Advanced Search
DSpace@MIT

Browsing MIT Open Access Articles by Author "Langer, Robert"

Research and Teaching Output of the MIT Community

Browsing MIT Open Access Articles by Author "Langer, Robert"

Sort by: Order: Results:

  • Polat, Baris E.; Seto, Jennifer E.; Blankschtein, Daniel; Langer, Robert (Wiley Blackwell, 2011-02)
    This study investigated the effect of sodium lauryl sulfate (SLS) on skin structural perturbation when utilized simultaneously with low-frequency sonophoresis (LFS). Pig full-thickness skin (FTS) and pig split-thickness ...
  • Siegwart, Daniel J.; Leiendecker, Matthias; Langer, Robert; Anderson, Daniel Griffith (American Chemical Society, 2012-02)
    Conventional synthesis of polymers by ATRP is relatively low throughput, involving iterative optimization of conditions in an inert atmosphere. Automated, high-throughput controlled radical polymerization was developed to ...
  • Love, Kevin T.; Langer, Robert; Anderson, Daniel Griffith; Haq, Rizwan; Yokoyama, Satoru; Hawryluk, Elena B.; Jonsson, Goran B.; Frederick, Dennie Tompers; McHenry, Kevin; Porter, Dale; Tran, Thanh-Nga; Garraway, Levi A.; Duncan, Lyn McDivitt; Morton, Donald L.; Hoon, Dave S. B.; Wargo, Jennifer A.; Song, Jun S.; Fisher, David E. (National Academy of Sciences (U.S.), 2013-02)
    Although targeting oncogenic mutations in the BRAF serine/threonine kinase with small molecule inhibitors can lead to significant clinical responses in melanoma, it fails to eradicate tumors in nearly all patients. Successful ...
  • Wang, Jane; Bettinger, Christopher J.; Langer, Robert; Borenstein, Jeffrey T. (Landes Bioscience, 2010-10)
    Biodegradable polymers with high mechanical strength, flexibility and optical transparency, optimal degradation properties and biocompatibility are critical to the success of tissue engineered devices and drug delivery ...
  • Sharei, Armon Reza; Cho, Nahyun; Mao, Shirley; Jackson, Emily; Poceviciute, Roberta; Adamo, Andrea; Zoldan, Janet; Langer, Robert; Jensen, Klavs F. (MyJoVE Corporation, 2013-11)
    Rapid mechanical deformation of cells has emerged as a promising, vector-free method for intracellular delivery of macromolecules and nanomaterials. This technology has shown potential in addressing previously challenging ...
  • Abrahamsson, Christoffer K.; Yang, Fan; Park, Hyoungshin; Brunger, Jonathan M.; Valonen, Piia K.; Langer, Robert; Welter, Jean F.; Caplan, Arnold I.; Guilak, Farshid; Freed, Lisa E. (Mary Ann Liebert, Inc., 2010-07)
    Human mesenchymal stem cells (hMSCs) and three-dimensional (3D) woven poly(ɛ-caprolactone) (PCL) scaffolds are promising tools for skeletal tissue engineering. We hypothesized that in vitro culture duration and medium ...
  • Mei, Ying; Saha, Krishanu; Bogatyrev, Said R.; Yang, Jing; Hook, Andrew L.; Kalcioglu, Zeynep Ilke; Cho, Seung-Woo; Mitalipova, Maisam; Pyzocha, Neena; Rojas, Fredrick P.; Van Vliet, Krystyn J.; Davies, Martyn C.; Alexander, Morgan R.; Langer, Robert; Jaenisch, Rudolf; Anderson, Daniel G. (Nature Publishing Group, 2010-08)
    Both human embryonic stem cells and induced pluripotent stem cells can self-renew indefinitely in culture; however, present methods to clonally grow them are inefficient and poorly defined for genetic manipulation and ...
  • Hook, Andrew L; Chang, Chien-Yi; Yang, Jing; Luckett, Jeni; Cockayne, Alan; Atkinson, Steve; Mei, Ying; Bayston, Roger; Irvine, Derek J; Langer, Robert; Williams, Paul; Davies, Martyn C; Alexander, Morgan R; Anderson, Daniel Griffith (Nature Publishing Group, 2012-08)
    Bacterial attachment and subsequent biofilm formation pose key challenges to the optimal performance of medical devices. In this study, we determined the attachment of selected bacterial species to hundreds of polymeric ...
  • Sun, Shuo; Wang, Ming; Knupp, Sarah A.; Soto-Feliciano, Yadira; Hu, Xiao; Kaplan, David L.; Langer, Robert; Anderson, Daniel G.; Xu, Qiaobing (American Chemical Society, 2012-01)
    A combinatorial library of lipidoids was constructed and studied for in vitro gene delivery. The library of lipidoids was synthesized by reacting commercially available amines with lipophilic acrylates, acrylamides, or ...
  • Siegwart, Daniel; Whitehead, Kathryn Ann; Nuhn, Lutz; Sahay, Gaurav; Cheng, Hao; Jiang, Shan; Ma, Minglin; Lytton-Jean, Abigail K. R.; Vegas, Arturo; Fenton, Patrick; Levins, Christopher G.; Love, Kevin T.; Lee, Haeshin; Cortez, Christina; Collins, Sean P.; Li, Ying Fei; Jang, Janice; Querbes, William; Zurenko, Christopher; Novobrantseva, Tatiana; Langer, Robert; Anderson, Daniel G. (National Academy of Sciences (U.S.), 2011-08)
    Analogous to an assembly line, we employed a modular design for the high-throughput study of 1,536 structurally distinct nanoparticles with cationic cores and variable shells. This enabled elucidation of complexation, ...
  • Eltoukhy, Ahmed A.; Chen, Delai; Alabi, Christopher A.; Langer, Robert; Anderson, Daniel Griffith (Wiley-VCH Verlag GmbH & Co., 2013-03)
    Degradable, cationic poly(β-amino ester)s (PBAEs) with alkyl side chains are developed for non-viral gene delivery. Nanoparticles formed from these PBAE terpolymers exhibit significantly enhanced DNA transfection potency ...
  • Langer, Robert; Kamaly, Nazila; Fredman, Gabrielle; Subramanian, Manikandan; Gadde, Suresh; Pesic, Alexsandar; Cheung, Louis; Fayad, Zahi Adel; Tabas, Ira; Cameron Farokhzad, Omid (National Academy of Sciences (U.S.), 2013-03)
    Excessive inflammation and failed resolution of the inflammatory response are underlying components of numerous conditions such as arthritis, cardiovascular disease, and cancer. Hence, therapeutics that dampen inflammation ...
  • Langer, Robert; Farokhzad, Omid C.; Gadde, Suresh; Kamaly, Nazila; Fredman, Gabrielle; Subramanian, Manikandan; Pesic, Aleksandar; Cheung, Louis; Fayad, Zahi Adel; Tabas, Ira (National Academy of Sciences (U.S.), 2013-03)
    Excessive inflammation and failed resolution of the inflammatory response are underlying components of numerous conditions such as arthritis, cardiovascular disease, and cancer. Hence, therapeutics that dampen inflammation ...
  • Alabi, Christopher A.; Sahay, Gaurav; Langer, Robert; Anderson, Daniel Griffith (Royal Society of Chemistry, 2012-08)
    One important barrier facing the delivery of short interfering RNAs (siRNAs) via synthetic nanoparticles is the rate of nanoparticle disassembly. However, our ability to optimize the release kinetics of siRNAs from ...
  • Shapiro, Mikhail G.; Westmeyer, Gil Gregor; Szablowski, Jerzy O.; Küster, Benedict; Shah, Ameer; Langer, Robert; Jasanoff, Alan Pradip; Romero, Philip A.; Arnold, Frances H.; Otey, Christopher R. (Nature Publishing Company, 2010-02)
    The development of molecular probes that allow in vivo imaging of neural signaling processes with high temporal and spatial resolution remains challenging. Here we applied directed evolution techniques to create magnetic ...
  • Hook, Andrew L.; Chang, Chien-Yi; Yang, Jing; Atkinson, Steve; Langer, Robert; Davies, Martyn C.; Williams, Paul; Alexander, Morgan R.; Anderson, Daniel Griffith (Wiley Blackwell, 2013-02)
    A new class of bacteria-attachment-resistant materials is discovered using a multi-generation polymer microarray methodology that reduces bacterial attachment by up to 99.3% compared with a leading commercially available ...
  • Sahay, Gaurav; Querbes, William; Alabi, Christopher; Eltoukhy, Ahmed A.; Sarkar, Sovan; Zurenko, Christopher; Karagiannis, Emmanouil; Love, Kevin; Chen, Delai; Zoncu, Roberto; Buganim, Yosef; Schroeder, Avi; Langer, Robert; Anderson, Daniel Griffith (2013-06)
    Despite efforts to understand the interactions between nanoparticles and cells, the cellular processes that determine the efficiency of intracellular drug delivery remain unclear. Here we examine cellular uptake of short ...
  • Mieszawska, Aneta J.; Gianella, Anita; Cormode, David P.; Zhao, Yiming; Meijerink, Andries; Langer, Robert; Farokhzad, Omid C.; Fayad, Zahi A.; Mulder, Willem J. M. (Royal Society of Chemistry, 2012-05)
    Polylactic-co-glycolic acid (PLGA) based nanoparticles are biocompatible and biodegradable and therefore have been extensively investigated as therapeutic carriers. Here, we engineered diagnostically active PLGA nanoparticles ...
  • Kolishetti, Nagesh; Dhar, Shanta; Valencia, Pedro Miguel; Lin, Lucy Q.; Karnik, Rohit N.; Lippard, Stephen J.; Langer, Robert; Farokhzad, Omid C. (National Academy of Sciences (U.S.), 2010-10)
    The genomic revolution has identified therapeutic targets for a plethora of diseases, creating a need to develop robust technologies for combination drug therapy. In the present work, we describe a self-assembled polymeric ...
  • Xiao, Zeyu; Levy-Nissenbaum, Etgar; Alexis, Frank; Lupták, Andrej; Teply, Benjamin A.; Chan, Juliana M.; Shi, Jinjun; Digga, Elise; Cheng, Judy; Langer, Robert; Farokhzad, Omid C. (American Chemical Society, 2012-01)
    One of the major challenges in the development of targeted nanoparticles (NPs) for cancer therapy is to discover targeting ligands that allow for differential binding and uptake by the target cancer cells. Using prostate ...
Open Access