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Browsing MIT Open Access Articles by Author "Sasisekharan, Ram"

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Browsing MIT Open Access Articles by Author "Sasisekharan, Ram"

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  • Shriver, Zachary; Trevejo, Jose M.; Sasisekharan, Ram (Frontiers Research Foundation, 2015-07)
    Passive immunization using antibodies is a promising alternative to other antiviral treatment options. The potential for seasonal protection arising from a single injection of antibodies is appealing and has been pursued ...
  • Tharakaraman, Kannan; Raman, Rahul; Stebbins, Nathan W.; Viswanathan, Karthik; Sasisekharan, Viswanathan; Sasisekharan, Ram (Nature Publishing Group, 2013-05)
    The 2009 swine-origin H1N1 influenza, though antigenically novel to the population at the time, was antigenically similar to the 1918 H1N1 pandemic influenza, and consequently was considered to be “archived” in the swine ...
  • Tharakaraman, Kannan; Subramanian, Vidya; Viswanathan, Karthik; Sloan, Susan; Yen, Hui-Ling; Barnard, Dale L.; Leung, Y. H. Connie; Szretter, Kristy J.; Koch, Tyree J.; Delaney, James C.; Babcock, Gregory J.; Wogan, Gerald N.; Sasisekharan, Ram; Shriver, Zachary (National Academy of Sciences (U.S.), 2015-09)
    Emerging strains of influenza represent a significant public health threat with potential pandemic consequences. Of particular concern are the recently emerged H7N9 strains which cause pneumonia with acute respiratory ...
  • Tharakaraman, Kannan; Subramanian, Vidya; Cain, David; Sasisekharan, Viswanathan; Sasisekharan, Ram (Elsevier, 2014-05)
    Broadly neutralizing antibodies (bNAb) that target a conserved region of a viral antigen hold significant therapeutic promise. CR8020 is a bNAb that targets the stem region of influenza A virus (IAV) hemagglutinin (HA). ...
  • Bosques, Carlos J.; Collins, Brian E.; Meador, James W.; Sarvaiya, Hetal; Murphy, Jennifer L.; DelloRusso, Guy; Bulik, Dorota A.; Hsu, I-Hsuan; Washburn, Nathaniel; Sipsey, Sandra F.; Myette, James R.; Raman, Rahul; Sasisekharan, Ram; Venkataraman, Ganesh; Shriver, Zachary H. (Nature Publishing Group, 2010-11)
    Chinese hamster ovary (CHO) cells are widely used for the manufacture of biotherapeutics, in part because of their ability to produce proteins with desirable properties, including 'human-like' glycosylation profiles. For ...
  • Aich, Udayanath; Shriver, Zachary H.; Tharakaraman, Kannan; Raman, Rahul; Sasisekharan, Ram (American Chemical Society, 2011-08)
    Heparin and the low molecular weight heparins are extensively used as medicinal products to prevent and treat the formation of venous and arterial thrombi. In early 2008, administration of some heparin lots was associated ...
  • Raman, Rahul; Viswanathan, Karthik; Sasisekharan, Ram; Shriver, Zachary H. (Elsevier, 2009-08)
    Protein-glycan interactions are important regulators of a variety of biological processes, ranging from immune recognition to anticoagulation. An important area of active research is directed toward understanding the role ...
  • Jayaraman, Akila; Chandrasekaran, Aarthi; Viswanathan, Karthik; Raman, Rahul; Fox, James G.; Sasisekharan, Ram (Public Library of Science, 2012-02)
    Ferrets are widely used as animal models for studying influenza A viral pathogenesis and transmissibility. Human-adapted influenza A viruses primarily target the upper respiratory tract in humans (infection of the lower ...
  • Viswanathan, Karthik; Koh, Xiaoying; Chandrasekaran, Aarthi; Pappas, Claudia; Raman, Rahul; Srinivasan, Aravind; Shriver, Zachary; Tumpey, Terrence M.; Sasisekharan, Ram (Public Library of Science, 2010-10)
    The H2N2 subtype of influenza A virus was responsible for the Asian pandemic of 1957-58. However, unlike other subtypes that have caused pandemics such as H1N1 and H3N2, which continue to circulate among humans, H2N2 stopped ...
  • Belser, Jessica A.; Pappas, Claudia; Zeng, Hui; Cox, Nancy J.; Katz, Jacqueline M.; Tumpey, Terrence M.; Jayaraman, Akila; Raman, Rahul; Sasisekharan, Ram (Public Library of Science, 2011-09)
    Influenza viruses isolated during the 2009 H1N1 pandemic generally lack known molecular determinants of virulence associated with previous pandemic and highly pathogenic avian influenza viruses. The frequency of the amino ...
  • Maines, Taronna R.; Chen, Li-Mei; Van Hoeven, Neal; Tumpey, Terrence M.; Blixt, Ola; Belser, Jessica A.; Gustin, Kortney M.; Pearce, Melissa B.; Pappas, Claudia; Stevens, James; Cox, Nancy J.; Paulson, James C.; Raman, Rahul; Sasisekharan, Ram; Katz, Jacqueline M.; Donis, Ruben O. (Elsevier, 2011-03)
    Although H5N1 influenza viruses have been responsible for hundreds of human infections, these avian influenza viruses have not fully adapted to the human host. The lack of sustained transmission in humans may be due, in ...
  • Tharakaraman, Kannan; Jayaraman, Akila; Raman, Rahul; Viswanathan, Karthik; Stebbins, Nathan W.; Johnson, David Alan; Shriver, Zachary H.; Sasisekharan, V.; Sasisekharan, Ram; Stebbins, Nathan W. (Elsevier B.V., 2013-06)
    The advent of H7N9 in early 2013 is of concern for a number of reasons, including its capability to infect humans, the lack of clarity in the etiology of infection, and because the human population does not have pre-existing ...
  • Raman, Rahul; Tharakaraman, Kannan; Jayaraman, Akila; Sasisekharan, Ram; Shriver, Zachary H.; Sasisekharan, Viswanathan (Elsevier, 2014-08)
    Influenza A viruses are rapidly evolving pathogens with the potential for novel strains to emerge and result in pandemic outbreaks in humans. Some avian-adapted subtypes have acquired the ability to bind to human glycan ...
  • Viswanathan, Karthik; Chandrasekaran, Aarthi; Srinivasan, Aravind; Raman, Rahul; Sasisekharan, V.; Sasisekharan, Ram (2010-08)
    Influenza A viruses, members of the Orthomyxoviridae family, are responsible for annual seasonal influenza epidemics and occasional global pandemics. The binding of viral coat glycoprotein hemagglutinin (HA) to sialylated ...
  • Eavarone, David A.; Kiziltepe, Tanyel; Sasisekharan, Ram; Sengupta, Shiladitya; Harfouche, Rania; Hentschel, Dirk M.; Piecewicz, Stephanie; Basu, Sudipta; Print, Cristin (American Heart Association, 2009-10)
    Background— Therapeutic vasculogenesis is an emerging concept that can potentially be harnessed for the management of ischemic pathologies. The present study elucidates the potential coregulation of vasculogenesis by the ...
  • Aich, Udayanath; Beckley, Nia; Shriver, Zachary H.; Raman, Rahul; Viswanathan, Karthik; Hobbie, Sven N.; Sasisekharan, Ram (John Wiley & Sons, Inc, 2011-05)
    Agglutination of red blood cells (RBCs), including chicken RBCs (cRBCs), has been used extensively to estimate viral titer, to screen glycan-receptor binding preference, and to assess the protective response of vaccines. ...
  • Jayaraman, Akila; Koh, Xiaoying; Li, Jing; Raman, Rahul; Viswanathan, Karthik; Shriver, Zachary H.; Sasisekharan, Ram (Portland Press, 2012-05)
    The glycoprotein HA (haemagglutinin) on the surface of influenza A virus plays a central role in recognition and binding to specific host cell-surface glycan receptors and in fusion of viral membrane to the host nuclear ...
  • Robinson, Luke N.; Artpradit, Charlermchai; Raman, Rahul; Shriver, Zachary H.; Ruchirawat, Mathuros; Sasisekharan, Ram (Wiley Blackwell, 2012-04)
    Glycans, or complex carbohydrates, are a ubiquitous class of biological molecule which impinge on a variety of physiological processes ranging from signal transduction to tissue development and microbial pathogenesis. In ...
  • Hensley, Scott E.; Das, Suman R.; Bailey, Adam L.; Schmidt, Loren M.; Hickman, Heather D.; Bennink, Jack R.; Yewdell, Jonathan W.; Jayaraman, Akila; Viswanathan, Karthik; Raman, Rahul; Sasisekharan, Ram (American Association for the Advancement of Science, 2009-10)
    Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we passaged virus in mice immunized with influenza vaccine. Neutralizing ...
  • Shriver, Zachary H.; Capila, Ishan; Venkataraman, Ganesh; Sasisekharan, Ram (Springer-Verlag Berlin Heidelberg, 2012)
    The structural microheterogeneity of heparin and heparan sulfate is one of the major reasons for the multifunctionality exhibited by this class of molecules. In a physiological context, these molecules primarily exert their ...
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