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Browsing MIT Open Access Articles by Author "Sasisekharan, Ram"

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Browsing MIT Open Access Articles by Author "Sasisekharan, Ram"

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  • Tharakaraman, Kannan; Raman, Rahul; Stebbins, Nathan W.; Viswanathan, Karthik; Sasisekharan, Viswanathan; Sasisekharan, Ram (Nature Publishing Group, 2013-05)
    The 2009 swine-origin H1N1 influenza, though antigenically novel to the population at the time, was antigenically similar to the 1918 H1N1 pandemic influenza, and consequently was considered to be “archived” in the swine ...
  • Bosques, Carlos J; Collins, Brian E; Meador, James W; Sarvaiya, Hetal; Murphy, Jennifer L; DelloRusso, Guy; Bulik, Dorota A; Hsu, I-Hsuan; Washburn, Nathaniel; Sipsey, Sandra F; Myette, James R; Raman, Rahul; Sasisekharan, Ram; Venkataraman, Ganesh; Shriver, Zachary H. (Nature Publishing Group, 2010-11)
    Chinese hamster ovary (CHO) cells are widely used for the manufacture of biotherapeutics, in part because of their ability to produce proteins with desirable properties, including 'human-like' glycosylation profiles. For ...
  • Aich, Udayanath; Shriver, Zachary H.; Tharakaraman, Kannan; Raman, Rahul; Sasisekharan, Ram (American Chemical Society, 2011-08)
    Heparin and the low molecular weight heparins are extensively used as medicinal products to prevent and treat the formation of venous and arterial thrombi. In early 2008, administration of some heparin lots was associated ...
  • Jayaraman, Akila; Chandrasekaran, Aarthi; Viswanathan, Karthik; Raman, Rahul; Fox, James G.; Sasisekharan, Ram (Public Library of Science, 2012-02)
    Ferrets are widely used as animal models for studying influenza A viral pathogenesis and transmissibility. Human-adapted influenza A viruses primarily target the upper respiratory tract in humans (infection of the lower ...
  • Viswanathan, Karthik; Koh, Xiaoying; Chandrasekaran, Aarthi; Pappas, Claudia; Raman, Rahul; Srinivasan, Aravind; Shriver, Zachary; Tumpey, Terrence M.; Sasisekharan, Ram (Public Library of Science, 2010-10)
    The H2N2 subtype of influenza A virus was responsible for the Asian pandemic of 1957-58. However, unlike other subtypes that have caused pandemics such as H1N1 and H3N2, which continue to circulate among humans, H2N2 stopped ...
  • Belser, Jessica A.; Pappas, Claudia; Zeng, Hui; Cox, Nancy J.; Katz, Jacqueline M.; Tumpey, Terrence M.; Jayaraman, Akila; Raman, Rahul; Sasisekharan, Ram (Public Library of Science, 2011-09)
    Influenza viruses isolated during the 2009 H1N1 pandemic generally lack known molecular determinants of virulence associated with previous pandemic and highly pathogenic avian influenza viruses. The frequency of the amino ...
  • Tharakaraman, Kannan; Jayaraman, Akila; Raman, Rahul; Viswanathan, Karthik; Stebbins, Nathan W.; Johnson, David Alan; Shriver, Zachary H.; Sasisekharan, V.; Sasisekharan, Ram; Stebbins, Nathan W. (Elsevier B.V., 2013-06)
    The advent of H7N9 in early 2013 is of concern for a number of reasons, including its capability to infect humans, the lack of clarity in the etiology of infection, and because the human population does not have pre-existing ...
  • Viswanathan, Karthik; Chandrasekaran, Aarthi; Srinivasan, Aravind; Raman, Rahul; Sasisekharan, V.; Sasisekharan, Ram (2010-08)
    Influenza A viruses, members of the Orthomyxoviridae family, are responsible for annual seasonal influenza epidemics and occasional global pandemics. The binding of viral coat glycoprotein hemagglutinin (HA) to sialylated ...
  • Eavarone, David; Kiziltepe, Tanyel; Sasisekharan, Ram; Sengupta, Shiladitya; Harfouche, Rania; Hentschel, Dirk M.; Piecewicz, Stephanie; Basu, Sudipta; Print, Cristin (American Heart Association, 2009-10)
    Background— Therapeutic vasculogenesis is an emerging concept that can potentially be harnessed for the management of ischemic pathologies. The present study elucidates the potential coregulation of vasculogenesis by the ...
  • Aich, Udayanath; Beckley, Nia; Shriver, Zachary H.; Raman, Rahul; Viswanathan, Karthik; Hobbie, Sven; Sasisekharan, Ram (John Wiley & Sons, Inc, 2011-05)
    Agglutination of red blood cells (RBCs), including chicken RBCs (cRBCs), has been used extensively to estimate viral titer, to screen glycan-receptor binding preference, and to assess the protective response of vaccines. ...
  • Jayaraman, Akila; Koh, Xiaoying; Li, Jing; Raman, Rahul; Viswanathan, Karthik; Shriver, Zachary H.; Sasisekharan, Ram (Portland Press, 2012-05)
    The glycoprotein HA (haemagglutinin) on the surface of influenza A virus plays a central role in recognition and binding to specific host cell-surface glycan receptors and in fusion of viral membrane to the host nuclear ...
  • Robinson, Luke N.; Artpradit, Charlermchai; Raman, Rahul; Shriver, Zachary H.; Ruchirawat, Mathuros; Sasisekharan, Ram (Wiley Blackwell, 2012-04)
    Glycans, or complex carbohydrates, are a ubiquitous class of biological molecule which impinge on a variety of physiological processes ranging from signal transduction to tissue development and microbial pathogenesis. In ...
  • Hensley, Scott E.; Das, Suman R.; Bailey, Adam L.; Schmidt, Loren M.; Hickman, Heather D.; Bennink, Jack R.; Yewdell, Jonathan W.; Jayaraman, Akila; Viswanathan, Karthik; Raman, Rahul; Sasisekharan, Ram (American Association for the Advancement of Science, 2009-10)
    Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza vaccine. Neutralizing ...
  • Shriver, Zachary H.; Capila, Ishan; Venkataraman, Ganesh; Sasisekharan, Ram (Springer-Verlag Berlin Heidelberg, 2012)
    The structural microheterogeneity of heparin and heparan sulfate is one of the major reasons for the multifunctionality exhibited by this class of molecules. In a physiological context, these molecules primarily exert their ...
  • Shriver, Zachary H.; Sasisekharan, Ram (Nature Publishing Group, 2013-07)
    Heparin is an anionic polysaccharide that has tremendous clinical importance as an anticoagulant. Several dyes have been developed that can detect heparin, and the latest example — named Mallard Blue — has now been shown ...
  • Hobbie, Sven N; Viswanathan, Karthik; Bachelet, Ido; Aich, Udayanath; Subramanian, Vidya; Raman, Rahul; Sasisekharan, Ram; Shriver, Zachary H.; Shriver, Zachary (BioMed Central Ltd, 2013-04)
    Background: The ongoing global efforts to control influenza epidemics and pandemics require high-throughput technologies to detect, quantify, and functionally characterize viral isolates. The 2009 influenza pandemic as ...
  • Soundararajan, Venkataramanan; Zheng, Shu; Patel, Neel; Warnock, Ken; Raman, Rahul; Wilson, Ian A.; Raguram, S.; Sasisekharan, V.; Sasisekharan, Ram (Nature Publishing Group, 2011-12)
    Influenza viral passaging through pre-vaccinated mice shows that emergent antigenic site mutations on the viral hemagglutinin (HA) impact host receptor-binding affinity and, therefore, the evolution of fitter influenza ...
  • Shriver, Zachary; Langer, Robert; Sasisekharan, Ram; Guerrini, Marco; Zhang, Zhenqing; Naggi, Annamaria; Masuko, Sayaka; Casu, Casu; Linhardt, Robert J.; Torri, Giangiacomo (National Academy of Sciences (U.S.), 2009-09)
    Heparin is a widely used anticoagulant and antithrombotic agent. Recently, a contaminant, oversulfated chondroitin sulfate (OSCS), was discovered within heparin preparations. The presence of OSCS within heparin likely led ...
  • Srinivasan, Karunya; Raman, Rahul; Jayaraman, Akila; Viswanathan, Karthik; Sasisekharan, Ram (Public Library of Science, 2013-02)
    In the context of recently emerged novel influenza strains through reassortment, avian influenza subtypes such as H5N1, H7N7, H7N2, H7N3 and H9N2 pose a constant threat in terms of their adaptation to the human host. Among ...
  • Morris, Melody K.; Sasisekharan, Ram; Lauffenburger, Douglas A.; Shriver, Zachary H. (Wiley Blackwell, 2011-11)
    Mathematical models have substantially improved our ability to predict the response of a complex biological system to perturbation, but their use is typically limited by difficulties in specifying model topology and parameter ...
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