jonathan David; VanVeller, Brett; Langer, Robert; Blankschtein, Daniel (American Chemical Society (ACS), 2011-01)
    Sulforhodamine B (SRB), a common fluorescent dye, is often considered to be a purely hydrophilic molecule, having no impact on bulk or interfacial properties of aqueous solutions. This assumption is due to the high water ...
  • Alabi, Christopher Akinleye; Love, Kevin T.; Sahay, Gaurav; Stutzman, Tina M.; Young, Whitney T.; Langer, Robert; Anderson, Daniel Griffith (American Chemical Society, 2012-06)
    The assembly, stability, and timely disassembly of short interfering RNA (siRNA) nanocomplexes have the potential to affect the efficiency of siRNA delivery and gene silencing. As such, the design of new probes that can ...
  • Yang, Fan; Cho, Seung Woo; Son, Sun Mi; Bogatyrev, Said R.; Singh, Deepika; Green, Jordan; Mei, Ying; Park, Sohyun; Bhang, Suk Ho; Kim, Byung-Soo; Langer, Robert; Anderson, Daniel G. (National Academy of Sciences, 2010-02)
    Stem cells hold great potential as cell-based therapies to promote vascularization and tissue regeneration. However, the use of stem cells alone to promote angiogenesis remains limited because of insufficient expression ...
  • Kohane, Daniel S.; Fink, Gerald R.; Langer, Robert; Hudson, Sarah (Elsevier, 2009-11)
    Invasive fungal infections can be devastating, particularly in immunocompromised patients, and difficult to treat with systemic drugs. Furthermore, systemic administration of those medications can have severe side effects. ...
  • Bonner, Daniel K.; Leung, Cheuk; Chen-Liang, Jane; Chingozha, Loice; Langer, Robert; Hammond, Paula T. (American Chemical Society, 2011-08)
    The delivery of nucleic acids has the potential to revolutionize medicine by allowing previously untreatable diseases to be clinically addressed. Viral delivery systems have shown immunogenicity and toxicity dangers, but ...
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